JASN -- Table of Contents (16 [7])

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THIS MONTH'S HIGHLIGHTS:

This Month’s Highlights: J Am Soc Nephrol 16: 1869-1870. [Full Text] [PDF]

Nephrology beyond JASN:

Thromboembolism—Another Threat to the Polymorbid Patient with Vasculitis?: High Incidence of Venous Thrombotic Events among Patients with Wegener Granulomatosis: The Wegener’s Clinical Occurrence of Thrombosis (WeCLOT) Study. Ann Intern Med 142: 620–626, 2005: P Merkel, GH Lo, JT Holbrook, AK Tibbs, NB Allen, JC Davis, GS Hoffman, WJ McCune, EW St Clair, U Specks, R Spiera, M Petri, JH Stone, J Lin, SR Patel, X Cheng, EA Cho, I Levitan, M Ullenbruch, SH Phan, JM Park, GR Dressler, G Opelz, B Döhler, G Laux for the Collaborative Transplant Study Group; J Am Soc Nephrol 16: 1871-1877. [Full Text] [PDF]

Editorials:

Rapamycin: A New String to the Antiproteinuric Bow?: Nigel J. Brunskill; J Am Soc Nephrol 16: 1878-1879. [Full Text] [PDF]

Association of Metabolic Syndrome in Nondiabetic Patients with Increased Risk for Chronic Kidney Disease: The Fat Lady Sings: John R. Sedor and Jeffrey R. Schelling; J Am Soc Nephrol 16: 1880-1882. [Full Text] [PDF]

Albuminuria, Just a Marker for Cardiovascular Disease, Or Is It More?: Dick de Zeeuw; J Am Soc Nephrol 16: 1883-1885. [Full Text] [PDF]

Special Feature: ASN Renal Research Report:

American Society of Nephrology Renal Research Report: J Am Soc Nephrol 16: 1886-1903. [Abstract] [Full Text] [PDF]

Fast Track:

Crystal Surface Adhesion Explains the Pathological Activity of Calcium Oxalate Hydrates in Kidney Stone Formation: Xiaoxia Sheng, Michael D. Ward, and Jeffrey A. Wesson; J Am Soc Nephrol 16: 1904-1908. [Abstract] [Full Text] [PDF]

Review:

Essential Hypertension, Progressive Renal Disease, and Uric Acid: A Pathogenetic Link?: Richard J. Johnson, Mark S. Segal, Titte Srinivas, Ahsan Ejaz, Wei Mu, Carlos Roncal, Laura G. Sánchez-Lozada, Michael Gersch, Bernardo Rodriguez-Iturbe, Duk-Hee Kang, and Jaime Herrera Acosta; J Am Soc Nephrol 16: 1909-1919. [Abstract] [Full Text] [PDF]

Cell and Transport Physiology:

Vasopressin-V2 Receptor Stimulation Reduces Sodium Excretion in Healthy Humans: Lise Bankir, Sandrine Fernandes, Pascale Bardoux, Nadine Bouby, and Daniel G. Bichet; J Am Soc Nephrol 16: 1920-1928. [Abstract] [Full Text] [PDF]

Endothelin-Induced Increased Aldosterone Activity Mediates Augmented Distal Nephron Acidification as a Result of Dietary Protein: Apurv Khanna, Jan Simoni, and Donald E. Wesson; J Am Soc Nephrol 16: 1929-1935. [Abstract] [Full Text] [PDF]

Cell Biology:

Statins Prevent Oxidized LDL-Induced Injury of Glomerular Podocytes by Activating the Phosphatidylinositol 3-Kinase/AKT-Signaling Pathway: Benedetta Bussolati, Maria Chiara Deregibus, Valentina Fonsato, Sophie Doublier, Tiziana Spatola, Simone Procida, Francesco Di Carlo, and Giovanni Camussi; J Am Soc Nephrol 16: 1936-1947. [Abstract] [Full Text] [PDF]

Nitric Oxide Upregulates Induction of PDGF Receptor- ${alpha}$ Expression in Rat Renal Mesangial Cells and in Anti-Thy-1 Glomerulonephritis: Karl-Friedrich Beck, Gülmisal Güder, Liliana Schaefer, Miriam Pleskova, Andrea Babelova, Meik H. Behrens, Daniel Mihalik, Martina Beck, Roland M. Schaefer, and Josef Pfeilschifter; J Am Soc Nephrol 16: 1948-1957. [Abstract] [Full Text] [PDF]

Sam68-Like Mammalian Protein 2, Identified by Digital Differential Display as Expressed by Podocytes, Is Induced in Proteinuria and Involved in Splice Site Selection of Vascular Endothelial Growth Factor: Clemens D. Cohen, Peter P. Doran, Simone M. Blattner, Monika Merkle, Guo Q. Wang, Holger Schmid, Peter W. Mathieson, Moin A. Saleem, Anna Henger, Maria P. Rastaldi, and Matthias Kretzler; J Am Soc Nephrol 16: 1958-1965. [Abstract] [Full Text] [PDF]

Formation and Phosphorylation of the PINCH-1–Integrin Linked Kinase– ${alpha}$ -Parvin Complex Are Important for Regulation of Renal Glomerular Podocyte Adhesion, Architecture, and Survival: Yanqiang Yang, Lida Guo, Simone M. Blattner, Peter Mundel, Matthias Kretzler, and Chuanyue Wu; J Am Soc Nephrol 16: 1966-1976. [Abstract] [Full Text] [PDF]

RhoGTPase Activation Is a Key Step in Renal Epithelial Mesenchymal Transdifferentiation: Sharmila Patel, Ken-ichro Takagi, Jun Suzuki, Atsushi Imaizumi, Tsuyoshi Kimura, Roger M Mason, Takashi Kamimura, and Zhi Zhang; J Am Soc Nephrol 16: 1977-1984. [Abstract] [Full Text] [PDF]

Endoplasmic Reticulum Stress–Associated Caspase 12 Mediates Cisplatin-Induced LLC-PK1 Cell Apoptosis: Hua Liu and Radhakrishna Baliga; J Am Soc Nephrol 16: 1985-1992. [Abstract] [Full Text] [PDF]

Genetics and Development:

Novel Regulators of Kidney Development from the Tips of the Ureteric Bud: Kai M. Schmidt-Ott, Jun Yang, Xia Chen, Howard Wang, Neal Paragas, Kiyoshi Mori, Jau-Yi Li, Benson Lu, Frank Costantini, Mario Schiffer, Erwin Bottinger, and Jonathan Barasch; J Am Soc Nephrol 16: 1993-2002. [Abstract] [Full Text] [PDF] [Data Supplement]

Basic Immunology and Pathology:

CD40 Ligand Increases Complement C3 Secretion by Proximal Tubular Epithelial Cells: Giuseppe Castellano, Valentina Cappiello, Nicoletta Fiore, Paola Pontrelli, Loreto Gesualdo, F. Paolo Schena, and Vincenzo Montinaro; J Am Soc Nephrol 16: 2003-2011. [Abstract] [Full Text] [PDF]

Glomerular Expression of CD80 and CD86 Is Required for Leukocyte Accumulation and Injury in Crescentic Glomerulonephritis: Dragana Odobasic, A. Richard Kitching, Timothy J. Semple, Jennifer R. Timoshanko, Peter G. Tipping, and Stephen R. Holdsworth; J Am Soc Nephrol 16: 2012-2022. [Abstract] [Full Text] [PDF]

IL-12p40 and IL-18 in Crescentic Glomerulonephritis: IL-12p40 is the Key Th1-Defining Cytokine Chain, Whereas IL-18 Promotes Local Inflammation and Leukocyte Recruitment: A. Richard Kitching, Amanda L. Turner, Gabrielle R.A. Wilson, Timothy Semple, Dragana Odobasic, Jennifer R. Timoshanko, Kim M. O’Sullivan, Peter G. Tipping, Kiyoshi Takeda, Shizuo Akira, and Stephen R Holdsworth; J Am Soc Nephrol 16: 2023-2033. [Abstract] [Full Text] [PDF]

Protection against Renal Ischemia Reperfusion Injury by CD44 Disruption: Kasper M. A. Rouschop, Joris J.T.H. Roelofs, Nike Claessen, Paula da Costa Martins, Jaap-Jan Zwaginga, Steven T. Pals, Jan J. Weening, and Sandrine Florquin; J Am Soc Nephrol 16: 2034-2043. [Abstract] [Full Text] [PDF]

Pathophysiology of Renal Disease and Progression:

Involvement of Renal Progenitor Tubular Cells in Epithelial-to-Mesenchymal Transition in Fibrotic Rat Kidneys: Shin Yamashita, Akito Maeshima, and Yoshihisa Nojima; J Am Soc Nephrol 16: 2044-2051. [Abstract] [Full Text] [PDF]

Androgen Receptor Pathway in Rats with Autosomal Dominant Polycystic Kidney Disease: Shizuko Nagao, Masatomo Kusaka, Kazuhiro Nishii, Tohru Marunouchi, Hiroki Kurahashi, Hisahide Takahashi, and Jared Grantham; J Am Soc Nephrol 16: 2052-2062. [Abstract] [Full Text] [PDF]

Rapamycin Ameliorates Proteinuria-Associated Tubulointerstitial Inflammation and Fibrosis in Experimental Membranous Nephropathy: Ramon G.B. Bonegio, Robert Fuhro, Zhiyong Wang, C. Robert Valeri, Christopher Andry, David J. Salant, and Wilfred Lieberthal; J Am Soc Nephrol 16: 2063-2072. [Abstract] [Full Text] [PDF]

Enhanced Intrarenal Angiotensinogen Contributes to Early Renal Injury in Spontaneously Hypertensive Rats: Hiroyuki Kobori, Yuri Ozawa, Yuki Suzaki, and Akira Nishiyama; J Am Soc Nephrol 16: 2073-2080. [Abstract] [Full Text] [PDF]

Impaired Autofeedback Regulation of Hypothalamic Norepinephrine Release in Experimental Uremia: Katrin Klein, Markus Daschner, Marcel Vogel, Jun Oh, Thomas J. Feuerstein, and Franz Schaefer; J Am Soc Nephrol 16: 2081-2087. [Abstract] [Full Text] [PDF]

Disease of the Month:

IgA Nephropathy: Jonathan Barratt and John Feehally; J Am Soc Nephrol 16: 2088-2097. [Full Text] [PDF]

Living-Donor Kidney Transplantation: A Review of the Current Practices for the Live Donor: Connie L. Davis and Francis L. Delmonico; J Am Soc Nephrol 16: 2098-2110. [Abstract] [Full Text] [PDF]

Clinical Nephrology:

Subcutaneous Ghrelin Enhances Acute Food Intake in Malnourished Patients Who Receive Maintenance Peritoneal Dialysis: A Randomized, Placebo-Controlled Trial: Katie Wynne, Kalli Giannitsopoulou, Caroline J. Small, Michael Patterson, Gary Frost, Mohammad A. Ghatei, Edwina A. Brown, Stephen R. Bloom, and Peter Choi; J Am Soc Nephrol 16: 2111-2118. [Abstract] [Full Text] [PDF]

Additive Antiproteinuric Effect of Pentoxifylline in Patients with Type 2 Diabetes under Angiotensin II Receptor Blockade: A Short-Term, Randomized, Controlled Trial: Juan F. Navarro, Carmen Mora, Mercedes Muros, and Javier García; J Am Soc Nephrol 16: 2119-2126. [Abstract] [Full Text] [PDF]

Chronic Kidney Disease:

Chronic Kidney Disease and Cognitive Impairment in the Elderly: The Health, Aging, and Body Composition Study: Manjula Kurella, Glenn M. Chertow, Linda F. Fried, Steven R. Cummings, Tamara Harris, Eleanor Simonsick, Suzanne Satterfield, Hilsa Ayonayon, and Kristine Yaffe; J Am Soc Nephrol 16: 2127-2133. [Abstract] [Full Text] [PDF]

Metabolic Syndrome and the Risk for Chronic Kidney Disease among Nondiabetic Adults: Manjula Kurella, Joan C. Lo, and Glenn M. Chertow; J Am Soc Nephrol 16: 2134-2140. [Abstract] [Full Text] [PDF]

Human Genetics:

De Novo Uroplakin IIIa Heterozygous Mutations Cause Human Renal Adysplasia Leading to Severe Kidney Failure: Dagan Jenkins, Maria Bitner-Glindzicz, Sue Malcolm, Chih-Chi A. Hu, Jennifer Allison, Paul J.D. Winyard, Ambrose M. Gullett, David F.M. Thomas, Rachel A. Belk, Sally A. Feather, Tung-Tien Sun, and Adrian S. Woolf; J Am Soc Nephrol 16: 2141-2149. [Abstract] [Full Text] [PDF]

Mutations in Complement Factor I Predispose to Development of Atypical Hemolytic Uremic Syndrome: David Kavanagh, Elizabeth J. Kemp, Elizabeth Mayland, Robin J. Winney, Jeremy S. Duffield, Graham Warwick, Anna Richards, Roy Ward, Judith A Goodship, and Timothy H.J. Goodship; J Am Soc Nephrol 16: 2150-2155. [Abstract] [Full Text] [PDF]

Epidemiology and Outcomes:

Relationship between Albuminuria and Cardiovascular Disease in Type 2 Diabetes: Barry I. Freedman, Carl D. Langefeld, Kurt K. Lohman, Donald W. Bowden, J. Jeffrey Carr, Stephen S. Rich, and Lynne E. Wagenknecht; J Am Soc Nephrol 16: 2156-2161. [Abstract] [Full Text] [PDF]

Intradialytic Blood Volume Monitoring in Ambulatory Hemodialysis Patients: A Randomized Trial: Donal N. Reddan, Lynda Anne Szczech, Vic Hasselblad, Edmund G. Lowrie, Robert M. Lindsay, Jonathan Himmelfarb, Robert D. Toto, John Stivelman, James F. Winchester, Linda A. Zillman, Robert M. Califf, and William F. Owen, Jr; J Am Soc Nephrol 16: 2162-2169. [Abstract] [Full Text] [PDF]

Impact of Achieved Blood Pressure on Cardiovascular Outcomes in the Irbesartan Diabetic Nephropathy Trial: Tomas Berl, Lawrence G. Hunsicker, Julia B. Lewis, Marc A. Pfeffer, Jerome G. Porush, Jean-Lucien Rouleau, Paul L. Drury, Enric Esmatjes, Donald Hricik, Marc Pohl, Itamar Raz, Philippe Vanhille, Thomas B. Wiegmann, Bernard M. Wolfe, Francesco Locatelli, Samuel Z. Goldhaber, Edmund J. Lewis for the Collaborative Study Group; J Am Soc Nephrol 16: 2170-2179. [Abstract] [Full Text] [PDF]

Clinical Dialysis:

Double-Blind Comparison of Full and Partial Anemia Correction in Incident Hemodialysis Patients without Symptomatic Heart Disease: Patrick S. Parfrey, Robert N. Foley, Barbara H. Wittreich, Daniel J. Sullivan, Martin J. Zagari, Dieter Frei for the Canadian European Study; J Am Soc Nephrol 16: 2180-2189. [Abstract] [Full Text] [PDF]

Human Mineral Metabolism and Bone Disease:

Calcium-Sensing Receptor Expression and Parathyroid Hormone Secretion in Hyperplastic Parathyroid Glands from Humans: Sagrario Cañadillas, Antonio Canalejo, Rafael Santamaría, Maria E. Rodríguez, Jose C. Estepa, Alejandro Martín-Malo, Juan Bravo, Blanca Ramos, Escolastico Aguilera-Tejero, Mariano Rodríguez, and Yolanda Almadén; J Am Soc Nephrol 16: 2190-2197. [Abstract] [Full Text] [PDF]

Increased Osteoblastic Activity and Expression of Receptor Activator of NF- ${kappa}$ B Ligand in Nonuremic Nephrotic Syndrome: Michael Freundlich, Evelyn Alonzo, Ezequiel Bellorin-Font, and Jose R. Weisinger; J Am Soc Nephrol 16: 2198-2204. [Abstract] [Full Text] [PDF]

Fibroblast Growth Factor-23 Mitigates Hyperphosphatemia but Accentuates Calcitriol Deficiency in Chronic Kidney Disease: Orlando Gutierrez, Tamara Isakova, Eugene Rhee, Anand Shah, Julie Holmes, Gina Collerone, Harald Jüppner, and Myles Wolf; J Am Soc Nephrol 16: 2205-2215. [Abstract] [Full Text] [PDF]

Clinical Immunology and Pathology:

Membrane Proteinase 3 Expression in Patients with Wegener’s Granulomatosis and in Human Hematopoietic Stem Cell–Derived Neutrophils: Adrian Schreiber, Bjoern Otto, Xinsheng Ju, Martin Zenke, Ursula Goebel, Friedrich C. Luft, and Ralph Kettritz; J Am Soc Nephrol 16: 2216-2224. [Abstract] [Full Text] [PDF]

Clinical Transplantation:

Recurrence of Membranoproliferative Glomerulonephritis Type II in Renal Allografts: The North American Pediatric Renal Transplant Cooperative Study Experience: Michael C. Braun, Don M. Stablein, Lorraine A. Hamiwka, Lorraine Bell, Sharon M. Bartosh, and C. Frederic Strife; J Am Soc Nephrol 16: 2225-2233. [Abstract] [Full Text] [PDF]

Cyclosporine Withdrawal from a Mycophenolate Mofetil–Containing Immunosuppressive Regimen: Results of a Five-Year, Prospective, Randomized Study: Daniel Abramowicz, Maria del Carmen Rial, Stefan Vitko, Domingo del Castillo, Derek Manas, Mieczyslaw Lao, Nesrin Gafner, Peter Wijngaard on behalf of the Cyclosporine Withdrawal Study Group; J Am Soc Nephrol 16: 2234-2240. [Abstract] [Full Text] [PDF]

Announcements:

Announcements: J Am Soc Nephrol 16: 2241. [Full Text] [PDF]

ASN News:

ASN News: J Am Soc Nephrol 16: A22-A24. [Full Text] [PDF]