THIS MONTH'S HIGHLIGHTS:

This Month’s Highlights

J Am Soc Nephrol 15: A34-A35. [Full Text]  

ASN NEWS:

ASN NEWS

J Am Soc Nephrol 15: A46-A48. [Full Text]  

BASIC SCIENCE:

Cell and Transport Physiology:

Cerivastatin Activates Endothelial Calcium–Activated Potassium Channels and Thereby Modulates Endothelial Nitric Oxide Production and Cell Proliferation

Christoph Rüdiger Wolfram Kuhlmann, Christine Gast, Fang Li, Matthias Schäfer, Harald Tillmanns, Bernd Waldecker, and Johannes Wiecha

J Am Soc Nephrol 15: 868-875. [Abstract] [Full Text]  

Differential Regulation of Collecting Duct Na⁺,K⁺-ATPase and K⁺ Excretion by Furosemide and Piretanide: Role of Bradykinin

Bénédicte Buffin-Meyer, Mauricio Younes-Ibrahim, Ghazi El Mernissi, Lydie Cheval, Sophie Marsy, Michèle Grima, Jean-Pierre Girolami, and Alain Doucet

J Am Soc Nephrol 15: 876-884. [Abstract] [Full Text]  

Impaired Regulation of Renal K⁺ Elimination in the sgk1-Knockout Mouse

Dan Yang Huang, Peer Wulff, Harald Völkl, Johannes Loffing, Kerstin Richter, Dietmar Kuhl, Florian Lang, and Volker Vallon

J Am Soc Nephrol 15: 885-891. [Abstract] [Full Text]  

Cell Biology:

Kidney-Specific Inactivation of the Megalin Gene Impairs Trafficking of Renal Inorganic Sodium Phosphate Cotransporter (NaPi-IIa)

Sebastian Bachmann, Uwe Schlichting, Beate Geist, Kerim Mutig, Thomas Petsch, Desa Bacic, Carsten A. Wagner, Brigitte Kaissling, Jürg Biber, Heini Murer, and Thomas E. Willnow

J Am Soc Nephrol 15: 892-900. [Abstract] [Full Text]  

Hemodynamics and Vascular Regulation:

Atorvastatin Improves the Course of Ischemic Acute Renal Failure in Aging Rats

Massimo Sabbatini, Antonio Pisani, Francesco Uccello, Vittorio Serio, Rosalba Serù, Roberto Paternò, Bruno Cianciaruso, Giorgio Fuiano, and Michele Andreucci

J Am Soc Nephrol 15: 901-909. [Abstract] [Full Text]  

Immunology and Pathology:

Contributions of IL-1 and IL-1 to Crescentic Glomerulonephritis in Mice

Jennifer R. Timoshanko, A. Richard Kitching, Yichiro Iwakura, Stephen R. Holdsworth, and Peter G. Tipping

J Am Soc Nephrol 15: 910-918. [Abstract] [Full Text]  

Modulation of Interferon-Induced Genes by Lipoxin Analogue in Anti–Glomerular Basement Membrane Nephritis

Takamoto Ohse, Tatsuru Ota, Niamh Kieran, Catherine Godson, Koei Yamada, Tetsuhiro Tanaka, Toshiro Fujita, and Masaomi Nangaku

J Am Soc Nephrol 15: 919-927. [Abstract] [Full Text]  

The Parietal Epithelial Cell: A Key Player in the Pathogenesis of Focal Segmental Glomerulosclerosis in Thy-1.1 Transgenic Mice

Bart Smeets, Nathalie A.J.M. Te Loeke, Henry B.P.M. Dijkman, Mark L.M. Steenbergen, Joost F.M. Lensen, Mark P.V. Begieneman, Toin H. van Kuppevelt, Jack F.M. Wetzels, and Eric J. Steenbergen

J Am Soc Nephrol 15: 928-939. [Abstract] [Full Text]  

Gene Therapy via Blockade of Monocyte Chemoattractant Protein-1 for Renal Fibrosis

Takashi Wada, Kengo Furuichi, Norihiko Sakai, Yasunori Iwata, Kiyoki Kitagawa, Yuko Ishida, Toshikazu Kondo, Hiroyuki Hashimoto, Yoshiro Ishiwata, Naofumi Mukaida, Naohisa Tomosugi, Kouji Matsushima, Kensuke Egashira, and Hitoshi Yokoyama

J Am Soc Nephrol 15: 940-948. [Abstract] [Full Text]  

Pathophysiology of Renal Disease and Progression:

Hypercholesterolemia in Rats Induces Podocyte Stress and Decreases Renal Cortical Nitric Oxide Synthesis via an Angiotensin II Type 1 Receptor–Sensitive Mechanism

Diana M. Attia, Olivier Feron, Roel Goldschmeding, Louk H. Radermakers, Nosratola D. Vaziri, Peter Boer, Jean-Luc Balligand, Hein A. Koomans, and Jaap A. Joles

J Am Soc Nephrol 15: 949-957. [Abstract] [Full Text]  

Antioxidant Intervention Blunts Renal Injury in Experimental Renovascular Disease

Alejandro R. Chade, Martin Rodriguez-Porcel, Joerg Herrmann, Xiangyang Zhu, Joseph P. Grande, Claudio Napoli, Amir Lerman, and Lilach O. Lerman

J Am Soc Nephrol 15: 958-966. [Abstract] [Full Text]  

Basic Transplantation:

Renal Transplantation Modulates Expression and Function of Receptors and Transporters of Rat Proximal Tubules

Ana Velic, Jochen R. Hirsch, Jasmin Bartel, Regina Thomas, Rita Schröter, Heike Stegemann, Bayram Edemir, Christian August, Eberhard Schlatter, and Gert Gabriëls

J Am Soc Nephrol 15: 967-977. [Abstract] [Full Text]  

Tubular Chimerism Occurs Regularly in Renal Allografts and Is Not Correlated to Outcome

Michael Mengel, Danny Jonigk, Magali Marwedel, Wolfram Kleeberger, Martin Bredt, Oliver Bock, Ulrich Lehmann, Wilfried Gwinner, Hermann Haller, and Hans Kreipe

J Am Soc Nephrol 15: 978-986. [Abstract] [Full Text]  

Modified Dendritic Cells Coexpressing Self and Allogeneic Major Histocompatability Complex Molecules: An Efficient Way to Induce Indirect Pathway Regulation

Vincenzo Mirenda, Ivan Berton, Joseph Read, Terence Cook, Jennifer Smith, Anthony Dorling, and Robert Ian Lechler

J Am Soc Nephrol 15: 987-997. [Abstract] [Full Text]  

CLINICAL SCIENCE:

Disease of the Month:

Evolving Concepts in Human Renal Dysplasia

Adrian S. Woolf, Karen L. Price, Peter J. Scambler, and Paul J.D. Winyard

J Am Soc Nephrol 15: 998-1007. [Abstract] [Full Text]  

Clinical Nephrology:

Abnormal HDL Apolipoprotein A-I and A-II Kinetics in Hemodialysis Patients: A Stable Isotope Study

Keiko Okubo, Katsunori Ikewaki, Soichi Sakai, Norio Tada, Yoshindo Kawaguchi, and Seibu Mochizuki

J Am Soc Nephrol 15: 1008-1015. [Abstract] [Full Text]  

Environmental Exposure to Lead and Progression of Chronic Renal Diseases: A Four-Year Prospective Longitudinal Study

Chun-Chen Yu, Ja-Liang Lin, and Dan-Tzu Lin-Tan

J Am Soc Nephrol 15: 1016-1022. [Abstract] [Full Text]  

Repeat Imaging for Intracranial Aneurysms in Patients with Autosomal Dominant Polycystic Kidney Disease with Initially Negative Studies: A Prospective Ten-Year Follow-up

Robert W. Schrier, Mark M. Belz, Ann M. Johnson, William D. Kaehny, Richard L. Hughes, David Rubinstein, and Patricia A. Gabow

J Am Soc Nephrol 15: 1023-1028. [Abstract] [Full Text]  

Epidemiology and Outcomes:

Prognostic Value of Echocardiographic Indicators of Left Ventricular Systolic Function in Asymptomatic Dialysis Patients

Carmine Zoccali, Francesco A. Benedetto, Francesca Mallamaci, Giovanni Tripepi, Giuseppe Giacone, Alessandro Cataliotti, Giuseppe Seminara, Benedetta Stancanelli, and Lorenzo S. Malatino

J Am Soc Nephrol 15: 1029-1037. [Abstract] [Full Text]  

Septicemia in the United States Dialysis Population, 1991 to 1999

Robert N. Foley, Haifeng Guo, Jon J. Snyder, David T. Gilbertson, and Allan J. Collins

J Am Soc Nephrol 15: 1038-1045. [Abstract] [Full Text]  

Renal Insufficiency and the Risk of Lower Extremity Peripheral Arterial Disease: Results from the Heart and Estrogen/Progestin Replacement Study (HERS)

Ann M. O’Hare, Eric Vittinghoff, Judith Hsia, and Michael G. Shlipak

J Am Soc Nephrol 15: 1046-1051. [Abstract] [Full Text]  

Patient and Graft Survival in Older Kidney Transplant Recipients: Does Age Matter?

Veronika Fabrizii, Wolfgang C. Winkelmayer, Renate Klauser, Josef Kletzmayr, Markus D. Säemann, Rudolf Steininger, Reinhard Kramar, Walter H. Hörl, and Josef Kovarik

J Am Soc Nephrol 15: 1052-1060. [Abstract] [Full Text]  

Dialysis:

Relative Contribution of Residual Renal Function and Different Measures of Adequacy to Survival in Hemodialysis Patients: An analysis of the Netherlands Cooperative Study on the Adequacy of Dialysis (NECOSAD)-2

Fabian Termorshuizen, Friedo W. Dekker, Jeannette G. van Manen, Johanna C. Korevaar, Elisabeth W. Boeschoten, and Raymond T. Krediet

J Am Soc Nephrol 15: 1061-1070. [Abstract] [Full Text]  

Features of Chronic Hemodialysis Practice after the Marmara Earthquake

Mehmet Sukru Sever, Ekrem Erek, Raymond Vanholder, Aykut Kalkan, Nevin Guney, Nesrin Usta, Cevdet Yilmaz, Cavit Kutanis, Ramazan Turgut, and Norbert Lameire

J Am Soc Nephrol 15: 1071-1076. [Abstract] [Full Text]  

Clinical Immunology and Pathology:

Increased Production of Urea Hydrogen Peroxide from Maillard Reaction and a UHP-Fenton Pathway Related to Glycoxidation Damage in Chronic Renal Failure

Akira Moh, Noriyuki Sakata, Shigeo Takebayashi, Kayoko Tateishi, Ryoji Nagai, Seikoh Horiuchi, and Junichi Chihara

J Am Soc Nephrol 15: 1077-1085. [Abstract] [Full Text]  

Transplantation:

Effect of Donor Recipient Age Match on Survival after First Deceased Donor Renal Transplantation

Douglas S. Keith, Angelo Demattos, Muralikrishna Golconda, Jonathan Prather, and Douglas Norman

J Am Soc Nephrol 15: 1086-1091. [Abstract] [Full Text]  

PRESIDENTIAL ADDRESS:

2003 Presidential Address: A Time for Morphogenesis, Growth, and Development

Norman J. Siegel

J Am Soc Nephrol 15: 839-843. [Abstract] [Full Text]  

REVIEWS:

Role of the Coagulation/Fibrinolysis System in Fibrin-Associated Glomerular Injury

Alexandre Hertig and Eric Rondeau

J Am Soc Nephrol 15: 844-853. [Abstract] [Full Text]  

Signaling Danger: Toll-Like Receptors and their Potential Roles in Kidney Disease

Hans-Joachim Anders, Bernhard Banas, and Detlef Schlöndorff

J Am Soc Nephrol 15: 854-867. [Abstract] [Full Text]  

SPECIAL COMMENTARY:

2003 Nobel Prize in Chemistry: Editor-in-Chief’s Comments

William G. Couser

J Am Soc Nephrol 15: 1092. [Full Text]  

Peter Agre, 2003 Nobel Prize Winner in Chemistry

Mark A. Knepper and Soren Nielsen

J Am Soc Nephrol 15: 1093-1095. [Abstract] [Full Text]  

Roderick MacKinnon, MD, Honored by 2003 Nobel Prize in Chemistry for Work on Elucidating the Structure of Ion Channels

Steven C. Hebert and Gerhard Giebisch

J Am Soc Nephrol 15: 1096-1097. [Full Text]  

EDITORIALS:

Statins’ Coat of Many Colors Receives Yet Another Hue

Michael S. Goligorsky and Wenhui Wang

J Am Soc Nephrol 15: 1098-1100. [Full Text]  

Donor Antigen and Transplant Tolerance Strategies: It Takes Two to Tango!

Karl L. Womer and Mohamed H. Sayegh

J Am Soc Nephrol 15: 1101-1103. [Full Text]  

ANNOUNCEMENTS:

J Am Soc Nephrol 15: 1104. [Full Text]  

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