Journal of the American Society of Nephrology
2008 JASN IMPACT FACTOR 7.505 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


Published ahead of print on August 10, 2005
Journal of the American Society of Nephrology
© 2005 American Society of Nephrology
doi: 10.1681/ASN.2004100875
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
ASN.2004100875v1
16/10/2913    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schreuder, M. F.
Right arrow Articles by Delemarre-van de Waal, H. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schreuder, M. F.
Right arrow Articles by Delemarre-van de Waal, H. A.

BASIC SCIENCE: Genetics and Development

Glomerular Number and Function Are Influenced by Spontaneous and Induced Low Birth Weight in Rats

Michiel F. Schreuder 1*, Jens R. Nyengaard 1, Mariann Fodor 1, Joanna A.E. van Wijk 1, Henriette A. Delemarre-van de Waal 1

1

*Department of Pediatrics, Institute for Cardiovascular Research, and {ddagger}Department of Pediatrics, Institute for Clinical and Experimental Neurosciences, VU University Medical Center, Amsterdam, The Netherlands; and {dagger}Stereology and Electron Microscopy Research Laboratory, University of Aarhus, Aarhus, Denmark


* To whom correspondence should be addressed. E-mail: mf.schreuder{at}vumc.nl.


  Abstract

A link exists between low birth weight and diseases in adulthood, such as hypertension, cardiovascular disease, and insulin resistance. Intrauterine growth restriction (IUGR) has been used to explain this association and has been shown to lead to a nephron endowment in humans. A reduction in glomerular number has been described in animal models with induced low birth weight as well but not in animals with spontaneous low birth weight. It therefore is debatable whether the models are suitable. The effect on glomerular number and size was studied in rats with naturally occurring IUGR and experimental IUGR, induced by bilateral uterine artery ligation. Design-based stereologic methods were used. Urinary protein excretion was determined as a measure of renal damage. Results showed a decrease of approximately 20% in glomerular number in both groups of IUGR (control 35,400, naturally occurring IUGR 30,900, and experimental IUGR 28,000 glomeruli per kidney). Mean glomerular volume was increased in both IUGR groups, which was associated with an increased proteinuria. It is concluded that IUGR leads to a nephron endowment with a compensatory glomerular enlargement. This compensation is associated with more proteinuria in the long run. Uterine artery ligation in the pregnant rat is a suitable model to study the effects of IUGR on the kidney.


This article has been cited by other articles:


Home page
 CJASNHome page
M. F. Schreuder, A. J. Wilhelm, A. Bokenkamp, S. M.H. Timmermans, H. A. Delemarre-van de Waal, and J. A.E. van Wijk
Impact of Gestational Age and Birth Weight on Amikacin Clearance on Day 1 of Life
Clin. J. Am. Soc. Nephrol., November 1, 2009; 4(11): 1774 - 1778.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K. M. Moritz, M. Q. Mazzuca, A. L. Siebel, A. Mibus, D. Arena, M. Tare, J. A. Owens, and M. E. Wlodek
Uteroplacental insufficiency causes a nephron deficit, modest renal insufficiency but no hypertension with ageing in female rats
J. Physiol., June 1, 2009; 587(11): 2635 - 2646.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
Y. Cheng, K. Wang, L. D. Kellam, Y. S. Lee, C.-G. Liang, Z. Han, N. R. Mtango, and K. E. Latham
Effects of Ooplasm Manipulation on DNA Methylation and Growth of Progeny in Mice
Biol Reprod, March 1, 2009; 80(3): 464 - 472.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
A. Drougia, V. Giapros, E. Hotoura, F. Papadopoulou, M. Argyropoulou, and S. Andronikou
The effects of gestational age and growth restriction on compensatory kidney growth
Nephrol. Dial. Transplant., January 1, 2009; 24(1): 142 - 148.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
N. Teeninga, M. F. Schreuder, A. Bokenkamp, H. A. D.-v. d. Waal, and J. A.E. v. Wijk
Influence of low birth weight on minimal change nephrotic syndrome in children, including a meta-analysis
Nephrol. Dial. Transplant., May 1, 2008; 23(5): 1615 - 1620.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K.-D. Nusken, J. Dotsch, M. Rauh, W. Rascher, and H. Schneider
Uteroplacental Insufficiency after Bilateral Uterine Artery Ligation in the Rat: Impact on Postnatal Glucose and Lipid Metabolism and Evidence for Metabolic Programming of the Offspring by Sham Operation
Endocrinology, March 1, 2008; 149(3): 1056 - 1063.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. F. Schreuder
Combined nephroprotective effect and low nephron endowment as a consequence of postnatal growth restriction in the rat?
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R276 - R276.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. F. Schreuder
Unravelling perinatal programming of the kidney
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R2159 - R2159.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. E. Wlodek, A. Mibus, A. Tan, A. L. Siebel, J. A. Owens, and K. M. Moritz
Normal Lactational Environment Restores Nephron Endowment and Prevents Hypertension after Placental Restriction in the Rat
J. Am. Soc. Nephrol., June 1, 2007; 18(6): 1688 - 1696.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Baserga, M. A. Hale, Z. M. Wang, X. Yu, C. W. Callaway, R. A. McKnight, and R. H. Lane
Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1943 - R1955.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
D. Hershkovitz, Z. Burbea, K. Skorecki, and B. M. Brenner
Fetal Programming of Adult Kidney Disease: Cellular and Molecular Mechanisms
Clin. J. Am. Soc. Nephrol., March 1, 2007; 2(2): 334 - 342.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. F. Schreuder, J. R. Nyengaard, F. Remmers, J. A. van Wijk, and H. A. Delemarre-van de Waal
Postnatal food restriction in the rat as a model for a low nephron endowment
Am J Physiol Renal Physiol, November 1, 2006; 291(5): F1104 - F1107.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
D. de Zeeuw, H.-H. Parving, and R. H. Henning
Microalbuminuria as an Early Marker for Cardiovascular Disease
J. Am. Soc. Nephrol., August 1, 2006; 17(8): 2100 - 2105.
[Abstract] [Full Text] [PDF]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673