Journal of the American Society of Nephrology, Vol 7, 1091-1097, Copyright © 1996 by American Society of Nephrology

REVIEWS

Inside-out signaling through integrins

RJ Faull and MH Ginsberg
Renal Unit, Royal Adelalde Hospital, South Australia.

Rapid and yet precisely controlled changes in cell adhesion are a hallmark of a number of basic physiological processes. Many of these processes directly impact upon nephrology, including: (1) cell migration, which occurs during leukocyte infiltration into inflammatory sites (e.g., in glomerulonephritis, interstitial nephritis, and renal transplant rejection) and during embryogenesis (e.g., in development of the genitourinary system): and (2) platelet aggregation at sites of clot formation (e.g., in glomerulonephritis). The integrins are a family of adhesion molecules whose function is controlled by the cells that express them, and this properly makes them eminently suitable receptors for those situations that demand flexibility of the cellular adhesive phenotype. The control of integrin function occurs via regulatory signals that originate within the cell cytoplasm and are then transmitted to the external ligand-binding domain of the receptor. The generation and transmission of these "inside-out" signals are the subjects of intensive research that will be summarized in this review article.

This article has been cited by other articles:

				B. Salanova, M. Choi, S. Rolle, M. Wellner, F. C. Luft, and R. Kettritz beta2-Integrins and Acquired Glycoprotein IIb/IIIa (GPIIb/IIIa) Receptors Cooperate in NF-{kappa}B Activation of Human Neutrophils J. Biol. Chem., September 21, 2007; 282(38): 27960 - 27969. [Abstract] [Full Text] [PDF]

				R. R. Hantgan, D. S. Lyles, T. C. Mallett, M. Rocco, C. Nagaswami, and J. W. Weisel Ligand Binding Promotes the Entropy-driven Oligomerization of Integrin alpha IIbbeta 3 J. Biol. Chem., January 24, 2003; 278(5): 3417 - 3426. [Abstract] [Full Text] [PDF]

				H. Pavenstadt, W. Kriz, and M. Kretzler Cell Biology of the Glomerular Podocyte Physiol Rev, January 1, 2003; 83(1): 253 - 307. [Abstract] [Full Text] [PDF]

				D. M. Rose, V. Grabovsky, R. Alon, and M. H. Ginsberg The Affinity of Integrin {alpha}4{beta}1 Governs Lymphocyte Migration J. Immunol., September 1, 2001; 167(5): 2824 - 2830. [Abstract] [Full Text] [PDF]

				R. Houtman, R. Ten Broeke, J. E. Blalock, M. Villain, A. S. Koster, and F. P. Nijkamp Attenuation of Very Late Antigen-5-Mediated Adhesion of Bone Marrow-Derived Mast Cells to Fibronectin by Peptides with Inverted Hydropathy to EF-Hands J. Immunol., January 15, 2001; 166(2): 861 - 867. [Abstract] [Full Text] [PDF]

				J. A. Kreidberg and J. M. Symons Integrins in kidney development, function, and disease Am J Physiol Renal Physiol, August 1, 2000; 279(2): F233 - F242. [Abstract] [Full Text] [PDF]

				K. J. Bayless, R. Salazar, and G. E. Davis RGD-Dependent Vacuolation and Lumen Formation Observed during Endothelial Cell Morphogenesis in Three-Dimensional Fibrin Matrices Involves the {alpha}v{beta}3 and {alpha}5{beta}1 Integrins Am. J. Pathol., May 1, 2000; 156(5): 1673 - 1683. [Abstract] [Full Text] [PDF]

				P. Anastasiadis and A. Reynolds The p120 catenin family: complex roles in adhesion, signaling and cancer J. Cell Sci., January 4, 2000; 113(8): 1319 - 1334. [Abstract] [PDF]

				M.-H. Disatnik and T. A. Rando Integrin-mediated Muscle Cell Spreading. THE ROLE OF PROTEIN KINASE C IN OUTSIDE-IN AND INSIDE-OUT SIGNALING AND EVIDENCE OF INTEGRIN CROSS-TALK J. Biol. Chem., November 5, 1999; 274(45): 32486 - 32492. [Abstract] [Full Text] [PDF]

				I. N. Gavrilovskaya, E. J. Brown, M. H. Ginsberg, and E. R. Mackow Cellular Entry of Hantaviruses Which Cause Hemorrhagic Fever with Renal Syndrome Is Mediated by beta 3 Integrins J. Virol., May 1, 1999; 73(5): 3951 - 3959. [Abstract] [Full Text]

				R. E. B. Seftor Role of the ß3 Integrin Subunit in Human Primary Melanoma Progression : Multifunctional Activities Associated with{alpha}vß3 Integrin Expression Am. J. Pathol., November 1, 1998; 153(5): 1347 - 1351. [Full Text] [PDF]

				A. Zuk, J. V. Bonventre, D. Brown, and K. S. Matlin Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney Am J Physiol Cell Physiol, September 1, 1998; 275(3): C711 - C731. [Abstract] [Full Text] [PDF]

				I. N. Gavrilovskaya, M. Shepley, R. Shaw, M. H. Ginsberg, and E. R. Mackow beta 3 integrins mediate the cellular entry of hantaviruses that cause respiratory failure PNAS, June 9, 1998; 95(12): 7074 - 7079. [Abstract] [Full Text] [PDF]

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673