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Journal of the American Society of Nephrology, Vol 6, 54-60, Copyright © 1995 by American Society of Nephrology

REGULAR ARTICLES

Transmission of cancer with cadaveric donor organs

PJ Conlon and SR Smith
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

A case is presented in which each of the recipients of a pair of cadaveric kidneys developed metastatic carcinoma. One of the recipients died, and the other demonstrated involution of metastatic deposits after graft nephrectomy and withdrawal of immunosuppression. By the use of polymerase chain reaction of minisatellite regions of donor and recipient DNA, the donor origin of the tumor was conclusively demonstrated. Although a relatively uncommon complication of cadaveric renal transplantation, the transmission of cancer with cadaveric organs may become more frequent as older donors are accepted for organ donation.


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 Nephrol Dial TransplantHome page
C. A. Wall, G. J. M. Mellotte, and J. A. B. Keogh
Low-grade lymphoma in a cadaveric renal transplant donor following organ transplantation: recipient management and outcome
Nephrol. Dial. Transplant., July 1, 2000; 15(7): 1069 - 1071.
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