Journal of the American Society of Nephrology
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J Am Soc Nephrol 17: 236-245, 2006
© 2006 American Society of Nephrology
doi: 10.1681/ASN.2006080920
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Supplement Articles

Urinary Albumin Excretion and Glomerular Filtration Rate across the Spectrum of Glucose Abnormalities in Essential Hypertension

Josep Redon*, Francisco Morales-Olivas{dagger}, Alberto Galgo{ddagger}, Miguel Ángel Brito§, Javier Mediavilla||, Rafael Marín, Pilar Rodríguez**, Salvador Tranche{dagger}{dagger}, José Vicente Lozano{ddagger}{ddagger}, Claudia Filozof§§ and and the MAGAL Group

* Internal Medicine Service, Hospital Clínico, and {dagger} Department of Pharmacology, University of Valencia, Valencia, {ddagger} Centro de Salud Espronceda and § Endocrinology, Hospital Puerta de Hierro, Madrid, || Centro de Salud Pampliega, Burgos, Nephrology Service, Hospital Universitario Central de Asturias, Oviedo, ** Fingoi Health CareCentre, Lugo, {dagger}{dagger} El Cristo Health Centre, Oviedo, {ddagger}{ddagger} Centro de Salud Serrería 2, Valencia, and § Scientific Department, Cardiovascular Section, Bristol-Myers-Squibb, Madrid, Spain

Address correspondence to: Dr. Josep Redon, Hypertension Clinic, Internal Medicine, Hospital Clinico, University of Valencia, 46010 Valencia, Spain. Phone: +34-963862647; Fax: +34-963862647; E-mail: josep.redon{at}uv.es


   Abstract
Top
 Abstract
Introduction
 Materials and Methods
 Results
 Discussion
 Conclusion
 References
 
The objective of this study was to assess the relationship between urinary albumin excretion (UAE) and GF across the spectrum of the glucose metabolism abnormalities in a large population of patients with hypertension. The Microaluminuria en Pacientes con Glucemia Basal Alterada (MAGAL) is a multicenter, cross-sectional study that was carried out by 1723 primary care physicians. A total of 6227 patients with essential hypertension (in three groups: [1] normal fasting glucose <100 mg/dl, [2] impaired fasting glucose ≥100 to 126 mg/dl, and [3] type 2 diabetes) were analyzed in this substudy. GFR was estimated by using the Modification of Diet in Renal Disease (MDRD) abbreviated equation. A single first-morning urine albumin/creatinine ratio was measured using Bayer reagent strip Microalbustix, a semiquantitative method. Abnormal UAE was defined as an albumin/creatinine ratio ≥3.4 mg/mmol (equivalent to ≥30 mg/g). The prevalence of abnormal UAE, ≥3.4 mg/mmol, increased across the spectrum of glucose abnormalities: 39.7, 46.2, 48.6, and 65.6% for normoglycemic, low-range, and high-range impaired fasting glucose and diabetes, respectively. UAE was positively related to SBP (P = 0.003) and inversely to GFR (P < 0.001). Renal insufficiency (GFR <60 ml/min per 1.73 m2) was present in 21.8% of the patients, more frequently older patients, women, and those with diabetes. The factors that were related to renal insufficiency were UAE ≥3.4 mg/mmol (odds ratio 1.86; 95% confidence interval 1.60 to 2.17) and diabetes (odds ratio 1.62; 95% confidence interval 1.29 to 2.04). There is a close relationship between abnormal UAE and renal insufficiency in essential hypertension. This is more marked in patients with diabetes and moderate in patients with high-range impaired fasting glucose.


   Introduction
Top
 Abstract
 Introduction
Materials and Methods
 Results
 Discussion
 Conclusion
 References
 
An increase in urinary albumin excretion (UAE) even to a small extent, microalbuminuria, has become a marker for cardiovascular and renal disease. Initially tested in diabetes, its prognostic value in hypertensive patients without diabetes and in subgroups of the general population has been well established during the past few years (1–11).

In both patients with diabetes and without diabetes, elevated SBP and glucose levels are the main factors related to development of increased UAE. One of the largest epidemiologic studies, the Australian Diabetes Obesity and Lifestyle Study (AusDiab) (12), clearly showed the interaction of both factors in the prevalence of microalbuminuria. The relationship between UAE and estimated GFR, however, has received less attention even though GFR, like UAE, is a predictor of cardiovascular risk.

Widespread use of formulas to calculate GFR has enabled the influence of renal function in cardiovascular risk to be assessed. Therefore, alterations in renal function have emerged as a predictive marker for cardiovascular disease, and it has been reflected as such in the guidelines for clinical management (13,14). Several studies have shown calculated GFR to be a risk indicator for general mortality and cardiovascular death after myocardial infarction (15–20) and also for mortality associated with heart failure (21). Likewise, a large health registry has revealed a gradual relationship between estimated GFR and the risk for death, cardiovascular events, and hospitalization, independent of other risk factors (22).

Microalbuminuria and renal insufficiency frequently run in parallel (23). Both of them are influenced by BP and glucose levels. Whereas BP is the major determinant of microalbuminuria, glucose level is the major determinant of renal insufficiency (23). Despite the frequent cluster of microalbuminuria and low GFR, the potential interaction between UAE and GFR is not well understood even though it can provide useful clinical information. Therefore, the objective of the present study was to analyze the relationship between UAE and GFR across the spectrum of the glucose metabolism abnormalities in a large population of patients with hypertension. Combining both glucose abnormalities and hypertension, we included a population that was prone to developing microalbuminuria and renal insufficiency, which enabled us to assess their potential interactions


   Materials and Methods
Top
 Abstract
 Introduction
 Materials and Methods
Results
 Discussion
 Conclusion
 References
 
This study was a post hoc analysis from the Microaluminuria en Pacientes con Glucemia Basal Alterada (MAGAL) study, the design of which is described elsewhere in this journal. In brief, it is a multicenter, cross-sectional, observational study that was carried out by 1723 primary care physicians all over Spain. Each physician consecutively enrolled six patients with essential hypertension and age >18 and ≤80 yr divided into three categories according to carbohydrate metabolism: (1) Normal fasting glucose (NFG): fasting plasma glucose <100 mg/dl; (2) impaired fasting glucose (IFG): fasting plasma glucose ≥100 and <126 mg/dl; and (3) type 2 diabetes. Hypertension was defined as a previous diagnosis of hypertension and/or receiving antihypertensive medication. Exclusion criteria were type 1 diabetes, pregnancy or breast-feeding, urinary tract infection, pyuria, hematuria, fever, and having done strenuous physical exercise during the 24 h before UAE determination. The study was approved by the Ethics and Clinical Trials Committee of the Hospital Central de Asturias. Informed consent of the patient was obtained in all cases.

Study Protocol
Demographic and clinical data were obtained for each patient. Physical examination that included weight, height, body mass index (BMI), and SBP and diastolic BP (DBP) measurements was carried out on the visit day. Sitting SBP and DBP were measured according to the Spanish Hypertension Society guidelines (24), after 5 min of rest and with the cuff fitted to the perimeter of the arm. Three readings were taken, and the mean value of the last two was accepted as valid.

Serum glucose levels, creatinine levels, and the lipid profile were determined in blood samples that were obtained after at least 8 h of fasting. Glucose status was stratified as NFG, IFG, and diabetes, as described previously. In addition, patients with IFG were subdivided into two groups, those with fasting glucose of between 100 and 109.9 mg/dl (low-range IFG) and the remainder between 110 and 125.9 mg/dl (high-range IFG), based on the current and the former criteria for IFG. GFR was estimated as ml/min per 1.73 m2 according to the abbreviated Modification of Diet in Renal Disease (MDRD) study equation (16), which includes serum creatinine level, age, and gender. Race was not applicable in our study because all of the patients were white. Patients were stratified according to the GFR categories of the Kidney Disease Outcomes Quality Initiative guidelines (25).

A single first-morning urine albumin/creatinine ratio was measured using Bayer reagent strip Microalbustix (Leverkusen, Germany), a semiquantitative method. Abnormal UAE was defined as an albumin/creatinine ratio ≥3.4 mg/mmol (equivalent to ≥30 mg/g). According to the manufacturer, the Bayer Microalbustix test has a sensitivity of 90% and a specificity of 88% for the albumin/creatinine ratio. As defined in the protocol, urine samples with creatinine concentrations of ≤10 mg/dl were ruled out because they were considered too diluted.

Statistical Analyses
The variables are presented as frequency (95% confidence interval [CI]), mean (SD), or median (25th to 75th percentiles) according to the distribution of the variable. ANOVA was used for comparisons among groups. The association between qualitative variables was evaluated using the {chi}2 or Fisher exact test, depending on the application conditions. All hypothesis contrasts rejected the null hypothesis with an {alpha} error <0.05.

The relationship between GFR and UAE was assessed by Pearson correlation coefficients and multiple regression analysis. Factors that were related to abnormal GFR were assessed by using a multiple logistic regression model. The odds ratio (OR) of these variables, together with their CI and level of significance, were reported. The analysis was carried out using SAS for Windows (version 9.1; SAS Institute, Cary, NC).


   Results
Top
 Abstract
 Introduction
 Materials and Methods
 Results
Discussion
 Conclusion
 References
 
General Characteristics of the Study Population
This post hoc analysis was performed in 6227 patients: 1138 (18%) in the NFG group, 2491 (40%) in the IFG group (591 [9%] in the low-range IFG, 1900 [31%] in the high-range IFG), and 2598 (41%) in the diabetes group. The characteristics of the patients as grouped by the glucose categories are shown in Table 1. Age increased progressively from NFG to diabetes and gender was equally distributed among the four groups. SBP increased significantly from the normal carbohydrate metabolism group to the diabetes group. A BP <140/90 mmHg was observed in 41.4% of the patients with NFG and in 36.9% of those with IFG. In the patients with diabetes, BP was controlled (<130/80 mmHg) in 11.5% of cases. BMI was higher in patients with abnormalities in glucose values as compared with normoglycemic patients. A progressive increment in fasting plasma glucose, by definition, and in triglycerides was observed from the NFG to the diabetes groups. HDL cholesterol, however, followed an inverse association.


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  		Table 1. General characteristics of the study population grouped by glucose metabolism statusa

 
UAE
The prevalence of abnormal UAE (≥3.4 mg/mmol) was 54.5%, which increased across the spectrum of glucose abnormalities (39.7, 46.2, 48.6, and 65.6% for normoglycemic, low-range IFG, high-range IFG, and diabetes, respectively). In a multiple regression analysis, UAE was positively related to the SBP (P = 0.003) and inversely to the GFR (P < 0.001). In normoalbuminuric patients, GFR values did not differ among the glucose categories: 76.7, 76.8, 75.9, and 74.6 ml/min per 1.73 m2 for NFG, low-range and high-range IFG, and diabetes, respectively. In contrast, in those with abnormal UAE, GFR was significantly lower in the diabetes group (67.9 ml/min per 1.73 m2) as compared with the other two groups (74.7, 74.4, and 74.3 ml/min per 1.73 m2; P < 0.01 for each comparison).

GFR
Most of the patients had a GFR between 60 and 90 ml/min per 1.73 m2 (3623 [58.2%]). Renal insufficiency (GFR <60 ml/min per 1.73 m2) was present in 1361 (21.8%) of the patients, but only 298 (4.8%) patients had a GFR ≤45 ml/min. The main characteristics of the patients in the various GFR categories are shown in Table 2. Patients with the lowest GFR more frequently were older and women and had diabetes. Although the selection criteria established a misbalanced number of study patients (more patients selected by inclusion criteria in the IFG group), the trend association between the glucose category and the GFR spectrum can be observed. The proportion of normoglycemic patients decreases from those with GFR >90 ml/min per 1.73 m2 to those with ≤45 ml/min per 1.73 m2; a similar trend is found for patients with IFG. In contrast, the proportion of diabetes increases as the GFR declines. For each GFR category, UAE values increase as well as the percentage of patients with abnormal UAE, although the increment is steeper for the diabetes group as compared with the other glucose categories (Table 3).


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  		Table 2. General characteristics of the study population grouped by eGFR

 

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  		Table 3. UAE and prevalence of abnormal UAE (>3.4 mg/mmol) grouped by glucose status and eGFR

 
The factors that were related to GFR ≤60 ml/min per 1.73 m2 were analyzed in a multiple logistic regression analysis. Abnormal UAE, presence of glucose abnormalities, and uncontrolled BP were related independently to the low GFR. UAE ≥3.4 mg/mmol increased the risk by 87% (OR 1.87; 95% CI 1.61 to 2.17), IFG and diabetes by 30% (OR 1.30; 95% CI 1.05 to 1.62), and BP ≥140/90 mmHg or ≥130/80 if diabetes by 23% (OR 1.23; 95% CI 1.04 to 1.45). When each of the glucose status categories was included separately in the model, abnormal UAE and diabetes were the only significant determinants of renal insufficiency. An elevated UAE (≥3.4 mg/mmol) increased the risk by 86% (OR 1.86; 95% CI 1.60 to 2.17) and diabetes by 62% (OR 1.62; 95% CI 1.29 to 2.04).


   Discussion
Top
 Abstract
 Introduction
 Materials and Methods
 Results
 Discussion
Conclusion
 References
 
In this large cohort of hypertensive patients from primary care, the proportion of patients with abnormal UAE was 54.5%, and 21.8% had renal insufficiency. This study shows a clear association between UAE and frequency of renal insufficiency with a higher prevalence among those with higher UAE. Urinary albumin excretion was inversely related to GFR, and an abnormal UAE increases the risk for renal insufficiency (GFR ≤60 ml/min per 1.73 m2) by 89%. This association between abnormal UAE and renal insufficiency was more evident in patients with diabetes as compared with those with NFG and IFG. Likewise, for each GFR category, UAE values increased as well as the percentage of patients with abnormal UAE, although the values were higher for the diabetes group as compared with patients with NFG and those with IFG. Figures for patients with IFG, both low range and high range, were between those of NFG and diabetes.

In this study, the prevalence of abnormal UAE was greater than that observed in other cross-sectional surveys (26). This probably is due to the method used for measuring UAE and the characteristics of the study population. It has been reported that a single UAE assessment may increase by at least one fifth the prevalence of abnormal UAE (27). Selecting patients with both hypertension and glucose disorders also increases the prevalence, because high BP and glucose values are among the most important causes of UAE elevation (28). In addition, mean age and BMI in our study population was higher than in other surveys, two factors that also have been associated with abnormal UAE.

The prevalence of renal insufficiency was 21.8%, although it might be slightly overestimated as a result of the use of the MDRD equation to calculate GFR (29). Several studies have examined the difference between this method and the corresponding gold standard: derived GFR calculated by isotopic techniques (30–32). In the range of normal values, with true GFR >60 ml/min, the GFR may be underestimated by up to 28% when the formula is applied. As true glomerular filtration decreases, the differences become smaller, reaching an underestimation of 6% when the true GFR is <30 ml/min (31).

The factors that were associated with a worsening in renal function behaved as expected. The mean age was greater among patients with lower GFR values, and the prevalence of diabetes was higher as compared with the other groups. Not only diabetes but also a previous stage, such as the IFG, increased the risk for renal insufficiency. Likewise, uncontrolled hypertension was associated with low GFR. There were no differences, however, in the degree of obesity, with mean values >29 kg/m2 in all of the groups.

Patients with the lowest GFR more frequently were older and women and had diabetes. Although increased age and the presence of diabetes have been widely accepted as conditions that are associated with renal insufficiency, the high rate in women is less recognized, but it is in agreement with previous surveys of renal insufficiency using the MDRD equation. Differences between genders in the prevalence of GFR <60 ml/min are noteworthy, with a higher prevalence in women as compared with men. This also has been observed in other large-scale studies (32–34). The differences in the prevalence of GFR <60 ml/min between genders increases across the age range: The older the higher (33). This contradicts that more men than women receive treatment for ESRD, and it seems that the higher prevalence of renal failure in women results from the excessive dominance of age and gender in the equation.

The relationship between GFR and UAE was analyzed. Lower GFR was observed in patients with abnormal UAE, mainly in patients with diabetes. Likewise, as the GFR declined, the UAE values, as well as the prevalence of abnormal UAE, increased, and both shared common causative factors: High BP and abnormal glucose. Despite that this is a cross-sectional study, it seems that the presence of UAE increases the risk for renal function worsening, as has been demonstrated in a follow-up study (35). In patients who are prone to developing an increment in UAE, the impact over time of both BP values and abnormal glucose lead to a faster GFR decline than in those who maintain normal values of UAE. Another factor that may contribute to the association between abnormal UAE and low GFR is that during antihypertensive treatment and for a given BP, UAE values in patients with renal insufficiency resist reduction.

The main strengths of the present study lies in the large number of patients analyzed in the cross-sectional survey and a large representation of the glucose metabolism status categories. However, its limitations are that the sample size is not population based and that selection bias by the participating physicians cannot be completely ruled out. This, however, does not invalidate the main goal of the study, which was to examine the relationship between GFR and UAE in various glucose conditions. Another limitation of the study was that creatinine measurement was not calibrated with reference standards by all of the participating physicians. Finally, an unresolved question is whether the poorer prognosis for cardiovascular outcomes that are associated with UAE and GFR overlaps or is additive. Only prospective studies can help us to resolve this key issue.


   Conclusion
Top
 Abstract
 Introduction
 Materials and Methods
 Results
 Discussion
 Conclusion
References
 
There is a close relationship between abnormal UAE and renal insufficiency in patients with essential hypertension. This was more marked in patients with diabetes and was moderate in patients in the highest IFG range The clinical relevance of this relationship needs to be established in terms of temporal trend, treatment changes, and impact on risk.


   Acknowledgments
 
This study was supported by a Grant from Bristol-Myers Squibb.

The following investigators participated in the MAGAL Study: Abarca Bujan Benjamín, Abordan Chanat Ruchdi Omar, Acosta Méndez Juan M., Acosta Socorro Antonio, Adelantado Pozuelo Esther, Afonso Navarro Carmen, Agote Cuesta Gabriel, Aguado Mori Ana Cristina, Agudo Codujón Beatriz, Aguilar Huertas Eva, Aguilera Zubizarreta Eulalia, Aguiló Furió Sara, Aguirre Miñana Teresa, Álamo Domínguez Aníbal, Alba Díaz Ángel, Albert Cuñat Vicente, Albors Valls Alberto, Alegret Crespi Santiago, Alegria Alonso Ramón, Alfaro Alonso Guillermo, Alfaya Carrera Juan Jose, Allut Vidal Germán, Almela Tejedo Teresa, Alonso Atienza Ma Del Carmen, Alonso Del Pino Elena, Alonso Díaz-Marta Manuel, Alonso Fernandez Lola, Alonso Matia Rafael, Alonso Quintanilla Carmelo, Alonso Patricio, Altarriba Cano Ma Luisa, Altuna Zuriarrain Manuel, Alvarado Tato Antonio M., Álvarez Blanco Antonio, Álvarez De Monrego Carina, Álvarez Fernandez Hortensia, álvarez García Antonio, Álvarez Guisasola Fernando, Álvarez Mejorada Enrique, Álvarez Sanchez Ignacio, Álvarez Taboas Jorge, Álvarez Valero Jesús, Álvarez Vicente Juan Carlos, Alvear García Martin Jorge, Amhed Loufty Kheder, Amigo Núñez Ma Elena, Amurrio Olartua Juan Ma, Andrés Pauls Inmaculada, Andrés Mayor Ma José, Andrés Santos Esther, Andreu Amoros Juan Luis, Angel Cavada Miguel, Angora Mazuecos Francisco, Anguiano Calvo José, Angulo Gonzalez Javier, Angulo Vallejo Ester, Angulo Yuste Enrique, Antolin Llinares, Asunción, Anton Ortega Javier, Antón Castelló José Luis, Antón García Francisco, Añel Rodríguez Rosa, Aramburu Aramburu Pedro, Arancegi Marticorena Izaskun, Arayo Sola Inmaculada, Arbesú Prieto José, Ardévol González Rómulo, Arenas Mosqueda Julián, Arias Gómez Ma Jesus, Arias Salgado-Robsy Ana María, Ariza Hernández Andrés, Arlandis Puig Antonio, Arnal Sanchez Jose, Aroca Sanz Ma Luisa, Arocas Pérez Ricardo, Arribas Aguirregaviría F. Javier, Arrieta Ma Jesús, Arrondo Beguiristain Ma Ángeles, Arroyo Azpa Concepción, Arteaga Herrera Domingo, Arteche Legorburu Miguel Ángel, Artigues Llull Isabel, Arujo Marisol, Arza Arteaga Alicia, Ascanio León Belén, Asenjo Cabrera Irene, Asenjo Martin Amparo, Asensi Peñarrocha Isabel, Atienza Gaona Jose Juan, Atxotegi Loizate Laura, Auza José Javier, Avilés Martínez Francisco Javier, Ayala Muñoz Francisco, Ayensa Esparza Javier, Aznar Ladrón De Guevara Ma Jose, Azorín Sanz Francisco Javier, Baamonde Mosquera Leopoldo, Badiola Elu Jose Luis, Badosa Sanuy Ana, Baeza Romero Manuel, Baixarias Tibau Joaquim, Bajo Garcia Julián, Balaguer Montesinos Francisco, Balanzategi Garmendia Inmaculada, Ballester Berenguer José Vicente, Ballester Díaz Trinidad Margarita, Ballester Orti Javier, Bañón García Raquel, Baños Martínez Ma Soledad, Baños Merino Isabel, Bañ Gago Ma Jesús, Barbeito Zaldua Edurne, Barceló Bartolomé, Barges Ponce Vicente, Barras Galán Domingo, Barreiro Mourentans Carlos, Barrera Pérez Manuel, Barrera Torres Vicente, Barruso Bares Carlos, Bartolomé Resano Javier, Bartolomé Resano Rafael, Baudet Dejean Chantal, Beaus Alonso José Luis, Becerra Becerra Alberto, Belayos Jiménez Enrique, Belenguer Márquez J.Maria, Belenguer Prieto Rafael, Belles Calvo Amadeo, Belmonte Santamaría Julia Elena, Beltrán Juana Jose, Benavides Fernández Encarnación, Benedicto Acebo Rosa, Benedito García Esther, Bengoa Goiri Ainhoa, Bengoetxea Zorrilla Juan, Benítez Ortiz Juan Pedro, Benítez Rivero Javier, Benito De La Cruz José-Luis, Benlloch Guillem José Blas, Berciano Márquez Eduardo, Bermejo Enjuto Carmen, Bermejo Garcia Begoñ, Bermejo Guillén Gonzalo, Bernad Guerrero Amparo, Bernal Soto Jose Antonio, Bernat Gil Luis Marcial, Besada Gesta Ricardo, Bethencourt Marante Jorge, Bijedick Snejada, Bilbao Armas Iñaki, Blanco Aparicio Javier, Blanco Arias Ana, Blanco Perdigón Luis, Blanco Ramos Cristina, Blanco Rodríguez Rubén, Bocos Ruiz José Ignacio, Bolinches Gandia Juan Jose, Bonet Garcia Jorge, Bordallo Huidobro Juan Ramón, Bordas Ignacio, Borges Mesa Ofelia, Borrachero Carmen, Borras Palle Carlos, Botella Gregori Ana, Bouzas Formoso Fernando, Bravo Bricien Ma Luz, Bravo Valverde Antonio, Brime Secades José Manuel, Brito Brito Elisenda, Brito Ma Jesús, Buendía Romero Alejandro, Bueno Lozano Mercedes, Buitrago Vera Carmen, Burgui Eslava Antonio, Busselo Lete Luis Miguel, Bustamante Caso Maria Luisa, Caamaño Mata Juan, Cabal Garcia Alberto, Cabaleiro Ubeira Dolores, Caballero Millan Pilar, Caballero Montanary Leónides, Cabanes Martín Teodorico, Cabanilla Valenzuela Antonio, Cacho Ángel, Cal Martínez Pablo, Calatayud Carreres Ma Del Carmen, Calatayud Climent Enrique, Calatayud Climent Enrique, Caldeiro Jiménez José Ma, Calderón Alva Juan, Calduch Herrera Lourdes, Calero Gonzalez Cloria, Callado Ramón Mariano, Calleja Delgado Ma Ángeles, Calvillo Navarro Ángel, Calviño Carballo Ramón, Calvo Hornillos Mercedes, Calvo Quintela Laura, Calzada Gil Manuel, Camarena Rodríguez José Ma, Campos Martos Ignacio, Candau Marcos Rafael, Candela Maetzu Macarena, Caneda Carmen, Caneiro López Ana Maria, Caniego Monreal Ángel, Cano Aparicio Pere, Cano Espín Agustina, Cantera Valls Nieves, Cañas Gonzalez Juan, Capdevila Falguera Dolors, Carballal Martínez Angelines, Carballo Albarate Jose Luis, Carballo Garcia Jose Juan, Carcas Sansuan José Luis, Carcedo Suárez Virgilio, Cárdenas Joyanes Ma Dolores, Cardona Rossello Federico, Carmona Segado Jose Manuel, Carrasco Gómez Consolación, Carrasco Herrera Jesús, Carrasco Pineda Marcos, Carretero Ramos Raquel, Carretero Salvador Olegario, Carrillo Lourdes, Carrio Garcia Guillermo, Carrión Valero Lucinio, Carvajal Trujillo Nicomedes, Casal Ardines Eliecer, Casal Osorio Antonio, Casal Redondo Fernando, Casanova Carlos, Casanueva Álvarez Rosa Ma, Cascan Martín Jose Ma, Castaño González Mercedes, Castell Victoria, Castello Esteve Luis, Castillejo Orozco Ana E, Castresana Arrate Ma Victoria, Castro Blanco Isabel, Catalán Maciá José, Catón Valdés Manuel, Cavero Clerencia Elena, Cazador Romero Pilar, Cebreiro Navalon Antonio, Cebrian Montolio Francisco, Cebrian Picazos Adolfo, Cejudo Serrano Rosa, Celades Moliner Pilar, Cenoz Osinaga Juan Carlos, Cerdan Oliver Miguel, Cereceda Pecilla Ricardo, Cervantes Chaves Alfredo, Cervera Moscardo Jose B, Chumilla Checa Celia, Cifuentes Gómez Pedro, Cirapozu Mendivil Juan, Cobo Domínguez Concepción, Cobo Rodrigo Ammonia, Codesido Blanco Teresa, Colomer Escuder Teresa, Colomer Lloret Mireya, Colomina Sarrió Pilar, Comas Samper Jose Manuel, Concheiro Coello Gonzalo, Contrera Enrique, Contreras Torres Juan A, Copeiro Del Villar Martínez Ana, Corell Dolz José, Coronado Reyes Pedro, Corralez Hava Joaquin, Correa Armero Rosario, Cortés Oliva Anna, Cortilla Santamaria Albert, Cozar Hernandez Antonio, Crespo Basterra Javier, Crespo Gargallo Antonio, Crespo Jimenez Floreal, Crespo Martínez Francisco, Crespo Rodríguez Rufina, Criado Gonzalez Luis, Cristobal Torras Joan, Cruz Villegas Inmaculada, Cubas Cubells Carmen, Cuende Chamorro Maria Jesús, Cuerpo Álvarez Francisco, Cueto Bulnes Ignacio, Cumplido Pérez Antonio, Damas Manuel, Dapena Barón Cristina, Davila Brun Carlos, De Diego Sierra David, De Felipe Medina Ricardo, De Frutos Marcos Concha, De La Fuente Fernández Teodoro, De La Fuente Mariño Rosa, De La Torre Edo Jorge, De La Vega Cuyás Arturo, De La Villa De Diego Ricardo, De Miguel Villamediana Begoña, De Simón Gutiérrez Raúl, Debon Belda Manuel, Dehesa Terreros José, Del Álamo Alonso Alberto, Del Alba Carballo Maria Rosa, Del Amo Rodríguez Concha, Del Amo Carmen, Del Campo Aguado Concepcion, Del Carmen Elcuaz Julián, Del Castillo Martínez Ma José, Del Jesús Clemente Amelia, Del Rivero Llano Enrique, Delás Gómez Enrique, Delfin Vázquez Marta, Delgado Dominguez Benito, Diaz Bernabé José Ramón, Diaz Fernandez Ma Del Carmen, Diaz Gomez Juan Manuel, Diaz Millán Almudena, Diaz Olea Emilia, Diaz Roger Teresa, Díaz Andrés Ma Luisa, Díaz Eraso Montserrat, Díaz Jiménez Jesús, Díaz Luis Carmen, Dieguez Estevez Agapito, Diez Blanco Felipe, Diez Garcia Manuel, Diez Ruiz Ana, Díez Cantalapiedra Eladio, Díez Cantarero Adolfo, Dimas Nuñez Fernando, Divison Garrote Juan Antonio, Dóiaz Ruisanchez Enrique, Domingo Platero Concepcion, Domingo Sancho Cesar, Dominguez Gonzalez Jesus, Domínguez Deben Daniel, Domínguez Pérez Juan A., Dosantos Hernandez Javier, Echeverria Arruabarrena Juan, Eguinoa Villanueva José Luis, Eiris Cambre M.Jesús, Ekek Jannura Miguel, El Kak Chaaban Raffat, Eliche Vilchez Julián, Elorriaga Campos Angel, Elorriaga Urquijo Eguzkiñe, Elorza Olabegoya Itziar, Elvira Perez Eladio, Encinoso Sánchez Candelaria, Enrriquez De Terry Alfonso, Epaizabal Mujika Xabier, Erdozain Corpas Juan Pedro, Erlanz Abad Arturo, Escobar Moreno Cesar, Espinosa Barrientos Lourdes, Estarriol Jiménez Carlos, Esteban Gaitero Juan Pedro, Esteban Marquez Juan José, Estebanez Auxina Alberto, Esteve Fuster Vicente, Estévez Ardit Anabel, Estévez González Pablo, Etxeberria Uribesalgo Carmelo, Etxevarria Etxevaria Juan Ignacio, Etxezarreta Crespo Ramon, Ezpeleta Albuixech Leonardo, Farouk Hendi Malas Mohamer, Farreres Pí Concepció, Faus Mascarell Emilia, Fenoll Pascual Federico, Fenoy Soriano Angel, Fernández Benitez Carlos, Fernandez Cabello Ma Luisa, Fernandez Cañadas Enrique, Fernandez Fernandez Carmen, Fernandez Fernandez Leandro, Fernandez Fernandez Luis, Fernandez Gomez Jose, Fernandez Hernandez Jose Ángel, Fernández López José Manuel, Fernandez Martinez Angel, Fernandez Martinez Juncal, Fernandez Moyano Fernando, Fernandez Peleteiro Jose Manuel, Fernandez Seoane Antonio, Fernandez Silva Ma Jesus, Fernandez Villaverde Jose Maria, Fernandez Yebra Esther, Fernández Arienza José, Fernández Barrial Manuel, Fernández Cañaveras Ma Isabel, Fernández Escalada Eugenio, Fernández Garcia Elisa, Fernández Garcia Jose Maria, Fernández González Angeles, Fernández González Manuel, Fernández Gutiérrez Maria Ángeles, Fernández Mouriño Ma Jesús, Fernández Prieto Dulce, Fernández Roces Ramonita, Fernández Rodriguez José Antonio, Fernández Sánchez Carlos, Fernández Simón Felisa, Ferrandiz Miquel Joaquin, Ferrandiz Miquel Joaquin, Ferreiro Alonso Pablo, Ferreiro Guri Jose Antonio, Ferrer Bascuñana Pedro, Ferrer Tomas Ramon, Fiallega Otero Rafael, Flores Hernandez Miguel Angel, Flores Holguera Antonio, Flórez Garcia José, Florit Anglada Antonio, Font Servera Jose, Forcada Lozano Eugenio, Formento Tirado Aurelio, Fraga Cabado José, Fraga Carballo Carmen, Fraga Gonzalez Camila, Franco Martinez Generosa, Fransi Galiana Amparo, Frasquet Todolí Concha, Fuentes Fernandez Fernando, Fuentes Vigil José, Fuster Bellido Tomás, Gabriel Escribano Ma Ángeles, Gacto Fernandez Socorro, Gadea Vicente Pilar, Gaga Garcia Alfredo, Gago Fernández Carlos, Gainza De Los Rios Luis, Gaisán Tomé Carmen, Galán Velasco José Antonio, Galarreta Calvo Javier, Galarza Amorrortu Ana, Galdamez Nuñez Ana Ma, Galindo Tobal Francisca, Gallardo Alonso Fernando, Gallego Berciano Pilar, Gallego Garcia Carmen, Gallo Trebol Fernando, Gallo Jaime, Gamarra Ortiz Javier, Gamero Perez Florencio, Gandia Moya Carmen, Garay Orte Jon, Garayoa Arraiza Javier, Garcia Andrés Luis Enrique, Garcia Blas Miguel, Garcia Cabarcos Juan Antonio, Garcia Campo Urbano, Garcia Cantos Elena, Garcia Castellanos Natividad, Garcia Cuadros Marta, Garcia De Francisco Ana, Garcia Exposito Esmeralda, Garcia Falide Nieves, Garcia Gallego Francisco, Garcia Gonzalez Carmen, Garcia Lombardero Jose Maria, Garcia Machado Ma Luisa, Garcia Martinez Jose Joaquín, Garcia Molinos Juan R, Garcia Nadal Ignacio, Garcia Ortiz Jose Pablo, Garcia Ortiz Luis, Garcia Ortiz Teresa, Garcia Panero Maria Luisa, Garcia Perez Rafael, Garcia Pérez Fina, Garcia Pindado Ma Ángeles, Garcia Prades Pascuala, Garcia Ramón Elpidio, Garcia Romanos Fernando, Garcia Sanchez Dolores, Garcia Sanchez Sofia, Garcia Serrano Angel, Garcia Sierra Alberto, Garcia Suarez Victor Ignacio, Garcia Valverde Concepcion, Garcia Velasco Guillermo, Garcia Velasco Pilar, García Palacios Carmen, García Vilamea José Carlos, Garcia-Reyes Ramos Mercedes, Gardoki Elorriaga Jose A., Garicano Lasa Critina, Garrido Marcos Cecilio, Garrote Florencio Timotea, Garrote Gutierrez Luis, Gascon Boto Fatima, Gasso Jiménez José Manuel, Gazquez Inmaculada, Genoves Esplugues Andres Vicente, Gerpe Rodriguez Oscar, Gijon Conde Teresa, Gil Correa Leopoldo, Gil Gil Cecilio, Gil Muñoz Julio, Gil Prats Pedro, Gil Tocados Guadalupe, Gil Velez Jaime, Gili Juan, Giménez González Manuel, Gobierno Hernández Jesús, Godoy García Isidro, Goenaga Badiola Eugenia, Goikoetxea Arrillaga Alejandro, Golpe Díaz Marcos, Gomez Abellas Enrique, Gomez Aguinaga Juan Manuel, Gomez Albadalejo Eduardo, Gomez Criado Maria Soledad, Gomez Dacal Maria Dolores, Gomez Galvez Cayetano, Gomez Garcia Beatriz, Gomez Queipo Belen, Gomez Rodriguez Adela, Gomez Saez Miguel Ángel, Gomez Sal Esther, Gomez Vazquez Jose Luis, Gomez Sonsoles, Gómez Del Río María Zulema, Gómez Marcos Manuel Ángel, Gómez Marín Elisa, Gonzalez Aller Manuel, González Acuña Eduardo, Gonzalez Alvarez Antonio, Gonzalez Candela Rosa, Gonzalez Espadas Ricardo, Gonzalez Gordillo Soledad, Gonzalez Hernández Luis, Gonzalez Loureiro Patricia, Gonzalez Lujan José Luis, Gonzalez Marcos Juanjo, Gonzalez Martin Carmen Teresa, Gonzalez Perez Carmen, Gonzalez Perez Ma Jesús, Gonzalez Ramos Elena, Gonzalez Reza Emilio, Gonzalez Rodriguez Manuel, Gonzalez Vicente Angel, González Aguado José Manuel, González Casado Ignacio, González Delgado Federico, González Fernández Maximino, González Gago José Antonio, González Garcia Angel, González Garcia Carmen, González Hernández José A., González Martin Angela, González Martin Carmen Teresa, González Méndez Magdalena, González Pozueco Yolanda, González Rodriguez Emilio, Gonzalez-Vals Gonzalez Ma Jose, Gonzalo Ines, Gorostiza Ormaetxea Javier, Gorrocategui Ereño Jesus, Granado Sanchez Francisco José, Granja Garrán Yolanda, Gregori Pellicer Juan-Ignasi, Guerrero Espejo Ma Carmen, Guija Villa Eduardo, Guillard Marie Martine, Guillen Hernandez Gaspar Elias, Guillot Valls Alfonso, Guinot Martinez Enrique, Gutierrez Angulo Marisa, Gutierrez Espinosa de los Montero Juan Antonio, Gutierrez Marin Francisco, Gutierrez Moreno Jose Abel, Gutierrez Miguel Ángel, Haya Guaita Amparo, Hermosa Hernan Juan Carlos, Hernaiz Valero Susana, Hernandez Iñarra Gabriel, Hernandez Manzano Carmen, Hernandez Martin Francisco Javier, Hernandez Mayle Colette, Hernández Gutiérrez Juana Isabel, Hernández Ollero Ma Dolores, Hernández Perlines Ma Vicenta, Hernando Mendivil Itziar, Hernando Zapatero Carlos, Hernani Bengoa Marta, Herraiz Rodriguez Ramón, Herrera Pelaez Antonio, Herrera Valladolid Carmen, Herrero Ballestar Jose Vte, Herrerozorriqueta Ma Jesús, Hervias Saiz Francisco José, Hevia Rodriguez Eduardo, Hidalgo Herrera Manuel, Homar Isern Bernardino, Hortal Gutierrez Felicidad, Ibañez Bernabeu Vicente, Ibañez Gomez Patricia, Ibarra Corbillón Angel, Ibeas Cristina, Iglesias Clemente José M., Iglesias Perez Eugenia, Iglesias Retamar Rafael, Igual Fraile Dimas, Ilizarri Ollauri Miren, Indurain Orduña Santos, Iñigo Espinosa Pedro A., Isidro Ortega Joan, Iturralde Iriso Jesus, Iturri Gaztelu Ana, Iznaola Sanchez Pedro Juan, Izquierdo Lopez Enrique, Izquierdo Sanz Jose Ramón, Izquierdo Yañez Ma José, Jalon Monzon Mercedes, Jamil Ala Ramzi, Jesús Casado Maria, Jimenez Perez Ramon, Jiménez Franco Julio, Jiménez Paredes Javier, Jiménez Redondo José Ramón, Jorge Bravo Maria Teresa, Jorge Rodriguez Fco.Jose, Jorques Navarro Juan Daniel, Jover Barber Juan Manuel, Juan Armas Julia, Juanes De La Peña Adrián, Jurado Toro Alberto, Labrador Gonzalez Alberto, Labrador Esther, Lado Llerena Angel, Lado Lopez Manuel, Laencina López Salvador, Lafuente Gutiérrez Jose Luis, Laguna Isabel, Lalanza Lasheras Juan Jose, Lamelas Garcia Jose A., Landin Vicuña Concha, Laporta Crespo Felix, Lara Moles Jesús, Larrinaga Kortabitarte Aitor, Lasarte Calderay Jose E., Lasheras Fernández Yolanda, Lazaro Rivera Mariano, Lazo Naudin Victor, Leal Correa Bartolme, Lebrero Sánchez Encarnación, Ledo Cabaleiro José María, Letona Antia Lurdes, Liñares Stolle Manuel, Lite Díaz Annabel, Lizarribar Sans Marta, Llario Sanjuán Miguel, Llido Vicedo Ricardo, Llinares Moreno Vicente, Lliteras Fleixas Gabriel, Llorens Edo Fernando, Llorente Martin Carmen, Lloscos Llavador German, Llull Sarralde Micaela, Lobato Delgado Luis Alberto, Lobato Fernández Manuel, Lobera Serrano Pedro, Loizaga Horno Juan, Lombillo De Oñate Margarita, Lopez Abietar Ma Isabel, Lopez Abril Juan, Lopez Aisa Blanca, Lopez Andrino Juan Carlos, Lopez Bazo Pedro, Lopez Cambeses Pilar, Lopez Cambeses Rosario, López Castañeda Elvia, Lopez Castro Antonio José, Lopez De Coca Fernandez-Valencia Enrique, Lopez De La Calle Fernando, Lopez De La Fuente Elena, Lopez Diaz Jesus, Lopez Hernandez Antonio, Lopez Leza Simon, Lopez Lopez Francisco, Lopez Martinez Mario, Lopez Moreno Ma Del Carmen, Lopez Muñoz Felix, Lopez Rodriguez Isidro, Lopez Rodriguez Jesus, Lopez Serrano Beatriz, Lopez Vazquez Luis Miguel, López Crespo Yolanda, López De La Fuente F. Javier, López Galindo Pedro Luis, López Muñoz Manuel, López Ortiz Franciso, López Ruiz Teresa, Lopez Perez Jose Manuel, Lopez-Cozar Fernandez Carmen, López Carmen, Lorente Lopez Enrique, Lorente Mayor Juan, Lorenzo Lorenzo Jesus Francisco, Lorenzo Salido Francisco, Lozano Chilet Inmaculada, Lucas Sánchez Roque, Lucero Aviña José Luis, Luengo Agüero Jesus, Luis Ruiz Cristina, Luna Estevez Sergio, Luna Estevez Sergio, Luque Jimenez Miguel, Madero Ambrojo Emilio, Madueño Caro Antonio J., Maestre Amat Luis, Maestre Amat Luis, Maestro Castellblanque Esperanza, Maffiotte Carrillo Nicolás, Mampel Almela Josep, Manzano Martinez Antonio, Marchena Consejero Manuel, Marco Macian Ma Dolores, Marcos Bailon Jesus, Marcos Fernandez Fco.Jose, Marcos Olea Javier Luis, Marcos Rodriguez Angel, Margeli Ana, Mari Solivellas Bartolome, Marin Castaño David, Marín Andrés Fernando, Marín Valero José, Marqués Calvo Inmaculada, Martel Martel Alberto, Martin Alfaro Maria Luisa, Martin Gomez Madel Carmen, Martin Martin Pedro, Martin Sanchez Jose, Martín Burillo Teresa, Martín García Lourdes, Martín Garito Enrique, Martín Martínez Enrique, Martín Millana Juan Carlos, Martín Moros José Ma, Martín Portal Alejandro, Martín Serrano Fernando, Martín Soledad José A, Martincano Jose Luis, Martinez Andueza Camino, Martinez Ausin Ma Carmen, Martinez Barrios Jesus, Martinez Bes Ma José, Martinez Cabrera Ana, Martinez Carrasco Jose Luis, Martinez Castellanos Mar, Martinez Correcher Francisca, Martinez Eizagirre Jose Manuel, Martinez Fernandez Montserrat, Martinez Galvan Luis Alfonso, Martinez Garcia Candido, Martinez Garcia Eladio, Martinez Gonzalez Esteban, Martinez González Mercedes, Martinez Hermosilla Alicia, Martinez Jativa Teresa, Martinez Lahuerta Juan José, Martinez Linuesa Remedios, Martinez Martinez Jose Ma, Martinez Montero Juan Alberto, Martinez Nuñez Elisa, Martinez Orozco Marino, Martinez Quess Dulce, Martinez Quilez Javier, Martinez Ramos Fco, Martinez Sanchez Luis, Martinez Vidal Angel, Martinez Vindel Juan Carlos, Martínez Guerola Carmen, Martínez Pardo Inmaculada, Martínez Pardo Rafael, Martínez Quintas María José, Martínez Vazquez Constantino, Martn Martin Araceli, Martorell Adsuara Vicente, Martos Calzado José, Martos Garcia Emilio, Mateo Cabrejas Jesús Javier, Mateos Mateos Jesús, Mateos Perez Mar, Matilla Alvarez Carmen, Maya Teresa, Mazquiarán Mendia Martín, Medina Castaño Antonio, Medina Cuenca Pedro, Medina Engler Berta, Medrano Gonzalez Maite, Megias Boils Araceli, Mejías González Santiago, Mejuto Bernabé Francisco J., Mellizo Moya Angel, Mena Garcia Juan, Mena Sastre Francisco Javier, Mencía De Castro Gaspar, Mencía Herreras José Ma, Mendez Gomez Begoña, Mendez Martinez Carmen, Mendez San Pedro Tomas, Mendieta Ruiz Ma Ángeles, Mendiguren Navascues Arantxa, Mendinueta Fernandez Carmen, Menedez Tamargo Jose Manuel, Menéndez Piquero Manuel, Mengual Moll, Vicente, Merino Muñoz Marta, Mesa Pedrero Carlos, Mesquida Jerónima, Mestre Llugany Joan, Mialdea Lozano Maria José, Milian Beser Susana, Minchero Arroyo Alberto, Minguez Villar José Carlos, Minguijon Barea Concha, Miniño Couto Gerardo, Minuesa Cortijo Francisco Javier, Miquel Mira Ma Jose, Mira Castejón Luis Alfredo, Miranda Ruiz Francisco, Modrego Navarro Angel, Molina Contreras Moises, Monfort Saez Rogelio, Monraba Capella Miquel, Monsalve Terrón Manuel, Montagud Moncho Miguel, Montañes Rustullet Carlos, Montero Luengo Juan, Montero Luque Javier, Mora Bresó Concha, Mora Díaz Juan De Dios, Mora Garcia Cristina, Morales Abad Manuel A., Morales Colas Ma Luz, Moranco Sengariz Ma Ángeles, Moreno De Mingo Javier, Moreno Gonzalez Antonia, Moreno Marín Germán, Moreno Minguez Vicente, Moreno Moreno Ana, Moreno Moreno Jose Manuel, Moreno Beatriz, Moreno Esther, Moro Jimenez Julián, Moro Torija Pilar, Moron Alejandre Angela, Morrell Rosario, Mosquera Martínez Juan, Mouriño Paz Amelia, Moya Cantarell Ma Victoria, Moya Santana Rafael, Mulet Sart Monserrat, Munar Mateu Juana Ana, Muñiz Fontaiñas Manuel, Muñiz Villa Candelas, Muñoz Conde Carmen, Muñoz Hernández José Gabriel, Muñoz Mora Francisco Javier, Muñoz Rodriguez Pepe, Mur Martí Teresa, Muriel Velasco Ana, Muruais Gonzalez Jesus, Napal Anaut Ma Olga, Naranjo Carrión Emilio Diego, Natal González Fernando, Navarro Martinez Victoria, Navarro Moreno Carlos, Navarro Soler Javier, Navarro Tarin Ricardo, Navarro Tarin Vicente, Navarro Valero Diego, Navarro Villena Manuel, Navascues Beltran German, Navaz Tejeiro Julio, Navaza Dafonte Ana Maria, Nevado Muñoz Rafael, Nicolau Pellicer Carmen, Niell Crespi Miguel, Nieto Hortal Pepe, Nogués Lobón Aurora, Novoa Rodriguez Belen, Núñez Jorge Carlos, Ocaña Cazalilla Carmelo, Ogallas Raya Fuensanta, Ojea Amoedo Enrique, Olea Carrasco Miriam, Olid Valle Antonio, Olina Iparragirre Anuska, Olivar Castrillón Carmen, Olivares Escribano Quintin, Olivera Cañadas Guadalupe, Olivera Ramos Ana G., Olmos Diaz Francisco, Ontañon Bort Juan Jose, Ordoñez Picón Roberto, Orgaz Gallego Pilar, Ormad Sebastian Javier, Orribo Rodríguez Severiana, Orruño Albizu Luis, Ortega De La Torre Llanos, Ortega Díaz Ángel Felipe, Ortega Motilla Natividad, Ortega Ríos Francisco Javier, Ortin Arronis José Manuel, Ortiz Forcada Josefina, Ortueta Ruiz De Arbulu Jesus, Otaduy Bengoa Santiago, Otero Arias Fernando, Otero Cotón José, Otero Lopez Jose Manuel, Otxoa Ibañez Iñaki, Oujo Pujales Juan, Pablos Herrero Eva, Paches Porcar Ma Dolores, Padin Montoto Fernando, Padron Chao Antonio, Padrón Pérez Marcos, Palacio Monedero Carmen, Palacios Claramunt Juan Andres, Palacios Del Cerro Antonio, Palacios Gonzalez Eleazar, Pallarés Hernández Maria Pilar, Palma Lafuente Javier, Palomares Fernández Sixto, Palomo Del Arco Jesús, Panero Juan Vicente, Pappalardo Ordiñana Eric, Pappalardo Ordiñana Eric, Pardo Diaz Beatriz, Paredes Martinez Ma Luz, Paredes Urraca Tomás, Parra Rodriguez Francisco, Parralejo Cano Francisco, Parrilla Rubio Margarita, Pascual Gil Octavio, Pascual González Oscar, Pascual Seara Benito, Pastor Benavent Carmen, Pastor Oliver José Francisco, Pastor Pastor Juan, Pastrana Gonzalez Victoria, Paya Perez José Antonio, Payán Godoy Josefa, Pazos Lopez José, Pedraz García Ma Isabel, Peiro Morant Juan, Pellit Ramil Jose Ignacio, Penades Vaya Vicente, Pensado Pousa José Francisco, Peña Forcada Carmen, Peñas Merino Antonio, Perales Bolado Javier, Peralta Munguía Lucía, Pereira Aparicio Ma Ángeles, Perera Pérez Carmen G., Perez Alemany Antonio, Perez Algar Ma José, Perez Alonso Manuel, Perez Bermudez Aurelio, Perez Domingo Elena, Perez Gallego Francisco, Perez Garcia Catalina, Perez Llamas Miguel, Perez Perez Jose Luis, Perez Urraza Gotzone, Perez Vera Juan Antonio, Pérez Martín Ma Del Puerto, Pérez Palmes M. Paz, Pérez Sánchez José Carlos, Pérez Vicente Antonio, Perez De Lis Fernandez Jesus, Perez De Olaguer Clavell Juan Jose, Perez-Blanco Fernández Antonio, Perez-Romero Martinez Jaime, Pericas Garcia Bartolome, Pericas Garcia Julio, Peris Velarde José Manuel, Peset Aleixandre Asunción, Picazo Moreno Eduardo, Pilar Claramonte Juan M, Pitarch Marco Florentina, Plá Vaya Rafael, Pleguezuelos Martinez Manuel, Ponce Buj Begoña, Poncela Costas Elvira, Ponzola Sanchez José Manuel, Porcel Llado Miquel, Porritt Lueiro Begoña, Portela Anton Jose, Porto Iglesias Jesus, Portus Vinyeta Teresa, Pousa Estevez Lorenzo, Poveda Grau Vicente, Pozo Teruel Amparo, Pradas Gonzalez Carmen, Pradela Leonardo Juan, Prados Cano Dolores, Prados Del Pino Javier, Prats Villagrasa M° Jose, Prieto Albino Luis, Prieto Carnicer Maria De Los Ángeles, Prieto Ferrer Nuria, Prieto Gonzalez Laureano, Prieto Seva Alvaro José, Prieto Carmen, Prol Raña Manuel, Puchalt Ana Maria, Pucholt Bergara Juan, Puente Galán Oscar, Puente Martinez Antonio, Puente Perez Pablo, Quevedo Rivera Julia, Quiles Añon Fernando, Quindimil Vazquez Jose Antonio, Quiros Alvarez Jesús, Raga Asins Martin, Raga Casasus José Vicente, Ralla Pablo Jordi, Rama Ferro Jesús, Ramia Mulet Jose Luis, Ramirez Aparicio Antonio, Ramírez Perez Carlos, Ramos Aleixades Adolfo, Ramos Hernández Santiago, Ramos Rodriguez Manuel, Ramos Rafael, Razón Angulo Emilio, Real. Balaguer Vicente, Reboso Reyes Cristina, Recio Ribote Lourdes, Reguillo Diaz Joaquina, Remón Soriano Agustina, Renteria Goirigolzarri Jon, Repiso Moreno Manuel, Requena Solera Juan, Retis Vazquez Julio, Retuerta García Ma Dolores, Revert Algarra Adoracion, Revert Algarra Adoración, Rey Suarez Salvador, Ribelles Cebrian Julio, Ribes Vicedo Juana, Ricart Cortes Jose Vicente, Ridaura Martí Amparo, Riera Calvo Andrés, Rios Gomez Prados, Rios Rey Teresa, Ripoll Sanchez Jaime, Rivero Macristo, Robres Oliete Mariano, Roca Baeza Ramon, Roca Bosch Jose Luis, Roca Martinez Amparo, Roca Verdú Antonio Ángel, Roche Del Toro Marciela, Rodilla Alonso Angel, Rodriguez Bacardit Neus, Rodriguez Fernandez Benito, Rodriguez Fernandez Concepcion, Rodriguez Gallego Concepcion, Rodriguez Garcia Amor, Rodriguez Ledo Pilar, Rodriguez Lopez Elisa, Rodriguez Lopez Isabel, Rodriguez Morua Javier, Rodriguez Ortiz De Zarate Ma Luisa, Rodriguez Perez Jose Carlos, Rodriguez Quintela Jesus, Rodriguez Romo Antonio, Rodriguez Soriano Ma Jose, Rodriguez Tebar Fabiola, Rodriguez Vivar Antonio, Rodríguez Alvarez Jesús, Rodríguez Bartolomé Emilio, Rodríguez Franco Mercedes, Rodríguez Gallego Concepción, Rodríguez Pérez Ana Denis, Rodríguez Portillo Fernando, Rodríguez Relucio Angela, Roig Valdivieso Monserrat, Rojo Calderón Aranzazu, Roldán Sanchez Pilar, Romero Conde Antonio, Romero Corroto Carmen, Romero De Lama Concepcion, Romero Garcia Cesar, Romero Mera Fernando, Ros Dominguez Jose, Rosell Cruchaga Luis, Rovira Peña Blanca, Rubert Escrig Carmina, Rubiera Alvarez Carlos, Rubio Arribas Victor, Rubio Beltran De Guevara Jesus, Rubio Fernandez Jose Félix, Rubio Gonzalez Manuela, Rubio Guerrero Manuel, Rubio Ruiz José Ma, Rubio Villar Montserrat, Rubio Teresa, Ruiz Aguilar Gloria, Ruiz Chamorro Manuel, Ruiz Lopez Jesus, Ruiz Pastor Luis, Ruiz Quintero Manuel, Ruiz Quintero Manuel, Ruiz Ramos Rosa, Ruiz Roig Joaquina, Ruiz Ruiz Ana María, Ruiz Vicente Julián, Ruiz Margarita, Ruz Franzi Ignacio, Saavedra Miján Juan, Saenz Garcia-Baquero Isabel, Saez Azucena, Sáez Sifre Salvador, Sagüillo Gonzalez Pedro, Said Heluani Mohamed, Salanova Peñalva Alejandro, Salas González Tomás, Salas Herrera Fernando, Salas Hospital Jose Carlos, Salcedo Peris Teresa, Salguero Chavez Emilio, Salguero Emilio, Salvador Hernandez Juan, Salvador Herrero Luis, Salvatierra Palacio Ma Luisa, San Andrés Hernández Inmaculada, San Juan Perez Begoña, Sanchez Calso Antonio, Sanchez De Enciso Miguel, Sanchez Escudero Alfonso, Sanchez Flores Marifé, Sanchez Garcia Jorge, Sanchez Jimenez Vicente, Sanchez Lozano Sandra, Sanchez Miralles Manuel, Sanchez Ortiz Pilar, Sanchez Peral Beatriz, Sanchez Ruiz Martino, Sanchez Santos Natividad, Sánchez Blanco Juan, Sánchez Carrasco Marisol, Sánchez García M. Isabel, Sánchez Gómez Ma Henar, Sánchez Lopez Eugenio, Sánchez Molla Manuel, Sánchez Pardo García Jesús, Sánchez-Villares Rodríguez Ma Teresa, Sanchidrian Velayos Ismael, Sandua Sada José Manuel, Saneleuterio Brines Rafael, Sangronid Uribarri Marisol, Sanmartin Fernandez Dolores, Sanso Rubert Pascual Patricia, Santacoloma Campos Idoia, Santana Fernández Juan A., Santos Altozano Carlos, Santos Bartolomé Antonio, Santos Benito Begoña, Sanz Arribas José, Sanz González Francisco, Seara Ma Luz, Sebastian Aparicio Ma Paz, Sebastian Milian Elena, Sedano Garcia Jose I., Segador Parra Jose, Serrano Cumplido Adalberto, Serrano Guerra-Librero Javier, Serrano Mallagray Luis, Serrano Vaverde Leticia, Sidro Bou Luisa Fda, Sieiro Prada Eudaldo, Siles Luna Maria Teresa, Siles Pozo Carmen, Simarro Rueda Marta, Sipan Sarrion Yolanda, Sirumal Hassamal Enrique, Sobrino Sorinas Eugenio, Soengas Vazquez Jose Antonio, Soler Carbó Montse, Soler David Vicente, Soler Lopez Tomas, Solera Albero Juan, SOriano FUentes Segundo, Sorlí Guerola José Vicente, Sosa Álvarez Cesar, Soto Figueiras Manuel, Soto Trigueros Juan De Dios, Suarez Alen José, Suarez Fernández Alejandro, Suarez Morán Ramón, Suárez Castro Nicanor, Suero Palancar José, Tardío López Manuel, Tarrío Tobar Manuel, Tejeda Serrano Ma Isabel, Tellado Rosello Jose L, Terron Ruiz Maria Jesús, Testillano Perez Enrique, Thalamas Atienza Aitor, Tienza Villalobos Marisa, Tirado Moliner Jose Ma, Toldos Villegas Gregorio, Tolosana Almale José María, Tomas Marin Carolina, Tomas Pruneda Pedro, Torcal Potente Ana, Toribio Espino Espino J.Manuel, Tormo Quiles Facundo, Tormos Felip Amparo, Torre Expósito Juan Simón, Torrero Atienza Araceli, Torres Hernandez Candelaria, Torres Vazquez Bernardo, Tranche Iparraguirre Salvador, Trujillo Pérez Isabel, Turegano Albarran Miguel, Unanue Aurrekoetxea Juan Tomás, Unceta Aramburu Fernando, Urbe Castelruiz Patxi, Urdangarin Tolosa Elena, Uribeetxeberria Garcia Lourdes, Usoz Otal Ramon, Valero Barceló Carmen, Valero Valero Rosana, Valero Valero Rosana, Valhondo Elias Juan Antonio, Valle Garcia Nicanor, Valledor Puente Juan, Vallés Romero Nuria, Valls Roca Francisco, Valverde Leis Jesus, Valverde Lizundia Anton, Vaquer Perez José Vicente, Vara González Luis Alberto, Varela Rotger Ciríaco, Vargas Negrín Francisco, Vargas Concha, Vargas Rafael, Vazquez Garcia Manuel, Vazquez Ortega Ma Dolores, Vazquez Ramos Elena, Velasco Escobar Pablo, Velasco Gemio Joaquin, Vendrell Torres Federico, Ventura Garcia Silvestre, Ventura Rodriguez Silvestre, Verdial Varela Jose Antonio, Vergara Ruiz Miguel, Vicente Diaz Juan Ignacio, Vicente Hernández Javier, Vicioso Pedro, Vidal Mesa Claudio, Vidal Pardo José, Vidal Planelles Francisca, Viejo Menendez Carmen, Vila Hernandez Luis, Vila Miró Ramon, Viladomiu Pascual Montserrat, Vilaplana Bernabeu Carlos, Villa Pérez Ma Jesús, Villalobos Martïn Juan Carlos, Villanueva Gomez Isabel, Villanueva Horn Luis, Villanueva Zarate Juan Ramón, Villar Guerrero Domingo, Villaró Gabarró Mercè, Villasevil Hernandez Raul, Villora Fernandez Angel, Villoria Echegaray Juan Manuel, Villuela González Fernando, Vilumbrales Llorente Roberto, Viota Esperanza, Viqueira Perez Bernardo, Zanon Gonzalez Emilio, Zaragoza Moreno Ampara, Zardoya Zardoya Milagros, Zubiria Sopena Carlos.


   References
Top
 Abstract
 Introduction
 Materials and Methods
 Results
 Discussion
 Conclusion
 References
 

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