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J Am Soc Nephrol 17: 178-188, 2006
© 2006 American Society of Nephrology
doi: 10.1681/ASN.2006080912
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Supplement Articles

Prevalence of Abnormal Urinary Albumin Excretion Rate in Hypertensive Patients with Impaired Fasting Glucose and Its Association with Cardiovascular Disease

Rafael Marín*, Pilar Rodríguez{dagger}, Salvador Tranche{ddagger}, José Redón§, Francisco Morales-Olivas||, Alberto Galgo, Miguel Ángel Brito**, Javier Mediavilla{dagger}{dagger}, José Vicente Lozano{ddagger}{ddagger}, Claudia Filozof§§ and the MAGAL group

* Nephrology Service, Hospital Universitario Central de Asturias, and {ddagger} El Cristo Health Centre, Oviedo, {dagger} Fingoi Health Centre, Lugo, § Internal Medicine Service, Hospital Clínico, || Department of Pharmacology, University of Valencia, and {ddagger}{ddagger} Valencia Health Centre, Valencia, Espronceda Health Centre and ** Endocrinology, Hospital Puerta de Hierro, Madrid, {dagger}{dagger} Pampliega Health Centre, Burgos, and §§ Scientific Department, Cardiovascular Section, Bristol-Myers-Squibb, Madrid, Spain

Address correspondence to: Dr. Rafael Marín, Servicio de Nefrología, Hospital Universitario Central de Asturias, C/Celestino Villamil s/n, 33006, Oviedo, Spain. Phone: +34-985-108000; Fax: +34-985-108015; E-mail: rmarini{at}hca.es


   Abstract
Top
 Abstract
Introduction
 Materials and Methods
 Results
 Discussion
 Conclusion
 References
 
The prevalence and significance of microalbuminuria in hypertensive patients with impaired fasting glucose (IFG) has received very little attention. A total of 10,320 hypertensive patients who attended primary care centers were enrolled in this study, and the final analysis was done in 7625 patients: 1459 without IFG (plasma glucose <100 mg/dl), 3010 with IFG (plasma glucose ≥100 mg/dl and <126 mg/dl), and 3156 with type 2 diabetes (plasma glucose >126 mg/dl). Microalbuminuria was determined using the Micro Albustix reactive strip from Bayer (high urinary albumin excretion [UAE]: Albumin/creatinine ratio ≥3.4 mg/mmol). The proportion of patients with high UAE was 39.4, 48.3, and 65.6%, respectively, in the three groups (P < 0.01 for the trend). The differences in UAE between the group with IFG and the group with normal fasting glucose persisted after adjustment for age, gender, systolic BP, fasting plasma glucose, and cardiovascular comorbidity (odds ratio 1.74; 95% confidence interval 1.08 to 2.80). Hypertensive patients with IFG and high UAE showed a higher prevalence of ischemic heart disease, cardiac insufficiency, left ventricular hypertrophy, atrial fibrillation, and renal insufficiency than the group with normal UAE. Global prevalence of cardiovascular conditions was 30.4% in the group with high UAE compared with 21.4% in the group with normal UAE (odds ratio 1.60; 95% confidence interval 1.31 to 1.95). It is concluded that almost half of hypertensive patients with IFG have high UAE and a higher prevalence of associated cardiovascular involvement and renal insufficiency.


   Introduction
Top
 Abstract
 Introduction
Materials and Methods
 Results
 Discussion
 Conclusion
 References
 
During the past 20 yr, epidemiologic evidence has indicated that microalbuminuria is predictive of increased renal and cardiovascular morbidity and mortality not only in patients with diabetes but also in the general population (1–4). This association has proved to be independent of traditional risk factors such as age, BP, dyslipidemia, or left ventricular hypertrophy (LVH) (5,6). These data led the latest report of the Joint National Committee in the United States to accept microalbuminuria as a first-degree cardiovascular risk factor (7).

The positive association between the albumin/creatinine ratio and cardiovascular and renal morbidity and mortality is evident from very low levels (>5 mg/g creatinine), well below the standard microalbuminuria threshold (30 mg/g creatinine) (8,9). Recently, post hoc studies showed that the reduction in microalbuminuria levels by therapy is associated with a reduction in cardiovascular events (8,10).

Only a few studies have assessed the prevalence of microalbuminuria in the general population (3,11,12), which ranges from 7.2 to 7.8% and can reach 16% in hypertensive patients and even 29 to 31% in patients with diabetes. In the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab), the prevalence of microalbuminuria in the subgroup with diabetes was 21% (13). This study showed a prevalence of microalbuminuria of 5.1% in patients with normal fasting glucose (NFG), which increased to 9.3% in those with impaired fasting glucose (IFG; ≥110 and <126 mg/dl). This continuous and direct relationship between urinary albumin excretion rate (UAE) and glucose tolerance already had been reported many years before in a study that involved a very low number of patients (14).

Cardiovascular risk that is associated with impaired carbohydrate metabolism (15) and microalbuminuria seems very likely to increase in hypertensive patients, although this has not yet been assessed. The main objective of our study was to assess the prevalence of elevated UAE (eUAE) in hypertensive patients who had IFG and attended primary care units and to compare it with the prevalence of eUAE in hypertensive patients with type 2 diabetes and with those with NFG. The secondary objectives were to analyze the association between eUAE and other cardiovascular risk factors and to evaluate its association with cardiovascular morbidity.


   Materials and Methods
Top
 Abstract
 Introduction
 Materials and Methods
Results
 Discussion
 Conclusion
 References
 
MicroAluminuria en pacientes con glucemia Basal ALterada (MAGAL) is a multicenter, cross-sectional, observational study that was carried out by 1723 primary care physicians between September and December 2005. Each physician consecutively enrolled six patients with essential hypertension in the following proportions: Three with IFG (≥100 mg/dl and <126 mg/dl), two with type 2 diabetes, and one with NFG (<100 mg/dl).

A total of 10,320 patients were enrolled. The inclusion criteria were age >18 and ≤80 yr, previous diagnosis of hypertension and BP ≥140/90 mmHg, or receiving antihypertensive medication. Patients with type 1 diabetes were excluded, as were pregnant or breast-feeding women; patients with urinary infection, pyuria, hematuria, or fever; and those who had done strenuous physical exercise during the 24 h before determination of microalbuminuria.

The study was approved by the Ethics and Clinical Trials Committee of the Hospital Central de Asturias. Informed consent of the patient was obtained in all cases.

Study Protocol
For each patient, the following were obtained: Demographic data (age and gender); clinical data (family history of premature cardiovascular disease, personal history of smoking and dyslipidemia, and presence of associated cardiovascular disease [ischemic heart disease, cardiac insufficiency, cerebrovascular disease, and peripheral artery disease]); and a physical examination that included weight, height, body mass index (BMI), abdominal waist circumference, and systolic (SBP) and diastolic BP (DBP). Plasma creatinine, glucose, HbA1c, total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides were measured after at least 8 h of fasting. UAE was determined in an isolated sample of first-morning urine by the semiquantitative method using the Micro Albustix reactive strip (Bayer, Milano, Italy). For calculation of renal function, the GFR was estimated (ml/min per 1.73 m2) according to the abbreviated equation of the Modification of Diet in Renal Disease (MDRD) study (16). An electrocardiogram was used to examine the presence of LVH (Sokolow and/or Cornell criteria) and auricular fibrillation. Similarly, we recorded patient medication data: Antihypertensive drugs, antidiabetics, and lipid-lowering and antiplatelet agents.

Sitting SBP and DBP were measured according to the recommendations of the Spanish Hypertension Society (Sociedad Española de Hipertensión) (17), after 5 min of rest and with the cuff fitted to the perimeter of the arm. Three readings were taken, and the mean value of the last two was accepted as valid.

According to the data that were obtained using the Bayer Micro Albustix reactive strips, abnormal UAE was defined as an albumin/creatinine ratio ≥3.4 mg/mmol (equivalent to ≥30 mg/g). According to the manufacturer, the Bayer Micro Albustix test has a sensitivity of 90% and a specificity of 88% for the albumin/creatinine ratio. As prespecified in the protocol, urine samples with concentrations of creatinine ≤10 mg/dl were not analyzed because they were considered too dilute.

The sample size estimation was based on the 95% confidence interval (CI) of the prevalence of microalbuminuria. Because we did not know the prevalence of microalbuminuria among hypertensive patients with IFG, the sample size was estimated using 50%, because any other value (lower or higher) would be estimated with more accuracy. Under this assumption and taking into consideration a clinically relevant difference of 4 to 5 units in UAE between the IFG and type 2 diabetes groups, a total of 1600 to 2500 patients were necessary in each group to estimate this prevalence with an accuracy of between 2 and 3%, accepting an {alpha} < 0.05 and a beta < 0.10 errors in a two-tailed P evaluation. Nevertheless, with the intention of analyzing subgroups and allowing for a 25% loss in the number of cases, the total number of patients was increased to that mentioned above.

Statistical Analyses
The variables are presented either as frequency and 95% CI, mean (SD), or median (25th to 75th percentiles) according to the distribution of the variable. The t test was used for two-group comparisons, and ANOVA was used for comparisons with more than two groups. The Tukey test was used to establish the difference between pairs of means when necessary. The association between qualitative variables was evaluated using the {chi}2 or Fisher exact test. Differences were considered significant at P < 0.05.

To evaluate the factors that explained the presence of a high UAE, we constructed a multiple logistic regression model using the variables that were statistically significant in the previously mentioned terms. Traditional risk factors also were included. The odds ratio (OR) of these variables was reported, together with their CI and level of significance. The analysis was carried out using SAS for Windows (version 9.1; SAS Institute, Cary, NC).


   Results
Top
 Abstract
 Introduction
 Materials and Methods
 Results
Discussion
 Conclusion
 References
 
The final analysis was made in 7625 patients: 1459 in the NFG group, 3010 in the IFG group, and 3156 in the type 2 diabetes group. A total of 2695 (26.1%) were excluded for one of the following causes of erroneous classification: Not fulfilling the age condition (n = 357), being classified in more than one metabolism group (n = 400), having normal BP and not receiving antihypertensive medication (n = 721), being included in the normal carbohydrate metabolism group or in the IFG group and receiving antidiabetes medication (n = 6 and n = 674, respectively), being in the type 2 diabetes group and having NFG with no antidiabetes medication (n = 30), being in the IFG group and presenting fasting glucose ≥126 mg/dl (n = 318), or being in the normal carbohydrate metabolism group and having HbA1c >7.5% (n = 189).

The characteristics of the patients who were included in the three groups are shown in Tables 1 and 2. Age was >60 yr in all of the groups and increased progressively from NFG to diabetes. Mean BP was >140/80 mmHg, and a continuous and significant increase in SBP was observed from the normal carbohydrate metabolism group to the type 2 diabetes group. A BP <140/90 mmHg was observed in 47.4% of the patients with NFG and in 42.9% of those with IFG. In the patients with diabetes, BP was controlled (<130/80 mmHg) in 12.5% of cases. A progressive increase in BMI, fasting plasma glucose, triglycerides, and creatinine also was observed from NFG to diabetes. This progressive increase also was verified in the associated cardiovascular morbidities or renal disease (defined as an estimated GFR [eGFR] <60 ml/min per 1.73 m2). The number of antihypertensive agents prescribed, and the use of renin-angiotensin system blockers and statins showed the same increasing tendency.


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  		Table 1. Characteristics of patientsa

 

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  		Table 2. Cardioprotective therapy in each groupa

 
UAE by albumin/creatinine ratio was determined in 5288 patients (70% of the total sample). The proportion of patients with UAE ≥3.4 mg/mmol was 39.4, 48.3, and 65.6% in the NFG, IFG, and type 2 diabetes groups, respectively (P < 0.01 for the trend). The differences in UAE between the IFG group and the NFG group persisted after adjustment for age, gender, SBP, triglyceride and glucose levels, and the number of patients with renal insufficiency and cardiovascular comorbidity (OR 1.74; 95% CI 1.08 to 2.80).

Patients with IFG
Relationship between UAE and Target Organ Damage.
In this group, UAE was determined in 2064 patients. High levels (UAE ≥3.4 mg/mmol) were observed in 48.3% of cases. Table 3 shows the differences between patients with UAE and those with normal UAE. In patients with UAE ≥3.4 mg/mmol, a higher SBP and DBP, higher creatinine, and lower eGFR were observed. There were no differences with regard to age, gender, BMI, or LDL cholesterol concentrations.


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  		Table 3. Associated risk factors in hypertensive patients with IFG according to UAEa

 
Relationship between UAE and Associated Clinical Disorders.
Compared with those who had normal UAE, hypertensive patients with IFG and high UAE showed a greater prevalence of ischemic heart disease, cardiac insufficiency, LVH, and atrial fibrillation. They also had a higher prevalence of renal insufficiency (19.9% [95% CI 17.5 to 22.6] versus 12.2% [95% CI 10.3 to 14.3], OR 1.80 [95% CI 1.41 to 2.28]) (Figure 1). There were no differences in the prevalence of cerebrovascular disease or peripheral artery disease (Table 4). The global prevalence of cardiovascular disease was 30.4% in the eUAE group compared with 21.4% in the group with normal UAE (OR 1.60; 95% CI 1.31 to 1.95). This difference persisted after adjustment for gender, family history of cardiovascular disease, smoking, fasting glucose, LDL cholesterol, eGFR, and use of hypertensive agents and/or statins (OR 1.42; 95% CI 1.08 to 1.88).


Figure 1
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  		Figure 1. Cardiovascular morbidities in hypertensive patients with impaired fasting glucose according to the presence of increased urinary albumin (UAE): Proportion of patients with renal and cardiovascular disease.

 

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  		Table 4. Associated cardiovascular disease in hypertensive patients with IFG according to UAE

 

   Discussion
Top
 Abstract
 Introduction
 Materials and Methods
 Results
 Discussion
Conclusion
 References
 
This is the first study in Spain to analyze the prevalence of eUAE in hypertensive patients with IFG. The results show that this prevalence reaches almost half the population studied with intermediate values between the two control groups: Hypertensive patients with NFG and hypertensive patients with associated type 2 diabetes.

This increased prevalence of UAE in patients with IFG was independent of other risk factors that traditionally have been associated with microalbuminuria, namely age, gender, SBP, BMI, and dyslipidemia (9,18), and of associated cardiovascular disease or renal insufficiency, which are known to be associated with higher levels of albuminuria. The more widespread use of cardioprotective agents in this group probably is a consequence of the higher prevalence of cardiovascular and renal disease in this group (and, therefore, higher number of drugs prescribed).

The role of microalbuminuria as an early marker of renal disease in patients with type 1 and 2 diabetes is widely known. However, although the relationship between microalbuminuria and hypertension was reported for the first time >30 yr ago (19), the significance of this relationship was not recognized fully until recently, when both its prevalence and its role in coronary disease were demonstrated (20). The latest epidemiologic studies have confirmed its independent relationship with total mortality and cardiovascular morbidity and mortality both in the general population and in patients with diabetes and high cardiovascular risk (2–6,21). Furthermore, the role of microalbuminuria in cardiovascular risk must not be considered as a categorical variable, because this risk is continuous from almost negligible levels (starting at >2 mg/g creatinine) in treated hypertensive patients (22).

Compared with patients without diabetes, patients with type 2 diabetes have a two to four times higher cardiovascular risk. Several studies have analyzed the possible existence of a threshold between fasting glucose and cardiovascular disease. This relationship appears at low levels of fasting plasma glucose, including those that are considered as IFG (100 to 125.9 mg/dl), especially in patients with impaired glucose tolerance (23–26). Our study showed that the progressive deterioration in carbohydrate metabolism is related directly to both nonmodifiable (age and male gender) and modifiable risk factors (SBP, BMI, and triglycerides) and confirmed their relationship with a greater presence of cardiovascular events. Few studies have assessed the relationship between renal disease and glucose tolerance (13,27). Despite that renal disease is well recognized in hypertensive patients—even more so in patients with diabetes—it has been less acknowledged in patients with IFG.

In our study, the prevalence of high UAE was greater than that reported in the Third National Health and Nutrition Examination Survey (NHANES III) population studies (14) or in studies in the population with diabetes that were carried out in Australia or Italy (11,13,28). This may be related to the presence of arterial hypertension, older age, and a different method of detecting UAE.

To date, no published studies have analyzed specifically the significance of the high UAE in hypertensive patients with IFG, who already have a high vascular risk. The additional presence of a high UAE was associated directly with BP and with glycemia and creatinine levels. Emphasis must be placed on its association with intermediate variables (LVH and atrial fibrillation) and, more important, with a greater prevalence of global cardiovascular morbidity, specifically coronary disease and cardiac insufficiency. This association persisted after adjustment for the presence of other traditional cardiovascular risk factors and drugs that can modify UAE, such as angiotensin-converting inhibitors, angiotensin II receptor blockers, or statins. The greater prevalence of renal insufficiency also was significant.

Prediabetic patients, such as those who were analyzed in our study, have an increased risk for coronary disease also described in patients with high UAE. Microalbuminuria, IFG, and arterial hypertension form part of the so-called metabolic syndrome, which has been recognized as a favorable condition for greater prevalence of cardiovascular disease and chronic renal disease (29,30). The pathogenic connection among microalbuminuria, IFG, and hypertension is not known but may reflect the presence of generalized vascular lesions that are increased by each of these processes individually. Microalbuminuria is considered a marker of endothelial dysfunction, favoring atherosclerosis and cardiovascular morbidity. Even in patients without diabetes, microalbuminuria also may be an expression of the same degree of glomerular capillary dysfunction. Some studies in patients with essential hypertension have shown that high UAE is a predictor of future deterioration of renal function (31). Furthermore, several recent studies showed that a GFR of <60 ml/min per 1.73 m2 is an independent risk factor for total mortality, cardiovascular events, and hospitalization (32). Therapeutic intervention studies with UAE-reducing agents such as angiotensin II receptor blockers have proved to be effective in reducing vascular morbidity in hypertensive patients without diabetes and the progression of renal disease in type 2 diabetes (2,10). This medication must form part of a multifactorial strategy. In patients with several risk factors, antihypertensive agents, statins, antiplatelet agents, and, when necessary, oral antidiabetes medication or insulin should be included. Early initiation of microalbuminuria-lowering drugs should form part of the therapeutic arsenal in patients with a high vascular risk (33).

Our study has several limitations. First, UAE was determined in only one sample. Although this is common in epidemiologic studies (11,13), clinical practice requires at least three samples (two of these with high values) to establish the diagnosis. Our single measurement does not allow us to accept conclusively the diagnosis of microalbuminuria. Second, determination of the albumin/creatinine ratio by the reactive strip that was used in the semiquantitative method is less widely known, although a recent study with a series of 24,000 patients used this technique (34). Our study also is limited by its cross-sectional and multicenter design, although the size of the sample can reduce potential bias. Furthermore, the prevalence of some potentially life-threatening cardiovascular events (e.g., stroke, myocardial infarction) cannot be included in this type of design and may alter the true magnitude of associated cardiovascular disease.


   Conclusion
Top
 Abstract
 Introduction
 Materials and Methods
 Results
 Discussion
 Conclusion
References
 
Hypertensive patients with IFG show higher UAE than hypertensive patients with NFG and, consequently, a greater prevalence of associated cardiovascular disease and renal insufficiency. Early and multifactorial therapeutic intervention including a strict control of BP and renin-angiotensin system blockers can prevent or defer vascular/renal morbidity and mortality in this type of patient. Nevertheless, long-term, prospective studies with a more accurate method of detecting UAE are warranted to corroborate our results.


   Acknowledgments
 
This study was supported by a grant from Bristol-Myers-Squibb, Madrid, Spain.

The following investigators participated in the MAGAL Study: Abarca Bujan Benjamín, Abordan Chanat Ruchdi Omar, Acosta Méndez Juan M., Acosta Socorro Antonio, Adelantado Pozuelo Esther, Afonso Navarro Carmen, Agote Cuesta Gabriel, Aguado Mori Ana Cristina, Agudo Codujón Beatriz, Aguilar Huertas Eva, Aguilera Zubizarreta Eulalia, Aguiló Furió Sara, Aguirre Miñana Teresa, Álamo Domínguez Aníbal, Alba Díaz Ángel, Albert Cuñat Vicente, Albors Valls Alberto, Alegret Crespi Santiago, Alegria Alonso Ramón, Alfaro Alonso Guillermo, Alfaya Carrera Juan Jose, Allut Vidal Germán, Almela Tejedo Teresa, Alonso Atienza Ma Del Carmen, Alonso Del Pino Elena, Alonso Díaz-Marta Manuel, Alonso Fernandez Lola, Alonso Matia Rafael, Alonso Quintanilla Carmelo, Alonso Patricio, Altarriba Cano Ma Luisa, Altuna Zuriarrain Manuel, Alvarado Tato Antonio M., Álvarez Blanco Antonio, Álvarez De Monrego Carina, Álvarez Fernandez Hortensia, Álvarez García Antonio, Álvarez Guisasola Fernando, Álvarez Mejorada Enrique, Álvarez Sanchez Ignacio, Álvarez Taboas Jorge, Álvarez Valero Jesús, Ávarez Vicente Juan Carlos, Alvear García Martin Jorge, Amhed Loufty Kheder, Amigo Núñez Ma Elena, Amurrio Olartua Juan Ma, Andrés Pauls Inmaculada, Andrés Mayor Ma José, Andrés Santos Esther, Andreu Amoros Juan Luis, Angel Cavada Miguel, Angora Mazuecos Francisco, Anguiano Calvo José, Angulo Gonzalez Javier, Angulo Vallejo Ester, Angulo Yuste Enrique, Antolin Llinares, Asunción, Anton Ortega Javier, Antón Castelló José Luis, Antón García Francisco, Añel Rodríguez Rosa, Aramburu Aramburu Pedro, Arancegi Marticorena Izaskun, Arayo Sola Inmaculada, Arbesú Prieto José, Ardévol González Rómulo, Arenas Mosqueda Julián, Arias Gómez Ma Jesus, Arias Salgado-Robsy Ana María, Ariza Hernández Andrés, Arlandis Puig Antonio, Arnal Sanchez Jose, Aroca Sanz Ma Luisa, Arocas Pérez Ricardo, Arribas Aguirregaviría F. Javier, Arrieta Ma Jesús, Arrondo Beguiristain Ma Ángeles, Arroyo Azpa Concepción, Arteaga Herrera Domingo, Arteche Legorburu Miguel Ángel, Artigues Llull Isabel, Arujo Marisol, Arza Arteaga Alicia, Ascanio León Belén, Asenjo Cabrera Irene, Asenjo Martin Amparo, Asensi Peñarrocha Isabel, Atienza Gaona Jose Juan, Atxotegi Loizate Laura, Auza José Javier, Avilés Martínez Francisco Javier, Ayala Muñoz Francisco, Ayensa Esparza Javier, Aznar Ladrón De Guevara Ma Jose, Azorín Sanz Francisco Javier, Baamonde Mosquera Leopoldo, Badiola Elu Jose Luis, Badosa Sanuy Ana, Baeza Romero Manuel, Baixarias Tibau Joaquim, Bajo Garcia Julián, Balaguer Montesinos Francisco, Balanzategi Garmendia Inmaculada, Ballester Berenguer José Vicente, Ballester Díaz Trinidad Margarita, Ballester Orti Javier, Bañón García Raquel, Baños Martínez Ma Soledad, Baños Merino Isabel, Bañuelos Gago Ma Jesús, Barbeito Zaldua Edurne, Barceló Bartolomé, Barges Ponce Vicente, Barras Galán Domingo, Barreiro Mourentans Carlos, Barrera Pérez Manuel, Barrera Torres Vicente, Barruso Bares Carlos, Bartolomé Resano Javier, Bartolomé Resano Rafael, Baudet Dejean Chantal, Beaus Alonso José Luis, Becerra Becerra Alberto, Belayos Jiménez Enrique, Belenguer Márquez J.Maria, Belenguer Prieto Rafael, Belles Calvo Amadeo, Belmonte Santamaría Julia Elena, Beltrán Juana Jose, Benavides Fernández Encarnación, Benedicto Acebo Rosa, Benedito García Esther, Bengoa Goiri Ainhoa, Bengoetxea Zorrilla Juan, Benítez Ortiz Juan Pedro, Benítez Rivero Javier, Benito De La Cruz José-Luis, Benlloch Guillem José Blas, Berciano Márquez Eduardo, Bermejo Enjuto Carmen, Bermejo Garcia Begoña, Bermejo Guillén Gonzalo, Bernad Guerrero Amparo, Bernal Soto Jose Antonio, Bernat Gil Luis Marcial, Besada Gesta Ricardo, Bethencourt Marante Jorge, Bijedick Snejada, Bilbao Armas Iñaki, Blanco Aparicio Javier, Blanco Arias Ana, Blanco Perdigón Luis, Blanco Ramos Cristina, Blanco Rodríguez Rubén, Bocos Ruiz José Ignacio, Bolinches Gandia Juan Jose, Bonet Garcia Jorge, Bordallo Huidobro Juan Ramón, Bordas Ignacio, Borges Mesa Ofelia, Borrachero Carmen, Borras Palle Carlos, Botella Gregori Ana, Bouzas Formoso Fernando, Bravo Bricien Ma Luz, Bravo Valverde Antonio, Brime Secades José Manuel, Brito Brito Elisenda, Brito Ma Jesús, Buendía Romero Alejandro, Bueno Lozano Mercedes, Buitrago Vera Carmen, Burgui Eslava Antonio, Busselo Lete Luis Miguel, Bustamante Caso Maria Luisa, Caamaño Mata Juan, Cabal Garcia Alberto, Cabaleiro Ubeira Dolores, Caballero Millan Pilar, Caballero Montanary Leónides, Cabanes Martín Teodorico, Cabanilla Valenzuela Antonio, Cacho Ángel, Cal Martínez Pablo, Calatayud Carreres Ma Del Carmen, Calatayud Climent Enrique, Calatayud Climent Enrique, Caldeiro Jiménez José Ma, Calderón Alva Juan, Calduch Herrera Lourdes, Calero Gonzalez Cloria, Callado Ramón Mariano, Calleja Delgado Ma Ángeles, Calvillo Navarro Ángel, Calviño Carballo Ramón, Calvo Hornillos Mercedes, Calvo Quintela Laura, Calzada Gil Manuel, Camarena Rodríguez José Ma, Campos Martos Ignacio, Candau Marcos Rafael, Candela Maetzu Macarena, Caneda Carmen, Caneiro López Ana Maria, Caniego Monreal Ángel, Cano Aparicio Pere, Cano Espín Agustina, Cantera Valls Nieves, Cañas Gonzalez Juan, Capdevila Falguera Dolors, Carballal Martínez Angelines, Carballo Albarate Jose Luis, Carballo Garcia Jose Juan, Carcas Sansuan José Luis, Carcedo Suárez Virgilio, Cárdenas Joyanes Ma Dolores, Cardona Rossello Federico, Carmona Segado Jose Manuel, Carrasco Gómez Consolación, Carrasco Herrera Jesús, Carrasco Pineda Marcos, Carretero Ramos Raquel, Carretero Salvador Olegario, Carrillo Lourdes, Carrio Garcia Guillermo, Carrión Valero Lucinio, Carvajal Trujillo Nicomedes, Casal Ardines Eliecer, Casal Osorio Antonio, Casal Redondo Fernando, Casanova Carlos, Casanueva Álvarez Rosa Ma, Cascan Martín Jose Ma, Castaño González Mercedes, Castell Victoria, Castello Esteve Luis, Castillejo Orozco Ana E, Castresana Arrate Ma Victoria, Castro Blanco Isabel, Catalán Maciá José, Catón Valdés Manuel, Cavero Clerencia Elena, Cazador Romero Pilar, Cebreiro Navalon Antonio, Cebrian Montolio Francisco, Cebrian Picazos Adolfo, Cejudo Serrano Rosa, Celades Moliner Pilar, Cenoz Osinaga Juan Carlos, Cerdan Oliver Miguel, Cereceda Pecilla Ricardo, Cervantes Chaves Alfredo, Cervera Moscardo Jose B, Chumilla Checa Celia, Cifuentes Gómez Pedro, Cirapozu Mendivil Juan, Cobo Domínguez Concepción, Cobo Rodrigo Ammonia, Codesido Blanco Teresa, Colomer Escuder Teresa, Colomer Lloret Mireya, Colomina Sarrió Pilar, Comas Samper Jose Manuel, Concheiro Coello Gonzalo, Contrera Enrique, Contreras Torres Juan A, Copeiro Del Villar Martínez Ana, Corell Dolz José, Coronado Reyes Pedro, Corralez Hava Joaquin, Correa Armero Rosario, Cortés Oliva Anna, Cortilla Santamaria Albert, Cozar Hernandez Antonio, Crespo Basterra Javier, Crespo Gargallo Antonio, Crespo Jimenez Floreal, Crespo Martínez Francisco, Crespo Rodríguez Rufina, Criado Gonzalez Luis, Cristobal Torras Joan, Cruz Villegas Inmaculada, Cubas Cubells Carmen, Cuende Chamorro Maria Jesús, Cuerpo Álvarez Francisco, Cueto Bulnes Ignacio, Cumplido Pérez Antonio, Damas Manuel, Dapena Barón Cristina, Davila Brun Carlos, De Diego Sierra David, De Felipe Medina Ricardo, De Frutos Marcos Concha, De La Fuente Fernández Teodoro, De La Fuente Mariño Rosa, De La Torre Edo Jorge, De La Vega Cuyás Arturo, De La Villa De Diego Ricardo, De Miguel Villamediana Begoña, De Simón Gutiérrez Raúl, Debon Belda Manuel, Dehesa Terreros José, Del Álamo Alonso Alberto, Del Alba Carballo Maria Rosa, Del Amo Rodríguez Concha, Del Amo Carmen, Del Campo Aguado Concepcion, Del Carmen Elcuaz Julián, Del Castillo Martínez Ma José, Del Jesús Clemente Amelia, Del Rivero Llano Enrique, Delás Gómez Enrique, Delfin Vázquez Marta, Delgado Dominguez Benito, Diaz Bernabé José Ramón, Diaz Fernandez Ma Del Carmen, Diaz Gomez Juan Manuel, Diaz Millán Almudena, Diaz Olea Emilia, Diaz Roger Teresa, Díaz Andrés Ma Luisa, Díaz Eraso Montserrat, Díaz Jiménez Jesús, Díaz Luis Carmen, Dieguez Estevez Agapito, Diez Blanco Felipe, Diez Garcia Manuel, Diez Ruiz Ana, Díez Cantalapiedra Eladio, Díez Cantarero Adolfo, Dimas Nuñez Fernando, Divison Garrote Juan Antonio, Dóiaz Ruisanchez Enrique, Domingo Platero Concepcion, Domingo Sancho Cesar, Dominguez Gonzalez Jesus, Domínguez Deben Daniel, Domínguez Pérez Juan A., Dosantos Hernandez Javier, Echeverria Arruabarrena Juan, Eguinoa Villanueva José Luis, Eiris Cambre M.Jesús, Ekek Jannura Miguel, El Kak Chaaban Raffat, Eliche Vilchez Julián, Elorriaga Campos Angel, Elorriaga Urquijo Eguzkiñe, Elorza Olabegoya Itziar, Elvira Perez Eladio, Encinoso Sánchez Candelaria, Enrriquez De Terry Alfonso, Epaizabal Mujika Xabier, Erdozain Corpas Juan Pedro, Erlanz Abad Arturo, Escobar Moreno Cesar, Espinosa Barrientos Lourdes, Estarriol Jiménez Carlos, Esteban Gaitero Juan Pedro, Esteban Marquez Juan José, Estebanez Auxina Alberto, Esteve Fuster Vicente, Estévez Ardit Anabel, Estévez González Pablo, Etxeberria Uribesalgo Carmelo, Etxevarria Etxevaria Juan Ignacio, Etxezarreta Crespo Ramon, Ezpeleta Albuixech Leonardo, Farouk Hendi Malas Mohamer, Farreres Pí Concepció, Faus Mascarell Emilia, Fenoll Pascual Federico, Fenoy Soriano Angel, Fernández Benitez Carlos, Fernandez Cabello Ma Luisa, Fernandez Cañadas Enrique, Fernandez Fernandez Carmen, Fernandez Fernandez Leandro, Fernandez Fernandez Luis, Fernandez Gomez Jose, Fernandez Hernandez Jose Ángel, Fernández López José Manuel, Fernandez Martinez Angel, Fernandez Martinez Juncal, Fernandez Moyano Fernando, Fernandez Peleteiro Jose Manuel, Fernandez Seoane Antonio, Fernandez Silva Ma Jesus, Fernandez Villaverde Jose Maria, Fernandez Yebra Esther, Fernández Arienza José, Fernández Barrial Manuel, Fernández Cañaveras Ma Isabel, Fernández Escalada Eugenio, Fernández Garcia Elisa, Fernández Garcia Jose Maria, Fernández González Angeles, Fernández González Manuel, Fernández Gutiérrez Maria Ángeles, Fernández Mouriño Ma Jesús, Fernández Prieto Dulce, Fernández Roces Ramonita, Fernández Rodriguez José Antonio, Fernández Sánchez Carlos, Fernández Simón Felisa, Ferrandiz Miquel Joaquin, Ferrandiz Miquel Joaquin, Ferreiro Alonso Pablo, Ferreiro Guri Jose Antonio, Ferrer Bascuñana Pedro, Ferrer Tomas Ramon, Fiallega Otero Rafael, Flores Hernandez Miguel Angel, Flores Holguera Antonio, Flórez Garcia José, Florit Anglada Antonio, Font Servera Jose, Forcada Lozano Eugenio, Formento Tirado Aurelio, Fraga Cabado José, Fraga Carballo Carmen, Fraga Gonzalez Camila, Franco Martinez Generosa, Fransi Galiana Amparo, Frasquet Todolí Concha, Fuentes Fernandez Fernando, Fuentes Vigil José, Fuster Bellido Tomás, Gabriel Escribano Ma Ángeles, Gacto Fernandez Socorro, Gadea Vicente Pilar, Gaga Garcia Alfredo, Gago Fernández Carlos, Gainza De Los Rios Luis, Gaisán Tomé Carmen, Galán Velasco José Antonio, Galarreta Calvo Javier, Galarza Amorrortu Ana, Galdamez Nuñez Ana Ma, Galindo Tobal Francisca, Gallardo Alonso Fernando, Gallego Berciano Pilar, Gallego Garcia Carmen, Gallo Trebol Fernando, Gallo Jaime, Gamarra Ortiz Javier, Gamero Perez Florencio, Gandia Moya Carmen, Garay Orte Jon, Garayoa Arraiza Javier, Garcia Andrés Luis Enrique, Garcia Blas Miguel, Garcia Cabarcos Juan Antonio, Garcia Campo Urbano, Garcia Cantos Elena, Garcia Castellanos Natividad, Garcia Cuadros Marta, Garcia De Francisco Ana, Garcia Exposito Esmeralda, Garcia Falide Nieves, Garcia Gallego Francisco, Garcia Gonzalez Carmen, Garcia Lombardero Jose Maria, Garcia Machado Ma Luisa, Garcia Martinez Jose Joaquín, Garcia Molinos Juan R, Garcia Nadal Ignacio, Garcia Ortiz Jose Pablo, Garcia Ortiz Luis, Garcia Ortiz Teresa, Garcia Panero Maria Luisa, Garcia Perez Rafael, Garcia Pérez Fina, Garcia Pindado Ma Ángeles, Garcia Prades Pascuala, Garcia Ramón Elpidio, Garcia Romanos Fernando, Garcia Sanchez Dolores, Garcia Sanchez Sofia, Garcia Serrano Angel, Garcia Sierra Alberto, Garcia Suarez Victor Ignacio, Garcia Valverde Concepcion, Garcia Velasco Guillermo, Garcia Velasco Pilar, García Palacios Carmen, García Vilamea José Carlos, Garcia-Reyes Ramos Mercedes, Gardoki Elorriaga Jose A., Garicano Lasa Critina, Garrido Marcos Cecilio, Garrote Florencio Timotea, Garrote Gutierrez Luis, Gascon Boto Fatima, Gasso Jiménez José Manuel, Gazquez Inmaculada, Genoves Esplugues Andres Vicente, Gerpe Rodriguez Oscar, Gijon Conde Teresa, Gil Correa Leopoldo, Gil Gil Cecilio, Gil Muñoz Julio, Gil Prats Pedro, Gil Tocados Guadalupe, Gil Velez Jaime, Gili Juan, Giménez González Manuel, Gobierno Hernández Jesús, Godoy García Isidro, Goenaga Badiola Eugenia, Goikoetxea Arrillaga Alejandro, Golpe Díaz Marcos, Gomez Abellas Enrique, Gomez Aguinaga Juan Manuel, Gomez Albadalejo Eduardo, Gomez Criado Maria Soledad, Gomez Dacal Maria Dolores, Gomez Galvez Cayetano, Gomez Garcia Beatriz, Gomez Queipo Belen, Gomez Rodriguez Adela, Gomez Saez Miguel Ángel, Gomez Sal Esther, Gomez Vazquez Jose Luis, Gomez Sonsoles, Gómez Del Río María Zulema, Gómez Marcos Manuel Ángel, Gómez Marín Elisa, Gonzalez Aller Manuel, González Acuña Eduardo, Gonzalez Alvarez Antonio, Gonzalez Candela Rosa, Gonzalez Espadas Ricardo, Gonzalez Gordillo Soledad, Gonzalez Hernández Luis, Gonzalez Loureiro Patricia, Gonzalez Lujan José Luis, Gonzalez Marcos Juanjo, Gonzalez Martin Carmen Teresa, Gonzalez Perez Carmen, Gonzalez Perez Ma Jesús, Gonzalez Ramos Elena, Gonzalez Reza Emilio, Gonzalez Rodriguez Manuel, Gonzalez Vicente Angel, González Aguado José Manuel, González Casado Ignacio, González Delgado Federico, González Fernández Maximino, González Gago José Antonio, González Garcia Angel, González Garcia Carmen, González Hernández José A., González Martin Angela, González Martin Carmen Teresa, González Méndez Magdalena, González Pozueco Yolanda, González Rodriguez Emilio, Gonzalez-Vals Gonzalez Ma Jose, Gonzalo Ines, Gorostiza Ormaetxea Javier, Gorrocategui Ereño Jesus, Granado Sanchez Francisco José, Granja Garrán Yolanda, Gregori Pellicer Juan-Ignasi, Guerrero Espejo Ma Carmen, Guija Villa Eduardo, Guillard Marie Martine, Guillen Hernandez Gaspar Elias, Guillot Valls Alfonso, Guinot Martinez Enrique, Gutierrez Angulo Marisa, Gutierrez Espinosa de los Montero Juan Antonio, Gutierrez Marin Francisco, Gutierrez Moreno Jose Abel, Gutierrez Miguel Ángel, Haya Guaita Amparo, Hermosa Hernan Juan Carlos, Hernaiz Valero Susana, Hernandez Iñarra Gabriel, Hernandez Manzano Carmen, Hernandez Martin Francisco Javier, Hernandez Mayle Colette, Hernández Gutiérrez Juana Isabel, Hernández Ollero Ma Dolores, Hernández Perlines Ma Vicenta, Hernando Mendivil Itziar, Hernando Zapatero Carlos, Hernani Bengoa Marta, Herraiz Rodriguez Ramón, Herrera Pelaez Antonio, Herrera Valladolid Carmen, Herrero Ballestar Jose Vte, Herrerozorriqueta Ma Jesús, Hervias Saiz Francisco José, Hevia Rodriguez Eduardo, Hidalgo Herrera Manuel, Homar Isern Bernardino, Hortal Gutierrez Felicidad, Ibañez Bernabeu Vicente, Ibañez Gomez Patricia, Ibarra Corbillón Angel, Ibeas Cristina, Iglesias Clemente José M., Iglesias Perez Eugenia, Iglesias Retamar Rafael, Igual Fraile Dimas, Ilizarri Ollauri Miren, Indurain Orduña Santos, Iñigo Espinosa Pedro A., Isidro Ortega Joan, Iturralde Iriso Jesus, Iturri Gaztelu Ana, Iznaola Sanchez Pedro Juan, Izquierdo Lopez Enrique, Izquierdo Sanz Jose Ramón, Izquierdo Yañez Ma José, Jalon Monzon Mercedes, Jamil Ala Ramzi, Jesús Casado Maria, Jimenez Perez Ramon, Jiménez Franco Julio, Jiménez Paredes Javier, Jiménez Redondo José Ramón, Jorge Bravo Maria Teresa, Jorge Rodriguez Fco.Jose, Jorques Navarro Juan Daniel, Jover Barber Juan Manuel, Juan Armas Julia, Juanes De La Peña Adrián, Jurado Toro Alberto, Labrador Gonzalez Alberto, Labrador Esther, Lado Llerena Angel, Lado Lopez Manuel, Laencina López Salvador, Lafuente Gutiérrez Jose Luis, Laguna Isabel, Lalanza Lasheras Juan Jose, Lamelas Garcia Jose A., Landin Vicuña Concha, Laporta Crespo Felix, Lara Moles Jesús, Larrinaga Kortabitarte Aitor, Lasarte Calderay Jose E., Lasheras Fernández Yolanda, Lazaro Rivera Mariano, Lazo Naudin Victor, Leal Correa Bartolme, Lebrero Sánchez Encarnación, Ledo Cabaleiro José María, Letona Antia Lurdes, Liñares Stolle Manuel, Lite Díaz Annabel, Lizarribar Sans Marta, Llario Sanjuán Miguel, Llido Vicedo Ricardo, Llinares Moreno Vicente, Lliteras Fleixas Gabriel, Llorens Edo Fernando, Llorente Martin Carmen, Lloscos Llavador German, Llull Sarralde Micaela, Lobato Delgado Luis Alberto, Lobato Fernández Manuel, Lobera Serrano Pedro, Loizaga Horno Juan, Lombillo De Oñate Margarita, Lopez Abietar Ma Isabel, Lopez Abril Juan, Lopez Aisa Blanca, Lopez Andrino Juan Carlos, Lopez Bazo Pedro, Lopez Cambeses Pilar, Lopez Cambeses Rosario, López Castañeda Elvia, Lopez Castro Antonio José, Lopez De Coca Fernandez-Valencia Enrique, Lopez De La Calle Fernando, Lopez De La Fuente Elena, Lopez Diaz Jesus, Lopez Hernandez Antonio, Lopez Leza Simon, Lopez Lopez Francisco, Lopez Martinez Mario, Lopez Moreno Ma Del Carmen, Lopez Muñoz Felix, Lopez Rodriguez Isidro, Lopez Rodriguez Jesus, Lopez Serrano Beatriz, Lopez Vazquez Luis Miguel, López Crespo Yolanda, López De La Fuente F. Javier, López Galindo Pedro Luis, López Muñoz Manuel, López Ortiz Franciso, López Ruiz Teresa, Lopez Perez Jose Manuel, Lopez-Cozar Fernandez Carmen, López Carmen, Lorente Lopez Enrique, Lorente Mayor Juan, Lorenzo Lorenzo Jesus Francisco, Lorenzo Salido Francisco, Lozano Chilet Inmaculada, Lucas Sánchez Roque, Lucero Aviña José Luis, Luengo Agüero Jesus, Luis Ruiz Cristina, Luna Estevez Sergio, Luna Estevez Sergio, Luque Jimenez Miguel, Madero Ambrojo Emilio, Madueño Caro Antonio J., Maestre Amat Luis, Maestre Amat Luis, Maestro Castellblanque Esperanza, Maffiotte Carrillo Nicolás, Mampel Almela Josep, Manzano Martinez Antonio, Marchena Consejero Manuel, Marco Macian Ma Dolores, Marcos Bailon Jesus, Marcos Fernandez Fco.Jose, Marcos Olea Javier Luis, Marcos Rodriguez Angel, Margeli Ana, Mari Solivellas Bartolome, Marin Castaño David, Marín Andrés Fernando, Marín Valero José, Marqués Calvo Inmaculada, Martel Martel Alberto, Martin Alfaro Maria Luisa, Martin Gomez Madel Carmen, Martin Martin Pedro, Martin Sanchez Jose, Martín Burillo Teresa, Martín García Lourdes, Martín Garito Enrique, Martín Martínez Enrique, Martín Millana Juan Carlos, Martín Moros José Ma, Martín Portal Alejandro, Martín Serrano Fernando, Martín Soledad José A, Martincano Jose Luis, Martinez Andueza Camino, Martinez Ausin Ma Carmen, Martinez Barrios Jesus, Martinez Bes Ma José, Martinez Cabrera Ana, Martinez Carrasco Jose Luis, Martinez Castellanos Mar, Martinez Correcher Francisca, Martinez Eizagirre Jose Manuel, Martinez Fernandez Montserrat, Martinez Galvan Luis Alfonso, Martinez Garcia Candido, Martinez Garcia Eladio, Martinez Gonzalez Esteban, Martinez González Mercedes, Martinez Hermosilla Alicia, Martinez Jativa Teresa, Martinez Lahuerta Juan José, Martinez Linuesa Remedios, Martinez Martinez Jose Ma, Martinez Montero Juan Alberto, Martinez Nuñez Elisa, Martinez Orozco Marino, Martinez Quess Dulce, Martinez Quilez Javier, Martinez Ramos Fco, Martinez Sanchez Luis, Martinez Vidal Angel, Martinez Vindel Juan Carlos, Martínez Guerola Carmen, Martínez Pardo Inmaculada, Martínez Pardo Rafael, Martínez Quintas María José, Martínez Vazquez Constantino, Martn Martin Araceli, Martorell Adsuara Vicente, Martos Calzado José, Martos Garcia Emilio, Mateo Cabrejas Jesús Javier, Mateos Mateos Jesús, Mateos Perez Mar, Matilla Alvarez Carmen, Maya Teresa, Mazquiarán Mendia Martín, Medina Castaño Antonio, Medina Cuenca Pedro, Medina Engler Berta, Medrano Gonzalez Maite, Megias Boils Araceli, Mejías González Santiago, Mejuto Bernabé Francisco J., Mellizo Moya Angel, Mena Garcia Juan, Mena Sastre Francisco Javier, Mencía De Castro Gaspar, Mencía Herreras José Ma, Mendez Gomez Begoña, Mendez Martinez Carmen, Mendez San Pedro Tomas, Mendieta Ruiz Ma Ángeles, Mendiguren Navascues Arantxa, Mendinueta Fernandez Carmen, Menedez Tamargo Jose Manuel, Menéndez Piquero Manuel, Mengual Moll, Vicente, Merino Muñoz Marta, Mesa Pedrero Carlos, Mesquida Jerónima, Mestre Llugany Joan, Mialdea Lozano Maria José, Milian Beser Susana, Minchero Arroyo Alberto, Minguez Villar José Carlos, Minguijon Barea Concha, Miniño Couto Gerardo, Minuesa Cortijo Francisco Javier, Miquel Mira Ma Jose, Mira Castejón Luis Alfredo, Miranda Ruiz Francisco, Modrego Navarro Angel, Molina Contreras Moises, Monfort Saez Rogelio, Monraba Capella Miquel, Monsalve Terrón Manuel, Montagud Moncho Miguel, Montañes Rustullet Carlos, Montero Luengo Juan, Montero Luque Javier, Mora Bresó Concha, Mora Díaz Juan De Dios, Mora Garcia Cristina, Morales Abad Manuel A., Morales Colas Ma Luz, Moranco Sengariz Ma Ángeles, Moreno De Mingo Javier, Moreno Gonzalez Antonia, Moreno Marín Germán, Moreno Minguez Vicente, Moreno Moreno Ana, Moreno Moreno Jose Manuel, Moreno Beatriz, Moreno Esther, Moro Jimenez Julián, Moro Torija Pilar, Moron Alejandre Angela, Morrell Rosario, Mosquera Martínez Juan, Mouriño Paz Amelia, Moya Cantarell Ma Victoria, Moya Santana Rafael, Mulet Sart Monserrat, Munar Mateu Juana Ana, Muñiz Fontaiñas Manuel, Muñiz Villa Candelas, Muñoz Conde Carmen, Muñoz Hernández José Gabriel, Muñoz Mora Francisco Javier, Muñoz Rodriguez Pepe, Mur Martí Teresa, Muriel Velasco Ana, Muruais Gonzalez Jesus, Napal Anaut Ma Olga, Naranjo Carrión Emilio Diego, Natal González Fernando, Navarro Martinez Victoria, Navarro Moreno Carlos, Navarro Soler Javier, Navarro Tarin Ricardo, Navarro Tarin Vicente, Navarro Valero Diego, Navarro Villena Manuel, Navascues Beltran German, Navaz Tejeiro Julio, Navaza Dafonte Ana Maria, Nevado Muñoz Rafael, Nicolau Pellicer Carmen, Niell Crespi Miguel, Nieto Hortal Pepe, Nogués Lobón Aurora, Novoa Rodriguez Belen, Núñez Jorge Carlos, Ocaña Cazalilla Carmelo, Ogallas Raya Fuensanta, Ojea Amoedo Enrique, Olea Carrasco Miriam, Olid Valle Antonio, Olina Iparragirre Anuska, Olivar Castrillón Carmen, Olivares Escribano Quintin, Olivera Cañadas Guadalupe, Olivera Ramos Ana G., Olmos Diaz Francisco, Ontañon Bort Juan Jose, Ordoñez Picón Roberto, Orgaz Gallego Pilar, Ormad Sebastian Javier, Orribo Rodríguez Severiana, Orruño Albizu Luis, Ortega De La Torre Llanos, Ortega Díaz Ángel Felipe, Ortega Motilla Natividad, Ortega Ríos Francisco Javier, Ortin Arronis José Manuel, Ortiz Forcada Josefina, Ortueta Ruiz De Arbulu Jesus, Otaduy Bengoa Santiago, Otero Arias Fernando, Otero Cotón José, Otero Lopez Jose Manuel, Otxoa Ibañez Iñaki, Oujo Pujales Juan, Pablos Herrero Eva, Paches Porcar Ma Dolores, Padin Montoto Fernando, Padron Chao Antonio, Padrón Pérez Marcos, Palacio Monedero Carmen, Palacios Claramunt Juan Andres, Palacios Del Cerro Antonio, Palacios Gonzalez Eleazar, Pallarés Hernández Maria Pilar, Palma Lafuente Javier, Palomares Fernández Sixto, Palomo Del Arco Jesús, Panero Juan Vicente, Pappalardo Ordiñana Eric, Pappalardo Ordiñana Eric, Pardo Diaz Beatriz, Paredes Martinez Ma Luz, Paredes Urraca Tomás, Parra Rodriguez Francisco, Parralejo Cano Francisco, Parrilla Rubio Margarita, Pascual Gil Octavio, Pascual González Oscar, Pascual Seara Benito, Pastor Benavent Carmen, Pastor Oliver José Francisco, Pastor Pastor Juan, Pastrana Gonzalez Victoria, Paya Perez José Antonio, Payán Godoy Josefa, Pazos Lopez José, Pedraz García Ma Isabel, Peiro Morant Juan, Pellit Ramil Jose Ignacio, Penades Vaya Vicente, Pensado Pousa José Francisco, Peña Forcada Carmen, Peñas Merino Antonio, Perales Bolado Javier, Peralta Munguía Lucía, Pereira Aparicio Ma ángeles, Perera Pérez Carmen G., Perez Alemany Antonio, Perez Algar Ma José, Perez Alonso Manuel, Perez Bermudez Aurelio, Perez Domingo Elena, Perez Gallego Francisco, Perez Garcia Catalina, Perez Llamas Miguel, Perez Perez Jose Luis, Perez Urraza Gotzone, Perez Vera Juan Antonio, Pérez Martín Ma Del Puerto, Pérez Palmes M. Paz, Pérez Sánchez José Carlos, Pérez Vicente Antonio, Perez De Lis Fernandez Jesus, Perez De Olaguer Clavell Juan Jose, Perez-Blanco Fernández Antonio, Perez-Romero Martinez Jaime, Pericas Garcia Bartolome, Pericas Garcia Julio, Peris Velarde José Manuel, Peset Aleixandre Asunción, Picazo Moreno Eduardo, Pilar Claramonte Juan M, Pitarch Marco Florentina, Plá Vaya Rafael, Pleguezuelos Martinez Manuel, Ponce Buj Begoña, Poncela Costas Elvira, Ponzola Sanchez José Manuel, Porcel Llado Miquel, Porritt Lueiro Begoña, Portela Anton Jose, Porto Iglesias Jesus, Portus Vinyeta Teresa, Pousa Estevez Lorenzo, Poveda Grau Vicente, Pozo Teruel Amparo, Pradas Gonzalez Carmen, Pradela Leonardo Juan, Prados Cano Dolores, Prados Del Pino Javier, Prats Villagrasa M° Jose, Prieto Albino Luis, Prieto Carnicer Maria De Los Ángeles, Prieto Ferrer Nuria, Prieto Gonzalez Laureano, Prieto Seva Alvaro José, Prieto Carmen, Prol Raña Manuel, Puchalt Ana Maria, Pucholt Bergara Juan, Puente Galán Oscar, Puente Martinez Antonio, Puente Perez Pablo, Quevedo Rivera Julia, Quiles Añon Fernando, Quindimil Vazquez Jose Antonio, Quiros Alvarez Jesús, Raga Asins Martin, Raga Casasus José Vicente, Ralla Pablo Jordi, Rama Ferro Jesús, Ramia Mulet Jose Luis, Ramirez Aparicio Antonio, Ramírez Perez Carlos, Ramos Aleixades Adolfo, Ramos Hernández Santiago, Ramos Rodriguez Manuel, Ramos Rafael, Razón Angulo Emilio, Real. Balaguer Vicente, Reboso Reyes Cristina, Recio Ribote Lourdes, Reguillo Diaz Joaquina, Remón Soriano Agustina, Renteria Goirigolzarri Jon, Repiso Moreno Manuel, Requena Solera Juan, Retis Vazquez Julio, Retuerta García Ma Dolores, Revert Algarra Adoracion, Revert Algarra Adoración, Rey Suarez Salvador, Ribelles Cebrian Julio, Ribes Vicedo Juana, Ricart Cortes Jose Vicente, Ridaura Martí Amparo, Riera Calvo Andrés, Rios Gomez Prados, Rios Rey Teresa, Ripoll Sanchez Jaime, Rivero Macristo, Robres Oliete Mariano, Roca Baeza Ramon, Roca Bosch Jose Luis, Roca Martinez Amparo, Roca Verdú Antonio Ángel, Roche Del Toro Marciela, Rodilla Alonso Angel, Rodriguez Bacardit Neus, Rodriguez Fernandez Benito, Rodriguez Fernandez Concepcion, Rodriguez Gallego Concepcion, Rodriguez Garcia Amor, Rodriguez Ledo Pilar, Rodriguez Lopez Elisa, Rodriguez Lopez Isabel, Rodriguez Morua Javier, Rodriguez Ortiz De Zarate Ma Luisa, Rodriguez Perez Jose Carlos, Rodriguez Quintela Jesus, Rodriguez Romo Antonio, Rodriguez Soriano Ma Jose, Rodriguez Tebar Fabiola, Rodriguez Vivar Antonio, Rodríguez Alvarez Jesús, Rodríguez Bartolomé Emilio, Rodríguez Franco Mercedes, Rodríguez Gallego Concepción, Rodríguez Pérez Ana Denis, Rodríguez Portillo Fernando, Rodríguez Relucio Angela, Roig Valdivieso Monserrat, Rojo Calderón Aranzazu, Roldán Sanchez Pilar, Romero Conde Antonio, Romero Corroto Carmen, Romero De Lama Concepcion, Romero Garcia Cesar, Romero Mera Fernando, Ros Dominguez Jose, Rosell Cruchaga Luis, Rovira Peña Blanca, Rubert Escrig Carmina, Rubiera Alvarez Carlos, Rubio Arribas Victor, Rubio Beltran De Guevara Jesus, Rubio Fernandez Jose Félix, Rubio Gonzalez Manuela, Rubio Guerrero Manuel, Rubio Ruiz José Ma, Rubio Villar Montserrat, Rubio Teresa, Ruiz Aguilar Gloria, Ruiz Chamorro Manuel, Ruiz Lopez Jesus, Ruiz Pastor Luis, Ruiz Quintero Manuel, Ruiz Quintero Manuel, Ruiz Ramos Rosa, Ruiz Roig Joaquina, Ruiz Ruiz Ana María, Ruiz Vicente Julián, Ruiz Margarita, Ruz Franzi Ignacio, Saavedra Miján Juan, Saenz Garcia-Baquero Isabel, Saez Azucena, Sáez Sifre Salvador, Sagüillo Gonzalez Pedro, Said Heluani Mohamed, Salanova Peñalva Alejandro, Salas González Tomás, Salas Herrera Fernando, Salas Hospital Jose Carlos, Salcedo Peris Teresa, Salguero Chavez Emilio, Salguero Emilio, Salvador Hernandez Juan, Salvador Herrero Luis, Salvatierra Palacio Ma Luisa, San Andrés Hernández Inmaculada, San Juan Perez Begoña, Sanchez Calso Antonio, Sanchez De Enciso Miguel, Sanchez Escudero Alfonso, Sanchez Flores Marifé, Sanchez Garcia Jorge, Sanchez Jimenez Vicente, Sanchez Lozano Sandra, Sanchez Miralles Manuel, Sanchez Ortiz Pilar, Sanchez Peral Beatriz, Sanchez Ruiz Martino, Sanchez Santos Natividad, Sánchez Blanco Juan, Sánchez Carrasco Marisol, Sánchez García M. Isabel, Sánchez Gómez Ma Henar, Sánchez Lopez Eugenio, Sánchez Molla Manuel, Sánchez Pardo García Jesús, Sánchez-Villares Rodríguez Ma Teresa, Sanchidrian Velayos Ismael, Sandua Sada José Manuel, Saneleuterio Brines Rafael, Sangronid Uribarri Marisol, Sanmartin Fernandez Dolores, Sanso Rubert Pascual Patricia, Santacoloma Campos Idoia, Santana Fernández Juan A., Santos Altozano Carlos, Santos Bartolomé Antonio, Santos Benito Begoña, Sanz Arribas José, Sanz González Francisco, Seara Ma Luz, Sebastian Aparicio Ma Paz, Sebastian Milian Elena, Sedano Garcia Jose I., Segador Parra Jose, Serrano Cumplido Adalberto, Serrano Guerra-Librero Javier, Serrano Mallagray Luis, Serrano Vaverde Leticia, Sidro Bou Luisa Fda, Sieiro Prada Eudaldo, Siles Luna Maria Teresa, Siles Pozo Carmen, Simarro Rueda Marta, Sipan Sarrion Yolanda, Sirumal Hassamal Enrique, Sobrino Sorinas Eugenio, Soengas Vazquez Jose Antonio, Soler Carbó Montse, Soler David Vicente, Soler Lopez Tomas, Solera Albero Juan, SOriano FUentes Segundo, Sorlí Guerola José Vicente, Sosa Álvarez Cesar, Soto Figueiras Manuel, Soto Trigueros Juan De Dios, Suarez Alen José, Suarez Fernández Alejandro, Suarez Morán Ramón, Suárez Castro Nicanor, Suero Palancar José, Tardío López Manuel, Tarrío Tobar Manuel, Tejeda Serrano Ma Isabel, Tellado Rosello Jose L, Terron Ruiz Maria Jesús, Testillano Perez Enrique, Thalamas Atienza Aitor, Tienza Villalobos Marisa, Tirado Moliner Jose Ma, Toldos Villegas Gregorio, Tolosana Almale José María, Tomas Marin Carolina, Tomas Pruneda Pedro, Torcal Potente Ana, Toribio Espino Espino J.Manuel, Tormo Quiles Facundo, Tormos Felip Amparo, Torre Expósito Juan Simón, Torrero Atienza Araceli, Torres Hernandez Candelaria, Torres Vazquez Bernardo, Tranche Iparraguirre Salvador, Trujillo Pérez Isabel, Turegano Albarran Miguel, Unanue Aurrekoetxea Juan Tomás, Unceta Aramburu Fernando, Urbe Castelruiz Patxi, Urdangarin Tolosa Elena, Uribeetxeberria Garcia Lourdes, Usoz Otal Ramon, Valero Barceló Carmen, Valero Valero Rosana, Valero Valero Rosana, Valhondo Elias Juan Antonio, Valle Garcia Nicanor, Valledor Puente Juan, Vallés Romero Nuria, Valls Roca Francisco, Valverde Leis Jesus, Valverde Lizundia Anton, Vaquer Perez José Vicente, Vara González Luis Alberto, Varela Rotger Ciríaco, Vargas Negrín Francisco, Vargas Concha, Vargas Rafael, Vazquez Garcia Manuel, Vazquez Ortega Ma Dolores, Vazquez Ramos Elena, Velasco Escobar Pablo, Velasco Gemio Joaquin, Vendrell Torres Federico, Ventura Garcia Silvestre, Ventura Rodriguez Silvestre, Verdial Varela Jose Antonio, Vergara Ruiz Miguel, Vicente Diaz Juan Ignacio, Vicente Hernández Javier, Vicioso Pedro, Vidal Mesa Claudio, Vidal Pardo José, Vidal Planelles Francisca, Viejo Menendez Carmen, Vila Hernandez Luis, Vila Miró Ramon, Viladomiu Pascual Montserrat, Vilaplana Bernabeu Carlos, Villa Pérez Ma Jesús, Villalobos Martïn Juan Carlos, Villanueva Gomez Isabel, Villanueva Horn Luis, Villanueva Zarate Juan Ramón, Villar Guerrero Domingo, Villaró Gabarró Mercè, Villasevil Hernandez Raul, Villora Fernandez Angel, Villoria Echegaray Juan Manuel, Villuela González Fernando, Vilumbrales Llorente Roberto, Viota Esperanza, Viqueira Perez Bernardo, Zanon Gonzalez Emilio, Zaragoza Moreno Ampara, Zardoya Zardoya Milagros, and Zubiria Sopena Carlos.


   References
Top
 Abstract
 Introduction
 Materials and Methods
 Results
 Discussion
 Conclusion
 References
 

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