Journal of the American Society of Nephrology, Vol 7, 1189-1197, Copyright © 1996 by American Society of Nephrology

REGULAR ARTICLES

Ovariectomy decreases plasma triglyceride levels and both prevents and alleviates glomerular disease in uninephrectomized female analbuminemic rats

JA Joles, H van Goor, ML van der Horst, A van Tol, JJ Weening and HA Koomans
Department of Nephrology, Utrecht University, The Netherlands.

Female Nagase analbuminemic rats (NAR) are profoundly hypertriglyceridemic and develop proteinuria and glomerulosclerosis when aging and after uninephrectomy (UNX). Ovariectomy (OVX) markedly decreases plasma triglyceride levels in this species. This study evaluated whether decreasing triglyceride levels by OVX could prevent renal disease or alleviate its progression in UNX female NAR. Female NAR underwent OVX at 0, 12, 24, or 36 wk after UNX. In the absence of OVX, the animals developed progressive proteinuria from 18 wk after UNX and showed extensive glomerular sclerosis, lipid deposition, and hypertrophy at euthanasia (49 wk after UNX). These changes were prevented by OVX carried out at 0 or 12 wk, and attenuated by OVX at 24 wk after UNX. If performed at 36 wk after UNX, OVX had no effect on glomerulosclerosis, although it reduced proteinuria. In 95% (20 of 21) of the rats with proteinuria over 10 mg/day, proteinuria decreased in the first 6 wk after OVX. The percentage decrease in proteinuria correlated inversely with the glomerulosclerosis score at euthanasia (r = -0.58, P < 0.01). OVX had no effect on hyperfiltration and hyperperfusion in the UNX rats. OVX consistently reduced plasma triglyceride levels in rats both with and without proteinuria, and it also reduced plasma cholesterol, but only in conjunction with reduction in proteinuria. It was concluded that OVX in UNX female NAR prevents glomerulosclerosis if performed before proteinuria and attenuates further development of established renal disease if performed in a timely manner. This study's data suggest that in UNX female NAR, the lowering of plasma triglyceride levels plays a central role in the renoprotective action of OVX.

This article has been cited by other articles:

				Y. Shin, N. D. Vaziri, N. Willekes, C. H. Kim, and J. A. Joles Effects of gender on hepatic HMG-CoA reductase, cholesterol 7{alpha}-hydroxylase, and LDL receptor in hereditary analbuminemia Am J Physiol Endocrinol Metab, December 1, 2005; 289(6): E993 - E998. [Abstract] [Full Text] [PDF]

				J. Neugarten Gender and the Progression of Renal Disease J. Am. Soc. Nephrol., November 1, 2002; 13(11): 2807 - 2809. [Full Text] [PDF]

				R. K. Dubey and E. K. Jackson Estrogen-induced cardiorenal protection: potential cellular, biochemical, and molecular mechanisms Am J Physiol Renal Physiol, March 1, 2001; 280(3): F365 - F388. [Abstract] [Full Text] [PDF]

				J. S. Stern, M. D. Gades, C. M. Wheeldon, and A. T. Borchers Calorie Restriction in Obesity: Prevention of Kidney Disease in Rodents J. Nutr., March 1, 2001; 131(3): 913S - 917. [Abstract] [Full Text]

				J. A. JOLES, U. KUNTER, U. JANSSEN, W. KRIZ, T. J. RABELINK, H. A. KOOMANS, and J. FLOEGE Early Mechanisms of Renal Injury in Hypercholesterolemic or Hypertriglyceridemic Rats J. Am. Soc. Nephrol., April 1, 2000; 11(4): 669 - 683. [Abstract] [Full Text] [PDF]

Copyright © 2008 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673