THIS MONTH'S HIGHLIGHTS:

This Month’s Highlights

J Am Soc Nephrol 14: A13-A15. [Full Text]  

ASN NEWS:

ASN NEWS

J Am Soc Nephrol 14: A31-A32. [Full Text]  

BASIC SCIENCE:

Cell and Transport Physiology:

Localization and Regulation of the Epithelial Ca²⁺ Channel TRPV6 in the Kidney

Tom Nijenhuis, Joost G. J. Hoenderop, Annemiete W. C. M. van der Kemp, and René J. M. Bindels

J Am Soc Nephrol 14: 2731-2740. [Abstract] [Full Text]  

Impaired Renal Secretion of Substrates for the Multidrug Resistance Protein 2 in Mutant Transport–Deficient (TR^-) Rats

Rosalinde Masereeuw, Sylvia Notenboom, Pascal H. E. Smeets, Alfons C. Wouterse, and Frans G. M. Russel

J Am Soc Nephrol 14: 2741-2749. [Abstract] [Full Text]  

Inhibition of Erythrocyte Cation Channels by Erythropoietin

Svetlana Myssina, Stephan M. Huber, Christina Birka, Philipp A. Lang, Karl S. Lang, Björn Friedrich, Teut Risler, Thomas Wieder, and Florian Lang

J Am Soc Nephrol 14: 2750-2757. [Abstract] [Full Text]  

Cell Biology:

Urea Restrains Aldosterone-Induced Development of Peanut Agglutinin–Binding on Embryonic Renal Collecting Duct Epithelia

Karl Schumacher, Raimund Strehl, and Will W. Minuth

J Am Soc Nephrol 14: 2758-2766. [Abstract] [Full Text]  

Genetics and Development:

Ureteric Bud Apoptosis and Renal Hypoplasia in Transgenic PAX2-Bax Fetal Mice Mimics the Renal-Coloboma Syndrome

Alison Dziarmaga, Patsy Clark, Cherie Stayner, Jean Pierre Julien, Elena Torban, Paul Goodyer, and Michael Eccles

J Am Soc Nephrol 14: 2767-2774. [Abstract] [Full Text]  

Hemodynamics and Vascular Regulation:

Salt Intake, Oxidative Stress, and Renal Expression of NADPH Oxidase and Superoxide Dismutase

Chagriya Kitiyakara, Tina Chabrashvili, Yifan Chen, Jonathan Blau, Alex Karber, Shakil Aslam, William J. Welch, and Christopher S. Wilcox

J Am Soc Nephrol 14: 2775-2782. [Abstract] [Full Text]  

Role of Oxidative Stress in Endothelial Dysfunction and Enhanced Responses to Angiotensin II of Afferent Arterioles from Rabbits Infused with Angiotensin II

Dan Wang, Yifan Chen, Tina Chabrashvili, Shakil Aslam, Lillian J. Borrego Conde, Jason G. Umans, and Christopher S. Wilcox

J Am Soc Nephrol 14: 2783-2789. [Abstract] [Full Text]  

Nitric Oxide Inhibits Stretch-Induced MAPK Activation in Mesangial Cells Through RhoA Inactivation

Joan C. Krepinsky, Alistair J. Ingram, Damu Tang, Dongcheng Wu, Lieqi Liu, and James W. Scholey

J Am Soc Nephrol 14: 2790-2800. [Abstract] [Full Text]  

Immunology and Pathology:

The Fine Specificity and Cytokine Profile of T-Helper Cells Responsive to the 3 Chain of Type IV Collagen in Goodpasture’s Disease

Lindsay S. Cairns, Richard G. Phelps, Laura Bowie, Andrew M. Hall, Walaa W.M. Saweirs, Andrew J. Rees, and Robert N. Barker

J Am Soc Nephrol 14: 2801-2812. [Abstract] [Full Text]  

Intrinsic Renal Cell Expression of CD40 Directs Th1 Effectors Inducing Experimental Crescentic Glomerulonephritis

Amanda-Jane Ruth, A. Richard Kitching, Timothy J. Semple, Peter G. Tipping, and Stephen R. Holdsworth

J Am Soc Nephrol 14: 2813-2822. [Abstract] [Full Text]  

Differential Usage of Class II Transactivator Promoters PI and PIV during Inflammation and Injury in Kidney

Oki Takeuchi, Tasha N. Sims, Yutaka Takei, Vido Ramassar, Konrad S. Famulski, and Philip F. Halloran

J Am Soc Nephrol 14: 2823-2832. [Abstract] [Full Text]  

Pathophysiology of Renal Disease:

Reversal of Glomerulosclerosis after High-Dose Enalapril Treatment in Subtotally Nephrectomized Rats

Marcin Adamczak, Marie-Luise Gross, Jan Krtil, Andreas Koch, Karin Tyralla, Kerstin Amann, and Eberhard Ritz

J Am Soc Nephrol 14: 2833-2842. [Abstract] [Full Text]  

CLINICAL SCIENCE:

Clinical Nephrology:

Genetic Variation in the Renin-Angiotensin System and Progression of Diabetic Nephropathy

Peter Jacobsen, Lise Tarnow, Bendix Carstensen, Peter Hovind, Odette Poirier, and Hans-Henrik Parving

J Am Soc Nephrol 14: 2843-2850. [Abstract] [Full Text]  

Hemodialysis and Peritoneal Dialysis: Comparison of Adjusted Mortality Rates According to the Duration of Dialysis: Analysis of the Netherlands Cooperative Study on the Adequacy of Dialysis 2

Fabian Termorshuizen, Johanna C. Korevaar, Friedo W. Dekker, Jeannette G. van Manen, Elisabeth W. Boeschoten, and Raymond T. Krediet

J Am Soc Nephrol 14: 2851-2860. [Abstract] [Full Text]  

Angiotensin-Converting Enzyme Inhibition but not Angiotensin II Receptor Blockade Regulates Matrix Metalloproteinase Activity in Patients with Glomerulonephritis

Nadège Lods, Paolo Ferrari, Felix J. Frey, Andreas Kappeler, Celine Berthier, Bruno Vogt, and Hans-Peter Marti

J Am Soc Nephrol 14: 2861-2872. [Abstract] [Full Text]  

Human Genetics:

Molecular Analysis of the SGLT2 Gene in Patients with Renal Glucosuria

René Santer, Martina Kinner, Christoph L. Lassen, Reinhard Schneppenheim, Paul Eggert, Martin Bald, Johannes Brodehl, Markus Daschner, Jochen H.H. Ehrich, Markus Kemper, Salvatore Li Volti, Thomas Neuhaus, Flemming Skovby, Peter G.F. Swift, Jürgen Schaub, and Dan Klaerke

J Am Soc Nephrol 14: 2873-2882. [Abstract] [Full Text]  

A Cluster of Mutations in the UMOD Gene Causes Familial Juvenile Hyperuricemic Nephropathy with Abnormal Expression of Uromodulin

Karin Dahan, Olivier Devuyst, Michèle Smaers, Didier Vertommen, Guy Loute, Jean-Michel Poux, Béatrice Viron, Christian Jacquot, Marie-France Gagnadoux, Dominique Chauveau, Mathias Büchler, Pierre Cochat, Jean-Pierre Cosyns, Béatrice Mougenot, Mark H. Rider, Corinne Antignac, Christine Verellen-Dumoulin, and Yves Pirson

J Am Soc Nephrol 14: 2883-2893. [Abstract] [Full Text]  

Epidemiology and Outcomes:

Obesity Is Associated with Worse Peritoneal Dialysis Outcomes in the Australia and New Zealand Patient Populations

Stephen P. McDonald, John F. Collins, and David W. Johnson

J Am Soc Nephrol 14: 2894-2901. [Abstract] [Full Text]  

Racial Differences in the Progression from Chronic Renal Insufficiency to End-Stage Renal Disease in the United States

Chi-yuan Hsu, Feng Lin, Eric Vittinghoff, and Michael G Shlipak

J Am Soc Nephrol 14: 2902-2907. [Abstract] [Full Text]  

Hepatitis C and Renal Transplantation in the Era of Modern Immunosuppression

Kevin C. Abbott, Jay R. Bucci, Cal S. Matsumoto, S. John Swanson, Lawrence Y.C. Agodoa, Kent C. Holtzmuller, David F. Cruess, and Thomas G. Peters

J Am Soc Nephrol 14: 2908-2918. [Abstract] [Full Text]  

Association of High Serum Creatinine and Anemia Increases the Risk of Coronary Events: Results from the Prospective Community-Based Atherosclerosis Risk in Communities (ARIC) Study

Claudine T. Jurkovitz, Jerome L. Abramson, L. Viola Vaccarino, William S. Weintraub, and William M. McClellan

J Am Soc Nephrol 14: 2919-2925. [Abstract] [Full Text]  

High Proteinase 3-Anti-Neutrophil Cytoplasmic Antibody (ANCA) Level Measured by the Capture Enzyme-Linked Immunosorbent Assay Method Is Associated with Decreased Patient Survival in ANCA-Associated Vasculitis with Renal Involvement

Kerstin W. A. Westman, Daina Selga, Per-Erik Isberg, Anna Bladström, and Håkan Olsson

J Am Soc Nephrol 14: 2926-2933. [Abstract] [Full Text]  

Risk Factors for Chronic Kidney Disease: A Prospective Study of 23,534 Men and Women in Washington County, Maryland

Melanie K. Haroun, Bernard G. Jaar, Sandra C. Hoffman, George W. Comstock, Michael J. Klag, and Josef Coresh

J Am Soc Nephrol 14: 2934-2941. [Abstract] [Full Text]  

Dialysis:

Comparison of Arteriovenous Grafts in the Thigh and Upper Extremities in Hemodialysis Patients

Christopher D. Miller, Michelle L. Robbin, Jill Barker, and Michael Allon

J Am Soc Nephrol 14: 2942-2947. [Abstract] [Full Text]  

Survival of Functionally Anuric Patients on Automated Peritoneal Dialysis: The European APD Outcome Study

Edwina A. Brown, Simon J. Davies, Peter Rutherford, Frederique Meeus, Mercedes Borras, Werner Riegel, Jose C. Divino Filho, Edward Vonesh, and Monique Van Bree

J Am Soc Nephrol 14: 2948-2957. [Abstract] [Full Text]  

Human Renal Pathology:

Gene Expression Profiles of Podocyte-Associated Molecules as Diagnostic Markers in Acquired Proteinuric Diseases

Holger Schmid, Anna Henger, Clemens D. Cohen, Karin Frach, Hermann-Josef Gröne, Detlef Schlöndorff, and Matthias Kretzler

J Am Soc Nephrol 14: 2958-2966. [Abstract] [Full Text]  

Transplantation:

Nomogram for Predicting the Likelihood of Delayed Graft Function in Adult Cadaveric Renal Transplant Recipients

William D. Irish, David A. McCollum, Raymond J. Tesi, Art B. Owen, Daniel C. Brennan, Jane E. Bailly, and Mark A. Schnitzler

J Am Soc Nephrol 14: 2967-2974. [Abstract] [Full Text]  

Preventing Bone Loss in Renal Transplant Recipients with Vitamin D

Amgad E. El-Agroudy, Amr A. El-Husseini, Moharam El-Sayed, and Mohamed A. Ghoneim

J Am Soc Nephrol 14: 2975-2979. [Abstract] [Full Text]  

Long-Term Graft Survival with Neoral and Tacrolimus: A Paired Kidney Analysis

Bruce Kaplan, Jesse D. Schold, and Herwig-Ulf Meier-Kriesche

J Am Soc Nephrol 14: 2980-2984. [Abstract] [Full Text]  

FRONTIERS IN NEPHROLOGY:

Overview: Integrating Renal Hypoxic Signals in Development and Disease

Thomas O. Daniel

J Am Soc Nephrol 14: 2693-2694. [Full Text]  

Targeting of the VHL-Hypoxia-Inducible Factor-Hypoxia-Induced Gene Pathway for Renal Cell Carcinoma Therapy

Jeffrey A. Sosman

J Am Soc Nephrol 14: 2695-2702. [Abstract] [Full Text]  

The von Hippel-Lindau Gene, Kidney Cancer, and Oxygen Sensing

William G. Kaelin, Jr.

J Am Soc Nephrol 14: 2703-2711. [Abstract] [Full Text]  

HIF-1: An Oxygen Response System with Special Relevance to the Kidney

Patrick Maxwell

J Am Soc Nephrol 14: 2712-2722. [Full Text]  

Hypoxia-Inducible Factors and Kidney Vascular Development

Paul B. Freeburg and Dale R. Abrahamson

J Am Soc Nephrol 14: 2723-2730. [Abstract] [Full Text]  

EDITORIALS:

Angiotensin II and Oxidative Stress: An Unholy Alliance

Eberhard Ritz and Volker Haxsen

J Am Soc Nephrol 14: 2985-2987. [Full Text]  

Tolerance and Autoimmunity in Anti-GBM Disease

Alan D. Salama and Jeremy B. Levy

J Am Soc Nephrol 14: 2988-2989. [Full Text]  

Regression Lines in Chronic Kidney Disease

Agnes B. Fogo

J Am Soc Nephrol 14: 2990-2991. [Full Text]  

ERRATA:

Erratum

J Am Soc Nephrol 14: 2992. [Full Text]  

ANNOUNCEMENTS:

J Am Soc Nephrol 14: 2993. [Full Text]  

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