Journal of the American Society of Nephrology, Vol 7, 653-660, Copyright © 1996 by American Society of Nephrology

REGULAR ARTICLES

Angiotensin II modulates glomerular capillary permselectivity in rat isolated perfused kidney

R Lapinski, N Perico, A Remuzzi, F Sangalli, A Benigni and G Remuzzi
Mario Negri Institute for Pharmacological Research, Bergamo, Italy.

Studies in experimental animals and humans have documented that inhibition of the renin-angiotensin system by angiotensin-converting enzyme inhibitors reduces urinary protein excretion rate and retards the development of renal injury. Here we sought to investigate whether angiotensin II (All) modified the size-selective properties to macromolecules of the glomerular capillary barrier in isolated perfused rat kidney preparation. Compared with basal values, continuous All infusion into the renal artery at the rate of 3 or 8 ng/min, but not at 0.6 ng/min, induced a progressive and significant increase in urinary protein excretion rate. Evaluation of the sieving properties of the glomerular barrier by fractional clearance of polydisperse Ficoll showed that All significantly enhanced the filtration of tracer molecules of radil > or = 34A. All-induced changes in urinary protein excretion rate and in Ficoll fractional clearance were completely prevented by pretreatment with the specific All Type 1 receptor antagonist SR 47436.

This article has been cited by other articles:

				A. Whaley-Connell, J. Habibi, R. Nistala, S. A. Cooper, P. R. Karuparthi, M. R. Hayden, N. Rehmer, V. G. DeMarco, B. T. Andresen, Y. Wei, et al. Attenuation of NADPH Oxidase Activation and Glomerular Filtration Barrier Remodeling With Statin Treatment Hypertension, February 1, 2008; 51(2): 474 - 480. [Abstract] [Full Text] [PDF]

				H. Ideura, K. Hiromura, N. Hiramatsu, T. Shigehara, S. Takeuchi, M. Tomioka, T. Sakairi, S. Yamashita, A. Maeshima, Y. Kaneko, et al. Angiotensin II provokes podocyte injury in murine model of HIV-associated nephropathy Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1214 - F1221. [Abstract] [Full Text] [PDF]

				A. T. Whaley-Connell, N. A. Chowdhury, M. R. Hayden, C. S. Stump, J. Habibi, C. E. Wiedmeyer, P. E. Gallagher, E. Ann Tallant, S. A. Cooper, C. D. Link, et al. Oxidative stress and glomerular filtration barrier injury: role of the renin-angiotensin system in the Ren2 transgenic rat Am J Physiol Renal Physiol, December 1, 2006; 291(6): F1308 - F1314. [Abstract] [Full Text] [PDF]

				M. Ye, J. Wysocki, J. William, M. J. Soler, I. Cokic, and D. Batlle Glomerular Localization and Expression of Angiotensin-Converting Enzyme 2 and Angiotensin-Converting Enzyme: Implications for Albuminuria in Diabetes J. Am. Soc. Nephrol., November 1, 2006; 17(11): 3067 - 3075. [Abstract] [Full Text] [PDF]

				D. Macconi, M. Abbate, M. Morigi, S. Angioletti, M. Mister, S. Buelli, M. Bonomelli, P. Mundel, K. Endlich, A. Remuzzi, et al. Permselective Dysfunction of Podocyte-Podocyte Contact upon Angiotensin II Unravels the Molecular Target for Renoprotective Intervention Am. J. Pathol., April 1, 2006; 168(4): 1073 - 1085. [Abstract] [Full Text] [PDF]

				M. C. Liebau, D. Lang, J. Bohm, N. Endlich, M. J. Bek, I. Witherden, P. W. Mathieson, M. A. Saleem, H. Pavenstadt, and K.-G. Fischer Functional expression of the renin-angiotensin system in human podocytes Am J Physiol Renal Physiol, March 1, 2006; 290(3): F710 - F719. [Abstract] [Full Text] [PDF]

				P. K. Jacobsen Preventing end stage renal disease in diabetic patients -- genetic aspect (part I) Journal of Renin-Angiotensin-Aldosterone System, March 1, 2005; 6(1): 1 - 14. [Abstract] [PDF]

				A. Benigni, D. Corna, C. Zoja, L. Longaretti, E. Gagliardini, N. Perico, T. M. Coffman, and G. Remuzzi Targeted Deletion of Angiotensin II Type 1A Receptor Does not Protect Mice from Progressive Nephropathy of Overload Proteinuria J. Am. Soc. Nephrol., October 1, 2004; 15(10): 2666 - 2674. [Abstract] [Full Text] [PDF]

				H. Suzuki, T. Yamamoto, N. Ikegaya, and A. Hishida Dietary salt intake modulates progression of antithymocyte serum nephritis through alteration of glomerular angiotensin II receptor expression Am J Physiol Renal Physiol, February 1, 2004; 286(2): F267 - F277. [Abstract] [Full Text] [PDF]

				A. Benigni, C. Zoja, D. Corna, C. Zatelli, S. Conti, M. Campana, E. Gagliardini, D. Rottoli, C. Zanchi, M. Abbate, et al. Add-On Anti-TGF-{beta} Antibody to ACE Inhibitor Arrests Progressive Diabetic Nephropathy in the Rat J. Am. Soc. Nephrol., July 1, 2003; 14(7): 1816 - 1824. [Abstract] [Full Text] [PDF]

				P. Bardoux, D. G. Bichet, H. Martin, Y. Gallois, M. Marre, M.-F. Arthus, M. Lonergan, N. Ruel, N. Bouby, and L. Bankir Vasopressin increases urinary albumin excretion in rats and humans: involvement of V2 receptors and the renin-angiotensin system Nephrol. Dial. Transplant., March 1, 2003; 18(3): 497 - 506. [Abstract] [Full Text] [PDF]

				S.-L. Lin, Y.-M. Chen, C.-T. Chien, W.-C. Chiang, C.-C. Tsai, and T.-J. Tsai Pentoxifylline Attenuated the Renal Disease Progression in Rats with Remnant Kidney J. Am. Soc. Nephrol., December 1, 2002; 13(12): 2916 - 2929. [Abstract] [Full Text] [PDF]

				G. Ding, K. Reddy, A. A. Kapasi, N. Franki, N. Gibbons, B. S. Kasinath, and P. C. Singhal Angiotensin II induces apoptosis in rat glomerular epithelial cells Am J Physiol Renal Physiol, July 1, 2002; 283(1): F173 - F180. [Abstract] [Full Text] [PDF]

				N. Uhlenius, O. Vuolteenaho, and I. Tikkanen Renin-angiotensin blockade improves renal cGMP production via non-AT2-receptor mediated mechanisms in hypertension-induced by chronic NOS inhibition in rat Journal of Renin-Angiotensin-Aldosterone System, December 1, 2001; 2(4): 233 - 239. [Abstract] [PDF]

				T. Elung-Jensen, J. Heisterberg, A.-L. Kamper, J. Sonne, S. Strandgaard, and N. E. Larsen High serum enalaprilat in chronic renal failure Journal of Renin-Angiotensin-Aldosterone System, December 1, 2001; 2(4): 240 - 245. [Abstract] [PDF]

				S. A. Mezzano, M. Ruiz-Ortega, and J. Egido Angiotensin II and Renal Fibrosis Hypertension, September 1, 2001; 38(3): 635 - 638. [Abstract] [Full Text] [PDF]

				A. BENIGNI, S. TOMASONI, E. GAGLIARDINI, C. ZOJA, J. A. GRUNKEMEYER, R. KALLURI, and G. REMUZZI Blocking Angiotensin II Synthesis/Activity Preserves Glomerular Nephrin in Rats with Severe Nephrosis J. Am. Soc. Nephrol., May 1, 2001; 12(5): 941 - 948. [Abstract] [Full Text]

				D. Roccatello, G. Mengozzi, G. Gigliola, D. Rossi, R. Mosso, G. Cacace, R. Polloni, G. Cesano, G. Picciotto, L. Paradisi, et al. Effects of angiotensin II blockade on nitric oxide blood levels in IgA nephropathy Nephrol. Dial. Transplant., July 1, 2000; 15(7): 988 - 993. [Abstract] [Full Text] [PDF]

				M. Fukagawa, M. Noda, T. Shimizu, and K. Kurokawa Chronic progressive interstitial fibrosis in renal disease--are there novel pharmacological approaches? Nephrol. Dial. Transplant., December 1, 1999; 14(12): 2793 - 2795. [Full Text] [PDF]

				G. GRUDEN, S. THOMAS, D. BURT, W. ZHOU, G. CHUSNEY, L. GNUDI, and G. VIBERTI Interaction of Angiotensin II and Mechanical Stretch on Vascular Endothelial Growth Factor Production by Human Mesangial Cells J. Am. Soc. Nephrol., April 1, 1999; 10(4): 730 - 737. [Abstract] [Full Text]

				A. Remuzzi, N. Perico, F. Sangalli, G. Vendramin, M. Moriggi, P. Ruggenenti, and G. Remuzzi ACE inhibition and ANG II receptor blockade improve glomerular size-selectivity in IgA nephropathy Am J Physiol Renal Physiol, March 1, 1999; 276(3): F457 - F466. [Abstract] [Full Text] [PDF]

				G. Remuzzi and T. Bertani Pathophysiology of Progressive Nephropathies N. Engl. J. Med., November 12, 1998; 339(20): 1448 - 1456. [Full Text] [PDF]

				D. Casellas, N. Bouriquet, and A. Herizi Bosentan Prevents Preglomerular Alterations During Angiotensin II Hypertension Hypertension, December 1, 1997; 30(6): 1613 - 1620. [Abstract] [Full Text]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673