THIS MONTH'S HIGHLIGHTS:

This Month's Highlights

J Am Soc Nephrol 15: A34-A36 [Full Text]  

BASIC SCIENCE:

Cell and Transport Physiology:

Early Nongenomic Events in Aldosterone Action in Renal Collecting Duct Cells: PKC Activation, Mineralocorticoid Receptor Phosphorylation, and Cross-Talk with the Genomic Response

Cathy Le Moëllic, Antoine Ouvrard-Pascaud, Claudia Capurro, Francoise Cluzeaud, Michel Fay, Frederic Jaisser, Nicolette Farman, and Marcel Blot-Chabaud

J Am Soc Nephrol 15: 1145-1160 [Abstract] [Full Text]  

Upregulation of Urea Transporter UT-A2 and Water Channels AQP2 and AQP3 in Mice Lacking Urea Transporter UT-B

Janet D. Klein, Jeff M. Sands, Liman Qian, Xiaodan Wang, and Baoxue Yang

J Am Soc Nephrol 15: 1161-1167 [Abstract] [Full Text]  

Evolutionary Conservation of Drosophila Polycystin-2 as a Calcium-Activated Cation Channel

Charles J. Venglarik, Zhiqian Gao, and Xiangyi Lu

J Am Soc Nephrol 15: 1168-1177 [Abstract] [Full Text]  

Cell Biology:

Reduction of Perlecan Synthesis and Induction of TGF-1 in Human Peritoneal Mesothelial Cells Due to High Dialysate Glucose Concentration: Implication in Peritoneal Dialysis

Susan Yung, Xiao-Rui Chen, Ryan CW Tsang, Qing Zhang, and Tak Mao Chan

J Am Soc Nephrol 15: 1178-1188 [Abstract] [Full Text]  

Cycloxygenase-2 Is Expressed in Vasculature of Normal and Ischemic Adult Human Kidney and Is Colocalized with Vascular Prostaglandin E₂ EP4 Receptors

Karina L. Therland, Jane Stubbe, Helle C. Thiesson, Peter D. Ottosen, Steen Walter, Grith L. Sørensen, Ole Skøtt, and Boye L. Jensen

J Am Soc Nephrol 15: 1189-1198 [Abstract] [Full Text]  

BMP-7 Modulates Hyaluronan-Mediated Proximal Tubular Cell-Monocyte Interaction

Wisam Selbi, Carol de la Motte, Vincent Hascall, and Aled Phillips

J Am Soc Nephrol 15: 1199-1211 [Abstract] [Full Text]  

Reversal of Collapsing Glomerulopathy in Mice with the Cyclin-Dependent Kinase Inhibitor CYC202

Dana Gherardi, Vivette D’Agati, Te-Hua Tearina Chu, Anna Barnett, Athos Gianella-Borradori, Irwin H. Gelman, and Peter J. Nelson

J Am Soc Nephrol 15: 1212-1222 [Abstract] [Full Text]  

Genetics and Development:

Characterization of an Aquaporin-2 Water Channel Gene Mutation Causing Partial Nephrogenic Diabetes Insipidus in a Mexican Family: Evidence of Increased Frequency of the Mutation in the Town of Origin

Cristina Boccalandro, Fabrizio de Mattia, Dong-Chuan Guo, Li Xue, Philip Orlander, Terri M. King, Prateek Gupta, Peter M.T. Deen, Victor R Lavis, and Dianna M. Milewicz

J Am Soc Nephrol 15: 1223-1231 [Abstract] [Full Text]  

Hemodynamics and Vascular Regulation:

Neonatal Losartan Treatment Suppresses Renal Expression of Molecules Involved in Cell-Cell and Cell-Matrix Interactions

Yun Chen, Daina Lasaitiene, Britt G. Gabrielsson, Lena M.S. Carlsson, Håkan Billig, Björn Carlsson, Niels Marcussen, Xiao-Feng Sun, and Peter Friberg

J Am Soc Nephrol 15: 1232-1243 [Abstract] [Full Text]  

Soluble Epoxide Hydrolase Inhibition Protects the Kidney from Hypertension-Induced Damage

Xueying Zhao, Tatsuo Yamamoto, John W. Newman, In-Hae Kim, Takaho Watanabe, Bruce D. Hammock, Janet Stewart, Jennifer S. Pollock, David M. Pollock, and John D. Imig

J Am Soc Nephrol 15: 1244-1253 [Abstract] [Full Text]  

Increased Activity of cGMP-Specific Phosphodiesterase (PDE5) Contributes to Resistance to Atrial Natriuretic Peptide Natriuresis in the Pregnant Rat

Xi-Ping Ni, Massy Safai, Rahul Rishi, Chris Baylis, and Michael H. Humphreys

J Am Soc Nephrol 15: 1254-1260 [Abstract] [Full Text]  

Pathophysiology of Renal Disease and Progression:

Hematopoietic Stem Cell Mobilization–Associated Granulocytosis Severely Worsens Acute Renal Failure

Florian Tögel, Jorge Isaac, and Christof Westenfelder

J Am Soc Nephrol 15: 1261-1267 [Abstract] [Full Text]  

Local Actions of Endogenous Angiotensin II in Injured Glomeruli

Ji Ma, Taiji Matsusaka, Haichun Yang, Hiroshi Kawachi, Fujio Shimizu, Yoshitaka Isaka, Enyu Imai, Valentina Kon, and Iekuni Ichikawa

J Am Soc Nephrol 15: 1268-1276 [Abstract] [Full Text]  

Evidence of Tubular Hypoxia in the Early Phase in the Remnant Kidney Model

Krissanapong Manotham, Tetsuhiro Tanaka, Makiko Matsumoto, Takamoto Ohse, Toshio Miyata, Reiko Inagi, Kiyoshi Kurokawa, Toshiro Fujita, and Masaomi Nangaku

J Am Soc Nephrol 15: 1277-1288 [Abstract] [Full Text]  

Basic Dialysis:

Endotoxin-Induced Chemokine Expression in Murine Peritoneal Mesothelial Cells: The Role of Toll-Like Receptor 4

Sawako Kato, Yukio Yuzawa, Naotake Tsuboi, Shoichi Maruyama, Yoshiki Morita, Tetsuya Matsuguchi, and Seiichi Matsuo

J Am Soc Nephrol 15: 1289-1299 [Abstract] [Full Text]  

CLINICAL SCIENCE:

Clinical Nephrology:

Cost of Medical Care for Chronic Kidney Disease and Comorbidity among Enrollees in a Large HMO Population

David H. Smith, Christina M. Gullion, Gregory Nichols, Douglas Scott Keith, and Jonathan Betz Brown

J Am Soc Nephrol 15: 1300-1306 [Abstract] [Full Text]  

Epidemiology and Outcomes:

Chronic Kidney Disease as a Risk Factor for Cardiovascular Disease and All-Cause Mortality: A Pooled Analysis of Community-Based Studies

Daniel E. Weiner, Hocine Tighiouart, Manish G. Amin, Paul C. Stark, Bonnie MacLeod, John L. Griffith, Deeb N. Salem, Andrew S. Levey, and Mark J. Sarnak

J Am Soc Nephrol 15: 1307-1315 [Abstract] [Full Text]  

Drawbacks of the Use of Indirect Estimates of Renal Function to Evaluate the Effect of Risk Factors on Renal Function

Jacobien C. Verhave, Ron T. Gansevoort, Hans L. Hillege, Dick de Zeeuw, Gary C. Curhan, and Paul E. de Jong

J Am Soc Nephrol 15: 1316-1322 [Abstract] [Full Text]  

Results of a Nationwide Screening for Anderson-Fabry Disease among Dialysis Patients

Peter Kotanko, Reinhard Kramar, Danijela Devrnja, Eduard Paschke, Till Voigtländer, Martin Auinger, Klaus Demmelbauer, Matthias Lorenz, Anna-Christine Hauser, Hans-Jörg Kofler, Karl Lhotta, Ulrich Neyer, Wolfgang Pronai, Manfred Wallner, Clemens Wieser, Martin Wiesholzer, Herbert Zodl, Manuela Födinger, and Gere Sunder-Plassmann

J Am Soc Nephrol 15: 1323-1329 [Abstract] [Full Text]  

Differential Risk of Hypertensive Disorders of Pregnancy among Hispanic Women

Myles Wolf, Anand Shah, Ricardo Jimenez-Kimble, Jenny Sauk, Jeffrey L. Ecker, and Ravi Thadhani

J Am Soc Nephrol 15: 1330-1338 [Abstract] [Full Text]  

Clinical Dialysis:

Prospective Study of the Immune Effects of Normalizing the Hemoglobin Concentration in Hemodialysis Patients Who Receive Recombinant Human Erythropoietin

Renato M.B. Roman, Peter I. Lobo, Ronald P. Taylor, David A. Goodkin, John LaBrecque, Kathy L. Powers, and W. Kline Bolton

J Am Soc Nephrol 15: 1339-1346 [Abstract] [Full Text]  

Clinical Transplantation:

Pharmacoepidemiology of Anemia in Kidney Transplant Recipients

Wolfgang C. Winkelmayer, Reshma Kewalramani, Mark Rutstein, Steven Gabardi, Tania Vonvisger, and Anil Chandraker

J Am Soc Nephrol 15: 1347-1352 [Abstract] [Full Text]  

ERRATA:

Correction

J Am Soc Nephrol 15: A8 [Full Text]  

Correction

J Am Soc Nephrol 15: A9 [Full Text]  

ANNOUNCEMENTS:

ASN NEWS

J Am Soc Nephrol 15: A25-A26 [Full Text]  

Announcements

J Am Soc Nephrol 15: 1365 [Full Text]  

FRONTIERS IN NEPHROLOGY:

Overview: Future Approaches to Renal Replacement and Regeneration

Mohamed H. Sayegh and Jeffrey L. Platt

J Am Soc Nephrol 15: 1105 [Full Text]  

Xenotransplantation and the Future of Renal Replacement

Marilia Cascalho, Brenda M. Ogle, and Jeffrey L. Platt

J Am Soc Nephrol 15: 1106-1112 [Full Text]  

Tissue Engineering, Stem Cells, and Cloning: Opportunities for Regenerative Medicine

Chester J. Koh and Anthony Atala

J Am Soc Nephrol 15: 1113-1125 [Full Text]  

Renal Organogenesis from Transplanted Metanephric Primordia

Marc R. Hammerman

J Am Soc Nephrol 15: 1126-1132 [Abstract] [Full Text]  

Allogeneic Stem Cell–Derived "Repair Unit" Therapy and the Barriers to Clinical Deployment

Terry B. Strom, Loren J. Field, and Manfred Ruediger

J Am Soc Nephrol 15: 1133-1139 [Abstract] [Full Text]  

Somatic Cell Cloning: The Ultimate Form of Nuclear Reprogramming?

Jorge A. Piedrahita, Bashir Mir, Scott Dindot, and Shawn Walker

J Am Soc Nephrol 15: 1140-1144 [Abstract] [Full Text]  

SPECIAL FEATURE:

The ACEI/ARB Controversy: Editor-in-Chief’s Comment

William G. Couser

J Am Soc Nephrol 15: 1353 [Full Text]  

Regarding: "Management of Glomerular Proteinuria: A Commentary"

Barry M. Brenner

J Am Soc Nephrol 15: 1354-1355 [Full Text]  

Response to Dr. Brenner’s Comments

Lee A. Hebert, Brad H. Rovin, and Christopher J. Hebert

J Am Soc Nephrol 15: 1356-1357 [Full Text]  

ACE Inhibitors versus Angiotensin Receptor Blockers in Diabetic Nephropathy: Is There a Winner?

Edmund J. Lewis and Julia B. Lewis

J Am Soc Nephrol 15: 1358-1360 [Full Text]  

EDITORIALS:

Negatively Regulating the Cell Cycle Can Be Positive

Keiju Hiromura and Stuart J. Shankland

J Am Soc Nephrol 15: 1361-1362 [Full Text]  

The Consequences and Costs of Chronic Kidney Disease Before ESRD

Lawrence G. Hunsicker

J Am Soc Nephrol 15: 1363-1364 [Full Text]  

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