THIS MONTH'S HIGHLIGHTS:

This Month’s Highlights

J Am Soc Nephrol 16: 2815-2816. [Full Text] [PDF]  

Nephrology beyond JASN:

Which Comes First—Renal Dysfunction or High Blood Pressure?: Elevated Blood Pressure and Risk of End-Stage Renal Disease in Subjects without Baseline Kidney Disease. Arch Intern Med 165: 923–928, 2005

Hsu CY, McCulloch CE, Darbinian J, Go AS, Iribarren C, Takimoto E, Champion HC, Li M, Ren S, Rodriguez ER, Tavazzi B, Lazzarino G, Paolocci N, Gabrielson KL, Wang Y, Kass DA, Janssen B, Hohenadel D, Brinkkoetter P, Peters V, Rind N, Fischer C, Rychlik I, Cerna M, Romzova M, de Heer E, Baelde H, Bakker SJ, Zirie M, Rondeau E, Mathieson P, Saleem MA, Meyer J, Köppel H, Sauerhoefer S, Bartram CR, Nawroth P, Hammes HP, Yard BA, Zschokke J, and van der Woude FJ

J Am Soc Nephrol 16: 2817-2820. [Full Text] [PDF]  

Editorials:

Molecular Physiology of Renal Aquaporins and Sodium Transporters: Exciting Approaches to Understand Regulation of Renal Water Handling

Jørgen Frøkiær, Søren Nielsen, and Mark A. Knepper

J Am Soc Nephrol 16: 2827-2829. [Full Text] [PDF]  

Role of Podocytes in Focal Sclerosis: Defining the Point of No Return

Matthias Kretzler

J Am Soc Nephrol 16: 2830-2832. [Full Text] [PDF]  

Intravenous Iron: How Much Is Too Much?

Tilman B. Drüeke and Ziad A. Massy

J Am Soc Nephrol 16: 2833-2835. [Full Text] [PDF]  

Reviews:

Molecular Biology of Hereditary Diabetes Insipidus

T. Mary Fujiwara and Daniel G. Bichet

J Am Soc Nephrol 16: 2836-2846. [Abstract] [Full Text] [PDF]  

Fast Track:

The kd/kd Mouse Is a Model of Collapsing Glomerulopathy

Laura Barisoni, Michael P. Madaio, Maria Eraso, David L. Gasser, and Peter J. Nelson

J Am Soc Nephrol 16: 2847-2851. [Abstract] [Full Text] [PDF]  

Cell and Transport Physiology:

Combined Proteomics and Pathways Analysis of Collecting Duct Reveals a Protein Regulatory Network Activated in Vasopressin Escape

Ewout J. Hoorn, Jason D. Hoffert, and Mark A. Knepper

J Am Soc Nephrol 16: 2852-2863. [Abstract] [Full Text] [PDF] [Data Supplement]  

Molecular Mechanisms of Impaired Urinary Concentrating Ability in Glucocorticoid-Deficient Rats

Yung-Chang Chen, Melissa A. Cadnapaphornchai, Sandra N. Summer, Sandor Falk, Chunling Li, Weidong Wang, and Robert W. Schrier

J Am Soc Nephrol 16: 2864-2871. [Abstract] [Full Text] [PDF]  

Lack of Arginine Vasopressin–Induced Phosphorylation of Aquaporin-2 Mutant AQP2-R254L Explains Dominant Nephrogenic Diabetes Insipidus

Fabrizio de Mattia, Paul J.M. Savelkoul, Erik-Jan Kamsteeg, Irene B.M. Konings, Peter van der Sluijs, Rudolf Mallmann, Alexander Oksche, and Peter M.T. Deen

J Am Soc Nephrol 16: 2872-2880. [Abstract] [Full Text] [PDF]  

Bradykinin Signaling Counteracts cAMP-Elicited Aquaporin 2 Translocation in Renal Cells

Grazia Tamma, Monica Carmosino, Maria Svelto, and Giovanna Valenti

J Am Soc Nephrol 16: 2881-2889. [Abstract] [Full Text] [PDF]  

Redistribution of Myosin VI from Top to Base of Proximal Tubule Microvilli during Acute Hypertension

Li E. Yang, Arvid B. Maunsbach, Patrick K.K. Leong, and Alicia A. McDonough

J Am Soc Nephrol 16: 2890-2896. [Abstract] [Full Text] [PDF]  

Cell Biology:

Hypoxia Increases Group IIA Phospholipase A₂ Expression under Inflammatory Conditions in Rat Renal Mesangial Cells

Claudia Petry, Andrea Huwiler, Wolfgang Eberhardt, Marietta Kaszkin, and Josef Pfeilschifter

J Am Soc Nephrol 16: 2897-2905. [Abstract] [Full Text] [PDF]  

Aldosterone Stimulates Reactive Oxygen Species Production through Activation of NADPH Oxidase in Rat Mesangial Cells

Kayoko Miyata, Matlubur Rahman, Takatomi Shokoji, Yukiko Nagai, Guo-Xing Zhang, Guang-Ping Sun, Shoji Kimura, Tokihito Yukimura, Hideyasu Kiyomoto, Masakazu Kohno, Youichi Abe, and Akira Nishiyama

J Am Soc Nephrol 16: 2906-2912. [Abstract] [Full Text] [PDF]  

Genetics and Development:

Glomerular Number and Function Are Influenced by Spontaneous and Induced Low Birth Weight in Rats

Michiel F. Schreuder, Jens R. Nyengaard, Mariann Fodor, Joanna A.E. van Wijk, and Henriette A. Delemarre-van de Waal

J Am Soc Nephrol 16: 2913-2919. [Abstract] [Full Text] [PDF]  

Basic Mineral Metabolism:

Multifunctional Roles for Serum Protein Fetuin-A in Inhibition of Human Vascular Smooth Muscle Cell Calcification

Joanne L. Reynolds, Jeremy N. Skepper, Rosamund McNair, Takeshi Kasama, Kunal Gupta, Peter L. Weissberg, Willi Jahnen-Dechent, and Catherine M. Shanahan

J Am Soc Nephrol 16: 2920-2930. [Abstract] [Full Text] [PDF] [Supplemental Material]  

Hemodynamics and Vascular Regulation:

Disparity in Osmolarity-Induced Vascular Reactivity

El Rasheid Zakaria, C. Michelle Hunt, Na Li, Patrick D. Harris, and R. Neal Garrison

J Am Soc Nephrol 16: 2931-2940. [Abstract] [Full Text] [PDF]  

Pathophysiology of Renal Disease and Progression:

Podocyte Depletion Causes Glomerulosclerosis: Diphtheria Toxin–Induced Podocyte Depletion in Rats Expressing Human Diphtheria Toxin Receptor Transgene

Bryan L. Wharram, Meera Goyal, Jocelyn E. Wiggins, Silja K. Sanden, Sabiha Hussain, Wanda E. Filipiak, Thomas L. Saunders, Robert C. Dysko, Kenji Kohno, Lawrence B. Holzman, and Roger C. Wiggins

J Am Soc Nephrol 16: 2941-2952. [Abstract] [Full Text] [PDF]  

Podocyte Hypertrophy, "Adaptation," and "Decompensation" Associated with Glomerular Enlargement and Glomerulosclerosis in the Aging Rat: Prevention by Calorie Restriction

Jocelyn E. Wiggins, Meera Goyal, Silja K. Sanden, Bryan L. Wharram, Kerby A. Shedden, David E. Misek, Rork D. Kuick, and Roger C. Wiggins

J Am Soc Nephrol 16: 2953-2966. [Abstract] [Full Text] [PDF]  

Proteomic Patterns and Prediction of Glomerulosclerosis and Its Mechanisms

Baogang J. Xu, Yu Shyr, Xiubin Liang, Li-jun Ma, Ellen M. Donnert, Jeremy D. Roberts, Xueqiong Zhang, Valentina Kon, Nancy J. Brown, Richard M. Caprioli, and Agnes B. Fogo

J Am Soc Nephrol 16: 2967-2975. [Abstract] [Full Text] [PDF]  

Interactions between Renin Angiotensin System and Advanced Glycation in the Kidney

Merlin C. Thomas, Christos Tikellis, Wendy M. Burns, Katarzyna Bialkowski, Zemin Cao, Melinda T. Coughlan, Karen Jandeleit-Dahm, Mark E. Cooper, and Josephine M. Forbes

J Am Soc Nephrol 16: 2976-2984. [Abstract] [Full Text] [PDF]  

Y-Box Protein 1 Mediates PDGF-B Effects in Mesangioproliferative Glomerular Disease

Claudia R.C. van Roeyen, Frank Eitner, Sandra Martinkus, Sabrina R. Thieltges, Tammo Ostendorf, Dirk Bokemeyer, Bernhard Lüscher, Juliane M. Lüscher-Firzlaff, Juergen Floege, and Peter R. Mertens

J Am Soc Nephrol 16: 2985-2996. [Abstract] [Full Text] [PDF]  

Protection of Endothelial Cells by Dextran Sulfate in Rats with Thrombotic Microangiopathy

Nobuaki Eto, Ichiro Kojima, Noriko Uesugi, Reiko Inagi, Toshio Miyata, Toshiro Fujita, Richard J. Johnson, Stuart J. Shankland, and Masaomi Nangaku

J Am Soc Nephrol 16: 2997-3005. [Abstract] [Full Text] [PDF]  

Mutant Tamm-Horsfall Glycoprotein Accumulation in Endoplasmic Reticulum Induces Apoptosis Reversed by Colchicine and Sodium 4-Phenylbutyrate

Sung Won Choi, Ok Hee Ryu, Sun Jin Choi, In Sun Song, Anthony J. Bleyer, and Thomas C. Hart

J Am Soc Nephrol 16: 3006-3014. [Abstract] [Full Text] [PDF]  

Disease of the Month:

Chronic Renal Allograft Dysfunction

Jeremy R. Chapman, Philip J. O’Connell, and Brian J. Nankivell

J Am Soc Nephrol 16: 3015-3026. [Abstract] [Full Text] [PDF]  

Clinical Nephrology:

Independent and Additive Impact of Blood Pressure Control and Angiotensin II Receptor Blockade on Renal Outcomes in the Irbesartan Diabetic Nephropathy Trial: Clinical Implications and Limitations

Marc A. Pohl, Samuel Blumenthal, Daniel J. Cordonnier, Fernando De Alvaro, Giacomo DeFerrari, Gilbert Eisner, Enric Esmatjes, Richard E. Gilbert, Lawrence G. Hunsicker, Jose B. Lopes de Faria, Ruggero Mangili, Jack Moore, Jr., Efrain Reisin, Eberhard Ritz, Guntram Schernthaner, Samuel Spitalewitz, Hilary Tindall, Roger A. Rodby, Edmund J. Lewis for the Collaborative Study Group

J Am Soc Nephrol 16: 3027-3037. [Abstract] [Full Text] [PDF]  

Additional Antiproteinuric Effect of Ultrahigh Dose Candesartan: A Double-Blind, Randomized, Prospective Study

Roland E. Schmieder, Arnfried U. Klingbeil, Erwin H. Fleischmann, Roland Veelken, and Christian Delles

J Am Soc Nephrol 16: 3038-3045. [Abstract] [Full Text] [PDF]  

Urine IL-18 Is an Early Diagnostic Marker for Acute Kidney Injury and Predicts Mortality in the Intensive Care Unit

Chirag R. Parikh, Edward Abraham, Marek Ancukiewicz, Charles L. Edelstein for the Acute Respiratory Distress Syndrome (ARDS) Network

J Am Soc Nephrol 16: 3046-3052. [Abstract] [Full Text] [PDF]  

Human Genetics:

Endothelial Nitric Oxide Synthase Gene/Gender Interactions and the Renal Hemodynamic Response to Angiotensin II

Andrea Page, Heather Reich, Joyce Zhou, Vesta Lai, Daniel C. Cattran, James W. Scholey, and Judith A. Miller

J Am Soc Nephrol 16: 3053-3060. [Abstract] [Full Text] [PDF]  

Novel TRPM6 Mutations in 21 Families with Primary Hypomagnesemia and Secondary Hypocalcemia

Karl P. Schlingmann, Martin C. Sassen, Stefanie Weber, Ulla Pechmann, Kerstin Kusch, Lutz Pelken, Daniel Lotan, Maria Syrrou, Jeffrey J. Prebble, David E.C. Cole, Daniel L. Metzger, Shamima Rahman, Toshihiro Tajima, San-Ging Shu, Siegfried Waldegger, Hannsjoerg W. Seyberth, and Martin Konrad

J Am Soc Nephrol 16: 3061-3069. [Abstract] [Full Text] [PDF]  

Epidemiology and Outcomes:

Time-Dependent Associations between Iron and Mortality in Hemodialysis Patients

Kamyar Kalantar-Zadeh, Deborah L. Regidor, Charles J. McAllister, Beckie Michael, and David G. Warnock

J Am Soc Nephrol 16: 3070-3080. [Abstract] [Full Text] [PDF]  

Antihypertensive Agents for Primary Prevention of Diabetic Nephropathy

Giovanni F.M. Strippoli, Maria Craig, Francesco P. Schena, and Jonathan C. Craig

J Am Soc Nephrol 16: 3081-3091. [Abstract] [Full Text] [PDF]  

General Medical Care among Patients with Chronic Kidney Disease: Opportunities for Improving Outcomes

Annamaria T. Kausz, Haifeng Guo, Brian J.G. Pereira, Allan J. Collins, and David T. Gilbertson

J Am Soc Nephrol 16: 3092-3101. [Abstract] [Full Text] [PDF]  

Clinical Immunology and Pathology:

Determinants of Glomerular Volume in Different Cortical Zones of the Human Kidney

Terry Samuel, Wendy E. Hoy, Rebecca Douglas-Denton, Michael D. Hughson, and John F. Bertram

J Am Soc Nephrol 16: 3102-3109. [Abstract] [Full Text] [PDF]  

Circulating Inflammatory Endothelial Cells Contribute to Endothelial Progenitor Cell Dysfunction in Patients with Vasculitis and Kidney Involvement

Carolina Holmén, Elzafir Elsheikh, Peter Stenvinkel, Abdul Rashid Qureshi, Erna Pettersson, Sirpa Jalkanen, and Suchitra Sumitran-Holgersson

J Am Soc Nephrol 16: 3110-3120. [Abstract] [Full Text] [PDF]  

Clinical Transplantation:

Access to Quality: Evaluation of the Allocation of Deceased Donor Kidneys for Transplantation

Jesse D. Schold, Bruce Kaplan, Neale R. Chumbler, Richard J. Howard, Titte R. Srinivas, Linan Ma, and Herwig-Ulf Meier-Kriesche

J Am Soc Nephrol 16: 3121-3127. [Abstract] [Full Text] [PDF]  

Glucose Metabolism in Renal Transplant Recipients: Effect of Calcineurin Inhibitor Withdrawal and Conversion to Sirolimus

Annalisa Teutonico, Paolo F. Schena, and Salvatore Di Paolo

J Am Soc Nephrol 16: 3128-3135. [Abstract] [Full Text] [PDF]  

Announcements:

Announcements

J Am Soc Nephrol 16: 3136. [Full Text] [PDF]  

ASN News:

ASN News

J Am Soc Nephrol 16: A20-A21. [Full Text] [PDF]  

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