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UP FRONT MATTERS: Brief Review

Dendritic Cells in the Kidney

Rohan John and Peter J. Nelson ¹

Division of Nephrology, New York University School of Medicine, New York, New York

¹ To whom correspondence should be addressed. E-mail: nelsop02{at}popmail.med.nyu.edu.

	Abstract

Dendritic cells (DC) in nonlymphoid organs function at the crossroads of innate and adaptive immunity, self-tolerance, and tissue homeostasis. This review provides an overview of the study of DC in the kidney, tracing its history leading to the current knowledge of the origins, migration, and function of renal DC. Together, these studies suggest that renal DC play a critical role in the health and disease of the kidney, opening the way to direct targeting of renal DC for therapeutic benefit.

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Copyright © 2009 by the American Society of Nephrology. Online ISSN: 1533-3450 Print ISSN: 1046-6673