THIS MONTH'S HIGHLIGHTS:

This Month’s Highlights

J Am Soc Nephrol 14: A9-A11. [Full Text]  

ASN NEWS:

ASN News

J Am Soc Nephrol 14: A25-A26. [Full Text]  

ARTICLES:

Cell and Transport Physiology:

Protein Kinase C Activation Downregulates Human Organic Anion Transporter 1-Mediated Transport through Carrier Internalization

Natascha A. Wolff, Karen Thies, Nicola Kuhnke, Glen Reid, Björn Friedrich, Florian Lang, and Gerhard Burckhardt

J Am Soc Nephrol 14: 1959-1968. [Abstract] [Full Text]  

Hormones, Growth Factors, Cell Signaling, Cell Biology and Structure:

Cytoskeletal Rearrangement and Signal Transduction in TGF-1–Stimulated Mesangial Cell Collagen Accumulation

Susan C. Hubchak, Constance E. Runyan, Jeffrey I. Kreisberg, and H. William Schnaper

J Am Soc Nephrol 14: 1969-1980. [Abstract] [Full Text]  

Immunology and Pathology:

Lymphatic Microvessels in the Rat Remnant Kidney Model of Renal Fibrosis: Aminopeptidase P and Podoplanin Are Discriminatory Markers for Endothelial Cells of Blood and Lymphatic Vessels

Katsuyuki Matsui, Katalyn Nagy-Bojarsky, Pirjo Laakkonen, Sigurd Krieger, Karl Mechtler, Shunya Uchida, Silvana Geleff, Due-Hee Kang, Richard J. Johnson, and Dontscho Kerjaschki

J Am Soc Nephrol 14: 1981-1989. [Abstract] [Full Text]  

Aldosterone Plays a Pivotal Role in the Pathogenesis of Thrombotic Microangiopathy in SHRSP

Praveen N. Chander, Ricardo Rocha, Jeffrey Ranaudo, Gagan Singh, Andrea Zuckerman, and Charles T. Stier, Jr.

J Am Soc Nephrol 14: 1990-1997. [Abstract] [Full Text]  

Molecular Medicine, Genetics, and Development:

Inducible Podocyte-Specific Gene Expression in Transgenic Mice

Tetsuya Shigehara, Concepcion Zaragoza, Chagriya Kitiyakara, Hideko Takahashi, Huiyan Lu, Marcus Moeller, Lawrence B. Holzman, and Jeffrey B. Kopp

J Am Soc Nephrol 14: 1998-2003. [Abstract] [Full Text]  

Milder Presentation of Recessive Polycystic Kidney Disease Requires Presence of Amino Acid Substitution Mutations

Laszlo Furu, Luiz F. Onuchic, Ali Gharavi, Xiaoying Hou, Ernie L. Esquivel, Yasuyuki Nagasawa, Carsten Bergmann, Jan Senderek, Ellis Avner, Klaus Zerres, Gregory G. Germino, Lisa M. Guay-Woodford, and Stefan Somlo

J Am Soc Nephrol 14: 2004-2014. [Abstract] [Full Text]  

Identification of a Common Risk Haplotype for Diabetic Nephropathy at the Protein Kinase C-1 (PRKCB1) Gene Locus

Shin-ichi Araki, Daniel P.K. Ng, Bozena Krolewski, Lucjan Wyrwicz, John J. Rogus, Luis Canani, Yuichiro Makita, Masakazu Haneda, James H. Warram, and Andrzej S. Krolewski

J Am Soc Nephrol 14: 2015-2024. [Abstract] [Full Text]  

Bioengineered Implantation of Megalin-Expressing Cells: A Potential Intracorporeal Therapeutic Model for Uremic Toxin Protein Clearance in Renal Failure

Akihiko Saito, Junichiro J. Kazama, Noriaki Iino, Kenji Cho, Nobuo Sato, Hajime Yamazaki, Yuko Oyama, Tetsuro Takeda, Robert A. Orlando, Fujio Shimizu, Yasuhiko Tabata, and Fumitake Gejyo

J Am Soc Nephrol 14: 2025-2032. [Abstract] [Full Text]  

Distinct Molecular and Morphogenetic Properties of Mutations in the Human HNF1 Gene That Lead to Defective Kidney Development

Silvia Bohn, Heike Thomas, Gülüzar Turan, Sian Ellard, Coralie Bingham, Andrew T. Hattersley, and Gerhart U. Ryffel

J Am Soc Nephrol 14: 2033-2041. [Abstract] [Full Text]  

Use of the Tetracycline System for Inducible Protein Synthesis in the Kidney

Anna Rachel Gallagher, Kai Schönig, Nelson Brown, Hermann Bujard, and Ralph Witzgall

J Am Soc Nephrol 14: 2042-2051. [Abstract] [Full Text]  

Pathophysiology of Renal Disease:

Tissue Transglutaminase and the Progression of Human Renal Scarring

Timothy S. Johnson, Ahmed F. El-Koraie, N. James Skill, Nahed M. Baddour, A. Meguid El Nahas, Melvin Njloma, Ahmed G. Adam, and Martin Griffin

J Am Soc Nephrol 14: 2052-2062. [Abstract] [Full Text]  

Expression of Podocyte-Associated Molecules in Acquired Human Kidney Diseases

Klaas Koop, Michael Eikmans, Hans J. Baelde, Hiroshi Kawachi, Emile de Heer, Leendert C. Paul, and Jan A. Bruijn

J Am Soc Nephrol 14: 2063-2071. [Abstract] [Full Text]  

Protease-Activated Receptor-2 Expression in IgA Nephropathy: A Potential Role in the Pathogenesis of Interstitial Fibrosis

Giuseppe Grandaliano, Paola Pontrelli, Giuseppina Cerullo, Raffaella Monno, Elena Ranieri, Michele Ursi, Antonella Loverre, Loreto Gesualdo, and Francesco P. Schena

J Am Soc Nephrol 14: 2072-2083. [Abstract] [Full Text]  

Clinical Nephrology:

Cholesterol and the Risk of Renal Dysfunction in Apparently Healthy Men

Elke S. Schaeffner, Tobias Kurth, Gary C. Curhan, Robert J. Glynn, Kathryn M. Rexrode, Colin Baigent, Julie E. Buring, and J. Michael Gaziano

J Am Soc Nephrol 14: 2084-2091. [Abstract] [Full Text]  

Evidence that Clearance of Hepatitis C Virus RNA after -Interferon Therapy in Dialysis Patients Is Sustained after Renal Transplantation

Nassim Kamar, Olivier Toupance, Matthias Buchler, Karine Sandres-Saune, Jacques Izopet, Dominique Durand, and Lionel Rostaing

J Am Soc Nephrol 14: 2092-2098. [Abstract] [Full Text]  

The Spectrum of Systemic Involvement in Adults Presenting with Renal Lesion and Mitochondrial tRNA(Leu) Gene Mutation

Bruno Guéry, Gabriel Choukroun, Laure-Hélène Noël, Pierre Clavel, Agnès Rötig, Sophie Lebon, Pierre Rustin, Christine Bellané-Chantelot, Béatrice Mougenot, Jean-Pierre Grünfeld, and Dominique Chauveau

J Am Soc Nephrol 14: 2099-2108. [Abstract] [Full Text]  

Dialysis:

Inhibition of the Interaction of AGE–RAGE Prevents Hyperglycemia-Induced Fibrosis of the Peritoneal Membrane

An S. De Vriese, Allan Flyvbjerg, Siska Mortier, Ronald G. Tilton, and Norbert H. Lameire

J Am Soc Nephrol 14: 2109-2118. [Abstract] [Full Text]  

Oral Sodium Bicarbonate for the Treatment of Metabolic Acidosis in Peritoneal Dialysis Patients: A Randomized Placebo-Control Trial

Cheuk-Chun Szeto, Teresa Yuk-Hwa Wong, Kai-Ming Chow, Chi-Bon Leung, and Philip Kam-Tao Li

J Am Soc Nephrol 14: 2119-2126. [Abstract] [Full Text]  

Noninvasive Interventions to Decrease Hospitalization and Associated Costs for Pediatric Patients Receiving Hemodialysis

Stuart L. Goldstein, Carolyn M. Smith, and Helen Currier

J Am Soc Nephrol 14: 2127-2131. [Abstract] [Full Text]  

Epidemiology and Outcomes:

Bias in Assessment of Health-Related Quality of Life in a Hemodialysis Population: A Comparison of Self-Administered and Interviewer-Administered Surveys in the HEMO Study

Mark Unruh, Guofen Yan, Milena Radeva, Ron D. Hays, Robert Benz, Nicolaos V. Athienites, John Kusek, Andrew S. Levey, and Klemens B. Meyer

J Am Soc Nephrol 14: 2132-2141. [Abstract] [Full Text]  

Transplantation:

Early Interstitial Accumulation of Collagen Type I Discriminates Chronic Rejection from Chronic Cyclosporine Nephrotoxicity

Rene C. Bakker, Klaas Koop, Yvo W. Sijpkens, Michael Eikmans, Ingeborg M. Bajema, Emile de Heer, Jan A. Bruijn, and Leendert C. Paul

J Am Soc Nephrol 14: 2142-2149. [Abstract] [Full Text]  

Islet Transplantation Is Associated with Improvement of Renal Function among Uremic Patients with Type I Diabetes Mellitus and Kidney Transplants

Paolo Fiorina, Franco Folli, Gianpaolo Zerbini, Paola Maffi, Chiara Gremizzi, Valerio Di Carlo, Carlo Socci, Federico Bertuzzi, Michael Kashgarian, and Antonio Secchi

J Am Soc Nephrol 14: 2150-2158. [Abstract] [Full Text]  

Blood Pressure Evaluation among Older Living Kidney Donors

Stephen C. Textor, Sandra J. Taler, Timothy S. Larson, Mikel Prieto, Matthew Griffin, James Gloor, Scott Nyberg, Jorge Velosa, Thomas Schwab, and Mark Stegall

J Am Soc Nephrol 14: 2159-2167. [Abstract] [Full Text]  

Allorecognition and Effector Pathways of Islet Allograft Rejection in Normal versus Nonobese Diabetic Mice

Leila Makhlouf, Akira Yamada, Toshiro Ito, Reza Abdi, Mohammed Javeed I. Ansari, Chau Q. Khuong, Henry J. Winn, Hugh Auchincloss, Jr., and Mohamed H. Sayegh

J Am Soc Nephrol 14: 2168-2175. [Abstract] [Full Text]  

FRONTIERS IN NEPHROLOGY:

Acute Renal Failure: Directions for the Next Decade

Norman J. Siegel and Sudhir V. Shah

J Am Soc Nephrol 14: 2176-2177. [Full Text]  

Acute Renal Failure Definitions and Classification: Time for Change?

Ravindra L. Mehta and Glenn M. Chertow

J Am Soc Nephrol 14: 2178-2187. [Full Text]  

Newly Developed Techniques to Study and Diagnose Acute Renal Failure

Pierre C. Dagher, Stefan Herget-Rosenthal, Stefan G. Ruehm, Sang-Kyung Jo, Robert A. Star, Rajiv Agarwal, and Bruce A. Molitoris

J Am Soc Nephrol 14: 2188-2198. [Abstract] [Full Text]  

Recent Advances in the Pathophysiology of Ischemic Acute Renal Failure

Joseph V. Bonventre and Joel M. Weinberg

J Am Soc Nephrol 14: 2199-2210. [Full Text]  

EDITORIALS:

Cell Therapy: Leveraging Nature’s Therapeutic Potential

H. David Humes

J Am Soc Nephrol 14: 2211-2213. [Full Text]  

Islet Transplants and Impact on Secondary Diabetic Complications: Does C-Peptide Protect the Kidney?

A. M. James Shapiro

J Am Soc Nephrol 14: 2214-2216. [Full Text]  

ANNOUNCEMENTS:

J Am Soc Nephrol 14: 2217. [Full Text]  

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