Journal of the American Society of Nephrology
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Journal of the American Society of Nephrology, Vol 6, 165-170, Copyright © 1995 by American Society of Nephrology


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Cholesterol emboli presenting as acute allograft dysfunction after renal transplantation

I Singh, PD Killen and AB Leichtman
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109-0364, USA.

Cholesterol emboli are a common complication of atherosclerotic vascular disease. A 40-yr-old renal transplant recipient who developed acute allograft dysfunction 1 day after the initiation of cyclosporine therapy and 6 days after transplantation is described. A renal allograft biopsy revealed cholesterol emboli in interlobular arteries and in glomeruli. Four previously reported cases of cholesterol emboli in renal allografts are described, and the cause and pathogenesis of atheroembolic disease are reviewed. Atheroemboli causing injury to the renal allograft may arise from either donor or recipient vessels. Vigilance for the occurrence of these emboli needs to be maintained when donor or recipient vessels demonstrate evidence of significant atherosclerotic vascular disease.


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