Journal of the American Society of Nephrology
2007 JASN IMPACT FACTOR 7.111 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eddy, A. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eddy, A. A.

Journal of the American Society of Nephrology, Vol 7, 2495-2508, Copyright © 1996 by American Society of Nephrology

REVIEWS

Molecular insights into renal interstitial fibrosis

AA Eddy

Progressive interstitial fibrosis accompanied by loss of renal tubules and interstitial capillaries typifies all progressive renal diseases. Dynamic and complex, the process evidently overlaps with matrix remodeling; it may even be reversible. The interstitial fibrous tissue comprises several normal and novel matrix proteins, proteoglycans, and glycoproteins. Interstitial myofibroblasts are a major site of matrix protein overproduction, although resident fibroblasts, tubular cells, and inflammatory cells may contribute. Inadequate matrix degradation also appears to contribute to the fibrogenic process. Two protease cascades, the metalloproteinases and the plasminogen activator/ plasmin family of serine proteases, are implicated in the turnover of interstitial matrix proteins; upregulated expression of protease inhibitors has been observed in each. Increased tissue inhibitor of metalloproteinase-1 and plasminogen activator inhibitor-1 levels suggest that the intrinsic renal activity of the metalloproteinases and serine proteases are inhibited while matrix proteins accumulate in the interstitium. Several signals that may direct the interstitial fibrogenic process have been identified, but not yet proved to cause it. Upregulated expression of transforming growth factor beta-1, the proteotypic fibrogenic cytokine, has been observed in experimental and human models; it probably does not act alone. There may be supportive roles for platelet-derived growth factor, interleukin-1, basic fibroblast growth factor, angiotensin II, and endothelin-1. Although it is not known why interstitial fibrosis compromises renal function, atrophy of renal tubules may be pivotal. Ischemic necrosis and/or apoptosis may generate nonfunctioning atubular and sclerotic glomeruli. Future studies must delineate the molecular basis of the differences between renal repair and renal destruction by fibrosis, two processes that share many common features.


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
E. M. Zeisberg, S. E. Potenta, H. Sugimoto, M. Zeisberg, and R. Kalluri
Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition
J. Am. Soc. Nephrol., December 1, 2008; 19(12): 2282 - 2287.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Stoessel, A. Paliege, F. Theilig, F. Addabbo, B. Ratliff, J. Waschke, D. Patschan, M. S. Goligorsky, and S. Bachmann
Indolent course of tubulointerstitial disease in a mouse model of subpressor, low-dose nitric oxide synthase inhibition
Am J Physiol Renal Physiol, September 1, 2008; 295(3): F717 - F725.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
H. Kitamura, Y. Isaka, Y. Takabatake, R. Imamura, C. Suzuki, S. Takahara, and E. Imai
Nonerythropoietic derivative of erythropoietin protects against tubulointerstitial injury in a unilateral ureteral obstruction model
Nephrol. Dial. Transplant., May 1, 2008; 23(5): 1521 - 1528.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
M. Li, K. S. Hering-Smith, E. E. Simon, and V. Batuman
Myeloma light chains induce epithelial-mesenchymal transition in human renal proximal tubule epithelial cells
Nephrol. Dial. Transplant., March 1, 2008; 23(3): 860 - 870.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
V. Pollack, R. Sarkozi, Z. Banki, E. Feifel, S. Wehn, G. Gstraunthaler, H. Stoiber, G. Mayer, R. Montesano, F. Strutz, et al.
Oncostatin M-induced effects on EMT in human proximal tubular cells: differential role of ERK signaling
Am J Physiol Renal Physiol, November 1, 2007; 293(5): F1714 - F1726.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Zhang, Z. Jia, X. Guo, and T. Yang
Aldosterone induces epithelial-mesenchymal transition via ROS of mitochondrial origin
Am J Physiol Renal Physiol, September 1, 2007; 293(3): F723 - F731.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
N. I. Chaudhary, G. J. Roth, F. Hilberg, J. Muller-Quernheim, A. Prasse, G. Zissel, A. Schnapp, and J. E. Park
Inhibition of PDGF, VEGF and FGF signalling attenuates fibrosis
Eur. Respir. J., May 1, 2007; 29(5): 976 - 985.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
B. Bauvois, N. Mothu, J. Nguyen, T. Nguyen-Khoa, L.-H. Noel, and P. Jungers
Specific changes in plasma concentrations of matrix metalloproteinase-2 and -9, TIMP-1 and TGF-{beta}1 in patients with distinct types of primary glomerulonephritis
Nephrol. Dial. Transplant., April 1, 2007; 22(4): 1115 - 1122.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. K. Meldrum, R. Misseri, P. Metcalfe, C. A. Dinarello, K. L. Hile, and D. R. Meldrum
TNF-{alpha} neutralization ameliorates obstruction-induced renal fibrosis and dysfunction
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1456 - R1464.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
H. Y. Li, F. F. Hou, X. Zhang, P. Y. Chen, S. X. Liu, J. X. Feng, Z. Q. Liu, Y. X. Shan, G. B. Wang, Z. M. Zhou, et al.
Advanced Oxidation Protein Products Accelerate Renal Fibrosis in a Remnant Kidney Model
J. Am. Soc. Nephrol., February 1, 2007; 18(2): 528 - 538.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. O'Riordan, N. Mendelev, S. Patschan, D. Patschan, J. Eskander, L. Cohen-Gould, P. Chander, and M. S. Goligorsky
Chronic NOS inhibition actuates endothelial-mesenchymal transformation
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H285 - H294.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
O. Vagin, E. Tokhtaeva, and G. Sachs
The Role of the beta1 Subunit of the Na,K-ATPase and Its Glycosylation in Cell-Cell Adhesion
J. Biol. Chem., December 22, 2006; 281(51): 39573 - 39587.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Zhang, M.-H. Wang, Z. Dong, and T. Yang
Prostaglandin E2 is a potent inhibitor of epithelial-to-mesenchymal transition: interaction with hepatocyte growth factor
Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1323 - F1331.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Zhang, Z. Dong, and T. Yang
Prostaglandin D2 inhibits TGF-beta1-induced epithelial-to-mesenchymal transition in MDCK cells
Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1332 - F1342.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Zhang, D. Fraser, and A. Phillips
ERK, p38, and Smad Signaling Pathways Differentially Regulate Transforming Growth Factor-{beta}1 Autoinduction in Proximal Tubular Epithelial Cells
Am. J. Pathol., October 1, 2006; 169(4): 1282 - 1293.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Furuichi, J.-L. Gao, and P. M. Murphy
Chemokine Receptor CX3CR1 Regulates Renal Interstitial Fibrosis after Ischemia-Reperfusion Injury
Am. J. Pathol., August 1, 2006; 169(2): 372 - 387.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
I. M. D. Pecly, R. G. Goncalves, E. P. Rangel, C. M. Takiya, F. S. Taboada, C. A. Martinusso, M. S. G. Pavao, and M. Leite Jr
Effects of low molecular weight heparin in obstructed kidneys: decrease of collagen, fibronectin and TGF-{beta}, and increase of chondroitin/dermatan sulfate proteoglycans and macrophage infiltration
Nephrol. Dial. Transplant., May 1, 2006; 21(5): 1212 - 1222.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. H. Kim, J. I. Yang, M. H. Jung, J. S. Hwa, K.-R. Kang, D. J. Park, G. S. Roh, G. J. Cho, W. S. Choi, and S.-H. Chang
Heme Oxygenase-1 Protects Rat Kidney from Ureteral Obstruction via an Antiapoptotic Pathway
J. Am. Soc. Nephrol., May 1, 2006; 17(5): 1373 - 1381.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. I. Chaudhary, A. Schnapp, and J. E. Park
Pharmacologic Differentiation of Inflammation and Fibrosis in the Rat Bleomycin Model
Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 769 - 776.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. Omata, H. Taniguchi, D. Koya, K. Kanasaki, R. Sho, Y. Kato, R. Kojima, M. Haneda, and N. Inomata
N-Acetyl-Seryl-Aspartyl-Lysyl-Proline Ameliorates the Progression of Renal Dysfunction and Fibrosis in WKY Rats with Established Anti-Glomerular Basement Membrane Nephritis
J. Am. Soc. Nephrol., March 1, 2006; 17(3): 674 - 685.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S.-L. Lin, R.-H. Chen, Y.-M. Chen, W.-C. Chiang, C.-F. Lai, K.-D. Wu, and T.-J. Tsai
Pentoxifylline Attenuates Tubulointerstitial Fibrosis by Blocking Smad3/4-Activated Transcription and Profibrogenic Effects of Connective Tissue Growth Factor
J. Am. Soc. Nephrol., September 1, 2005; 16(9): 2702 - 2713.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
W. Ito, A. Kanehiro, K. Matsumoto, A. Hirano, K. Ono, H. Maruyama, M. Kataoka, T. Nakamura, E. W. Gelfand, and M. Tanimoto
Hepatocyte Growth Factor Attenuates Airway Hyperresponsiveness, Inflammation, and Remodeling
Am. J. Respir. Cell Mol. Biol., April 1, 2005; 32(4): 268 - 280.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
D. Y. Rhyu, Y. Yang, H. Ha, G. T. Lee, J. S. Song, S.-t. Uh, and H. B. Lee
Role of Reactive Oxygen Species in TGF-{beta}1-Induced Mitogen-Activated Protein Kinase Activation and Epithelial-Mesenchymal Transition in Renal Tubular Epithelial Cells
J. Am. Soc. Nephrol., March 1, 2005; 16(3): 667 - 675.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
H. Okada, T. Kikuta, T. Kobayashi, T. Inoue, Y. Kanno, M. Takigawa, T. Sugaya, J. B. Kopp, and H. Suzuki
Connective Tissue Growth Factor Expressed in Tubular Epithelium Plays a Pivotal Role in Renal Fibrogenesis
J. Am. Soc. Nephrol., January 1, 2005; 16(1): 133 - 143.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. S. Samuel, E. N. Unemori, I. Mookerjee, R. A. D. Bathgate, S. L. Layfield, J. Mak, G. W. Tregear, and X.-J. Du
Relaxin Modulates Cardiac Fibroblast Proliferation, Differentiation, and Collagen Production and Reverses Cardiac Fibrosis in Vivo
Endocrinology, September 1, 2004; 145(9): 4125 - 4133.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Fukasawa, T. Yamamoto, A. Togawa, N. Ohashi, Y. Fujigaki, T. Oda, C. Uchida, K. Kitagawa, T. Hattori, S. Suzuki, et al.
Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
PNAS, June 8, 2004; 101(23): 8687 - 8692.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
H. Yokoi, M. Mukoyama, T. Nagae, K. Mori, T. Suganami, K. Sawai, T. Yoshioka, M. Koshikawa, T. Nishida, M. Takigawa, et al.
Reduction in Connective Tissue Growth Factor by Antisense Treatment Ameliorates Renal Tubulointerstitial Fibrosis
J. Am. Soc. Nephrol., June 1, 2004; 15(6): 1430 - 1440.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
K. Manotham, T. Tanaka, M. Matsumoto, T. Ohse, T. Miyata, R. Inagi, K. Kurokawa, T. Fujita, and M. Nangaku
Evidence of Tubular Hypoxia in the Early Phase in the Remnant Kidney Model
J. Am. Soc. Nephrol., May 1, 2004; 15(5): 1277 - 1288.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. H. Li, W. Wang, X. R. Huang, M. Oldfield, A. M. Schmidt, M. E. Cooper, and H. Y. Lan
Advanced Glycation End Products Induce Tubular Epithelial-Myofibroblast Transition through the RAGE-ERK1/2 MAP Kinase Signaling Pathway
Am. J. Pathol., April 1, 2004; 164(4): 1389 - 1397.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
Y. Liu
Epithelial to Mesenchymal Transition in Renal Fibrogenesis: Pathologic Significance, Molecular Mechanism, and Therapeutic Intervention
J. Am. Soc. Nephrol., January 1, 2004; 15(1): 1 - 12.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. Yamashita, A. Maeshima, I. Kojima, and Y. Nojima
Activin A Is a Potent Activator of Renal Interstitial Fibroblasts
J. Am. Soc. Nephrol., January 1, 2004; 15(1): 91 - 101.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
R. Gong, A. Rifai, E. M. Tolbert, J. N. Centracchio, and L. D. Dworkin
Hepatocyte Growth Factor Modulates Matrix Metalloproteinases and Plasminogen Activator/Plasmin Proteolytic Pathways in Progressive Renal Interstitial Fibrosis
J. Am. Soc. Nephrol., December 1, 2003; 14(12): 3047 - 3060.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Zeisberg, C. Bottiglio, N. Kumar, Y. Maeshima, F. Strutz, G. A. Muller, and R. Kalluri
Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models
Am J Physiol Renal Physiol, December 1, 2003; 285(6): F1060 - F1067.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. Mishra, P. Leahy, and M. S. Simonson
Gene expression profile of endothelin-1-induced growth in glomerular mesangial cells
Am J Physiol Cell Physiol, November 1, 2003; 285(5): C1109 - C1115.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
M. Praga, C. F. Andrade, J. Luno, M. Arias, R. Poveda, J. Mora, M. V. Prat, F. Rivera, J. M. Galceran, J. M. Ara, et al.
Antiproteinuric efficacy of losartan in comparison with amlodipine in non-diabetic proteinuric renal diseases: a double-blind, randomized clinical trial
Nephrol. Dial. Transplant., September 1, 2003; 18(9): 1806 - 1813.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
C. Lindschau, P. Quass, J. Menne, F. Guler, A. Fiebeler, M. Leitges, F. C. Luft, and H. Haller
Glucose-Induced TGF-{beta}1 and TGF-{beta} Receptor-1 Expression in Vascular Smooth Muscle Cells Is Mediated by Protein Kinase C-{alpha}
Hypertension, September 1, 2003; 42(3): 335 - 341.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. Rossert, B. Fouqueray, and J. J. Boffa
Anemia Management and the Delay of Chronic Renal Failure Progression
J. Am. Soc. Nephrol., July 1, 2003; 14(90002): S173 - 177.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
H. Y. Lan, W. Mu, N. Tomita, X. R. Huang, J. H. Li, H.-J. Zhu, R. Morishita, and R. J. Johnson
Inhibition of Renal Fibrosis by Gene Transfer of Inducible Smad7 Using Ultrasound-Microbubble System in Rat UUO Model
J. Am. Soc. Nephrol., June 1, 2003; 14(6): 1535 - 1548.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
G. Zhang, H. Kim, X. Cai, J. M. Lopez-Guisa, C. E. Alpers, Y. Liu, P. Carmeliet, and A. A. Eddy
Urokinase Receptor Deficiency Accelerates Renal Fibrosis in Obstructive Nephropathy
J. Am. Soc. Nephrol., May 1, 2003; 14(5): 1254 - 1271.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
R. M. Mason and N. A. Wahab
Extracellular Matrix Metabolism in Diabetic Nephropathy
J. Am. Soc. Nephrol., May 1, 2003; 14(5): 1358 - 1373.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Masszi, C. Di Ciano, G. Sirokmany, W. T. Arthur, O. D. Rotstein, J. Wang, C. A. G. McCulloch, L. Rosivall, I. Mucsi, and A. Kapus
Central role for Rho in TGF-beta 1-induced alpha -smooth muscle actin expression during epithelial-mesenchymal transition
Am J Physiol Renal Physiol, May 1, 2003; 284(5): F911 - F924.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Dai, J. Yang, and Y. Liu
Transforming Growth Factor-beta 1 Potentiates Renal Tubular Epithelial Cell Death by a Mechanism Independent of Smad Signaling
J. Biol. Chem., March 28, 2003; 278(14): 12537 - 12545.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Yang and Y. Liu
Delayed administration of hepatocyte growth factor reduces renal fibrosis in obstructive nephropathy
Am J Physiol Renal Physiol, February 1, 2003; 284(2): F349 - F357.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
I. Herrero-Fresneda, J. Torras, J. M. Cruzado, E. Condom, A. Vidal, M. Riera, N. Lloberas, J. Alsina, and J. M. Grinyo
Do Alloreactivity and Prolonged Cold Ischemia Cause Different Elementary Lesions in Chronic Allograft Nephropathy?
Am. J. Pathol., January 1, 2003; 162(1): 127 - 137.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. Morcos, A. A.R. Sayed, A. Bierhaus, B. Yard, R. Waldherr, W. Merz, I. Kloeting, E. Schleicher, S. Mentz, R. F. Abd el Baki, et al.
Activation of Tubular Epithelial Cells in Diabetic Nephropathy
Diabetes, December 1, 2002; 51(12): 3532 - 3544.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Klahr and J. Morrissey
Obstructive nephropathy and renal fibrosis
Am J Physiol Renal Physiol, November 1, 2002; 283(5): F861 - F875.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. Yang, C. Dai, and Y. Liu
Hepatocyte Growth Factor Gene Therapy and Angiotensin II Blockade Synergistically Attenuate Renal Interstitial Fibrosis in Mice
J. Am. Soc. Nephrol., October 1, 2002; 13(10): 2464 - 2477.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
D. J. Kelly, J. L. Wilkinson-Berka, S. D. Ricardo, A. J. Cox, and R. E. Gilbert
Progression of tubulointerstitial injury by osteopontin-induced macrophage recruitment in advanced diabetic nephropathy of transgenic (mRen-2)27 rats
Nephrol. Dial. Transplant., June 1, 2002; 17(6): 985 - 991.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. H. Li, H.-J. Zhu, X. R. Huang, K. N. Lai, R. J. Johnson, and H. Y. Lan
Smad7 Inhibits Fibrotic Effect of TGF-{beta} on Renal Tubular Epithelial Cells by Blocking Smad2 Activation
J. Am. Soc. Nephrol., June 1, 2002; 13(6): 1464 - 1472.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. Morrissey, G. Guo, K. Moridaira, M. Fitzgerald, R. McCracken, T. Tolley, and S. Klahr
Transforming Growth Factor-{beta} Induces Renal Epithelial Jagged-1 Expression in Fibrotic Disease
J. Am. Soc. Nephrol., June 1, 2002; 13(6): 1499 - 1508.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Zeisberg, Y. Maeshima, B. Mosterman, and R. Kalluri
Renal Fibrosis : Extracellular Matrix Microenvironment Regulates Migratory Behavior of Activated Tubular Epithelial Cells
Am. J. Pathol., June 1, 2002; 160(6): 2001 - 2008.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. Yokoi, M. Mukoyama, A. Sugawara, K. Mori, T. Nagae, H. Makino, T. Suganami, K. Yahata, Y. Fujinaga, I. Tanaka, et al.
Role of connective tissue growth factor in fibronectin expression and tubulointerstitial fibrosis
Am J Physiol Renal Physiol, May 1, 2002; 282(5): F933 - F942.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
Y. Ben-Yosef, N. Lahat, S. Shapiro, H. Bitterman, and A. Miller
Regulation of Endothelial Matrix Metalloproteinase-2 by Hypoxia/Reoxygenation
Circ. Res., April 19, 2002; 90(7): 784 - 791.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
G. Remuzzi, P. Ruggenenti, and N. Perico
Chronic Renal Diseases: Renoprotective Benefits of Renin-Angiotensin System Inhibition
Ann Intern Med, April 16, 2002; 136(8): 604 - 615.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. Schaefer, K. Macakova, I. Raslik, M. Micegova, H.-J. Grone, E. Schonherr, H. Robenek, F. G. Echtermeyer, S. Grassel, P. Bruckner, et al.
Absence of Decorin Adversely Influences Tubulointerstitial Fibrosis of the Obstructed Kidney by Enhanced Apoptosis and Increased Inflammatory Reaction
Am. J. Pathol., March 1, 2002; 160(3): 1181 - 1191.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
J. Yang and Y. Liu
Blockage of Tubular Epithelial to Myofibroblast Transition by Hepatocyte Growth Factor Prevents Renal Interstitial Fibrosis
J. Am. Soc. Nephrol., January 1, 2002; 13(1): 96 - 107.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
Y. Suzuki, O. Lopez-Franco, D. Gomez-Garre, N. Tejera, C. Gomez-Guerrero, T. Sugaya, R. Bernal, J. Blanco, L. Ortega, and J. Egido
Renal Tubulointerstitial Damage Caused by Persistent Proteinuria Is Attenuated in AT1-Deficient Mice : Role of Endothelin-1
Am. J. Pathol., November 1, 2001; 159(5): 1895 - 1904.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Essig, F. Terzi, M. Burtin, and G. Friedlander
Mechanical strains induced by tubular flow affect the phenotype of proximal tubular cells
Am J Physiol Renal Physiol, October 1, 2001; 281(4): F751 - F762.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
P. J. Stahl and D. Felsen
Transforming Growth Factor-{beta}, Basement Membrane, and Epithelial-Mesenchymal Transdifferentiation : Implications for Fibrosis in Kidney Disease
Am. J. Pathol., October 1, 2001; 159(4): 1187 - 1192.
[Full Text]

Home page
 Am. J. Pathol.Home page
M. Zeisberg, G. Bonner, Y. Maeshima, P. Colorado, G. A. Muller, F. Strutz, and R. Kalluri
Renal Fibrosis : Collagen Composition and Assembly Regulates Epithelial-Mesenchymal Transdifferentiation
Am. J. Pathol., October 1, 2001; 159(4): 1313 - 1321.
[Abstract] [Full Text]

Home page
 Am. J. Pathol.Home page
J. Yang and Y. Liu
Dissection of Key Events in Tubular Epithelial to Myofibroblast Transition and Its Implications in Renal Interstitial Fibrosis
Am. J. Pathol., October 1, 2001; 159(4): 1465 - 1475.
[Abstract] [Full Text]

Home page
 J. Am. Soc. Nephrol.Home page
S. KONDO, S. KAGAMI, H. KIDO, F. STRUTZ, G. A. MULLER, and Y. KURODA
Role of Mast Cell Tryptase in Renal Interstitial Fibrosis
J. Am. Soc. Nephrol., August 1, 2001; 12(8): 1668 - 1676.
[Abstract] [Full Text] [PDF]

Home page