2008 JASN IMPACT FACTOR 7.505	HOME   AUTHOR INFO   EDITORIAL BOARD   SUBSCRIBE   FEEDBACK   ALERTS   HELP
advanced	CURRENT ISSUE	ARCHIVES	JASN Express	ONLINE SUBMISSION

This Article Full Text (Rapid PDF) All Versions of this Article: ASN.2006111216v1 18/11/2912    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Seeliger, E. Articles by Persson, P. B. Search for Related Content PubMed PubMed Citation Articles by Seeliger, E. Articles by Persson, P. B.

Received November 8, 2006
Accepted on June 19, 2007

BASIC RESEARCH: Basic Research

Viscosity of Contrast Media Perturbs Renal Hemodynamics

Erdmann Seeliger ^*, Bert Flemming ^*, Thomas Wronski ^*, Mechthild Ladwig ^*, Karen Arakelyan ^*, Michael Godes ^*, Martin Möckel , and Pontus B. Persson ^*1

*Institut für Vegetative Physiologie and Medizinische Klinik–Kardiologie, Charité Universitätsmedizin Berlin, Berlin, Germany; and Physiology Department, Yerevan State Medical University, Yerevan, Armenia

*Institut für Vegetative Physiologie and Medizinische Klinik–Kardiologie, Charité Universitätsmedizin Berlin, Berlin, Germany; and Physiology Department, Yerevan State Medical University, Yerevan, Armenia

¹ To whom correspondence should be addressed. E-mail: pontus.persson{at}charite.de.

	Abstract

Contrast-induced nephropathy is a common cause of acute renal failure, and the mechanisms underlying this injury are not completely understood. We sought to determine how physicochemical properties of contrast media may contribute to kidney damage in rats. We administered contrast media of equivalent iodine concentrations but differing physiocochemical properties: the high-osmolality iopromide was compared to the high-viscosity iodixanol. In addition, the non-iodinated substances mannitol (equivalent osmolality to iopromide) and dextran (equivalent viscosity to iodixanol) were also studied. Both types of contrast media transiently increased renal and hindquarter blood flow. The high-osmolality agents iopromide and mannitol markedly increased urine production whereas iodixanol, which caused less diuresis, significantly enhanced urine viscosity. Only the high-viscosity agents iodixanol and dextran decreased renal medullary blood flux, erythrocyte concentration, and pO₂. Moreover, iodixanol prolonged the tubuloglomerular feedback response and increased plasma creatinine levels to a greater extent than iopromide or dextran. Therefore, the viscosity of contrast media may play a significant role in contrast-induced nephropathy.

This article has been cited by other articles:

				M. Sendeski, A. Patzak, T. L. Pallone, C. Cao, A. E. Persson, and P. B. Persson Iodixanol, Constriction of Medullary Descending Vasa Recta, and Risk for Contrast Medium-induced Nephropathy Radiology, June 1, 2009; 251(3): 697 - 704. [Abstract] [Full Text] [PDF]

				M. C. Heinrich, L. Haberle, V. Muller, W. Bautz, and M. Uder Nephrotoxicity of Iso-osmolar Iodixanol Compared with Nonionic Low-osmolar Contrast Media: Meta-analysis of Randomized Controlled Trials Radiology, January 1, 2009; 250(1): 68 - 86. [Abstract] [Full Text] [PDF]

				G. Romano, C. Briguori, C. Quintavalle, C. Zanca, N. V. Rivera, A. Colombo, and G. Condorelli Contrast agents and renal cell apoptosis Eur. Heart J., October 2, 2008; 29(20): 2569 - 2576. [Abstract] [Full Text] [PDF]

				M. F. Kheda and H. M. Szerlip Two cases of iodixanol-induced pancreatitis NDT Plus, October 1, 2008; 1(5): 296 - 299. [Full Text] [PDF]

				F. F. Behrendt, A. H. Mahnken, S. Stanzel, P. Seidensticker, E. Jost, R. W. Gunther, and G. Muhlenbruch Intraindividual Comparison of Contrast Media Concentrations for Combined Abdominal and Thoracic MDCT Am. J. Roentgenol., July 1, 2008; 191(1): 145 - 150. [Abstract] [Full Text] [PDF]

Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673