THIS MONTH'S HIGHLIGHTS:

This Month’s Highlights

J Am Soc Nephrol 16: 2243-2244. [Full Text] [PDF]  

Nephrology beyond JASN:

Anorexia and Cachexia in Renal Failure—Is Leptin the Culprit?: Role of Leptin and Melanocortin Signaling in Uremia-Associated Cachexia. J Clin Invest 115: 1659–1665, 2005

Cheung W, Yu PX, Little BM, Cone RD, Marks DL, Mak RH, Ibsen H, Olsen MH, Wachtell K, Borch-Johnsen K, Lindholm LH, Mogensen CE, Dahlöf B, Devereux RB, de Faire U, Fyhrquist F, Julius S, Kjeldsen SE, Lederballe-Pedersen O, Nieminen MS, Omvik P, Oparil S, and Wan Y

J Am Soc Nephrol 16: 2245-2250. [Full Text] [PDF]  

Editorials:

Angiotensin-Converting Enzyme Inhibition in Diabetic Nephropathy: It’s All the RAGE

Raymond Harris

J Am Soc Nephrol 16: 2251-2253. [Full Text] [PDF]  

Asymmetric Dimethylarginine and Kidney Disease—Marker or Mediator?

Patrick Vallance and James Leiper

J Am Soc Nephrol 16: 2254-2256. [Full Text] [PDF]  

Fast track:

Permanent Genetic Tagging of Podocytes: Fate of Injured Podocytes in a Mouse Model of Glomerular Sclerosis

Takako Asano, Fumio Niimura, Ira Pastan, Agnes B. Fogo, Iekuni Ichikawa, and Taiji Matsusaka

J Am Soc Nephrol 16: 2257-2262. [Abstract] [Full Text] [PDF]  

Special Feature:

American Society of Pediatric Nephrology Position Paper on Linking Reimbursement to Quality of Care

Sharon P. Andreoli, Eileen D. Brewer, Sandra Watkins, Barbara Fivush, Neil Powe, Jennifer Shevchek, and John Foreman

J Am Soc Nephrol 16: 2263-2269. [Full Text] [PDF]  

Cell and Transport Physiology:

Functional Analysis of NBC1 Mutants Associated with Proximal Renal Tubular Acidosis and Ocular Abnormalities

Shoko Horita, Hideomi Yamada, Jun Inatomi, Nobuo Moriyama, Takashi Sekine, Takashi Igarashi, Yoko Endo, Majed Dasouki, Mesiha Ekim, Lihadh Al-Gazali, Mitsunobu Shimadzu, George Seki, and Toshiro Fujita

J Am Soc Nephrol 16: 2270-2278. [Abstract] [Full Text] [PDF]  

Aldosterone-Induced Serum and Glucocorticoid-Induced Kinase 1 Expression Is Accompanied by Nedd4-2 Phosphorylation and Increased Na⁺ Transport in Cortical Collecting Duct Cells

Sandra Y. Flores, Dominique Loffing-Cueni, Elena Kamynina, Dorothée Daidié, Carole Gerbex, Sting Chabanel, Jean Dudler, Johannes Loffing, and Olivier Staub

J Am Soc Nephrol 16: 2279-2287. [Abstract] [Full Text] [PDF]  

Roles of Insulin Receptor Substrates in Insulin-Induced Stimulation of Renal Proximal Bicarbonate Absorption

Yanan Zheng, Hideomi Yamada, Ken Sakamoto, Shoko Horita, Motoei Kunimi, Yoko Endo, Yuehong Li, Kazuyuki Tobe, Yasuo Terauchi, Takashi Kadowaki, George Seki, and Toshiro Fujita

J Am Soc Nephrol 16: 2288-2295. [Abstract] [Full Text] [PDF]  

Cell Biology:

Aldosterone Stimulates Proliferation of Mesangial Cells by Activating Mitogen-Activated Protein Kinase 1/2, Cyclin D1, and Cyclin A

Yoshio Terada, Takahiko Kobayashi, Hitoshi Kuwana, Hiroyuki Tanaka, Seiji Inoshita, Michio Kuwahara, and Sei Sasaki

J Am Soc Nephrol 16: 2296-2305. [Abstract] [Full Text] [PDF]  

Tubular Expression of Angiotensin II Receptors and Their Regulation in IgA Nephropathy

Loretta Y.Y. Chan, Joseph C.K. Leung, Sydney C.W. Tang, Cindy B.Y. Choy, and Kar Neng Lai

J Am Soc Nephrol 16: 2306-2317. [Abstract] [Full Text] [PDF]  

Effect of Nitric Oxide-cGMP-Dependent Protein Kinase Activation on Advanced Glycation End-Product–Induced Proliferation in Renal Fibroblasts

Jau-Shyang Huang, Lea-Yea Chuang, Jinn-Yuh Guh, Chorng-Jia Chen, Yu-Lin Yang, Tai-An Chiang, Min-Yuan Hung, and Tung-Nan Liao

J Am Soc Nephrol 16: 2318-2329. [Abstract] [Full Text] [PDF]  

Contribution of Cubilin and Amnionless to Processing and Membrane Targeting of Cubilin–Amnionless Complex

Gwénaëlle Coudroy, Jakub Gburek, Renata Kozyraki, Mette Madsen, Germain Trugnan, Søren K. Moestrup, Pierre J. Verroust, and Michèle Maurice

J Am Soc Nephrol 16: 2330-2337. [Abstract] [Full Text] [PDF]  

Basic Mineral Metabolism:

Intraperitoneal Administration of Recombinant Receptor-Associated Protein Causes Phosphaturia via an Alteration in Subcellular Distribution of the Renal Sodium Phosphate Co-Transporter

Masayo Yamagata, Keiichi Ozono, Yuta Hashimoto, Yoshiteru Miyauchi, Hiroki Kondou, and Toshimi Michigami

J Am Soc Nephrol 16: 2338-2345. [Abstract] [Full Text] [PDF]  

Hemodynamics and Vascular Regulation:

N-Acetylcysteine Decreases Angiotensin II Receptor Binding in Vascular Smooth Muscle Cells

Michael E. Ullian, Andrew K. Gelasco, Wayne R. Fitzgibbon, C. Nicole Beck, and Thomas A. Morinelli

J Am Soc Nephrol 16: 2346-2353. [Abstract] [Full Text] [PDF]  

Dominant Role of Prostaglandin E₂ EP4 Receptor in Furosemide-Induced Salt-Losing Tubulopathy: A Model for Hyperprostaglandin E Syndrome/Antenatal Bartter Syndrome

Rolf M. Nüsing, Antje Treude, Christian Weissenberger, Boye Jensen, Martin Bek, Charlotte Wagner, Shuh Narumiya, and Hannsjörg W. Seyberth

J Am Soc Nephrol 16: 2354-2362. [Abstract] [Full Text] [PDF]  

Pathophysiology of Renal Disease and Progression:

Modulation of Soluble Receptor for Advanced Glycation End Products by Angiotensin-Converting Enzyme-1 Inhibition in Diabetic Nephropathy

Josephine M. Forbes, Suzanne R. Thorpe, Vicki Thallas-Bonke, Josefa Pete, Merlin C. Thomas, Elizabeth R. Deemer, Sahar Bassal, Assam El-Osta, David M. Long, Sianna Panagiotopoulos, George Jerums, Tanya M. Osicka, and Mark E. Cooper

J Am Soc Nephrol 16: 2363-2372. [Abstract] [Full Text] [PDF]  

Wnt-Dependent -Catenin Signaling Is Activated after Unilateral Ureteral Obstruction, and Recombinant Secreted Frizzled-Related Protein 4 Alters the Progression of Renal Fibrosis

Kameswaran Surendran, Susan Schiavi, and Keith A. Hruska

J Am Soc Nephrol 16: 2373-2384. [Abstract] [Full Text] [PDF]  

Calorie Restriction Modulates Renal Expression of Sterol Regulatory Element Binding Proteins, Lipid Accumulation, and Age-Related Renal Disease

Tao Jiang, Scott E. Liebman, M. Scott Lucia, Carrie L. Phillips, and Moshe Levi

J Am Soc Nephrol 16: 2385-2394. [Abstract] [Full Text] [PDF]  

Peroxisome Proliferator-Activated Receptor / Exerts a Strong Protection from Ischemic Acute Renal Failure

Emmanuel Letavernier, Joëlle Perez, Elisabeth Joye, Agnès Bellocq, Bruno Fouqueray, Jean-Philippe Haymann, Didier Heudes, Walter Wahli, Béatrice Desvergne, and Laurent Baud

J Am Soc Nephrol 16: 2395-2402. [Abstract] [Full Text] [PDF]  

NF-B Regulates Fas-Mediated Apoptosis in HIV-Associated Nephropathy

Michael J. Ross, Scott Martinka, Vivette D. D’Agati, and Leslie A. Bruggeman

J Am Soc Nephrol 16: 2403-2411. [Abstract] [Full Text] [PDF]  

Disease of the Month:

Highly Active Antiretroviral Therapy and the Epidemic of HIV+ End-Stage Renal Disease

Elissa J. Schwartz, Lynda A. Szczech, Michael J. Ross, Mary E. Klotman, Jonathan A. Winston, and Paul E. Klotman

J Am Soc Nephrol 16: 2412-2420. [Abstract] [Full Text] [PDF]  

Protein-Leaking Membranes for Hemodialysis: A New Class of Membranes in Search of an Application?

Richard A. Ward

J Am Soc Nephrol 16: 2421-2430. [Abstract] [Full Text] [PDF]  

Clinical Nephrology:

Primed Peripheral Polymorphonuclear Leukocyte: A Culprit Underlying Chronic Low-Grade Inflammation and Systemic Oxidative Stress in Chronic Kidney Disease

Shifra Sela, Revital Shurtz-Swirski, Meital Cohen-Mazor, Rafi Mazor, Judith Chezar, Galina Shapiro, Kamal Hassan, Galina Shkolnik, Ronit Geron, and Batya Kristal

J Am Soc Nephrol 16: 2431-2438. [Abstract] [Full Text] [PDF]  

Chronic Kidney Disease:

Low Rates of Testing and Diagnostic Codes Usage in a Commercial Clinical Laboratory: Evidence for Lack of Physician Awareness of Chronic Kidney Disease

Lesley A. Stevens, George Fares, James Fleming, David Martin, Kalyani Murthy, Jiejing Qiu, Paul C. Stark, Katrin Uhlig, Frederick Van Lente, and Andrew S. Levey

J Am Soc Nephrol 16: 2439-2448. [Abstract] [Full Text] [PDF]  

Epidemiology and Outcomes:

Asymmetrical Dimethylarginine Predicts Progression to Dialysis and Death in Patients with Chronic Kidney Disease: A Competing Risks Modeling Approach

Pietro Ravani, Giovanni Tripepi, Fabio Malberti, Sophie Testa, Francesca Mallamaci, and Carmine Zoccali

J Am Soc Nephrol 16: 2449-2455. [Abstract] [Full Text] [PDF]  

Asymmetric Dimethylarginine and Progression of Chronic Kidney Disease: The Mild to Moderate Kidney Disease Study

Danilo Fliser, Florian Kronenberg, Jan T. Kielstein, Christian Morath, Stefanie M. Bode-Böger, Hermann Haller, and Eberhard Ritz

J Am Soc Nephrol 16: 2456-2461. [Abstract] [Full Text] [PDF]  

Effects of Fish Oil Supplementation on Kidney Transplantation: A Systematic Review and Meta-Analysis of Randomized, Controlled Trials

Athina Tatsioni, Mei Chung, Yannan Sun, Bruce Kupelnick, Alice H. Lichtenstein, Ronald Perrone, Priscilla Chew, Joseph Lau, and Peter A. Bonis

J Am Soc Nephrol 16: 2462-2470. [Abstract] [Full Text] [PDF]  

Birth Weight and Creatinine Clearance in Young Adult Twins: Influence of Genetic, Prenatal, and Maternal Factors

Marij Gielen, Sara-Joan Pinto-Sietsma, Maurice P. Zeegers, Ruth J. Loos, Robert Fagard, Peter W. de Leeuw, Gaston Beunen, Catherine Derom, and Robert Vlietinck

J Am Soc Nephrol 16: 2471-2476. [Abstract] [Full Text] [PDF]  

Clinical Dialysis:

Coagulation Cascade Activation Causes CC Chemokine Receptor-2 Gene Expression and Mononuclear Cell Activation in Hemodialysis Patients

Giovanni Pertosa, Simona Simone, Michela Soccio, Daniela Marrone, Loreto Gesualdo, Francesco Paolo Schena, and Giuseppe Grandaliano

J Am Soc Nephrol 16: 2477-2486. [Abstract] [Full Text] [PDF]  

Prevalence, Severity, and Importance of Physical and Emotional Symptoms in Chronic Hemodialysis Patients

Steven D. Weisbord, Linda F. Fried, Robert M. Arnold, Michael J. Fine, David J. Levenson, Rolf A. Peterson, and Galen E. Switzer

J Am Soc Nephrol 16: 2487-2494. [Abstract] [Full Text] [PDF]  

Human Mineral Metabolism and Bone Disease:

Reduced Plasma Pyrophosphate Levels in Hemodialysis Patients

Koba A. Lomashvili, Wassim Khawandi, and W. Charles O’Neill

J Am Soc Nephrol 16: 2495-2500. [Abstract] [Full Text] [PDF]  

Sevelamer Controls Parathyroid Hormone–Induced Bone Disease as Efficiently as Calcium Carbonate without Increasing Serum Calcium Levels during Therapy with Active Vitamin D Sterols

Isidro B. Salusky, William G. Goodman, Shobha Sahney, Barbara Gales, Ashley Perilloux, He-Jing Wang, Robert M. Elashoff, and Harald Jüppner

J Am Soc Nephrol 16: 2501-2508. [Abstract] [Full Text] [PDF]  

Clinical Transplantation:

Predictive Factors of Acute Rejection after Early Cyclosporine Withdrawal in Renal Transplant Recipients Who Receive Mycophenolate Mofetil: Results from a Prospective, Randomized Trial

Marc Hazzan, Myriam Labalette, Marie Christine Copin, François Glowacki, François Provôt, François-René Pruv, and Christian Noël

J Am Soc Nephrol 16: 2509-2516. [Abstract] [Full Text] [PDF]  

Announcements:

Announcements

J Am Soc Nephrol 16: 2517. [Full Text] [PDF]  

Errata:

Errata

J Am Soc Nephrol 16: 2518. [Full Text] [PDF]  

ASN News:

ASN News

J Am Soc Nephrol 16: A17-A193. [Full Text] [PDF]  

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