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Increased Fructose Associates with Elevated Blood Pressure

Division of Renal Diseases and Hypertension, University of Colorado Denver Health Sciences Center, Aurora, Colorado

Correspondence: Dr. Diana I. Jalal, Division of Renal Diseases and Hypertension, University of Colorado Denver Health Sciences Center, 12700 E. 19th Avenue, Research 2, C281, Aurora, CO 80045. Phone: 303-724-4867; Fax: 303-724-4831; E-mail: diana.jalal{at}ucdenver.edu

Received for publication November 4, 2009. Accepted for publication March 22, 2010.

The recent increase in fructose consumption in industrialized nations mirrors the rise in the prevalence of hypertension, but epidemiologic studies have inconsistently linked these observations. We investigated whether increased fructose intake from added sugars associates with an increased risk for higher BP levels in US adults without a history of hypertension. We conducted a cross-sectional analysis using the data collected from the National Health and Nutrition Examination Survey (NHANES 2003 to 2006) involving 4528 adults without a history of hypertension. Median fructose intake was 74 g/d, corresponding to 2.5 sugary soft drinks each day. After adjustment for demographics; comorbidities; physical activity; total kilocalorie intake; and dietary confounders such as total carbohydrate, alcohol, salt, and vitamin C intake, an increased fructose intake of 74 g/d independently and significantly associated with higher odds of elevated BP levels: It led to a 26, 30, and 77% higher risk for BP cutoffs of 135/85, 140/90, and 160/100 mmHg, respectively. These results suggest that high fructose intake, in the form of added sugar, independently associates with higher BP levels among US adults without a history of hypertension.

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J. Am. Soc. Nephrol. 2010 21: A9. [Full Text] [PDF]

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673