THIS MONTH'S HIGHLIGHTS:

This Month’s Highlights

J Am Soc Nephrol 16: 1523-1524. [Full Text] [PDF]  

Nephrology beyond JASN:

Is the Kidney Always the Cause of Hypertension?: Distinct Roles for the Kidney and Systemic Tissues in Blood Pressure Regulation by the Renin-Angiotensin System. J Clin Invest 115: 1092–1099, 2005

SD Crowley, SB Gurley, MI Oliverio, AK Pazmino, R Griffiths, PJ Flannery, RF Spurney, H-S Kim, O Smithies, TH Le, TM Coffman, J Boucher, B Masri, D Daviaud, S Gesta, C Guigné, A Mazzucotelli, I Castan-Laurell, I Tack, B Knibiehler, C Carpéné, Y Audigier, JS Saulnier-Blache, P Valet, S Engeli, J Böhnke, K Gorzelniak, J Janke, P Schling, M Bader, F Luft, and AM Sharma

J Am Soc Nephrol 16: 1525-1532. [Full Text] [PDF]  

Special Tribute:

In Memoriam Liliane Striker, MD 1937–2004

William G. Couser, Vicki Rubin-Kelley, and Sharon Adler

J Am Soc Nephrol 16: 1533-1534. [Full Text] [PDF]  

Editorials:

Regulating Renal Drug Elimination?

Florian Lang

J Am Soc Nephrol 16: 1535-1536. [Full Text] [PDF]  

Linking Metabolism and Immunology: Diabetic Nephropathy Is an Inflammatory Disease

Katherine R. Tuttle

J Am Soc Nephrol 16: 1537-1538. [Full Text] [PDF]  

Beyond Framingham: Cardiovascular Risk Profiling in ESRD

William M. McClellan and Glenn M. Chertow

J Am Soc Nephrol 16: 1539-1541. [Full Text] [PDF]  

Fast Track:

On the Intraoperative Molecular Status of Renal Allografts after Vascular Reperfusion and Clinical Outcomes

Yingyos Avihingsanon, Naili Ma, Martha Pavlakis, W. James Chon, Marc E. Uknis, Anthony P. Monaco, Christiane Ferran, Isaac Stillman, Asher D. Schachter, Christina Mottley, Xin Xiao Zheng, and Terry B. Strom

J Am Soc Nephrol 16: 1542-1548. [Abstract] [Full Text] [PDF]  

Homer W. Smith Award Lecture:

Chloride Transport in the Kidney: Lessons from Human Disease and Knockout Mice

Thomas J. Jentsch

J Am Soc Nephrol 16: 1549-1561. [Abstract] [Full Text] [PDF]  

Cell and Transport Physiology:

Individual PKC-Phosphorylation Sites in Organic Cation Transporter 1 Determine Substrate Selectivity and Transport Regulation

Giuliano Ciarimboli, Hermann Koepsell, Mariya Iordanova, Valentin Gorboulev, Brigitte Dürner, Detlef Lang, Bayram Edemir, Rita Schröter, Truc Van Le, and Eberhard Schlatter

J Am Soc Nephrol 16: 1562-1570. [Abstract] [Full Text] [PDF]  

Dual Effects of Hypertonicity on Aquaporin-2 Expression in Cultured Renal Collecting Duct Principal Cells

Udo Hasler, Manlio Vinciguerra, Alain Vandewalle, Pierre-Yves Martin, and Eric Féraille

J Am Soc Nephrol 16: 1571-1582. [Abstract] [Full Text] [PDF]  

Renal Phenotype of UT-A Urea Transporter Knockout Mice

Robert A. Fenton, Anneliese Flynn, Adetola Shodeinde, Craig P. Smith, Jurgen Schnermann, and Mark A. Knepper

J Am Soc Nephrol 16: 1583-1592. [Abstract] [Full Text] [PDF]  

Cell Biology:

Cultured Podocytes Establish a Size-Selective Barrier Regulated by Specific Signaling Pathways and Demonstrate Synchronized Barrier Assembly in a Calcium Switch Model of Junction Formation

Jennifer L. Hunt, Martin R. Pollak, and Bradley M. Denker

J Am Soc Nephrol 16: 1593-1602. [Abstract] [Full Text] [PDF]  

NF-B Mediated IL-6 Production by Renal Epithelial Cells Is Regulated by C-Jun NH₂-Terminal Kinase

Simone de Haij, Astrid C. Bakker, Reinier N. van der Geest, Guy Haegeman, Wim Vanden Berghe, Jamil Aarbiou, Mohamed R. Daha, and Cees van Kooten

J Am Soc Nephrol 16: 1603-1611. [Abstract] [Full Text] [PDF]  

Molecular Identification of Canine Podocalyxin-Like Protein 1 as a Renal Tubulogenic Regulator

Hsin-Yuan Cheng, Yu-Yu Lin, Chun-Ying Yu, Jen-Yau Chen, Kuo-Fang Shen, Wei-Ling Lin, Hsin-Kai Liao, Yu-Ju Chen, Chen-Hsuan Liu, Victor Fei Pang, and Tzuu-Shuh Jou

J Am Soc Nephrol 16: 1612-1622. [Abstract] [Full Text] [PDF] [Data Supplements]  

Genetics and Development:

Integration of Embryonic Stem Cells in Metanephric Kidney Organ Culture

Brooke M. Steenhard, Kathryn S. Isom, Patricia Cazcarro, Judy H. Dunmore, Alan R. Godwin, Patricia L. St. John, and Dale R. Abrahamson

J Am Soc Nephrol 16: 1623-1631. [Abstract] [Full Text] [PDF]  

Cited1 Is a Bifunctional Transcriptional Cofactor That Regulates Early Nephronic Patterning

Sergey Plisov, Michael Tsang, Genbin Shi, Scott Boyle, Kiyoshi Yoshino, Sally L. Dunwoodie, Igor B. Dawid, Toshi Shioda, Alan O. Perantoni, and Mark P. de Caestecker

J Am Soc Nephrol 16: 1632-1644. [Abstract] [Full Text] [PDF]  

Basic Mineral Metabolism:

Role of Matrix Extracellular Phosphoglycoprotein in the Pathogenesis of X-Linked Hypophosphatemia

Shiguang Liu, Thomas A. Brown, Jianping Zhou, Zhou-Sheng Xiao, Hani Awad, Farshid Guilak, and L. Darryl Quarles

J Am Soc Nephrol 16: 1645-1653. [Abstract] [Full Text] [PDF]  

Hemodynamics and Vascular Regulation:

Protein Kinase C Inhibition Attenuates Osteopontin Expression, Macrophage Recruitment, and Tubulointerstitial Injury in Advanced Experimental Diabetic Nephropathy

Darren J. Kelly, Anna Chanty, Renae M. Gow, Yuan Zhang, and Richard E. Gilbert

J Am Soc Nephrol 16: 1654-1660. [Abstract] [Full Text] [PDF]  

Akt Mediates Mechanical Strain-Induced Collagen Production by Mesangial Cells

Joan C. Krepinsky, Yanxia Li, Yanfei Chang, Lieqi Liu, Fangfang Peng, Dongcheng Wu, Damu Tang, James Scholey, and Alistair J. Ingram

J Am Soc Nephrol 16: 1661-1672. [Abstract] [Full Text] [PDF]  

Suppressors of Cytokine Signaling Regulate Angiotensin II-Activated Janus Kinase-Signal Transducers and Activators of Transcription Pathway in Renal Cells

Purificación Hernández-Vargas, Oscar López-Franco, Guillermo Sanjuán, Mónica Rupérez, Guadalupe Ortiz-Muñoz, Yusuke Suzuki, Pablo Aguado-Roncero, Gloria Pérez-Tejerizo, Julia Blanco, Jesús Egido, Marta Ruiz-Ortega, and Carmen Gómez-Guerrero

J Am Soc Nephrol 16: 1673-1683. [Abstract] [Full Text] [PDF]  

Hematopoietic Stem Cell Mobilization Therapy Accelerates Recovery of Renal Function Independent of Stem Cell Contribution

Geurt Stokman, Jaklien C. Leemans, Nike Claessen, Jan J. Weening, and Sandrine Florquin

J Am Soc Nephrol 16: 1684-1692. [Abstract] [Full Text] [PDF]  

Basic Immunology and Pathology:

NEPH2 Is Located at the Glomerular Slit Diaphragm, Interacts with Nephrin and Is Cleaved from Podocytes by Metalloproteinases

Peter Gerke, Lorenz Sellin, Oliver Kretz, Daniel Petraschka, Hanswalter Zentgraf, Thomas Benzing, and Gerd Walz

J Am Soc Nephrol 16: 1693-1702. [Abstract] [Full Text] [PDF]  

Pathophysiology of Renal Disease and Progression:

Heparan Sulfate of Perlecan Is Involved in Glomerular Filtration

Hiroyuki Morita, Ashio Yoshimura, Kiyoko Inui, Terukuni Ideura, Hideto Watanabe, Ling Wang, Raija Soininen, and Karl Tryggvason

J Am Soc Nephrol 16: 1703-1710. [Abstract] [Full Text] [PDF]  

Intercellular Adhesion Molecule-1 Deficiency Is Protective against Nephropathy in Type 2 Diabetic db/db Mice

Fiona Y. Chow, David J. Nikolic-Paterson, Elyce Ozols, Robert C. Atkins, and Gregory H. Tesch

J Am Soc Nephrol 16: 1711-1722. [Abstract] [Full Text] [PDF]  

Proliferation of Bone Marrow-Derived Cells Contributes to Regeneration after Folic Acid-Induced Acute Tubular Injury

Te-Chao Fang, Malcolm R. Alison, H. Terence Cook, Rosemary Jeffery, Nicholas A. Wright, and Richard Poulsom

J Am Soc Nephrol 16: 1723-1732. [Abstract] [Full Text] [PDF]  

Urinary Podocyte Loss Is a More Specific Marker of Ongoing Glomerular Damage than Proteinuria

Donghai Yu, Arndt Petermann, Uta Kunter, Song Rong, Stuart J. Shankland, and Juergen Floege

J Am Soc Nephrol 16: 1733-1741. [Abstract] [Full Text] [PDF]  

F₁F_O-ATPase Activity and ATP Dependence of Mitochondrial Energization in Proximal Tubules after Hypoxia/Reoxygenation

Thorsten Feldkamp, Andreas Kribben, and Joel M. Weinberg

J Am Soc Nephrol 16: 1742-1751. [Abstract] [Full Text] [PDF]  

Detection and Localization of Proteinuria by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using MS325

Yantian Zhang, Peter L. Choyke, Huiyan Lu, Hideko Takahashi, Roslyn B. Mannon, Xiaojie Zhang, Hani Marcos, King C.P. Li, and Jeffrey B. Kopp

J Am Soc Nephrol 16: 1752-1757. [Abstract] [Full Text] [PDF]  

Disease of the Month:

Viral Infection in the Renal Transplant Recipient

Camille N. Kotton and Jay A. Fishman

J Am Soc Nephrol 16: 1758-1774. [Abstract] [Full Text] [PDF]  

Clinical Nephrology:

Importance of Baseline Distribution of Proteinuria in Renal Outcomes Trials: Lessons from the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) Study

Zhongxin Zhang, Shahnaz Shahinfar, William F. Keane, Denise Ramjit, Tania Z. Dickson, Gilbert W. Gleim, Carl Erik Mogensen, Dick de Zeeuw, Barry M. Brenner, and Steven M. Snapinn

J Am Soc Nephrol 16: 1775-1780. [Abstract] [Full Text] [PDF]  

Human Genetics:

Familial Vesicoureteral Reflux: Testing Replication of Linkage in Seven New Multigenerational Kindreds

Simone Sanna-Cherchi, Adam Reese, Terry Hensle, Gianluca Caridi, Claudia Izzi, You Yeun Kim, Anita Konka, Luisa Murer, Francesco Scolari, Roberto Ravazzolo, Gian Marco Ghiggeri, and Ali G. Gharavi

J Am Soc Nephrol 16: 1781-1787. [Abstract] [Full Text] [PDF]  

Epidemiology and Outcomes:

Calcium, Phosphorus, Parathyroid Hormone, and Cardiovascular Disease in Hemodialysis Patients: The USRDS Waves 1, 3, and 4 Study

Yelena Slinin, Robert N. Foley, and Allan J. Collins

J Am Soc Nephrol 16: 1788-1793. [Abstract] [Full Text] [PDF]  

High Lipoprotein(a) Levels and Small Apolipoprotein(a) Size Prospectively Predict Cardiovascular Events in Dialysis Patients

J. Craig Longenecker, Michael J. Klag, Santica M. Marcovina, Yong-Mei Liu, Bernard G. Jaar, Neil R. Powe, Nancy E. Fink, Andrew S. Levey, and Josef Coresh

J Am Soc Nephrol 16: 1794-1802. [Abstract] [Full Text] [PDF]  

Effects of Anemia and Left Ventricular Hypertrophy on Cardiovascular Disease in Patients with Chronic Kidney Disease

Daniel E. Weiner, Hocine Tighiouart, Panagiotis T. Vlagopoulos, John L. Griffith, Deeb N. Salem, Andrew S. Levey, and Mark J. Sarnak

J Am Soc Nephrol 16: 1803-1810. [Abstract] [Full Text] [PDF]  

Low Total Vitamin C Plasma Level Is a Risk Factor for Cardiovascular Morbidity and Mortality in Hemodialysis Patients

Robert Deicher, Farzad Ziai, Christian Bieglmayer, Martin Schillinger, and Walter H. Hörl

J Am Soc Nephrol 16: 1811-1818. [Abstract] [Full Text] [PDF]  

Clinical Dialysis:

Pathochemical Toxicity of Perfluorocarbon-5070, a Liquid Test Performance Fluid Previously Used in Dialyzer Manufacturing, Confirmed in Animal Experiment

Bernard Canaud, Pedro Aljama, Christian Tielemans, Vladimir Gasparovic, Alberto Gutierrez, and Francesco Locatelli

J Am Soc Nephrol 16: 1819-1823. [Abstract] [Full Text] [PDF]  

Effect of Ultrafiltration on Thermal Variables, Skin Temperature, Skin Blood Flow, and Energy Expenditure during Ultrapure Hemodialysis

Frank M. van der Sande, Laura M. Rosales, Zohar Brener, Jeroen P. Kooman, Martin Kuhlmann, Garry Handelman, Roger N. Greenwood, Mary Carter, Daniel Schneditz, Karel M. Leunissen, and Nathan W. Levin

J Am Soc Nephrol 16: 1824-1831. [Abstract] [Full Text] [PDF]  

Asymmetrical Dimethylarginine Plasma Concentrations Are Related to Basal Nitric Oxide Release but Not Endothelium-Dependent Vasodilation of Resistance Arteries in Peritoneal Dialysis Patients

Friedrich Mittermayer, Georg Schaller, Johannes Pleiner, Andreas Vychytil, Gere Sunder-Plassmann, Walter H. Hörl, and Michael Wolzt

J Am Soc Nephrol 16: 1832-1838. [Abstract] [Full Text] [PDF]  

Clinical Transplantation:

Race and Electronically Measured Adherence to Immunosuppressive Medications after Deceased Donor Renal Transplantation

Francis L. Weng, Ajay K. Israni, Marshall M. Joffe, Tracey Hoy, Christina A. Gaughan, Melissa Newman, John D. Abrams, Malek Kamoun, Sylvia E. Rosas, Kevin C. Mange, Brian L. Strom, Kenneth L. Brayman, and Harold I. Feldman

J Am Soc Nephrol 16: 1839-1848. [Abstract] [Full Text] [PDF]  

Prediction of Acute Renal Allograft Rejection by Urinary Monokine Induced by IFN- (MIG)

Ingeborg A. Hauser, Sandra Spiegler, Eva Kiss, Stefan Gauer, Olaf Sichler, Ernst H. Scheuermann, Hanns Ackermann, Josef M. Pfeilschifter, Helmut Geiger, Hermann-Josef Gröne, and Heinfried H. Radeke

J Am Soc Nephrol 16: 1849-1858. [Abstract] [Full Text] [PDF]  

Impact of Cadaveric Renal Transplantation on Survival in Patients Listed for Transplantation

Gabriel C. Oniscu, Helen Brown, and John L.R. Forsythe

J Am Soc Nephrol 16: 1859-1865. [Abstract] [Full Text] [PDF]  

Announcements:

Announcements

J Am Soc Nephrol 16: 1866. [Full Text] [PDF]  

Errata:

Errata

J Am Soc Nephrol 16: 1867. [Full Text] [PDF]  

ASN News:

ASN News

J Am Soc Nephrol 16: A17-A18. [Full Text] [PDF]  

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