THIS MONTH'S HIGHLIGHTS:

This Month’s Highlights

J Am Soc Nephrol 16: 1151-1152. [Full Text] [PDF]  

Nephrology beyond JASN:

Amelioration of Acute Renal Failure by Stem Cell Therapy—Paracrine Secretion Versus Transdifferentiation into Resident Cells: Administered Mesenchymal Stem Cells Protect against Ischemic Acute Renal Failure through Differentiation-Independent Mechanisms. Am J Physiol Renal Physiol E-pub February 15, 2005

F. Togel, Z. Hu, K. Weiss, J. Isaac, C. Lange, C. Westenfelder, T. Stasko, M.D. Brown, J.A. Carucci, S. Euvrard, T.M. Johnson, R.D. Sengelmann, E. Stockfleth, W.D. Tope, International Transplant-Skin Cancer Collaborative, European Skin Care in Organ Transplant Patients Network, F.W. Asselbergs, G.F. Diercks, H.L. Hillege, A.J. van Boven, W.M. Janssen, A.A. Voors, D. de Zeeuw, P.E. de Jong, D.J. van Veldhuisen, W.H. van Gilst, and Prevention of Renal and Vascular Endstage Disease Intervention Trial (PREVEND IT) Investigators

J Am Soc Nephrol 16: 1153-1163. [Full Text] [PDF]  

Editorial:

Medicare ESRD Prospective Payment System: Weighing the Evidence

Jonathan Himmelfarb and Glenn M. Chertow

J Am Soc Nephrol 16: 1164-1165. [Full Text] [PDF]  

And You Thought the Age of Anatomic Discovery Was Over

Vivette D’Agati

J Am Soc Nephrol 16: 1166-1168. [Full Text] [PDF]  

Tipping the Balance in Glomerulonephritis

Alan D. Salama

J Am Soc Nephrol 16: 1169-1171. [Full Text] [PDF]  

Fast Track:

Economic Impact of Case-Mix Adjusting the Dialysis Composite Rate

Richard A. Hirth, Erik C. Roys, John R.C. Wheeler, Joseph M. Messana, Marc N. Turenne, Rajiv Saran, Alyssa S. Pozniak, and Robert A. Wolfe

J Am Soc Nephrol 16: 1172-1176. [Abstract] [Full Text] [PDF]  

Complement Factor H Mutation in Familial Thrombotic Thrombocytopenic Purpura with ADAMTS13 Deficiency and Renal Involvement

Marina Noris, Sara Bucchioni, Miriam Galbusera, Roberta Donadelli, Elena Bresin, Federica Castelletti, Jessica Caprioli, Simona Brioschi, Friedrich Scheiflinger, Giuseppe Remuzzi for the International Registry of Recurrent and Familial HUS/TTP

J Am Soc Nephrol 16: 1177-1183. [Abstract] [Full Text] [PDF]  

Frontiers in Nephrology: Membranous Nephropathy:

Membranous Nephropathy: A Long Road but Well Traveled

William G. Couser

J Am Soc Nephrol 16: 1184-1187. [Full Text] [PDF]  

Management of Membranous Nephropathy: When and What for Treatment

Daniel Cattran

J Am Soc Nephrol 16: 1188-1194. [Full Text] [PDF]  

Cellular Response to Injury in Membranous Nephropathy

Masaomi Nangaku, Stuart J. Shankland, and William G. Couser

J Am Soc Nephrol 16: 1195-1204. [Abstract] [Full Text] [PDF]  

Molecular Pathomechanisms of Membranous Nephropathy: From Heymann Nephritis to Alloimmunization

Pierre Ronco and Hanna Debiec

J Am Soc Nephrol 16: 1205-1213. [Abstract] [Full Text] [PDF]  

Contrasting Roles of Complement Activation and Its Regulation in Membranous Nephropathy

Patrick N. Cunningham and Richard J. Quigg

J Am Soc Nephrol 16: 1214-1222. [Abstract] [Full Text] [PDF]  

Cell and Transport Physiology:

Three-Dimensional Reconstruction of Glomeruli by Electron Microscopy Reveals a Distinct Restrictive Urinary Subpodocyte Space

Christopher R. Neal, Hayley Crook, Edward Bell, Steven J. Harper, and David O. Bates

J Am Soc Nephrol 16: 1223-1235. [Abstract] [Full Text] [PDF]  

Aminoglycosides Induce Acute Cell Signaling and Chronic Cell Death in Renal Cells that Express the Calcium-Sensing Receptor

Donald T. Ward, David Maldonado-Pérez, Laura Hollins, and Daniela Riccardi

J Am Soc Nephrol 16: 1236-1244. [Abstract] [Full Text] [PDF]  

Vacuolar H⁺-ATPase d2 Subunit: Molecular Characterization, Developmental Regulation, and Localization to Specialized Proton Pumps in Kidney and Bone

Annabel N. Smith, François Jouret, Sharyn Bord, Katherine J. Borthwick, Rafia S. Al-Lamki, Carsten A. Wagner, Deborah C. Ireland, Valerie Cormier-Daire, Annalisa Frattini, Anna Villa, Uwe Kornak, Olivier Devuyst, and Fiona E. Karet

J Am Soc Nephrol 16: 1245-1256. [Abstract] [Full Text] [PDF]  

The Endogenous CXXC Motif Governs the Cadmium Sensitivity of the Renal Na⁺/Glucose Co-Transporter

Xiaobing Xia, Gang Wang, Yanchun Peng, Ming-Gene Tu, Jimmy Jen, and Hongqing Fang

J Am Soc Nephrol 16: 1257-1265. [Abstract] [Full Text] [PDF]  

Cell Biology:

Albumin Activates ERK Via EGF Receptor in Human Renal Epithelial Cells

Heather Reich, David Tritchler, Andrew M. Herzenberg, Zamaneh Kassiri, Xiaohua Zhou, Wei Gao, and James W. Scholey

J Am Soc Nephrol 16: 1266-1278. [Abstract] [Full Text] [PDF]  

Localization and Functional Characterization of Glycosaminoglycan Domains in the Normal Human Kidney as Revealed by Phage Display-Derived Single Chain Antibodies

Joost F.M. Lensen, Angelique L.W.M.M. Rops, Tessa J.M. Wijnhoven, Theo Hafmans, Wouter F.J. Feitz, Egbert Oosterwijk, Bernhard Banas, René J.M. Bindels, Lambert P.W.J. van den Heuvel, Johan van der Vlag, Jo H.M. Berden, and Toin H. van Kuppevelt

J Am Soc Nephrol 16: 1279-1288. [Abstract] [Full Text] [PDF]  

Genetics and Development:

Genome-Wide Scan in a Novel IgA Nephropathy Model Identifies a Susceptibility Locus on Murine Chromosome 10, in a Region Syntenic to Human IGAN1 on Chromosome 6q22–23

Hitoshi Suzuki, Yusuke Suzuki, Takahiro Yamanaka, Sachiko Hirose, Hiroyuki Nishimura, Junichi Toei, Satoshi Horikoshi, and Yasuhiko Tomino

J Am Soc Nephrol 16: 1289-1299. [Abstract] [Full Text] [PDF]  

Basic Mineral Metabolism:

Regulation of Renal Calcium Receptor Gene Expression by 1,25-Dihydroxyvitamin D₃ in Genetic Hypercalciuric Stone-Forming Rats

Jim J. Yao, Shaochun Bai, Alexander J. Karnauskas, David A. Bushinsky, and Murray J. Favus

J Am Soc Nephrol 16: 1300-1308. [Abstract] [Full Text] [PDF]  

Hemodynamics and Vascular Regulation:

Graded Effects of Proteinuria on HDL Structure in Nephrotic Rats

Gregory C. Shearer, John W. Newman, Bruce D. Hammock, and George A. Kaysen

J Am Soc Nephrol 16: 1309-1319. [Abstract] [Full Text] [PDF]  

Relative Glomerular Hyperfiltration in Primary Aldosteronism

Jean Ribstein, Guilhem Du Cailar, Pierre Fesler, and Albert Mimran

J Am Soc Nephrol 16: 1320-1325. [Abstract] [Full Text] [PDF]  

Basic Immunology and Pathology:

Viral Double-Stranded RNA Aggravates Lupus Nephritis through Toll-Like Receptor 3 on Glomerular Mesangial Cells and Antigen-Presenting Cells

Prashant S. Patole, Hermann-Josef Gröne, Stephan Segerer, Raluca Ciubar, Emilia Belemezova, Anna Henger, Matthias Kretzler, Detlef Schlöndorff, and Hans-Joachim Anders

J Am Soc Nephrol 16: 1326-1338. [Abstract] [Full Text] [PDF]  

Novel Serpinopathy in Rat Kidney and Pancreas Induced by Overexpression of Megsin

Reiko Inagi, Masaomi Nangaku, Nobuteru Usuda, Akira Shimizu, Hiroshi Onogi, Yuko Izuhara, Kiyokazu Nakazato, Yasuhiko Ueda, Hisashi Oishi, Satoru Takahashi, Masayuki Yamamoto, Daisuke Suzuki, Kiyoshi Kurokawa, Charles van Ypersele de Strihou, and Toshio Miyata

J Am Soc Nephrol 16: 1339-1349. [Abstract] [Full Text] [PDF]  

Nasal Administration of Recombinant Rat 3(IV)NC1 Prevents the Development of Experimental Autoimmune Glomerulonephritis in the WKY Rat

John Reynolds, Evangelia I. Prodromidi, Jason K. Juggapah, Danielle S. Abbott, Kathryn A. Holthaus, Raghu Kalluri, and Charles D. Pusey

J Am Soc Nephrol 16: 1350-1359. [Abstract] [Full Text] [PDF]  

CD4⁺CD25⁺ Regulatory T Cells Inhibit Experimental Anti-Glomerular Basement Membrane Glomerulonephritis in Mice

Dominik Wolf, Kathrin Hochegger, Anna M. Wolf, Holger F. Rumpold, Guenther Gastl, Herbert Tilg, Gert Mayer, Eberhard Gunsilius, and Alexander R. Rosenkranz

J Am Soc Nephrol 16: 1360-1370. [Abstract] [Full Text] [PDF]  

Signaling Mechanism of TGF-1 in Prevention of Renal Inflammation: Role of Smad7

Wansheng Wang, Xiao R. Huang, Allen G. Li, Fang Liu, Jin-Hua Li, Luan D. Truong, Xiao J. Wang, and Hui Y. Lan

J Am Soc Nephrol 16: 1371-1383. [Abstract] [Full Text] [PDF]  

Pathophysiology of Renal Disease and Progression:

Role of Mammalian Target of Rapamycin Signaling in Compensatory Renal Hypertrophy

Jian-Kang Chen, Jianchun Chen, Eric G. Neilson, and Raymond C. Harris

J Am Soc Nephrol 16: 1384-1391. [Abstract] [Full Text] [PDF]  

Disease of the Month:

Membranoproliferative Glomerulonephritis Type II (Dense Deposit Disease): An Update

Gerald B. Appel, H. Terence Cook, Gregory Hageman, J. Charles Jennette, Michael Kashgarian, Michael Kirschfink, John D. Lambris, Lynne Lanning, Hans U. Lutz, Seppo Meri, Noel R. Rose, David J. Salant, Sanjeev Sethi, Richard J.H. Smith, William Smoyer, Hope F. Tully, Sean P. Tully, Patrick Walker, Michael Welsh, Reinhard Würzner, and Peter F. Zipfel

J Am Soc Nephrol 16: 1392-1403. [Abstract] [Full Text] [PDF]  

Clinical Nephrology:

Detection of Renal Function Decline in Patients with Diabetes and Normal or Elevated GFR by Serial Measurements of Serum Cystatin C Concentration: Results of a 4-Year Follow-Up Study

Bruce A. Perkins, Robert G. Nelson, Betsy E.P. Ostrander, Kristina L. Blouch, Andrzej S. Krolewski, Bryan D. Myers, and James H. Warram

J Am Soc Nephrol 16: 1404-1412. [Abstract] [Full Text] [PDF]  

Serum Creatinine as Marker of Kidney Function in South Asians: A Study of Reduced GFR in Adults in Pakistan

Tazeen H. Jafar, Christopher H. Schmid, and Andrew S. Levey

J Am Soc Nephrol 16: 1413-1419. [Abstract] [Full Text] [PDF]  

Incidence of Atherosclerosis by Race in the Dialysis Morbidity and Mortality Study: A Sample of the US ESRD Population

Rulan S. Parekh, Lin Zhang, Barbara A. Fivush, and Michael J. Klag

J Am Soc Nephrol 16: 1420-1426. [Abstract] [Full Text] [PDF]  

Epidemiology and Outcomes:

Assessing Health Status and Health Care Utilization in Adolescents with Chronic Kidney Disease

Arlene C. Gerson, Anne Riley, Barbara A. Fivush, Ngoc Pham, Jeffrey Fiorenza, Judy Robertson, Manju Chandra, Howard Trachtman, Robert Weiss, Susan L. Furth for the Council on Pediatric Nephrology and Urology of New York/New Jersey and the Kidney and Urology Foundation of America

J Am Soc Nephrol 16: 1427-1432. [Abstract] [Full Text] [PDF]  

Identifying Individuals with a Reduced GFR Using Ambulatory Laboratory Database Surveillance

Amit X. Garg, Muhammad Mamdani, David N. Juurlink, Carl van Walraven for the Network of Eastern Ontario Medical Laboratories (NEO-MeL)

J Am Soc Nephrol 16: 1433-1439. [Abstract] [Full Text] [PDF]  

Race, Gender, and Incident Dialysis Patients’ Reported Health Status and Quality of Life

Nancy G. Kutner, Rebecca Zhang, and Donna Brogan

J Am Soc Nephrol 16: 1440-1448. [Abstract] [Full Text] [PDF]  

Clinical Dialysis:

Type of Vascular Access and Survival among Incident Hemodialysis Patients: The Choices for Healthy Outcomes in Caring for ESRD (CHOICE) Study

Brad C. Astor, Joseph A. Eustace, Neil R. Powe, Michael J. Klag, Nancy E. Fink, Josef Coresh for the CHOICE Study

J Am Soc Nephrol 16: 1449-1455. [Abstract] [Full Text] [PDF]  

Randomized, Controlled Trial of Topical Exit-Site Application of Honey (Medihoney) versus Mupirocin for the Prevention of Catheter-Associated Infections in Hemodialysis Patients

David Wayne Johnson, Carolyn van Eps, David William Mudge, Kathryn Joan Wiggins, Kirsty Armstrong, Carmel Mary Hawley, Scott Bryan Campbell, Nicole Maree Isbel, Graeme Robert Nimmo, and Harry Gibbs

J Am Soc Nephrol 16: 1456-1462. [Abstract] [Full Text] [PDF]  

Structured Conversion from Thrice Weekly to Weekly Erythropoietic Regimens Using a Computerized Decision-Support System: A Randomized Clinical Study

Cae Tolman, Donald Richardson, Cherry Bartlett, and Eric Will

J Am Soc Nephrol 16: 1463-1470. [Abstract] [Full Text] [PDF]  

Profound Mishandling of Protein Glycation Degradation Products in Uremia and Dialysis

Stamatina Agalou, Naila Ahmed, Roya Babaei-Jadidi, Anne Dawnay, and Paul J. Thornalley

J Am Soc Nephrol 16: 1471-1485. [Abstract] [Full Text] [PDF]  

Dialysate as Food: Combined Amino Acid and Glucose Dialysate Improves Protein Anabolism in Renal Failure Patients on Automated Peritoneal Dialysis

Hoey Lan Tjiong, Jacobus W. van den Berg, Josias L. Wattimena, Trinet Rietveld, Laurens J. van Dijk, Adorée M. van der Wiel, Anneke M. van Egmond, Marien W. Fieren, and Roel Swart

J Am Soc Nephrol 16: 1486-1493. [Abstract] [Full Text] [PDF]  

Chronic Kidney Disease:

Altered Morphologic Properties of Large Arteries in Children with Chronic Renal Failure and after Renal Transplantation

Mieczyslaw Litwin, Elke Wühl, Claudia Jourdan, Justyna Trelewicz, Anna Niemirska, Kathrin Fahr, Katarzyna Jobs, Ryszard Grenda, Zbigniew T. Wawer, Pawel Rajszys, Jörgen Tröger, Otto Mehls, and Franz Schaefer

J Am Soc Nephrol 16: 1494-1500. [Abstract] [Full Text] [PDF]  

Clinical Transplantation:

ABCB1 Genotype of the Donor but Not of the Recipient Is a Major Risk Factor for Cyclosporine-Related Nephrotoxicity after Renal Transplantation

Ingeborg A. Hauser, Elke Schaeffeler, Stefan Gauer, Ernst H. Scheuermann, Binytha Wegner, Jan Gossmann, Hanns Ackermann, Christian Seidl, Berthold Hocher, Ulrich M. Zanger, Helmut Geiger, Michel Eichelbaum, and Matthias Schwab

J Am Soc Nephrol 16: 1501-1511. [Abstract] [Full Text] [PDF]  

Factors Associated with Improvement in Deceased Donor Renal Allograft Function in the 1990s

Douglas S. Keith, Angelo deMattos, Muralikrishna Golconda, Jonathan Prather, Marcelo Cantarovich, Steven Paraskevas, Jean Tchervenkov, and Douglas J. Norman

J Am Soc Nephrol 16: 1512-1521. [Abstract] [Full Text] [PDF]  

Announcements:

Announcements

J Am Soc Nephrol 16: 1522. [Full Text] [PDF]  

ASN News:

ASN News

J Am Soc Nephrol 16: A17-A18. [Full Text] [PDF]  

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