2008 JASN IMPACT FACTOR 7.505	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text (Rapid PDF) All Versions of this Article: ASN.2005121256v1 17/4/943    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dhaun, N. Articles by Webb, D. J. Search for Related Content PubMed PubMed Citation Articles by Dhaun, N. Articles by Webb, D. J.

REVIEWS

The Endothelin System and Its Antagonism in Chronic Kidney Disease

Neeraj Dhaun ^*1, Jane Goddard ^*, and David J. Webb

*Department of Renal Medicine, Royal Infirmary of Edinburgh, and Clinical Pharmacology Unit, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, Scotland

¹ To whom correspondence should be addressed. E-mail: bean.dhaun{at}ed.ac.uk.

	Abstract

The incidence of chronic kidney disease (CKD) is increasing worldwide. Cardiovascular disease (CVD) is strongly associated with CKD and constitutes one of its major causes of morbidity and mortality. Treatments that slow the progression of CKD and improve the cardiovascular risk profile of patients with CKD are needed. The endothelins (ET) are a family of related peptides, of which ET-1 is the most powerful endogenous vasoconstrictor and the predominant isoform in the cardiovascular and renal systems. The ET system has been widely implicated in both CVD and CKD. ET-1 contributes to the pathogenesis and maintenance of hypertension and arterial stiffness and more novel cardiovascular risk factors such as oxidative stress and inflammation. Through these, ET also contributes to endothelial dysfunction and atherosclerosis. By reversal of these effects, ET antagonists may reduce cardiovascular risk. In particular relation to the kidney, antagonism of the ET system may be of benefit in improving renal hemodynamics and reducing proteinuria. ET likely also is involved in progression of renal disease, and data are emerging to suggest a synergistic role for ET receptor antagonists with angiotensin-converting enzyme inhibitors in slowing CKD progression.

This article has been cited by other articles:

				M. Khatri, T. Nickolas, Y. P. Moon, M. C. Paik, T. Rundek, M. S. V. Elkind, R. L. Sacco, and C. B. Wright CKD Associates with Cognitive Decline J. Am. Soc. Nephrol., November 1, 2009; 20(11): 2427 - 2432. [Abstract] [Full Text] [PDF]

				N. Dhaun, I. M. MacIntyre, V. Melville, P. Lilitkarntakul, N. R. Johnston, J. Goddard, and D. J. Webb Blood Pressure-Independent Reduction in Proteinuria and Arterial Stiffness After Acute Endothelin-A Receptor Antagonism in Chronic Kidney Disease Hypertension, July 1, 2009; 54(1): 113 - 119. [Abstract] [Full Text] [PDF]

				N. Dhaun, P. Lilitkarntakul, I. M. MacIntyre, E. Muilwijk, N. R. Johnston, D. C. Kluth, D. J. Webb, and J. Goddard Urinary endothelin-1 in chronic kidney disease and as a marker of disease activity in lupus nephritis Am J Physiol Renal Physiol, June 1, 2009; 296(6): F1477 - F1483. [Abstract] [Full Text] [PDF]

				B. Fogelgren, S. Yang, I. C. Sharp, O. J. Huckstep, W. Ma, S. J. Somponpun, E. C. Carlson, C. F. T. Uyehara, and S. Lozanoff Deficiency in Six2 during prenatal development is associated with reduced nephron number, chronic renal failure, and hypertension in Br/+ adult mice Am J Physiol Renal Physiol, May 1, 2009; 296(5): F1166 - F1178. [Abstract] [Full Text] [PDF]

				N. Dhaun, J. Goddard, D. E. Kohan, D. M. Pollock, E. L. Schiffrin, and D. J. Webb Role of Endothelin-1 in Clinical Hypertension: 20 Years On Hypertension, September 1, 2008; 52(3): 452 - 459. [Full Text] [PDF]

				E. I. Boesen, J. M. Sasser, M. A. Saleh, W. A. Potter, M. Woods, T. D. Warner, J. S. Pollock, and D. M. Pollock Interleukin-1{beta}, but not interleukin-6, enhances renal and systemic endothelin production in vivo Am J Physiol Renal Physiol, August 1, 2008; 295(2): F446 - F453. [Abstract] [Full Text] [PDF]

				M. Khatri, C. B. Wright, T. L. Nickolas, M. Yoshita, M. C. Paik, G. Kranwinkel, R. L. Sacco, and C. DeCarli Chronic Kidney Disease Is Associated With White Matter Hyperintensity Volume: The Northern Manhattan Study (NOMAS) Stroke, December 1, 2007; 38(12): 3121 - 3126. [Abstract] [Full Text] [PDF]

				N. Dhaun, C. J. Ferro, A. P. Davenport, W. G. Haynes, J. Goddard, and D. J. Webb Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease Nephrol. Dial. Transplant., November 1, 2007; 22(11): 3228 - 3234. [Abstract] [Full Text] [PDF]

				M. A. Perazella Nephrogenic Systemic Fibrosis, Kidney Disease, and Gadolinium: Is There a Link? Clin. J. Am. Soc. Nephrol., March 1, 2007; 2(2): 200 - 202. [Full Text] [PDF]

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673