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Published ahead of print on July 26, 2006
Journal of the American Society of Nephrology
© 2006 American Society of Nephrology
doi: 10.1681/ASN.2006030218
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REVIEWS

Regrow or Repair: Potential Regenerative Therapies for the Kidney

Melissa H. Little 1

Institute for Molecular Bioscience, University of Queensland, St. Lucia, Queensland, Australia


1 To whom correspondence should be addressed. E-mail: m.little{at}imb.uq.edu.au.


  Abstract

Regenerative medicine is being heralded in a similar way as gene therapy was some 15 yr ago. It is an area of intense excitement and potential, as well as myth and disinformation. However, with the increasing rate of end-stage renal failure and limited alternatives for its treatment, we must begin to investigate seriously potential regenerative approaches for the kidney. This review defines which regenerative options there might be for renal disease, summarizes the progress that has been made to date, and investigates some of the unique obstacles to such treatments that the kidney presents. The options discussed include in situ organ repair via bone marrow recruitment or dedifferentiation; ex vivo stem cell therapies, including both autologous and nonautologous options; and bioengineering approaches for the creation of a replacement organ.


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