THIS MONTH'S HIGHLIGHTS:

This Month's Highlights

J Am Soc Nephrol 15: 1671-1674 [Full Text]  

SPECIAL TRIBUTE:

In Memoriam: Jack W. Coburn, MD: 1932-2004

Isidro B. Salusky and Keith L. Agre

J Am Soc Nephrol 15: 1675-1676 [Full Text]  

REVIEWS:

Discovery of Protein Biomarkers for Renal Diseases

Stephen M. Hewitt, James Dear, and Robert A. Star

J Am Soc Nephrol 15: 1677-1689 [Abstract] [Full Text]  

The Transient Receptor Potential Superfamily of Ion Channels

Chou-Long Huang

J Am Soc Nephrol 15: 1690-1699 [Abstract] [Full Text]  

BASIC SCIENCE:

Cell Biology:

The Invs Gene Encodes a Microtubule-Associated Protein

Jens Nürnberger, Andreas Kribben, Anabelle Opazo Saez, Gerd Heusch, Thomas Philipp, and Carrie L. Phillips

J Am Soc Nephrol 15: 1700-1710 [Abstract] [Full Text]  

Simvastatin Modulates Angiotensin II Signaling Pathway by Preventing Rac1-Mediated Upregulation of p27

Lixia Zeng, Hanshi Xu, Teng-Leong Chew, Rex Chisholm, Mehran M. Sadeghi, Yashpal S. Kanwar, and Farhad R. Danesh

J Am Soc Nephrol 15: 1711-1720 [Abstract] [Full Text]  

Genetics and Development:

Sidekick-1 Is Upregulated in Glomeruli in HIV-Associated Nephropathy

Lewis Kaufman, Kayo Hayashi, Michael J. Ross, Michael D. Ross, and Paul E. Klotman

J Am Soc Nephrol 15: 1721-1730 [Abstract] [Full Text]  

Defective Trafficking of Nephrin Missense Mutants Rescued by a Chemical Chaperone

Xiao Li Liu, Stefania Cotta Doné, Kunimasa Yan, Pekka Kilpeläinen, Timo Pikkarainen, and Karl Tryggvason

J Am Soc Nephrol 15: 1731-1738 [Abstract] [Full Text]  

Family-Based Association Study Showing that Immunoglobulin A Nephropathy Is Associated with the Polymorphisms 2093C and 2180T in the 3' Untranslated Region of the Megsin Gene

You-Ji Li, Yong Du, Cai-Xia Li, Hui Guo, Joseph C.K. Leung, Man F. Lam, Niansheng Yang, Fengxian Huang, Yun Chen, Ji-Qian Fang, Patrick H. Maxwell, Kar N. Lai, and Yiming Wang

J Am Soc Nephrol 15: 1739-1743 [Abstract] [Full Text]  

Renal Cysts of inv/inv Mice Resemble Early Infantile Nephronophthisis

Carrie L. Phillips, Karen J. Miller, Adele J. Filson, Jens Nürnberger, Jeffrey L. Clendenon, Gregory W. Cook, Kenneth W. Dunn, Paul A. Overbeek, Vincent H. Gattone, II, and Robert L. Bacallao

J Am Soc Nephrol 15: 1744-1755 [Abstract] [Full Text] [Data Supplement]  

Hemodynamics and Vascular Regulation:

Alterations in Renal Endothelial Nitric Oxide Synthase Expression by Salt Diet in Angiotensin Type-1a Receptor Gene Knockout Mice

Keiko Sato, Minoru Kihara, Tatsuo Hashimoto, Kei Matsushita, Yu-Ichi Koide, Koichi Tamura, Nobuhito Hirawa, Yoshiyuki Toya, Akiyoshi Fukamizu, and Satoshi Umemura

J Am Soc Nephrol 15: 1756-1763 [Abstract] [Full Text]  

Basic Immunology and Pathology:

Experimental Autoimmune Anti–Glomerular Basement Membrane Glomerulonephritis: A Protective Role for IFN-

A. Richard Kitching, Amanda L. Turner, Timothy Semple, Ming Li, Kristy L. Edgtton, Gabrielle R. Wilson, Jennifer R. Timoshanko, Billy G. Hudson, and Stephen R. Holdsworth

J Am Soc Nephrol 15: 1764-1774 [Abstract] [Full Text]  

Macrophage-Mediated Renal Injury Is Dependent on Signaling via the JNK Pathway

Yohei Ikezumi, Lyn Hurst, Robert C. Atkins, and David J. Nikolic-Paterson

J Am Soc Nephrol 15: 1775-1784 [Abstract] [Full Text]  

Nephritis-Associated Plasmin Receptor and Acute Poststreptococcal Glomerulonephritis: Characterization of the Antigen and Associated Immune Response

Nobuyuki Yoshizawa, Kazuo Yamakami, Masayuki Fujino, Takashi Oda, Kikuko Tamura, Koichi Matsumoto, Tetsuzo Sugisaki, and Michael D.P. Boyle

J Am Soc Nephrol 15: 1785-1793 [Abstract] [Full Text]  

Pathophysiology of Renal Disease and Progression:

Mesenchymal Stem Cells Are Renotropic, Helping to Repair the Kidney and Improve Function in Acute Renal Failure

Marina Morigi, Barbara Imberti, Carla Zoja, Daniela Corna, Susanna Tomasoni, Mauro Abbate, Daniela Rottoli, Stefania Angioletti, Ariela Benigni, Norberto Perico, Malcolm Alison, and Giuseppe Remuzzi

J Am Soc Nephrol 15: 1794-1804 [Abstract] [Full Text]  

Intrarenal Renin-Angiotensin System Is Upregulated in Experimental Model of Progressive Renal Disease Induced by Chronic Inhibition of Nitric Oxide Synthesis

Miguel Luis Graciano, Rita de Cassia Cavaglieri, Humberto Dellê, Wagner Vasquez Dominguez, Dulce Elena Casarini, Denise Maria Avancini Costa Malheiros, and Irene L. Noronha

J Am Soc Nephrol 15: 1805-1815 [Abstract] [Full Text]  

Antioxidant Intervention Prevents Renal Neovascularization in Hypercholesterolemic Pigs

Alejandro R. Chade, Michael D. Bentley, Xiangyang Zhu, Martin Rodriguez-Porcel, Sara Niemeyer, Beatriz Amores-Arriaga, Claudio Napoli, Erik L. Ritman, Amir Lerman, and Lilach O. Lerman

J Am Soc Nephrol 15: 1816-1825 [Abstract] [Full Text]  

Deletion of the Kinase Domain in Death-Associated Protein Kinase Attenuates Tubular Cell Apoptosis in Renal Ischemia-Reperfusion Injury

Masanori Kishino, Kazunori Yukawa, Katsuaki Hoshino, Akihiko Kimura, Nobuyuki Shirasawa, Haruhisa Otani, Tetsuji Tanaka, Kyoko Owada-Makabe, Yuji Tsubota, Masanobu Maeda, Masakazu Ichinose, Kiyoshi Takeda, Shizuo Akira, and Masatoshi Mune

J Am Soc Nephrol 15: 1826-1834 [Abstract] [Full Text]  

Activation of the Extracellular-Signal Regulated Protein Kinase Pathway in Human Glomerulopathies

Takao Masaki, Cosimo Stambe, Prudence A. Hill, John Dowling, Robert C. Atkins, and David J. Nikolic-Paterson

J Am Soc Nephrol 15: 1835-1843 [Abstract] [Full Text]  

Overexpression of SSAT in Kidney Cells Recapitulates Various Phenotypic Aspects of Kidney Ischemia-reperfusion Injury

Zhaohui Wang, Kamyar Zahedi, Sharon Barone, Kathy Tehrani, Hamid Rabb, Karl Matlin, Robert A. Casero, and Manoocher Soleimani

J Am Soc Nephrol 15: 1844-1852 [Abstract] [Full Text]  

Basic Transplantation:

Differential Expression of Chemokines and Chemokine Receptors in Murine Islet Allografts: The Role of CCR2 and CCR5 Signaling Pathways

Bernd Schröppel, Nan Zhang, Peng Chen, Weiping Zang, Dongmei Chen, Kelly L. Hudkins, William A. Kuziel, Randall Sung, Jonathan S. Bromberg, and Barbara Murphy

J Am Soc Nephrol 15: 1853-1861 [Abstract] [Full Text]  

CLINICAL SCIENCE:

Clinical Nephrology:

Early and Vigorous Fluid Resuscitation Prevents Acute Renal Failure in the Crush Victims of Catastrophic Earthquakes

Ali Ihsan Gunal, Huseyin Celiker, Ayhan Dogukan, Goksel Ozalp, Ercan Kirciman, Huseyin Simsekli, Izzettin Gunay, Mustafa Demircin, Oktay Belhan, Mustafa A. Yildirim, and Mehmet S. Sever

J Am Soc Nephrol 15: 1862-1867 [Abstract] [Full Text]  

Acute Renal Failure after Nonmyeloablative Hematopoietic Cell Transplantation

Chirag R. Parikh, Brenda M. Sandmaier, Rainer F. Storb, Karl G. Blume, Firoozeh Sahebi, David G. Maloney, Michael B. Maris, Yago Nieto, Charles L. Edelstein, Robert W. Schrier, and Peter McSweeney

J Am Soc Nephrol 15: 1868-1876 [Abstract] [Full Text]  

Pentoxifylline Improves Hemoglobin Levels in Patients with Erythropoietin-resistant Anemia in Renal Failure

Angela Cooper, Ashraf Mikhail, Mark W. Lethbridge, D. Michael Kemeny, and Iain C. Macdougall

J Am Soc Nephrol 15: 1877-1882 [Abstract] [Full Text]  

Severe Acute Respiratory Syndrome in Dialysis Patients

Bonnie Ching-Ha Kwan, Chi-Bon Leung, Cheuk-Chun Szeto, Vincent Wai-Sun Wong, Yuk-Lun Cheng, Alex Wai-Yin Yu, and Philip Kam-Tao Li

J Am Soc Nephrol 15: 1883-1888 [Abstract] [Full Text]  

Chronic Kidney Disease:

Enhanced Expression of Receptor for Advanced Glycation End Products in Chronic Kidney Disease

Fan Fan Hou, Hao Ren, William F. Owen, Jr, Zhi Jian Guo, Ping Yan Chen, Ann Marie Schmidt, Toshio Miyata, and Xun Zhang

J Am Soc Nephrol 15: 1889-1896 [Abstract] [Full Text]  

Epidemiology and Outcomes:

Kidney Dysfunction, Inflammation, and Coronary Events: A Prospective Study

Eric L. Knight, Eric B. Rimm, Jennifer K. Pai, Kathryn M. Rexrode, Carolyn C. Cannuscio, JoAnn E. Manson, Meir J. Stampfer, and Gary C. Curhan

J Am Soc Nephrol 15: 1897-1903 [Abstract] [Full Text]  

Moderate Renal Impairment and Risk of Dementia among Older Adults: The Cardiovascular Health Cognition Study

Stephen L. Seliger, David S. Siscovick, Catherine O. Stehman-Breen, Daniel L. Gillen, Annette Fitzpatrick, Anthony Bleyer, and Lew H. Kuller

J Am Soc Nephrol 15: 1904-1911 [Abstract] [Full Text]  

Medicare Patients with Cardiovascular Disease Have a High Prevalence of Chronic Kidney Disease and a High Rate of Progression to End-Stage Renal Disease

William M. McClellan, Robert D. Langston, and Rodney Presley

J Am Soc Nephrol 15: 1912-1919 [Abstract] [Full Text]  

Clinical Dialysis:

Nutritional Supplementation Acutely Increases Albumin Fractional Synthetic Rate in Chronic Hemodialysis Patients

Lara B. Pupim, Paul J. Flakoll, and T. Alp Ikizler

J Am Soc Nephrol 15: 1920-1926 [Abstract] [Full Text]  

Increasing Dialysate Flow and Dialyzer Mass Transfer Area Coefficient to Increase the Clearance of Protein-bound Solutes

Timothy W. Meyer, Evonne C. Leeper, Derek W. Bartlett, Thomas A. Depner, Yiming Zhao Lit, Channing R. Robertson, and Thomas H. Hostetter

J Am Soc Nephrol 15: 1927-1935 [Abstract] [Full Text]  

Late Creation of Vascular Access for Hemodialysis and Increased Risk of Sepsis

Matthew J. Oliver, Deanna M. Rothwell, Kinwah Fung, Janet E. Hux, and Charmaine E. Lok

J Am Soc Nephrol 15: 1936-1942 [Abstract] [Full Text]  

Human Mineral Metabolism and Bone Disease:

Arterial Calcifications and Bone Histomorphometry in End-Stage Renal Disease

Gérard M. London, Caroline Marty, Sylvain J. Marchais, Alain P. Guerin, Fabien Metivier, and Marie-Christine de Vernejoul

J Am Soc Nephrol 15: 1943-1951 [Abstract] [Full Text]  

Clinical Transplantation:

Alloreactivity in Renal Transplant Recipients with and without Chronic Allograft Nephropathy

Emilio D. Poggio, Michael Clemente, Jocelyn Riley, Meagan Roddy, Neil S. Greenspan, Cora Dejelo, Nader Najafian, Mohamed H. Sayegh, Donald E. Hricik, and Peter S. Heeger

J Am Soc Nephrol 15: 1952-1960 [Abstract] [Full Text]  

EDITORIALS:

Nephritis-Associated Streptococcal Antigens: Where Are We Now?

Bernardo Rodríguez-Iturbe

J Am Soc Nephrol 15: 1961-1962 [Full Text]  

The Renin-Angiotensin System: A 21^st Century Perspective

Ruth C. Campbell

J Am Soc Nephrol 15: 1963-1964 [Full Text]  

ANNOUNCEMENTS:

J Am Soc Nephrol 15: 1965 [Full Text]  

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