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Published ahead of print on December 19, 2007
Journal of the American Society of Nephrology
© 2007 American Society of Nephrology
doi: 10.1681/ASN.2007080854
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UP FRONT MATTERS: Science in Renal Medicine

Mechanisms of Vascular Calcification in Chronic Kidney Disease

Sharon M. Moe 1 and Neal X. Chen

Department of Medicine, Indiana University, Indianapolis, Indiana


1 To whom correspondence should be addressed. E-mail: smoe{at}iupui.edu.


  Abstract

Vascular calcification is common in chronic kidney disease and associated with increased morbidity and mortality. Its mechanism is multifactorial and incompletely understood. Patients with chronic kidney disease are at risk for vascular calcification because of multiple risk factors that induce vascular smooth muscle cells to change into a chondrocyte or osteoblast-like cell; high total body burden of calcium and phosphorus due to abnormal bone metabolism; low levels of circulating and locally produced inhibitors; impaired renal excretion; and current therapies. Together these factors increase risk and complicate the management of vascular calcification.


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