Journal of the American Society of Nephrology
2008 JASN IMPACT FACTOR 7.505 HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP 
    advanced
CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION


Published ahead of print on August 16, 2006
Journal of the American Society of Nephrology
© 2006 American Society of Nephrology
doi: 10.1681/ASN.2006060620
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
ASN.2006060620v1
17/9/2368    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Boron, W. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boron, W. F.

HOMER W. SMITH AWARD LECTURE

Acid-Base Transport by the Renal Proximal Tubule

Walter F. Boron 1

Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut


1 To whom correspondence should be addressed. E-mail: walter.boron{at}yale.edu.


  Abstract

One of the major tasks of the renal proximal tubule is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered HCO3- as well as generating new HCO3- for regulating blood pH. This review summarizes the cellular and molecular events that underlie four major processes in HCO3- reabsorption. The first is CO2 entry across the apical membrane, which in large part occurs via a gas channel (aquaporin 1) and acidifies the cell. The second process is apical H+ secretion via Na-H exchange and H+ pumping, processes that can be studied using the NH4+ prepulse technique. The third process is the basolateral exit of HCO3- via the electrogenic Na/HCO3 co-transporter, which is the subject of at least 10 mutations that cause severe proximal renal tubule acidosis in humans. The final process is the regulation of overall HCO3- reabsorption by CO2 and HCO3- sensors at the basolateral membrane. Together, these processes ensure that the proximal tubule responds appropriately to acute acid-base disturbances and thereby contributes to the regulation of blood pH.


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
J. C. Mathai, A. Missner, P. Kugler, S. M. Saparov, M. L. Zeidel, J. K. Lee, and P. Pohl
No facilitator required for membrane transport of hydrogen sulfide
PNAS, September 29, 2009; 106(39): 16633 - 16638.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
K.-H. Han, K. Mekala, V. Babida, H.-Y. Kim, M. E. Handlogten, J. W. Verlander, and I. D. Weiner
Expression of the gas-transporting proteins, Rh B glycoprotein and Rh C glycoprotein, in the murine lung
Am J Physiol Lung Cell Mol Physiol, July 1, 2009; 297(1): L153 - L163.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
D. Weihrauch, M. P. Wilkie, and P. J. Walsh
Ammonia and urea transporters in gills of fish and aquatic crustaceans
J. Exp. Biol., June 1, 2009; 212(11): 1716 - 1730.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Q. Zhu, R. Azimov, L. Kao, D. Newman, W. Liu, N. Abuladze, A. Pushkin, and I. Kurtz
NBCe1-A Transmembrane Segment 1 Lines the Ion Translocation Pathway
J. Biol. Chem., March 27, 2009; 284(13): 8918 - 8929.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
G. Romano, C. Briguori, C. Quintavalle, C. Zanca, N. V. Rivera, A. Colombo, and G. Condorelli
Contrast agents and renal cell apoptosis
Eur. Heart J., October 2, 2008; 29(20): 2569 - 2576.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
G. A. Prathapasinghe, Y. L. Siow, Z. Xu, and K. O
Inhibition of cystathionine-{beta}-synthase activity during renal ischemia-reperfusion: role of pH and nitric oxide
Am J Physiol Renal Physiol, October 1, 2008; 295(4): F912 - F922.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Kao, P. Sassani, R. Azimov, A. Pushkin, N. Abuladze, J. Peti-Peterdi, W. Liu, D. Newman, and I. Kurtz
Oligomeric Structure and Minimal Functional Unit of the Electrogenic Sodium Bicarbonate Cotransporter NBCe1-A
J. Biol. Chem., September 26, 2008; 283(39): 26782 - 26794.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Brandes, O. Oehlke, A. Schumann, S. Heidrich, F. Thevenod, and E. Roussa
Adaptive redistribution of NBCe1-A and NBCe1-B in rat kidney proximal tubule and striated ducts of salivary glands during acid-base disturbances
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2400 - R2411.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. Briguori, D. D'Andrea, A. Focaccio, B. Ricciardelli, F. Airoldi, N. Morici, I. Michev, M. Montorfano, M. Carlino, J. Cosgrave, et al.
Response to Letter Regarding Article, "Renal Insufficiency Following Contrast Media Administration Trial (REMEDIAL): A Randomized Comparison of 3 Preventive Strategies"
Circulation, August 21, 2007; 116(8): e311 - e311.
[Full Text] [PDF]

Home page
 CirculationHome page
C. Briguori, F. Airoldi, D. D'Andrea, E. Bonizzoni, N. Morici, A. Focaccio, I. Michev, M. Montorfano, M. Carlino, J. Cosgrave, et al.
Renal Insufficiency Following Contrast Media Administration Trial (REMEDIAL): A Randomized Comparison of 3 Preventive Strategies
Circulation, March 13, 2007; 115(10): 1211 - 1217.
[Abstract] [Full Text] [PDF]


HOME CURRENT ISSUE ARCHIVES JASN Express ONLINE SUBMISSION AUTHOR INFO
EDITORIAL BOARD SUBSCRIBE FEEDBACK ALERTS HELP

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673