THIS MONTH'S HIGHLIGHTS:

This Month’s Highlights

J Am Soc Nephrol 14: A9-A11. [Full Text]  

ASN NEWS:

ASN News

J Am Soc Nephrol 14: A29-A30. [Full Text]  

ARTICLES:

Cell and Transport Physiology:

Mutations in the Human Na-K-2Cl Cotransporter (NKCC2) Identified in Bartter Syndrome Type I Consistently Result in Nonfunctional Transporters

Patrick G.J.F. Starremans, Ferry F.J. Kersten, Nine V.A.M. Knoers, Lambertus P.W.J. van den Heuvel, and René J.M. Bindels

J Am Soc Nephrol 14: 1419-1426. [Abstract] [Full Text]  

Hormones, Growth Factors, Cell Signaling, Cell Biology and Structure:

The PI3-Kinase-Akt Pathway Promotes Mesangial Cell Survival and Inhibits Apoptosis In Vitro via NF-B and Bad

Haruko Shimamura, Yoshio Terada, Tomokazu Okado, Hiroyuki Tanaka, Seiji Inoshita, and Sei Sasaki

J Am Soc Nephrol 14: 1427-1434. [Abstract] [Full Text]  

Cyclosporine A Amplifies Ca²⁺ Signaling Pathway in LLC-PK1 Cells through the Inhibition of Plasma Membrane Ca²⁺ Pump

Vincenzo Calderaro, Mariarosaria Boccellino, Giovanni Cirillo, Lucio Quagliuolo, Domenico Cirillo, and Alfonso Giovane

J Am Soc Nephrol 14: 1435-1442. [Abstract] [Full Text]  

AngRem104, an Angiotensin II–Induced Novel Upregulated Gene in Human Mesangial Cells, Is Potentially Involved in the Regulation of Fibronectin Expression

Xiubin Liang, Hong Zhang, Anyu Zhou, and Haiyan Wang

J Am Soc Nephrol 14: 1443-1451. [Abstract] [Full Text]  

Cell Biological and Biochemical Characterization of Drebrin Complexes in Mesangial Cells and Podocytes of Renal Glomeruli

Wiebke K. Peitsch, Ilse Hofmann, Nicole Endlich, Silke Prätzel, Cäcilia Kuhn, Herbert Spring, Hermann-Josef Gröne, Wilhelm Kriz, and Werner W. Franke

J Am Soc Nephrol 14: 1452-1463. [Abstract] [Full Text]  

Hemodynamics, Hypertension and Vascular Regulation:

Lead-Induced Downregulation of Soluble Guanylate Cyclase in Isolated Rat Aortic Segments Mediated by Reactive Oxygen Species and Cyclooxygenase-2

Elise Courtois, Maria Marques, Alberto Barrientos, Santos Casado, and Antonio López-Farré

J Am Soc Nephrol 14: 1464-1470. [Abstract] [Full Text]  

Oxidized LDL and its Compound Lysophosphatidylcholine Potentiate AngII-Induced Vasoconstriction by Stimulation of RhoA

Jan Galle, Alexander Mameghani, Steffen-Sebastian Bolz, Stepan Gambaryan, Maria Görg, Thomas Quaschning, Ulrike Raff, Holger Barth, Stefan Seibold, Christoph Wanner, and Ulrich Pohl

J Am Soc Nephrol 14: 1471-1479. [Abstract] [Full Text]  

The Effects of Weight Loss on Renal Function in Patients with Severe Obesity

Avry Chagnac, Tali Weinstein, Michal Herman, Judith Hirsh, Uzi Gafter, and Yaacov Ori

J Am Soc Nephrol 14: 1480-1486. [Abstract] [Full Text]  

Immunology and Pathology:

Plasminogen Activator Inhibitor-1 Is a Significant Determinant of Renal Injury in Experimental Crescentic Glomerulonephritis

A. Richard Kitching, Yao Z. Kong, Xiao Ru Huang, Piers Davenport, Kristy L. Edgtton, Peter Carmeliet, Stephen R. Holdsworth, and Peter G. Tipping

J Am Soc Nephrol 14: 1487-1495. [Abstract] [Full Text]  

Anti-Monocyte Chemoattractant Protein-1 Gene Therapy Attenuates Renal Injury Induced by Protein-Overload Proteinuria

Hideaki Shimizu, Shoichi Maruyama, Yukio Yuzawa, Tomomi Kato, Yusuke Miki, Satoshi Suzuki, Waichi Sato, Yoshiki Morita, Hiroki Maruyama, Kensuke Egashira, and Seiichi Matsuo

J Am Soc Nephrol 14: 1496-1505. [Abstract] [Full Text]  

Molecular Medicine, Genetics and Development:

Nephrogenesis Is Induced by Partial Nephrectomy in the Elasmobranch Leucoraja erinacea

Marlies Elger, Hartmut Hentschel, Jennifer Litteral, Maren Wellner, Torsten Kirsch, Friedrich C. Luft, and Hermann Haller

J Am Soc Nephrol 14: 1506-1518. [Abstract] [Full Text]  

A Gene Locus for Steroid-Resistant Nephrotic Syndrome with Deafness Maps to Chromosome 14q24.2

Rainer G. Ruf, Matthias T. F. Wolf, Hans C. Hennies, Barbara Lucke, Christina Zinn, Verena Varnholt, Anne Lichtenberger, Andreas Pasch, Anita Imm, Sonia Briese, Thomas Lennert, Arno Fuchshuber, Peter Nurnberg, and Friedhelm Hildebrandt

J Am Soc Nephrol 14: 1519-1522. [Abstract] [Full Text]  

Activin A Produced by Ureteric Bud Is a Differentiation Factor For Metanephric Mesenchyme

Akito Maeshima, Shin Yamashita, Kyoko Maeshima, Itaru Kojima, and Yoshihisa Nojima

J Am Soc Nephrol 14: 1523-1534. [Abstract] [Full Text]  

Inhibition of Renal Fibrosis by Gene Transfer of Inducible Smad7 Using Ultrasound-Microbubble System in Rat UUO Model

Hui Y. Lan, Wei Mu, Naruya Tomita, Xiao R. Huang, Jin H. Li, Hong-Jian Zhu, Ryuichi Morishita, and Richard J. Johnson

J Am Soc Nephrol 14: 1535-1548. [Abstract] [Full Text]  

Pathophysiology of Renal Disease:

Distant Effects of Experimental Renal Ischemia/Reperfusion Injury

K. J. Kelly

J Am Soc Nephrol 14: 1549-1558. [Abstract] [Full Text]  

BMP-7 Is an Efficacious Treatment of Vascular Calcification in a Murine Model of Atherosclerosis and Chronic Renal Failure

Matthew R. Davies, Richard J. Lund, and Keith A. Hruska

J Am Soc Nephrol 14: 1559-1567. [Abstract] [Full Text]  

Clinical Nephrology:

The Contribution of Increased Diabetes Prevalence and Improved Myocardial Infarction and Stroke Survival to the Increase in Treated End-Stage Renal Disease

Paul Muntner, Josef Coresh, Neil R. Powe, and Michael J. Klag

J Am Soc Nephrol 14: 1568-1577. [Abstract] [Full Text]  

Treatment of IgA Nephropathy with ACE Inhibitors: A Randomized and Controlled Trial

Manuel Praga, Eduardo Gutiérrez, Ester González, Enrique Morales, and Eduardo Hernández

J Am Soc Nephrol 14: 1578-1583. [Abstract] [Full Text]  

Predictors of Renal and Patient Outcomes in Atheroembolic Renal Disease: A Prospective Study

Francesco Scolari, Pietro Ravani, Alessandra Pola, Simona Guerini, Roberto Zubani, Ezio Movilli, Silvana Savoldi, Fabio Malberti, and Rosario Maiorca

J Am Soc Nephrol 14: 1584-1590. [Abstract] [Full Text]  

Dialysis:

Ankle-Brachial Blood Pressure Index Predicts All-Cause and Cardiovascular Mortality in Hemodialysis Patients

Kumeo Ono, Akiyasu Tsuchida, Hironobu Kawai, Hidenori Matsuo, Ryouji Wakamatsu, Akira Maezawa, Shintarou Yano, Tomoyuki Kawada, and Yoshihisa Nojima

J Am Soc Nephrol 14: 1591-1598. [Abstract] [Full Text]  

Blood Flow Limitation In Vivo of Small Solute Transfer during Peritoneal Dialysis in Rats

Bert-Inge Rosengren and Bengt Rippe

J Am Soc Nephrol 14: 1599-1604. [Abstract] [Full Text]  

Effect of Pravastatin on Loss of Renal Function in People with Moderate Chronic Renal Insufficiency and Cardiovascular Disease

Marcello Tonelli, Lemuel Moyé, Frank M. Sacks, Thom Cole, and Gary C. Curhan

J Am Soc Nephrol 14: 1605-1613. [Abstract] [Full Text]  

Plasma Pentosidine Is Associated with Inflammation and Malnutrition in End-Stage Renal Disease Patients Starting on Dialysis Therapy

Mohammed E. Suliman, Olof Heimbürger, Peter Bárány, Björn Anderstam, Roberto Pecoits-Filho, Ernesto Rodríguez Ayala, A. Rashid Qureshi, Ingela Fehrman-Ekholm, Bengt Lindholm, and Peter Stenvinkel

J Am Soc Nephrol 14: 1614-1622. [Abstract] [Full Text]  

A Prospective Controlled Trial on Effect of Percutaneous Transluminal Angioplasty on Functioning Arteriovenous Fistulae Survival

Nicola Tessitore, Giancarlo Mansueto, Valeria Bedogna, Giovanni Lipari, Albino Poli, Linda Gammaro, Elda Baggio, Giovanni Morana, Carmelo Loschiavo, Alessandro Laudon, Lamberto Oldrizzi, and Giuseppe Maschio

J Am Soc Nephrol 14: 1623-1627. [Abstract] [Full Text]  

Epidemiology and Outcomes:

Hospitalized Psychoses after Renal Transplantation in the United States: Incidence, Risk Factors, and Prognosis

Kevin C. Abbott, Lawrence Y. Agodoa, and Patrick G. O’Malley

J Am Soc Nephrol 14: 1628-1635. [Abstract] [Full Text]  

The Change in Allograft Function among Long-Term Kidney Transplant Recipients

John S. Gill, Marcello Tonelli, Christian H. Mix, and Brian J.G. Pereira

J Am Soc Nephrol 14: 1636-1642. [Abstract] [Full Text]  

Transplantation:

Regulatory CD25⁺ T Cells in Human Kidney Transplant Recipients

Alan D. Salama, Nader Najafian, Michael R. Clarkson, William E. Harmon, and Mohamed H. Sayegh

J Am Soc Nephrol 14: 1643-1651. [Abstract] [Full Text]  

CD4⁺CD25⁺ Regulatory T Cells Do Not Significantly Contribute to Direct Pathway Hyporesponsiveness in Stable Renal Transplant Patients

David S. Game, Maria P. Hernandez-Fuentes, Afzal N. Chaudhry, and Robert I. Lechler

J Am Soc Nephrol 14: 1652-1661. [Abstract] [Full Text]  

Computerized Image Analysis of Sirius Red–Stained Renal Allograft Biopsies as a Surrogate Marker to Predict Long-Term Allograft Function

Paul C. Grimm, Peter Nickerson, Jim Gough, Rachel McKenna, Elzbieta Stern, John Jeffery, and David N. Rush

J Am Soc Nephrol 14: 1662-1668. [Abstract] [Full Text]  

DISEASE OF THE MONTH:

The Arteriovenous Fistula

Klaus Konner, Barbara Nonnast-Daniel, and Eberhard Ritz

J Am Soc Nephrol 14: 1669-1680. [Full Text]  

HOMER W. SMITH AWARD LECTURE:

The Juxtaglomerular Apparatus: From Anatomical Peculiarity to Physiological Relevance

Jurgen Schnermann

J Am Soc Nephrol 14: 1681-1694. [Full Text]  

PRESIDENTIAL ADDRESS:

Reflections on the Past, Transitions to the Future: The American Society of Nephrology

Roland C. Blantz

J Am Soc Nephrol 14: 1695-1703. [Full Text]  

EDITORIALS:

The Skate Weighs in on Kidney Regeneration

Iain Drummond

J Am Soc Nephrol 14: 1704-1705. [Full Text]  

Regulatory T Cells in Kidney Transplant Recipients: Active Players but to What Extent?

Yuan Zhai and Jerzy W. Kupiec-Weglinski

J Am Soc Nephrol 14: 1706-1708. [Full Text]  

ANNOUNCEMENTS:

J Am Soc Nephrol 14: 1709. [Full Text]  

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