Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leypoldt, J. K.
Right arrow Articles by Conis, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leypoldt, J. K.
Right arrow Articles by Conis, J. M.

Journal of the American Society of Nephrology, Vol 6, 214-219, Copyright © 1995 by American Society of Nephrology

REGULAR ARTICLES

Determination of circulating blood volume by continuously monitoring hematocrit during hemodialysis

JK Leypoldt, AK Cheung, RR Steuer, DH Harris and JM Conis
VA Medical Center, Salt Lake City, UT 84148, USA.

Dialysis-induced hypovolemia occurs because the rate of extracorporeal ultrafiltration exceeds the rate of refilling of the blood compartment. The purpose of this study was to evaluate a method for calculating circulating blood volume (BV) during hemodialysis (HD) from changes in hematocrit (Hct) shortly (2 to 10 min) before and after ultrafiltration (UF) was abruptly stopped. Hct was monitored continuously during 93 HD treatment sessions in 16 patients by an optical technique and at selected times by centrifugation of blood samples. Total plasma protein and albumin concentrations were also measured at selected times. Continuously monitored Hct correlated with Hct determined by centrifugation (R = 0.89, N = 579). Relative changes in BV determined by continuously monitored Hct were not different from those determined by total plasma protein concentration (P = 0.05; N = 273). Calculated BV at the start of dialysis (4.1 +/- 1.3 L) was not different (P = 0.18, N = 12) from that derived anthropometrically from the patient's dry weight (4.6 +/- 0.8 L), and calculated BV when UF was stopped was 3.2 +/- 0.5 L (46 +/- 7 ml/kg body wt). These latter estimates of BV are consistent with those determined previously by dilution techniques in HD patients. It was concluded that (1) relative changes in BV assessed by continuously monitored Hct were unbiased and (2) BV can be determined noninvasively during HD by continuously monitoring Hct and temporarily stopping UF.


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
K. L. Schroeder, J. E. Sallustio, and E. A. Ross
Continuous haematocrit monitoring during intradialytic hypotension: precipitous decline in plasma refill rates
Nephrol. Dial. Transplant., March 1, 2004; 19(3): 652 - 656.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
F. M. VAN DER SANDE, U. GLADZIWA, J. P. KOOMAN, G. BÖCKER, and K. M. L. LEUNISSEN
Energy Transfer Is the Single Most Important Factor for the Difference in Vascular Response between Isolated Ultrafiltration and Hemodialysis
J. Am. Soc. Nephrol., August 1, 2000; 11(8): 1512 - 1517.
[Abstract] [Full Text]

Home page
 J. Am. Soc. Nephrol.Home page
F. M. VAN DER SANDE, A. J. LUIK, J. P. KOOMAN, V. VERSTAPPEN, and K. M. L. LEUNISSEN
Effect of Intravenous Fluids on Blood Pressure Course during Hemodialysis in Hypotensive-Prone Patients
J. Am. Soc. Nephrol., March 1, 2000; 11(3): 550 - 555.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
F. M. VAN DER SANDE, J. P. KOOMAN, J. N. M. BARENDREGT, F. H. M. NIEMAN, and K. M. L. LEUNISSEN
Effect of Intravenous Saline, Albumin, or Hydroxyethylstarch on Blood Volume during Combined Ultrafiltration and Hemodialysis
J. Am. Soc. Nephrol., June 1, 1999; 10(6): 1303 - 1308.
[Abstract] [Full Text]

Home page
 J. Am. Soc. Nephrol.Home page
J. Q. JAEGER and R. L. MEHTA
Assessment of Dry Weight in Hemodialysis: An Overview
J. Am. Soc. Nephrol., February 1, 1999; 10(2): 392 - 403.
[Abstract] [Full Text]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673