THIS MONTH'S HIGHLIGHTS:

This Month’s Highlights

J Am Soc Nephrol 15: 2243-2245 [Full Text]  

REVIEWS:

Danger Signaling by Glomerular Podocytes Defines a Novel Function of Inducible B7-1 in the Pathogenesis of Nephrotic Syndrome

Jochen Reiser and Peter Mundel

J Am Soc Nephrol 15: 2246-2248 [Full Text]  

BASIC SCIENCE:

Cell and Transport Physiology:

Inhibitors of HMG-CoA Reductase Reduce Receptor-mediated Endocytosis in Human Kidney Proximal Tubular Cells

Anja Verhulst, Patrick C. D’Haese, and Marc E. De Broe

J Am Soc Nephrol 15: 2249-2257 [Abstract] [Full Text]  

Inhibitors of 3-Hydroxy-3-Methylglutaryl–CoA Reductase Reduce Receptor-Mediated Endocytosis in Opossum Kidney Cells

James E. Sidaway, Robert G. Davidson, Fergus McTaggart, Terry C. Orton, Robert C. Scott, Graham J. Smith, and Nigel J. Brunskill

J Am Soc Nephrol 15: 2258-2265 [Abstract] [Full Text]  

Increased Endothelin Activity Mediates Augmented Distal Nephron Acidification Induced by Dietary Protein

Apurv Khanna, Jan Simoni, Callenda Hacker, Marie-Josée Duran, and Donald E. Wesson

J Am Soc Nephrol 15: 2266-2275 [Abstract] [Full Text]  

Altered Renal Distal Tubule Structure and Renal Na⁺ and Ca²⁺ Handling in a Mouse Model for Gitelman’s Syndrome

Johannes Loffing, Volker Vallon, Dominique Loffing-Cueni, Fintan Aregger, Kerstin Richter, Laurence Pietri, May Bloch-Faure, Joost G.J. Hoenderop, Gary E. Shull, Pierre Meneton, and Brigitte Kaissling

J Am Soc Nephrol 15: 2276-2288 [Abstract] [Full Text]  

Cell Biology:

Podocalyxin Activates RhoA and Induces Actin Reorganization through NHERF1 and Ezrin in MDCK Cells

Sandra Schmieder, Masaaki Nagai, Robert A. Orlando, Tetsuro Takeda, and Marilyn G. Farquhar

J Am Soc Nephrol 15: 2289-2298 [Abstract] [Full Text]  

Growth Hormone–Mediated Janus Associated Kinase–Signal Transducers and Activators of Transcription Signaling in the Growth Hormone–Resistant Potassium-Deficient Rat

Franz Schaefer, Sun-Ae Yoon, Pouneh Nouri, Tanny Tsao, Padmaja Tummala, Ellen Deng, and Ralph Rabkin

J Am Soc Nephrol 15: 2299-2306 [Abstract] [Full Text]  

Inducible Nitric Oxide Synthase–Derived Nitric Oxide Promotes Glomerular Angiogenesis via Upregulation of Vascular Endothelial Growth Factor Receptors

Tammo Ostendorf, Claudia van Roeyen, Ralf Westenfeld, Alexander Gawlik, Masashi Kitahara, Emile de Heer, Dontscho Kerjaschki, Jürgen Floege, and Markus Ketteler

J Am Soc Nephrol 15: 2307-2319 [Abstract] [Full Text]  

Blockade of Calcium Influx through L-Type Calcium Channels Attenuates Mitochondrial Injury and Apoptosis in Hypoxic Renal Tubular Cells

Tetsuhiro Tanaka, Masaomi Nangaku, Toshio Miyata, Reiko Inagi, Takamoto Ohse, Julie R. Ingelfinger, and Toshiro Fujita

J Am Soc Nephrol 15: 2320-2333 [Abstract] [Full Text]  

Verotoxin (Shiga Toxin) Sensitizes Renal Epithelial Cells to Increased Heme Toxicity: Possible Implications for the Hemolytic Uremic Syndrome

Martin Bitzan, Brandi B. Bickford, and Gregory H. Foster

J Am Soc Nephrol 15: 2334-2343 [Abstract] [Full Text]  

Genetics and Development:

Identifying the Molecular Phenotype of Renal Progenitor Cells

Grant A. Challen, Gemma Martinez, Melissa J. Davis, Darrin F. Taylor, Mark Crowe, Rohan D. Teasdale, Sean M. Grimmond, and Melissa H. Little

J Am Soc Nephrol 15: 2344-2357 [Abstract] [Full Text]  

Hemodynamics and Vascular Regulation:

Thromboxane Receptor Mediates Renal Vasoconstriction and Contributes to Acute Renal Failure in Endotoxemic Mice

Jean-Jacques Boffa, Armin Just, Thomas M. Coffman, and William J. Arendshorst

J Am Soc Nephrol 15: 2358-2365 [Abstract] [Full Text]  

Basic Immunology and Pathology:

Leptin as a Uremic Toxin Interferes with Neutrophil Chemotaxis

Luciano Ottonello, Paola Gnerre, Maria Bertolotto, Marina Mancini, Patrizia Dapino, Rodolfo Russo, Giacomo Garibotto, Tommaso Barreca, and Franco Dallegri

J Am Soc Nephrol 15: 2366-2372 [Abstract] [Full Text]  

Endogenous IL-13 Limits Humoral Responses and Injury in Experimental Glomerulonephritis but Does Not Regulate Th1 Cell-Mediated Crescentic Glomerulonephritis

A. Richard Kitching, Amanda L. Turner, Gabriella R.A. Wilson, Kristy L. Edgtton, Peter G. Tipping, and Stephen R. Holdsworth

J Am Soc Nephrol 15: 2373-2382 [Abstract] [Full Text]  

Pathophysiology of Renal Disease and Progression:

CCAAT/Enhancer-Binding Protein Contributes to Myofibroblast Transdifferentiation and Renal Disease Progression

Masanobu Takeji, Noritaka Kawada, Toshiki Moriyama, Katsuyuki Nagatoya, Susumu Oseto, Shizuo Akira, Masatsugu Hori, Enyu Imai, and Takeshi Miwa

J Am Soc Nephrol 15: 2383-2390 [Abstract] [Full Text]  

Nephropathy in Zucker Diabetic Fat Rat Is Associated with Oxidative and Nitrosative Stress: Prevention by Chronic Therapy with a Peroxynitrite Scavenger Ebselen

Praveen N. Chander, Olga Gealekman, Sergey V. Brodsky, Saban Elitok, Akihiro Tojo, Mark Crabtree, Steven S. Gross, and Michael S. Goligorsky

J Am Soc Nephrol 15: 2391-2403 [Abstract] [Full Text]  

Bradykinin Decreases Plasminogen Activator Inhibitor-1 Expression and Facilitates Matrix Degradation in the Renal Tubulointerstitium under Angiotensin-Converting Enzyme Blockade

Hirokazu Okada, Yusuke Watanabe, Tomohiro Kikuta, Tatsuya Kobayashi, Yoshihiko Kanno, Takeshi Sugaya, and Hiromichi Suzuki

J Am Soc Nephrol 15: 2404-2413 [Abstract] [Full Text]  

Basic Transplantation:

Complement Activation Regulates the Capacity of Proximal Tubular Epithelial Cell to Stimulate Alloreactive T Cell Response

Ke Li, Hetal Patel, Conrad A. Farrar, Roseanna E.G. Hargreaves, Steven H. Sacks, and Wuding Zhou

J Am Soc Nephrol 15: 2414-2422 [Abstract] [Full Text]  

Mechanism of Action of Donor-Specific Transfusion in Inducing Tolerance: Role of Donor MHC Molecules, Donor Co-stimulatory Molecules, and Indirect Antigen Presentation

Koji Kishimoto, Xueli Yuan, Hugh Auchincloss, Jr., Arlene H. Sharpe, Didier A. Mandelbrot, and Mohamed H. Sayegh

J Am Soc Nephrol 15: 2423-2428 [Abstract] [Full Text]  

RhoA Activation Mediates Phosphatidylinositol 3-Kinase–Dependent Proliferation of Human Vascular Endothelial Cells: An Alloimmune Mechanism of Chronic Allograft Nephropathy

Stéphanie Coupel, Fabrice Leboeuf, Gwénola Boulday, Jean-Paul Soulillou, and Béatrice Charreau

J Am Soc Nephrol 15: 2429-2439 [Abstract] [Full Text]  

CLINICAL SCIENCE:

Disease of the Month:

New Aspects in the Pathophysiology of Preeclampsia

John M. Davison, Volker Homuth, Arun Jeyabalan, Kirk P. Conrad, S. Ananth Karumanchi, Susan Quaggin, Ralf Dechend, and Friedrich C. Luft

J Am Soc Nephrol 15: 2440-2448 [Abstract] [Full Text]  

Clinical Nephrology:

Oxidative Stress Is Increased in Critically Ill Patients with Acute Renal Failure

Jonathan Himmelfarb, Ellen McMonagle, Stephanie Freedman, Jennifer Klenzak, Elizabeth McMenamin, Phuong Le, Lara B. Pupim, T. Alp Ikizler, and The PICARD Group

J Am Soc Nephrol 15: 2449-2456 [Abstract] [Full Text]  

Human Genetics:

Genomewide Linkage Analysis to Serum Creatinine, GFR, and Creatinine Clearance in a Community-Based Population: The Framingham Heart Study

Caroline S. Fox, Qiong Yang, L. Adrienne Cupples, Chao-Yu Guo, Martin G. Larson, Eric P. Leip, Peter W.F. Wilson, and Daniel Levy

J Am Soc Nephrol 15: 2457-2461 [Abstract] [Full Text]  

Epidemiology and Outcomes:

"Renalism": Inappropriately Low Rates of Coronary Angiography in Elderly Individuals with Renal Insufficiency

Glenn M. Chertow, Sharon-Lise T. Normand, and Barbara J. McNeil

J Am Soc Nephrol 15: 2462-2468 [Abstract] [Full Text]  

Retinal Microvascular Abnormalities and Renal Dysfunction: The Atherosclerosis Risk in Communities Study

Tien Yin Wong, Josef Coresh, Ronald Klein, Paul Muntner, David J. Couper, A. Richey Sharrett, Barbara E.K. Klein, Gerardo Heiss, Larry D. Hubbard, and Bruce B. Duncan

J Am Soc Nephrol 15: 2469-2476 [Abstract] [Full Text]  

Is There an Epidemic of HIV Infection in the US ESRD Program?

Paul W. Eggers and Paul L. Kimmel

J Am Soc Nephrol 15: 2477-2485 [Abstract] [Full Text]  

Clinical Dialysis:

Effect of Intravenous Ascorbic Acid Medication on Serum Levels of Soluble Transferrin Receptor in Hemodialysis Patients

Der-Cherng Tarng, Szu-Chun Hung, and Tung-Po Huang

J Am Soc Nephrol 15: 2486-2493 [Abstract] [Full Text]  

Clinical Transplantation:

Presence of a Failed Kidney Transplant in Patients Who Are on Hemodialysis Is Associated with Chronic Inflammatory State and Erythropoietin Resistance

Juan M. López-Gómez, Isabel Pérez-Flores, Rosa Jofré, Diana Carretero, Patrocinio Rodríguez-Benitez, Maite Villaverde, Rafael Pérez-García, George M. Nassar, Enrique Niembro, and Juan Carlos Ayus

J Am Soc Nephrol 15: 2494-2501 [Abstract] [Full Text]  

EDITORIALS:

Statin Induced Proteinuria: Renal Injury or Renoprotection?

Rajiv Agarwal

J Am Soc Nephrol 15: 2502-2503 [Full Text]  

Bradykinin and Renal Fibrosis: Have We ACE’d it?

Jean-Loup Bascands and Joost P. Schanstra

J Am Soc Nephrol 15: 2504-2506 [Full Text]  

ASN NEWS:

ASN News

J Am Soc Nephrol 15: A36-A38 [Full Text]  

ANNOUNCEMENTS:

J Am Soc Nephrol 15: 2507 [Full Text]  

ERRATA:

Correction

J Am Soc Nephrol 15: A8 [Full Text]  

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