THIS MONTH'S HIGHLIGHTS:

This Month’s Highlights

J Am Soc Nephrol 13: A10-A12. [Full Text]  

ASN NEWS:

ASN News

J Am Soc Nephrol 13: A17-A18. [Full Text]  

ARTICLES:

Cell and Transport Physiology:

Regulation of the Proximal Tubular Sodium/Proton Exchanger NHE3 in Rats with Puromycin Aminonucleoside (PAN)-Induced Nephrotic Syndrome

Valérie Besse-Eschmann, Jelena Klisic, Vera Nief, Michel Le Hir, Brigitte Kaissling, and Patrice M. Ambühl

J Am Soc Nephrol 13: 2199-2206. [Abstract] [Full Text]  

Hemodynamics, Hypertension, and Vascular Regulation:

Renal Interstitial Fluid Angiotensin I and Angiotensin II Concentrations during Local Angiotensin-Converting Enzyme Inhibition

Akira Nishiyama, Dale M. Seth, and L. Gabriel Navar

J Am Soc Nephrol 13: 2207-2212. [Abstract] [Full Text]  

Prognostic Significance of Renal Function in Elderly Patients with Isolated Systolic Hypertension: Results from the Syst-Eur Trial

Peter W. de Leeuw, Lutgarde Thijs, Willem H. Birkenhäger, Sophia M. Voyaki, Aris D. Efstratopoulos, Robert H. Fagard, Gastone Leonetti, Choudomir Nachev, James C. Petrie, José L. Rodicio, Joseph J. Rosenfeld, Cinzia Sarti, and Jan A. Staessen

J Am Soc Nephrol 13: 2213-2222. [Abstract] [Full Text]  

Immunology and Pathology:

PPAR Agonists Amplify iNOS Expression While Inhibiting NF-B: Implications for Mesangial Cell Activation by Cytokines

Eva Cernuda-Morollón, Fernando Rodríguez-Pascual, Peter Klatt, Santiago Lamas, and Dolores Pérez-Sala

J Am Soc Nephrol 13: 2223-2231. [Abstract] [Full Text]  

Neutrophil Membrane Expression of Proteinase 3 (PR3) Is Related to Relapse in PR3-ANCA-Associated Vasculitis

Agnieszka A. Rarok, Coen A. Stegeman, Pieter C. Limburg, and Cees G. M. Kallenberg

J Am Soc Nephrol 13: 2232-2238. [Abstract] [Full Text]  

Molecular Basis for High Renal Cell Sensitivity to the Cytotoxic Effects of Shigatoxin-1: Upregulation of Globotriaosylceramide Expression

Alisa K. Hughes, Zuhal Ergonul, Peter K. Stricklett, and Donald E. Kohan

J Am Soc Nephrol 13: 2239-2245. [Abstract] [Full Text]  

Molecular Medicine, Genetics and Development:

Identification and Characterization of Pkhd1, the Mouse Orthologue of the Human ARPKD Gene

Yasuyuki Nagasawa, Sonja Matthiesen, Luiz F. Onuchic, Xiaoying Hou, Carsten Bergmann, Ernie Esquivel, Jan Senderek, Zhiyong Ren, Raoul Zeltner, Laszlo Furu, Ellis Avner, Markus Moser, Stefan Somlo, Lisa Guay-Woodford, Reinhard Büttner, Klaus Zerres, and Gregory G. Germino

J Am Soc Nephrol 13: 2246-2258. [Abstract] [Full Text] [Supplement to Nagasawa et al.]  

Pathophysiology of Renal Disease:

Functional Characterization of a Calcium-Sensing Receptor Mutation in Severe Autosomal Dominant Hypocalcemia with a Bartter-Like Syndrome

Rosa Vargas-Poussou, Chunfa Huang, Philippe Hulin, Pascal Houillier, Xavier Jeunemaître, Michel Paillard, Gabrielle Planelles, Michèle Déchaux, R. Tyler Miller, and Corinne Antignac

J Am Soc Nephrol 13: 2259-2266. [Abstract] [Full Text]  

Cell-Biologic and Functional Analyses of Five New Aquaporin-2 Missense Mutations that Cause Recessive Nephrogenic Diabetes Insipidus

Nannette Marr, Daniel G. Bichet, Susan Hoefs, Paul J. M. Savelkoul, Irene B. M. Konings, Fabrizio de Mattia, Michael P. J. Graat, Marie-Françoise Arthus, Michele Lonergan, T. Mary Fujiwara, Nine V. A. M. Knoers, Daniel Landau, William J. Balfe, Alexander Oksche, Walter Rosenthal, Dominik Müller, Carel H. van Os, and Peter M. T. Deen

J Am Soc Nephrol 13: 2267-2277. [Abstract] [Full Text]  

Evidence for the Existence of Two Distinct Functions for the Inducible NO Synthase in the Rat Kidney: Effect of Aminoguanidine in Rats with 5/6 Ablation

Clarice Kazue Fujihara, Ana Lúcia Mattar, José Mauro Vieira, Jr, Denise Maria Avancini Costa Malheiros, Irene de Lourdes Noronha, Anderson Ricardo Roman Gonçalves, Gilberto de Nucci, and Roberto Zatz

J Am Soc Nephrol 13: 2278-2287. [Abstract] [Full Text]  

Postischemic Acute Renal Failure Is Reduced by Short-Term Statin Treatment in a Rat Model

Faikah Gueler, Song Rong, Joon-Keun Park, Anette Fiebeler, Jan Menne, Marlies Elger, Dominik N. Mueller, Franziska Hampich, Ralf Dechend, Uta Kunter, Friedrich C. Luft, and Hermann Haller

J Am Soc Nephrol 13: 2288-2298. [Abstract] [Full Text]  

Mineral Metabolism and Bone Disease:

The Effects of Sevelamer Hydrochloride and Calcium Carbonate on Kidney Calcification in Uremic Rats

Mario Cozzolino, Adriana S. Dusso, Helen Liapis, Jane Finch, Yan Lu, Steven K. Burke, and Eduardo Slatopolsky

J Am Soc Nephrol 13: 2299-2308. [Abstract] [Full Text]  

Clinical Nephrology:

Characteristics of Polymeric -IgA Binding to Leukocytes in IgA Nephropathy

Kar Neng Lai, Loretta Y. Y. Chan, Sydney C. W. Tang, Anita W. L. Tsang, Hong Guo, Kai Chung Tse, Terrance Yip, and Joseph C. K. Leung

J Am Soc Nephrol 13: 2309-2319. [Abstract] [Full Text]  

Molecular Identification of SV40 Infection in Human Subjects and Possible Association with Kidney Disease

Rui-Mei Li, Mary H. Branton, Somsak Tanawattanacharoen, Ronald A. Falk, J. Charles Jennette, and Jeffrey B. Kopp

J Am Soc Nephrol 13: 2320-2330. [Abstract] [Full Text]  

Low-Intensity Warfarin Is Ineffective for the Prevention of PTFE Graft Failure in Patients on Hemodialysis: A Randomized Controlled Trial

Mark A. Crowther, Catherine M. Clase, Peter J. Margetts, Jim Julian, Kim Lambert, Denise Sneath, Ryuta Nagai, Sarah Wilson, and Alistair J. Ingram

J Am Soc Nephrol 13: 2331-2337. [Abstract] [Full Text]  

Dialysis:

Measuring the Efficacy of a Quality Improvement Program in Dialysis Adequacy with Changes in Center Effects

Jeffrey C. Fink, Min Zhan, Steven A. Blahut, Michael Soucie, and William M. McClellan

J Am Soc Nephrol 13: 2338-2344. [Abstract] [Full Text]  

Seasonal Variations in Clinical and Laboratory Variables among Chronic Hemodialysis Patients

Alfred K. Cheung, Guofen Yan, Tom Greene, John T. Daugirdas, Johanna T. Dwyer, Nathan W. Levin, Daniel B. Ornt, Gerald Schulman, and Garabed Eknoyan

J Am Soc Nephrol 13: 2345-2352. [Abstract] [Full Text]  

Epidemiology and Outcomes:

Comparing Mortality of Elderly Patients on Hemodialysis versus Peritoneal Dialysis: A Propensity Score Approach

Wolfgang C. Winkelmayer, Robert J. Glynn, Murray A. Mittleman, Raisa Levin, Joseph S. Pliskin, and Jerry Avorn

J Am Soc Nephrol 13: 2353-2362. [Abstract] [Full Text]  

Excess Risk of Chronic Kidney Disease among African-American versus White Subjects in the United States: A Population-Based Study of Potential Explanatory Factors

Michelle E. Tarver-Carr, Neil R. Powe, Mark S. Eberhardt, Thomas A. LaVeist, Raynard S. Kington, Josef Coresh, and Frederick L. Brancati

J Am Soc Nephrol 13: 2363-2370. [Abstract] [Full Text]  

Transplantation:

Capillary Deposition of Complement Split Product C4d in Renal Allografts is Associated with Basement Membrane Injury in Peritubular and Glomerular Capillaries: A Contribution of Humoral Immunity to Chronic Allograft Rejection

Heinz Regele, Georg A. Böhmig, Antje Habicht, Daniela Gollowitzer, Martin Schillinger, Susanne Rockenschaub, Bruno Watschinger, Dontscho Kerjaschki, and Markus Exner

J Am Soc Nephrol 13: 2371-2380. [Abstract] [Full Text]  

BRIEF COMMUNICATIONS:

Allergic Skin and Systemic Reactions in a Patient with Pure Red Cell Aplasia and Anti-Erythropoietin Antibodies Challenged with Different Epoetins

Gertrud Weber, Johann Gross, Arno Kromminga, Hans-H. Loew, and Kai-Uwe Eckardt

J Am Soc Nephrol 13: 2381-2383. [Abstract] [Full Text]  

DISEASE OF THE MONTH:

Genetics and Pathogenesis of Polycystic Kidney Disease

Peter Igarashi and Stefan Somlo

J Am Soc Nephrol 13: 2384-2398. [Full Text]  

REVIEWS:

Disturbances of Na/K Balance: Pseudohypoaldosteronism Revisited

Olivier Bonny and Bernard C. Rossier

J Am Soc Nephrol 13: 2399-2414. [Full Text]  

EDITORIALS:

Chronic Kidney Disease and Cardiovascular Risk: Time to Focus on Therapy

Donal N. Reddan and Preston S. Klassen

J Am Soc Nephrol 13: 2415-2416. [Full Text]  

C4d and the Fate of Organ Allografts

Jeffrey L. Platt

J Am Soc Nephrol 13: 2417-2419. [Full Text]  

Capillary C4d Deposition as a Marker of Humoral Immunity in Renal Allograft Rejection

Bruno Watschinger and Manuel Pascual

J Am Soc Nephrol 13: 2420-2423. [Full Text]  

ANNOUNCEMENTS:

J Am Soc Nephrol 13: 2424. [Full Text]  

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