THIS MONTH'S HIGHLIGHTS:

This Month’s Highlights

J Am Soc Nephrol 14: A9-A11. [Full Text]  

ASN NEWS:

ASN News

J Am Soc Nephrol 14: A31-A32. [Full Text]  

SPECIAL TRIBUTE:

In Memoriam Belding H. Scribner, MD: 1921–2003

William G. Couser

J Am Soc Nephrol 14: 2419-2420. [Full Text]  

BASIC SCIENCE:

Cell and Transport Physiology:

Functional Expression of the Human Thiazide-Sensitive NaCl Cotransporter in Madin-Darby Canine Kidney Cells

Joke C. de Jong, Peter H.G.M. Willems, Lambertus P.W.J. van den Heuvel, Nine V.A.M. Knoers, and René J.M. Bindels

J Am Soc Nephrol 14: 2428-2435. [Abstract] [Full Text]  

Cell Biology:

Protein Overload Induces Fractalkine Upregulation in Proximal Tubular Cells through Nuclear Factor B– and p38 Mitogen-Activated Protein Kinase–Dependent Pathways

Roberta Donadelli, Cristina Zanchi, Marina Morigi, Simona Buelli, Cristian Batani, Susanna Tomasoni, Daniela Corna, Daniela Rottoli, Ariela Benigni, Mauro Abbate, Giuseppe Remuzzi, and Carla Zoja

J Am Soc Nephrol 14: 2436-2446. [Abstract] [Full Text]  

Genetics and Development:

WNK1, a Gene within a Novel Blood Pressure Control Pathway, Tissue-Specifically Generates Radically Different Isoforms with and without a Kinase Domain

Michelle O’Reilly, Elaine Marshall, Helen J.L. Speirs, and Roger W. Brown

J Am Soc Nephrol 14: 2447-2456. [Abstract] [Full Text]  

Hemodynamics and Vascular Regulation:

Adenosine Induces Vasoconstriction through Gi-Dependent Activation of Phospholipase C in Isolated Perfused Afferent Arterioles of Mice

Pernille B. Hansen, Hayo Castrop, Josie Briggs, and Jurgen Schnermann

J Am Soc Nephrol 14: 2457-2465. [Abstract] [Full Text]  

Chronic Renal Failure Accelerates Atherogenesis in Apolipoprotein E–Deficient Mice

Susanne Bro, Jacob F. Bentzon, Erling Falk, Claus B. Andersen, Klaus Olgaard, and Lars B. Nielsen

J Am Soc Nephrol 14: 2466-2474. [Abstract] [Full Text]  

Neuronal Nitric Oxide Synthase: Its Role and Regulation in Macula Densa Cells

Gergely Kovács, Péter Komlósi, Amanda Fuson, János Peti-Peterdi, László Rosivall, and P. Darwin Bell

J Am Soc Nephrol 14: 2475-2483. [Abstract] [Full Text]  

Immunology and Pathology:

Evaluation of a Thick and Thin Section Method for Estimation of Podocyte Number, Glomerular Volume, and Glomerular Volume Per Podocyte in Rat Kidney with Wilms’ Tumor-1 Protein Used as a Podocyte Nuclear Marker

Silja K. Sanden, Jocelyn E. Wiggins, Meera Goyal, Lisa K. Riggs, and Roger C. Wiggins

J Am Soc Nephrol 14: 2484-2493. [Abstract] [Full Text]  

Transgenic Overexpression of GATA-3 in T Lymphocytes Improves Autoimmune Glomerulonephritis in Mice with a BXSB/MpJ-Yaa Genetic Background

Keigyou Yoh, Kazuko Shibuya, Naoki Morito, Takako Nakano, Kazusa Ishizaki, Homare Shimohata, Masato Nose, Shozo Izui, Akira Shibuya, Akio Koyama, James Douglas Engel, Masayuki Yamamoto, and Satoru Takahashi

J Am Soc Nephrol 14: 2494-2502. [Abstract] [Full Text]  

CCR2 Signaling Contributes to Ischemia-Reperfusion Injury in Kidney

Kengo Furuichi, Takashi Wada, Yasunori Iwata, Kiyoki Kitagawa, Ken-ichi Kobayashi, Hiroyuki Hashimoto, Yoshiro Ishiwata, Masahide Asano, Hui Wang, Kouji Matsushima, Motohiro Takeya, William A. Kuziel, Naofumi Mukaida, and Hitoshi Yokoyama

J Am Soc Nephrol 14: 2503-2515. [Abstract] [Full Text]  

Excessive Matrix Accumulation in the Kidneys of MRL/lpr Lupus Mice Is Dependent on Complement Activation

Lihua Bao, Jian Zhou, V. Michael Holers, and Richard J. Quigg

J Am Soc Nephrol 14: 2516-2525. [Abstract] [Full Text]  

Pathophysiology of Renal Disease and Progression:

Protection of Wistar Furth Rats from Chronic Renal Disease Is Associated with Maintained Renal Nitric Oxide Synthase

Aaron Erdely, Laszlo Wagner, Veronica Muller, Attila Szabo, and Chris Baylis

J Am Soc Nephrol 14: 2526-2533. [Abstract] [Full Text]  

Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal Injury

Jaya Mishra, Qing Ma, Anne Prada, Mark Mitsnefes, Kamyar Zahedi, Jun Yang, Jonathan Barasch, and Prasad Devarajan

J Am Soc Nephrol 14: 2534-2543. [Abstract] [Full Text]  

Obstructive Uropathy in Mice and Humans: Potential Role for PDGF-D in the Progression of Tubulointerstitial Injury

Sekiko Taneda, Kelly L. Hudkins, Stavros Topouzis, Debra G. Gilbertson, Vuddhidej Ophascharoensuk, Luan Truong, Richard J. Johnson, and Charles E. Alpers

J Am Soc Nephrol 14: 2544-2555. [Abstract] [Full Text]  

CLINICAL SCIENCE:

Disease of the Month:

How to Manage the Renal Patient with Coronary Heart Disease: The Agony and the Ecstasy of Opinion-Based Medicine

Charles A. Herzog

J Am Soc Nephrol 14: 2556-2572. [Full Text]  

Clinical Nephrology:

A Comparison of Prediction Equations for Estimating Glomerular Filtration Rate in Adults without Kidney Disease

Julie Lin, Eric L. Knight, Mary Lou Hogan, and Ajay K. Singh

J Am Soc Nephrol 14: 2573-2580. [Abstract] [Full Text]  

Aquaporin Expression in Normal Human Kidney and in Renal Disease

Jennifer J. Bedford, John P. Leader, and Robert J. Walker

J Am Soc Nephrol 14: 2581-2587. [Abstract] [Full Text]  

Urinary Excretion of Monocyte Chemoattractant Protein-1 in Autosomal Dominant Polycystic Kidney Disease

Danxia Zheng, Marieka Wolfe, Benjamin D. Cowley, Jr., Darren P. Wallace, Tamio Yamaguchi, and Jared J. Grantham

J Am Soc Nephrol 14: 2588-2595. [Abstract] [Full Text]  

Human Genetics:

Role of the Endothelin-1 Gene Locus for Renal Impairment in the General Nondiabetic Population

Sara-Joan Pinto-Sietsma, Stefan-Martin Herrmann, Klaus Schmidt-Petersen, Tianhua Niu, Hans L. Hillege, Wilbert M.T. Janssen, Dick de Zeeuw, Paul de Jong, and Reinhold Kreutz

J Am Soc Nephrol 14: 2596-2602. [Abstract] [Full Text]  

X-Linked Alport Syndrome: Natural History and Genotype-Phenotype Correlations in Girls and Women Belonging to 195 Families: A "European Community Alport Syndrome Concerted Action" Study

Jean Philippe Jais, Bertrand Knebelmann, Iannis Giatras, Mario De Marchi, Gianfranco Rizzoni, Alessandra Renieri, Manfred Weber, Oliver Gross, Kai-Olaf Netzer, Frances Flinter, Yves Pirson, Karin Dahan, Jörgen Wieslander, Ulf Persson, Karl Tryggvason, Paula Martin, Jens Michael Hertz, Cornelis Schröder, Marek Sanak, Maria Fernanda Carvalho, Juan Saus, Corinne Antignac, Hubert Smeets, and Marie Claire Gubler

J Am Soc Nephrol 14: 2603-2610. [Abstract] [Full Text]  

Epidemiology and Outcomes:

Prospective Study of Neuropeptide Y as an Adverse Cardiovascular Risk Factor in End-Stage Renal Disease

Carmine Zoccali, Francesca Mallamaci, Giovanni Tripepi, Francesco A. Benedetto, Saverio Parlongo, Sebastiano Cutrupi, Domenico Iellamo, Graziella Bonanno, Francesco Rapisarda, Pasquale Fatuzzo, Giuseppe Seminara, Alessandro Cataliotti, and Lorenzo Salvatore Malatino

J Am Soc Nephrol 14: 2611-2617. [Abstract] [Full Text]  

Hypertension and Progression of Chronic Renal Insufficiency in Children: A Report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS)

Mark Mitsnefes, Ping-Leung Ho, and Paul T. McEnery

J Am Soc Nephrol 14: 2618-2622. [Abstract] [Full Text]  

Risk Factors for Incident Stroke among Patients with End-Stage Renal Disease

Stephen L. Seliger, Daniel L. Gillen, David Tirschwell, Haimanot Wasse, Bryan R. Kestenbaum, and Catherine O. Stehman-Breen

J Am Soc Nephrol 14: 2623-2631. [Abstract] [Full Text]  

Dialysis:

Improved Acidosis Correction and Recovery of Mesothelial Cell Mass with Neutral-pH Bicarbonate Dialysis Solution among Children Undergoing Automated Peritoneal Dialysis

Susanne Haas, Claus Peter Schmitt, Klaus Arbeiter, Klaus-Eugen Bonzel, Michel Fischbach, Ulrike John, Anne-Kathrin Pieper, Thomas Patrick Schaub, Jutta Passlick-Deetjen, Otto Mehls, and Franz Schaefer

J Am Soc Nephrol 14: 2632-2638. [Abstract] [Full Text]  

Impairment of Transendothelial Leukocyte Migration by Iron Complexes

Gürkan Sengoelge, Josef Kletzmayr, Ilse Ferrara, Agnes Perschl, Walter H. Hörl, and Gere Sunder-Plassmann

J Am Soc Nephrol 14: 2639-2644. [Abstract] [Full Text]  

Regular Monitoring of Access Flow Compared with Monitoring of Venous Pressure Fails to Improve Graft Survival

Louise M. Moist, David N. Churchill, Andrew A. House, Steven F. Millward, James E. Elliott, Stewart W. Kribs, William J. DeYoung, Lesley Blythe, Lawrence W. Stitt, and Robert M. Lindsay

J Am Soc Nephrol 14: 2645-2653. [Abstract] [Full Text]  

Protocolized Anemia Management with Erythropoietin in Hemodialysis Patients: A Randomized Controlled Trial

K. Scott Brimble, Christian G. Rabbat, Pat McKenna, Kim Lambert, and Euan J. Carlisle

J Am Soc Nephrol 14: 2654-2661. [Abstract] [Full Text]  

Transplantation:

Estimation of Total Glomerular Number in Stable Renal Transplants

Xavier Fulladosa, Francesc Moreso, Jose A. Narváez, Josep M. Grinyó, and Daniel Serón

J Am Soc Nephrol 14: 2662-2668. [Abstract] [Full Text]  

Prevention of Bone Loss in Renal Transplant Recipients: A Prospective, Randomized Trial of Intravenous Pamidronate

Maria Coco, Daniel Glicklich, Marie Claude Faugere, Larry Burris, Istvan Bognar, Peter Durkin, Vivian Tellis, Stuart Greenstein, Richard Schechner, Katherine Figueroa, Patricia McDonough, Guodong Wang, and Hartmut Malluche

J Am Soc Nephrol 14: 2669-2676. [Abstract] [Full Text]  

Cross-Reactivity between Swine Leukocyte Antigen and Human Anti–HLA-Specific Antibodies in Sensitized Patients Awaiting Renal Transplantation

Inmaculada Díaz Varela, Pilar Sánchez Mozo, Alberto Centeno Cortés, Clara Alonso Blanco, and Francisco Valdés Cañedo

J Am Soc Nephrol 14: 2677-2683. [Abstract] [Full Text]  

REVIEWS:

Left Ventricular Geometry and Hypotension in End-Stage Renal Disease: A Mechanical Perspective

Giovanni de Simone

J Am Soc Nephrol 14: 2421-2427. [Abstract] [Full Text]  

EDITORIALS:

Can JASN Better Serve the Clinical Community?

William G. Couser

J Am Soc Nephrol 14: 2684-2685. [Full Text]  

Revisions to Instructions to JASN Authors Regarding Articles Reporting Studies Using DNA Arrays, DNA Polymorphisms, and Randomized Controlled Clinical Trials

William G. Couser

J Am Soc Nephrol 14: 2686-2687. [Full Text]  

Commentary on. . .Neuronal Nitric Oxide Synthase: Its Role and Regulation in Macula Densa Cells

Scott Thomson

J Am Soc Nephrol 14: 2688-2689. [Full Text]  

PDGF-D and Renal Disease: Yet Another One of Those Growth Factors?

Jürgen Floege, Frank Eitner, Claudia van Roeyen, and Tammo Ostendorf

J Am Soc Nephrol 14: 2690-2691. [Full Text]  

ANNOUNCEMENTS:

J Am Soc Nephrol 14: 2692. [Full Text]  

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