Xia X, et al.: The Endogenous CXXC Motif Governs the CadmiumSensitivity of the Renal Na+/Glucose Co-Transporter. J Am SocNephrol 16: 1257–1265, 2005.
In Results, found on page 1259, the correct amounts of sialicacid liberation in the absence and presence of Triton X-100was 85 ± 5 nmol/mg protein. The authors regret this error.
Glomerulosclerosis—can proteomics help us understand it better?
We currently identify sclerotic glomeruli only by light andelectron microscopy, but clearly there must be more subtle changesthat precede these. Others have searched for such changes withmolecular techniques such as DNA arrays with limited success.Xu et al. have employed a newer proteomic methodology to comparesclerotic to nonsclerotic and normal glomeruli in the remnantkidney model of secondary focal sclerosis. Not surprisingly,the sclerotic glomeruli differed substantially from normal ones.But of more interest, the nonsclerotic glomeruli in remnantkidneys were more like sclerotic than normal glomeruli, thusidentifying early changes that likely predict, and may evencause, the development of sclerosis. A clue is provided by furtherstudies of thymosin 4, one of the upregulated proteins, thatitself exerts a profibrotic effect by mediating angiotensininduction of PAI-1, which impairs breakdown of fibrin and extracellularmatrix. These studies are important because they not only showthe feasibility of applying proteomics to the detection andstudy of glomerular scarring, but also yield a new insight intowhat the mechanisms involved may be. See Wu et al., pages 2967–2875.
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Correction
Correction to October Highlights
4, one of the upregulated proteins, that itself exerts a profibrotic effect by mediating angiotensin induction of PAI-1, which impairs breakdown of fibrin and extracellular matrix. These studies are important because they not only show the feasibility of applying proteomics to the detection and study of glomerular scarring, but also yield a new insight into what the mechanisms involved may be. See Wu et al., pages 2967–2875. 
