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In Memoriam Norman J. Siegel, MD 1943–2006

Editor in Chief, Journal of the American Society of Nephrology

Allison A. Eddy, MD

Deputy Editor, Journal of the American Society of Nephrology Professor of Pediatrics University of Washington

The members of the American Society of Nephrology (ASN) and the international nephrology community were deeply shocked and saddened by the untimely death of a recent past president of the ASN, Dr. Norman Siegel, on April 28, 2006. Dr Siegel died unexpectedly while attending the annual meetings of the Pediatric Academic Societies in San Francisco, California.

A memorial service for Dr. Siegel was held at Yale University on Monday, June 5, at Battell Chapel, followed by a reception at the Graduate Club in New Haven, Connecticut.

Dr. Siegel was one of the world’s leading pediatric nephrologists and served on numerous ASN committees, as a member of the Council from 1996 to 2003 and as president of the society in 2002 to 2003. At his beloved Yale University, he was the founding director of the Section of Pediatric Nephrology and the former vice-chair of the Department of Pediatrics, as well as former interim chair of the department and physician-in-chief at Yale–New Haven Children’s Hospital.

A Texas native and Phi Beta Kappa graduate of Tulane and of the University of Texas Medical Branch in Galveston, Dr. Siegel came to Yale in 1968 as an intern in pediatrics. He continued on as a research fellow in nephrology at Yale in the laboratories of Drs. Michael Kashgarian and John Hayslett and rose through the ranks to become a tenured professor in 1982. He was elected to the American Society of Clinical Investigation in 1983 and held leadership positions in the ASN, the American Society of Pediatric Nephrology, the International Society of Pediatric Nephrology, the National Kidney Foundation, the Society for Pediatric Research, and the American Board of Pediatrics, among other organizations. He served on numerous scientific review groups of the National Institutes of Health (NIH).

Dr. Siegel made many contributions to medicine and to the life and governance of the Yale University School of Medicine. In his research with Dr. Fredric Finkelstein and others, he established the first classification system for the pathology of kidney transplant rejection, allowing clinicians to predict outcomes based on biopsy results. Dr. Siegel conducted innovative studies of kidney disease in children, particularly in the areas of glomerulonephritis, lupus, and minimal change disease. He led research in renal hemodynamics and metabolic alterations of the kidney during acute renal failure, and, with Dr. Robert Shulman, he pioneered the use of nuclear magnetic resonance methods of assessing adenine nucleotide metabolism of the kidney in vivo. His cellular and molecular biologic studies of the role of heat shock proteins in ischemic renal injury have provided insight into potential new therapeutic pathways for the management of acute kidney injury. He was active in research until the time of his death, authoring an NIH task force report on "Research Priorities in Chronic Kidney Disease in Children," which published in 2006, and serving as Guest Editor (with Sudhir Shah) of a Frontiers in Nephrology feature on "Acute Renal Failure: Directions for the Next Decade," which published in JASN in August 2004. In all, he was the author of more than 200 publications and served on the editorial boards of several scientific journals, including JASN. He was co-editor of the classic textbook Rudolph’s Pediatrics.

Dr. Siegel was also an outstanding teacher and mentor, nurturing the early careers of numerous postdoctoral fellows and pediatric residents who continued on to faculty positions around the nation. His teaching went beyond the instruction of medical students and residents to the education of the parents of the children he cared for, making lasting impressions that remained decades after their treatment.

Dr. Siegel is survived by his wife, Rise, his children, Andrew and Karen, his mother, Ida, and his brother, Bryan. The family has requested that contributions be sent to The Dr. Norman Siegel Memorial Fund, c/o Janney Montgomery Scott at 555 Long Wharf Drive, 5th Floor, New Haven, CT, 06511.

Dr. Siegel’s passing is an irreplaceable loss for the ASN, the Yale University School of Medicine, his patients, friends, and the worlds of nephrology and academic pediatrics. In his Presidential Address to the ASN in 2003, he began with an ancient proverb: "Tell me, I will forget; show me, I may remember; involve me, I will comprehend." Norman Siegel exemplified the very best of the physician-scientist in our discipline—a gentle man of enormous dignity, integrity, and concern for everyone around him. He involved all of us who knew him during his life and career, and he will be long remembered.

This Article Full Text (PDF) All Versions of this Article: ASN.2006050466v1 17/7/1765    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Couser, W. G. Articles by Eddy, A. A. Search for Related Content PubMed Articles by Couser, W. G. Articles by Eddy, A. A.