THIS MONTH' HIGHLIGHTS:

This Month’s Highlights

J Am Soc Nephrol 16: 3137-3138. [Full Text] [PDF]  

Nephrology beyond JASN:

Edema and Congestive Heart Failure from Thiazolidone Insulin Sensitizers—Excess Sodium Reabsoption in the Collecting Duct: Collecting Duct-Specific Deletion of Peroxisome Proliferator-Activated Receptor Blocks Thiazolidinedione-Induced Fluid Retention. Proc Nat Acad Sci U S A 102: 9406–9411, 2005

H. Zhang, A. Zhang, D.E. Kohan, R.D. Nelson, F.J. Gonzales, T. Yang, C. Schmidt-Lucke, L. Rössig, S. Fichtlscherer, M. Vasa, M. Britten, U. Kämper, S. Dimmeler, and A.M. Zeiher

J Am Soc Nephrol 16: 3139-3142. [Full Text] [PDF]  

Editorials:

More Targeted Treatments for Lupus Nephritis: Is the Future (Nearly) Here?

A. Richard Kitching

J Am Soc Nephrol 16: 3146-3148. [Full Text] [PDF]  

Towards a Definition and Classification of Acute Kidney Injury

David G. Warnock

J Am Soc Nephrol 16: 3149-3150. [Full Text] [PDF]  

Frontiers in Nephrology: Renal Sodium Handling: The Role of the Epithelial Sodium Channel:

Renal Sodium Handling: The Role of the Epithelial Sodium Channel

David G. Warnock and Bernard C. Rossier

J Am Soc Nephrol 16: 3151-3153. [Full Text] [PDF]  

Central Role for ENaC in Development of Hypertension

J. Howard Pratt

J Am Soc Nephrol 16: 3154-3159. [Abstract] [Full Text] [PDF]  

Lessons from Mouse Mutants of Epithelial Sodium Channel and Its Regulatory Proteins

Edith Hummler and Volker Vallon

J Am Soc Nephrol 16: 3160-3166. [Abstract] [Full Text] [PDF]  

Impact of Nedd4 Proteins and Serum and Glucocorticoid-Induced Kinases on Epithelial Na⁺ Transport in the Distal Nephron

Olivier Staub and François Verrey

J Am Soc Nephrol 16: 3167-3174. [Abstract] [Full Text] [PDF]  

Functional Domains of the Epithelial Sodium Channel

Johannes Loffing and Laurent Schild

J Am Soc Nephrol 16: 3175-3181. [Full Text] [PDF]  

Acute Regulation of Epithelial Sodium Channel by Anionic Phospholipids

He-Ping Ma and Douglas C. Eaton

J Am Soc Nephrol 16: 3182-3187. [Abstract] [Full Text] [PDF]  

Cell and Transport Physiology:

Hypervitaminosis D Mediates Compensatory Ca²⁺ Hyperabsorption in TRPV5 Knockout Mice

Kirsten Y. Renkema, Tom Nijenhuis, Bram C.J. van der Eerden, Annemiete W.C.M. van der Kemp, Harrie Weinans, Johannes P.T.M. van Leeuwen, René J.M. Bindels, and Joost G.J. Hoenderop

J Am Soc Nephrol 16: 3188-3195. [Abstract] [Full Text] [PDF]  

Increased Apical Targeting of Renal Epithelial Sodium Channel Subunits and Decreased Expression of Type 2 11-Hydroxysteroid Dehydrogenase in Rats with CCl₄-Induced Decompensated Liver Cirrhosis

Soo Wan Kim, Uffe K. Schou, Christian D. Peters, Sophie de Seigneux, Tae-Hwan Kwon, Mark A. Knepper, Thomas E.N. Jonassen, Jørgen Frøki, and Søren Nielsen

J Am Soc Nephrol 16: 3196-3210. [Abstract] [Full Text] [PDF]  

Cell Biology:

TGF- Concentration Specifies Differential Signaling Profiles of Growth Arrest/Differentiation and Apoptosis in Podocytes

Dona T. Wu, Markus Bitzer, Wenjun Ju, Peter Mundel, and Erwin P. Böttinger

J Am Soc Nephrol 16: 3211-3221. [Abstract] [Full Text] [PDF] [Data Supplement]  

Galectin-9 Inhibits Glomerular Hypertrophy in db/db Diabetic Mice via Cell-Cycle–Dependent Mechanisms

Masako Baba, Jun Wada, Jun Eguchi, Izumi Hashimoto, Tatsuo Okada, Akihiro Yasuhara, Kenichi Shikata, Yashpal S. Kanwar, and Hirofumi Makino

J Am Soc Nephrol 16: 3222-3234. [Abstract] [Full Text] [PDF]  

Genetics and Development:

Ubiquitous and Kidney-Specific Subunits of Vacuolar H⁺-ATPase Are Differentially Expressed during Nephrogenesis

François Jouret, Céline Auzanneau, Huguette Debaix, Ge-Hong Sun Wada, Chrystel Pretto, Etienne Marbaix, Fiona E. Karet, Pierre J. Courtoy, and Olivier Devuyst

J Am Soc Nephrol 16: 3235-3246. [Abstract] [Full Text] [PDF]  

Rapid Isolation of Glomeruli Coupled with Gene Expression Profiling Identifies Downstream Targets in Pod1 Knockout Mice

Shiying Cui, Chengjin Li, Masatsugu Ema, Jordan Weinstein, and Susan E. Quaggin

J Am Soc Nephrol 16: 3247-3255. [Abstract] [Full Text] [PDF] [Data Supplement]  

Basic Immunology and Pathology:

Activation of Glomerular Basement Membrane–Specific B Cells in the Renal Draining Lymph Node after T Cell–Mediated Glomerular Injury

Julie Robertson, Jean Wu, Jon Arends, Cindy Zhou, John McMahon, Lisa Torres, and Ya-Huan Lou

J Am Soc Nephrol 16: 3256-3263. [Abstract] [Full Text] [PDF]  

Interferon-: A Therapeutic for Autoimmune Lupus in MRL-Fas^lpr Mice

Andreas Schwarting, Kathrin Paul, Stefan Tschirner, Julia Menke, Torsten Hansen, Walburgis Brenner, Vicki Rubin Kelley, Manfred Relle, and Peter R. Galle

J Am Soc Nephrol 16: 3264-3272. [Abstract] [Full Text] [PDF]  

G-Rich DNA Suppresses Systemic Lupus

Prashant S. Patole, Daniel Zecher, Rahul D. Pawar, Hermann-Josef Gröne, Detlef Schlöndorff, and Hans-Joachim Anders

J Am Soc Nephrol 16: 3273-3280. [Abstract] [Full Text] [PDF]  

Effect of Human Anti-DNA Antibodies on Proximal Renal Tubular Epithelial Cell Cytokine Expression: Implications on Tubulointerstitial Inflammation in Lupus Nephritis

Susan Yung, Ryan C.W. Tsang, Yuling Sun, Jack K.H. Leung, and Tak Mao Chan

J Am Soc Nephrol 16: 3281-3294. [Abstract] [Full Text] [PDF]  

Pathophysiology of Renal Disease and Progression:

Immunoliposome Targeting to Mesangial Cells: A Promising Strategy for Specific Drug Delivery to the Kidney

Gérald Tuffin, Ernst Waelti, Jörg Huwyler, Caroline Hammer, and Hans-Peter Marti

J Am Soc Nephrol 16: 3295-3305. [Abstract] [Full Text] [PDF]  

Regression of Existing Glomerulosclerosis by Inhibition of Aldosterone

Jean Claude Aldigier, Talerngsak Kanjanbuch, Li-Jun Ma, Nancy J. Brown, and Agnes B. Fogo

J Am Soc Nephrol 16: 3306-3314. [Abstract] [Full Text] [PDF]  

Maladaptive Role of IL-6 in Ischemic Acute Renal Failure

Mariusz L. Kielar, Reji John, Michael Bennett, James A. Richardson, John M. Shelton, Liying Chen, D. Rohan Jeyarajah, Xin J. Zhou, Hui Zhou, Brett Chiquett, Glenn T. Nagami, and Christopher Y. Lu

J Am Soc Nephrol 16: 3315-3325. [Abstract] [Full Text] [PDF]  

Methotrexate Prevents Renal Injury in Experimental Diabetic Rats via Anti-Inflammatory Actions

Kosuke Yozai, Kenichi Shikata, Motofumi Sasaki, Atsuhiro Tone, Sakiko Ohga, Hitomi Usui, Shinichi Okada, Jun Wada, Ryo Nagase, Daisuke Ogawa, Yasushi Shikata, and Hirofumi Makino

J Am Soc Nephrol 16: 3326-3338. [Abstract] [Full Text] [PDF]  

Magnesium Supplementation Combined with N-Acetylcysteine Protects against Postischemic Acute Renal Failure

Magali de Araujo, Lucia Andrade, Terezila M. Coimbra, Adilson C. Rodrigues, Jr, and Antonio Carlos Seguro

J Am Soc Nephrol 16: 3339-3349. [Abstract] [Full Text] [PDF]  

Glomerular Permeability Is Altered by Loss of P0, a Myelin Protein Expressed in Glomerular Epithelial Cells

Emmanuelle Plaisier, Béatrice Mougenot, Marie Christine Verpont, Chantal Jouanneau, Joan J. Archelos, Rudolf Martini, Dontscho Kerjaschki, and Pierre Ronco

J Am Soc Nephrol 16: 3350-3356. [Abstract] [Full Text] [PDF]  

Basic Mineral Metabolism:

Myocardial Stiffness, Cardiac Remodeling, and Diastolic Dysfunction in Calcification-Prone Fetuin-A–Deficient Mice

Marc W. Merx, Cora Schäfer, Ralf Westenfeld, Vincent Brandenburg, Sylvia Hidajat, Christian Weber, Markus Ketteler, and Willi Jahnen-Dechent

J Am Soc Nephrol 16: 3357-3364. [Abstract] [Full Text] [PDF]  

Clinical Nephrology:

Acute Kidney Injury, Mortality, Length of Stay, and Costs in Hospitalized Patients

Glenn M. Chertow, Elisabeth Burdick, Melissa Honour, Joseph V. Bonventre, and David W. Bates

J Am Soc Nephrol 16: 3365-3370. [Abstract] [Full Text] [PDF]  

Association of Achieved Dialysis Dose with Mortality in the Hemodialysis Study: An Example of "Dose-Targeting Bias"

Tom Greene, John Daugirdas, Thomas Depner, Michael Allon, Gerald Beck, Cameron Chumlea, James Delmez, Frank Gotch, John W. Kusek, Nathan Levin, William Owen, Gerald Schulman, Robert Star, Robert Toto, Garabed Eknoyan for the Hemodialysis Study Group

J Am Soc Nephrol 16: 3371-3380. [Abstract] [Full Text] [PDF]  

Circulating Endothelial Microparticles Are Associated with Vascular Dysfunction in Patients with End-Stage Renal Failure

Nicolas Amabile, Alain P. Guérin, Aurélie Leroyer, Ziad Mallat, Clément Nguyen, Jacques Boddaert, Gérard M. London, Alain Tedgui, and Chantal M. Boulanger

J Am Soc Nephrol 16: 3381-3388. [Abstract] [Full Text] [PDF]  

Acute Phosphate Nephropathy following Oral Sodium Phosphate Bowel Purgative: An Underrecognized Cause of Chronic Renal Failure

Glen S. Markowitz, M. Barry Stokes, Jai Radhakrishnan, and Vivette D. D’Agati

J Am Soc Nephrol 16: 3389-3396. [Abstract] [Full Text] [PDF]  

Epidemiology and Outcomes:

Total Plasma Homocysteine and Arteriosclerotic Outcomes in Type 2 Diabetes with Nephropathy

Allon N. Friedman, Lawrence G. Hunsicker, Jacob Selhub, Andrew G. Bostom for the Collaborative Study Group

J Am Soc Nephrol 16: 3397-3402. [Abstract] [Full Text] [PDF]  

Anemia as a Risk Factor for Cardiovascular Disease and All-Cause Mortality in Diabetes: The Impact of Chronic Kidney Disease

Panagiotis T. Vlagopoulos, Hocine Tighiouart, Daniel E. Weiner, John Griffith, Dan Pettitt, Deeb N. Salem, Andrew S. Levey, and Mark J. Sarnak

J Am Soc Nephrol 16: 3403-3410. [Abstract] [Full Text] [PDF]  

Glycosylated Hemoglobin and Mortality in Patients with Nondiabetic Chronic Kidney Disease

Vandana Menon, Tom Greene, Arema A. Pereira, Xuelei Wang, Gerald J. Beck, John W. Kusek, Allan J. Collins, Andrew S. Levey, and Mark J. Sarnak

J Am Soc Nephrol 16: 3411-3417. [Abstract] [Full Text] [PDF]  

Clinical Dialysis:

Decreased Salivary Flow Rate as a Dipsogenic Factor in Hemodialysis Patients: Evidence from an Observational Study and a Pilocarpine Clinical Trial

Junne-Ming Sung, Shih-Chen Kuo, How-Ran Guo, Shu-Fen Chuang, Szu-Yuan Lee, and Jeng-Jong Huang

J Am Soc Nephrol 16: 3418-3429. [Abstract] [Full Text] [PDF]  

Removal of P-Cresol Sulfate by Hemodialysis

Andres W. Martinez, Natalie S. Recht, Thomas H. Hostetter, and Timothy W. Meyer

J Am Soc Nephrol 16: 3430-3436. [Abstract] [Full Text] [PDF]  

Clinical Transplantation:

Comorbid Conditions in Kidney Transplantation: Association with Graft and Patient Survival

Christine Wu, Idris Evans, Raymond Joseph, Ron Shapiro, Henkie Tan, Amit Basu, Cynthia Smetanka, Ahktar Khan, Jerry McCauley, and Mark Unruh

J Am Soc Nephrol 16: 3437-3444. [Abstract] [Full Text] [PDF]  

Announcements:

Announcements

J Am Soc Nephrol 16: 3445. [Full Text] [PDF]  

Errata:

Errata

J Am Soc Nephrol 16: 3446. [Full Text] [PDF]  

ASN News:

ASN News

J Am Soc Nephrol 16: A22-A23. [Full Text]  

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