JASN -- Table of Contents (15 [3])

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THIS MONTH'S HIGHLIGHTS:

This Month’s Highlights: J Am Soc Nephrol 15: A24-A26. [Full Text]

ASN NEWS:

ASN News: J Am Soc Nephrol 15: A39-A40. [Full Text]

BASIC SCIENCE:

Cell and Transport Physiology:

Downregulation of Ca²⁺ and Mg²⁺ Transport Proteins in the Kidney Explains Tacrolimus (FK506)-Induced Hypercalciuria and Hypomagnesemia: Tom Nijenhuis, Joost G.J. Hoenderop, and René J.M. Bindels; J Am Soc Nephrol 15: 549-557. [Abstract] [Full Text]

Aldosterone Decreases UT-A1 Urea Transporter Expression via the Mineralocorticoid Receptor: Randy A. Gertner, Janet D. Klein, James L. Bailey, Dong-un Kim, Xiao H. Luo, Serena M. Bagnasco, and Jeff M. Sands; J Am Soc Nephrol 15: 558-565. [Abstract] [Full Text]

Cell Biology:

Angiopoietin 1 and Vascular Endothelial Growth Factor Modulate Human Glomerular Endothelial Cell Barrier Properties: Simon C. Satchell, Karen L. Anderson, and Peter W. Mathieson; J Am Soc Nephrol 15: 566-574. [Abstract] [Full Text]

Exogenous Attenuation of p21^Waf1/Cip1 Decreases Mesangial Cell Hypertrophy as a Result of Hyperglycemia and IGF-1: Ya-ping Fan and Robert H. Weiss; J Am Soc Nephrol 15: 575-584. [Abstract] [Full Text]

The STAT3 DNA-Binding Domain Mediates Interaction with NF- ${kappa}$ B p65 and Inducible Nitric Oxide Synthase Transrepression in Mesangial Cells: Zhiyuan Yu and Bruce C. Kone; J Am Soc Nephrol 15: 585-591. [Abstract] [Full Text]

Genetics and Development:

The Autosomal Recessive Polycystic Kidney Disease Protein Is Localized to Primary Cilia, with Concentration in the Basal Body Area: Shixuan Wang, Ying Luo, Patricia D. Wilson, George B. Witman, and Jing Zhou; J Am Soc Nephrol 15: 592-602. [Abstract] [Full Text]

Immunology and Pathology:

Lymphatic Neoangiogenesis in Human Kidney Transplants Is Associated with Immunologically Active Lymphocytic Infiltrates: Dontscho Kerjaschki, Heinrich M. Regele, Isabella Moosberger, Katalyn Nagy-Bojarski, Bruno Watschinger, Afschin Soleiman, Peter Birner, Sigurd Krieger, Anny Hovorka, Georg Silberhumer, Pirjo Laakkonen, Tatiana Petrova, Brigitte Langer, and Ingrid Raab; J Am Soc Nephrol 15: 603-612. [Abstract] [Full Text]

Identification and Functional Characterization of Dendritic Cells in the Healthy Murine Kidney and in Experimental Glomerulonephritis: Thilo Krüger, Dirk Benke, Frank Eitner, Andreas Lang, Monika Wirtz, Emma E. Hamilton-Williams, Daniel Engel, Bernd Giese, Gerhard Müller-Newen, Jürgen Floege, and Christian Kurts; J Am Soc Nephrol 15: 613-621. [Abstract] [Full Text]

Glycosylation and Size of IgA1 Are Essential for Interaction with Mesangial Transferrin Receptor in IgA Nephropathy: Ivan C. Moura, Michelle Arcos-Fajardo, Charlotte Sadaka, Valérie Leroy, Marc Benhamou, Jan Novak, François Vrtovsnik, Elie Haddad, Koteswara R. Chintalacharuvu, and Renato C. Monteiro; J Am Soc Nephrol 15: 622-634. [Abstract] [Full Text]

Pathophysiology of Renal Disease and Progression:

Effect of Angiotensin II Receptor Blockage on Osteopontin Expression and Calcium Oxalate Crystal Deposition in Rat Kidneys: Tohru Umekawa, Yuji Hatanaka, Takashi Kurita, and Saeed R. Khan; J Am Soc Nephrol 15: 635-644. [Abstract] [Full Text]

Role of Leptin Deficiency in Early Acute Renal Failure during Endotoxemia in ob/ob Mice: Wei Wang, Brian Poole, Amit Mitra, Sandor Falk, Giamila Fantuzzi, Scott Lucia, and Robert Schrier; J Am Soc Nephrol 15: 645-649. [Abstract] [Full Text]

Alterations in the Renal Elastin-Elastase System in Type 1 Diabetic Nephropathy Identified by Proteomic Analysis: Visith Thongboonkerd, Michelle T. Barati, Kenneth R. McLeish, Charaf Benarafa, Eileen Remold-O’Donnell, Shirong Zheng, Brad H. Rovin, William M. Pierce, Paul N. Epstein, and Jon B. Klein; J Am Soc Nephrol 15: 650-662. [Abstract] [Full Text]

Mercuric Conjugates of Cysteine Are Transported by the Amino Acid Transporter System b^0,+: Implications of Molecular Mimicry: Christy C. Bridges, Christian Bauch, François Verrey, and Rudolfs K. Zalups; J Am Soc Nephrol 15: 663-673. [Abstract] [Full Text]

CD44 Deficiency Increases Tubular Damage But Reduces Renal Fibrosis in Obstructive Nephropathy: Kasper M.A. Rouschop, Miguel E. Sewnath, Nike Claessen, Joris J.T.H. Roelofs, Inge Hoedemaeker, Ronald van der Neut, Jan Aten, Steven T. Pals, Jan J. Weening, and Sandrine Florquin; J Am Soc Nephrol 15: 674-686. [Abstract] [Full Text]

Basic Transplantation:

Chronic Rejection: Insights from a Novel Immunosuppressive-Free Model of Kidney Transplantation: Martin Gasser, Ana Maria Waaga-Gasser, Joana E. Kist-van Holthe, Xueli Yuan, Susanne M. Lenhard, Kald A. Abdallah, and Anil Chandraker; J Am Soc Nephrol 15: 687-694. [Abstract] [Full Text]

IFN- ${gamma}$ Regulation in Anti-CD4 Antibody–Induced T Cell Unresponsiveness: Birgit Sawitzki, Brit Kieselbach, Marion Fisser, Christian Meisel, Katrin Vogt, Matthias Gaestel, Manfred Lehmann, Kirsten Risch, Gerald Grütz, and Hans-Dieter Volk; J Am Soc Nephrol 15: 695-703. [Abstract] [Full Text]

CLINICAL SCIENCE:

Clinical Nephrology:

Prospective Study of TNF ${alpha}$ Blockade with Infliximab in Anti-Neutrophil Cytoplasmic Antibody-Associated Systemic Vasculitis: Anthony Booth, Lorraine Harper, Tariq Hammad, Paul Bacon, Megan Griffith, Jeremy Levy, Caroline Savage, Charles Pusey, and David Jayne; J Am Soc Nephrol 15: 717-721. [Abstract] [Full Text]

Human Genetics:

Patients with Mutations in NPHS2 (Podocin) Do Not Respond to Standard Steroid Treatment of Nephrotic Syndrome: Rainer G. Ruf, Anne Lichtenberger, Stephanie M. Karle, Johannes P. Haas, Franzisco E. Anacleto, Michael Schultheiss, Isabella Zalewski, Anita Imm, Eva-Maria Ruf, Bettina Mucha, Arvind Bagga, Thomas Neuhaus, Arno Fuchshuber, Aysin Bakkaloglu, Friedhelm Hildebrandt, and the Arbeitsgemeinschaft für Pädiatrische Nephrologie Study Group; J Am Soc Nephrol 15: 722-732. [Abstract] [Full Text]

Epidemiology and Outcomes:

Malnutrition and Atherosclerosis in Dialysis Patients: Srinivasan Beddhu, Lisa M. Pappas, Nirupama Ramkumar, and Matthew H. Samore; J Am Soc Nephrol 15: 733-742. [Abstract] [Full Text]

Changes in Quality of Life during Hemodialysis and Peritoneal Dialysis Treatment: Generic and Disease Specific Measures: Albert W. Wu, Nancy E. Fink, Jane V.R. Marsh-Manzi, Klemens B. Meyer, Frederic O. Finkelstein, Michelle M. Chapman, and Neil R. Powe; J Am Soc Nephrol 15: 743-753. [Abstract] [Full Text]

A Randomized Evaluation of Two Health Care Quality Improvement Program (HCQIP) Interventions to Improve the Adequacy of Hemodialysis Care of ESRD Patients: Feedback Alone versus Intensive Intervention: William M. McClellan, Emily Hodgin, Stephen Pastan, Lisa McAdams, and Michael Soucie; J Am Soc Nephrol 15: 754-760. [Abstract] [Full Text]

N-Acetylcysteine for the Prevention of Radiocontrast Induced Nephropathy: A Meta-Analysis of Prospective Controlled Trials: Abhijit V. Kshirsagar, Charles Poole, Amy Mottl, David Shoham, Nora Franceschini, Gail Tudor, Malay Agrawal, Cindy Denu-Ciocca, E. Magnus Ohman, and William F. Finn; J Am Soc Nephrol 15: 761-769. [Abstract] [Full Text]

Mineral Metabolism and Bone Disease:

Calcium, Phosphate, and Parathyroid Hormone Levels in Combination and as a Function of Dialysis Duration Predict Mortality: Evidence for the Complexity of the Association between Mineral Metabolism and Outcomes: Lesley A. Stevens, Ognjenka Djurdjev, Savannah Cardew, E. C. Cameron, and Adeera Levin; J Am Soc Nephrol 15: 770-779. [Abstract] [Full Text]

Hemodynamics and Vascular Regulation:

Effects of Oral Contraceptive Use on the Renal and Systemic Vascular Response to Angiotensin II Infusion: Sofia B. Ahmed, Amrit K. Kang, Kevin D. Burns, Christopher R. J. Kennedy, Vesta Lai, Daniel C. Cattran, James W. Scholey, and Judith A. Miller; J Am Soc Nephrol 15: 780-786. [Abstract] [Full Text]

Clinical Immunology and Pathology:

Heterozygous and Homozygous Factor H Deficiencies Associated with Hemolytic Uremic Syndrome or Membranoproliferative Glomerulonephritis: Report and Genetic Analysis of 16 Cases: Marie-Agnès Dragon-Durey, Véronique Frémeaux-Bacchi, Chantal Loirat, Jacques Blouin, Patrick Niaudet, Georges Deschenes, Paul Coppo, Wolf Herman Fridman, and Laurence Weiss; J Am Soc Nephrol 15: 787-795. [Abstract] [Full Text]

Activation of Syk in Neutrophils by Antineutrophil Cytoplasm Antibodies Occurs via Fc ${gamma}$ Receptors and CD18: Peter Hewins, Julie M. Williams, Michael J.O. Wakelam, and Caroline O.S. Savage; J Am Soc Nephrol 15: 796-808. [Abstract] [Full Text]

Transplantation:

Long-Term Benefits with Sirolimus-Based Therapy after Early Cyclosporine Withdrawal: Henri Kreis, Rainer Oberbauer, Josep M. Campistol, Timothy Mathew, Pierre Daloze, Francesco P. Schena, James T. Burke, Yves Brault, Martine Gioud-Paquet, Joseph A. Scarola, and John F. Neylan; J Am Soc Nephrol 15: 809-817. [Abstract] [Full Text]

Leukocyte Reduction of Red Blood Cell Transfusions Does not Decrease Allosensitization Rates in Potential Kidney Transplant Candidates: Martin Karpinski, Denise Pochinco, Iga Dembinski, Willie Laidlaw, James Zacharias, and Peter Nickerson; J Am Soc Nephrol 15: 818-824. [Abstract] [Full Text]

FRONTIERS IN NEPHROLOGY:

Overview: Increased Cardiovascular Risk in Patients with Minor Renal Dysfunction: An Emerging Issue with Far-Reaching Consequences: Eberhard Ritz and William M. McClellan; J Am Soc Nephrol 15: 513-516. [Abstract] [Full Text]

How Does Minor Renal Dysfunction Influence Cardiovascular Risk and the Management of Cardiovascular Disease?: Tobias Pinkau, Karl F. Hilgers, Roland Veelken, and Johannes F. E. Mann; J Am Soc Nephrol 15: 517-523. [Abstract] [Full Text]

Sympathetic Hyperactivity in Chronic Renal Failure: A Wake-up Call: Hein A. Koomans, Peter J. Blankestijn, and Jaap A. Joles; J Am Soc Nephrol 15: 524-537. [Abstract] [Full Text]

The Role of Oxidative Stress–Altered Lipoprotein Structure and Function and Microinflammation on Cardiovascular Risk in Patients with Minor Renal Dysfunction: George A. Kaysen and Jason P. Eiserich; J Am Soc Nephrol 15: 538-548. [Abstract] [Full Text]

SPECIAL FEATURES:

Fighting Renal Diseases in Poor Countries: Building a Global Fund with the Help of the Pharmaceutical Industry: Arrigo Schieppati and Giuseppe Remuzzi; J Am Soc Nephrol 15: 704-707. [Abstract] [Full Text]

The Chronic Kidney Disease Initiative: Thomas F. Parker, III, Roland Blantz, Thomas Hostetter, Jonathan Himmelfarb, Alan Kliger, Michael Lazarus, Allen R. Nissenson, Brian Pereira, and James Weiss; J Am Soc Nephrol 15: 708-716. [Abstract] [Full Text]

EDITORIALS:

Not Just an Inhibitor: A Role for p21 Beyond The Cell Cycle—"The Truth Is Rarely Pure and Never Simple": Siân V. Griffin and Stuart J. Shankland; J Am Soc Nephrol 15: 825-826. [Full Text]

Emphatically Lymphatic: Robert B. Colvin; J Am Soc Nephrol 15: 827-829. [Full Text]

Off-Label Use of Approved Drugs: Therapeutic Opportunity and Challenges: William M. Bennett; J Am Soc Nephrol 15: 830-831. [Full Text]

Podocin and Nephrotic Syndrome: Implications for the Clinician: Patrick Niaudet; J Am Soc Nephrol 15: 832-834. [Full Text]

ERRATA:

Correction: J Am Soc Nephrol 15: 835-836. [Full Text]

Correction: J Am Soc Nephrol 15: 836. [Full Text]

ANNOUNCEMENTS:

: J Am Soc Nephrol 15: 837. [Full Text]