This Month's Highlights:

This Month’s Highlights

J Am Soc Nephrol 17: 2635-2636. [Full Text] [PDF]  

Nephrology beyond JASN:

Angiotensin-Converting Enzyme-2 (ACE2)—A New Player in the Genesis of Glomerular Injury?: Loss of Angiotensin-Converting Enzyme-2 Leads to the Late Development of Angiotensin II–Dependent Glomerulosclerosis. Am J Pathol 168: 1808–1820, 2006

G.Y. Oudit, A.M. Herzenberg, Z. Kassiri, D. Wong, H. Reich, R. Khokha, M.A. Crackower, P.H. Backx, J.M. Penninger, J.W. Scholey, M.J. Percy, Flores A. Zhao Q., C. Harrison, T.R. Lappin, P.H. Maxwell, M.F. McMullin, and F.S. Lee

J Am Soc Nephrol 17: 2637-2643. [Full Text] [PDF]  

Editorials:

Immunosuppression and Regulation: Cast in New Light?

David M. Rothstein

J Am Soc Nephrol 17: 2644-2646. [Full Text] [PDF]  

Renal Hypoplasia and Dysplasia: Starting to Put the Puzzle Together

Adrian S. Woolf

J Am Soc Nephrol 17: 2647-2649. [Full Text] [PDF]  

The Downside of a Drug-Crazed World

Eric G. Neilson

J Am Soc Nephrol 17: 2650-2651. [Full Text] [PDF]  

Reviews:

How Can We Measure Immunologic Tolerance in Humans?

Nader Najafian, Monica J. Albin, and Kenneth A. Newell

J Am Soc Nephrol 17: 2652-2663. [Abstract] [Full Text] [PDF]  

Fast Track:

Endothelial Nitric Oxide Synthase Deficiency Produces Accelerated Nephropathy in Diabetic Mice

Hui John Zhao, Suwan Wang, Huifang Cheng, Ming-zhi Zhang, Takamune Takahashi, Agnes B. Fogo, Matthew D. Breyer, and Raymond C. Harris

J Am Soc Nephrol 17: 2664-2669. [Abstract] [Full Text] [PDF]  

Cell and Transport Physiology:

Expression of the Ammonia Transporter, Rh C Glycoprotein, in Normal and Neoplastic Human Kidney

Ki-Hwan Han, Byron P. Croker, William L. Clapp, Dietrich Werner, Manisha Sahni, Jin Kim, Hye-Young Kim, Mary E. Handlogten, and I. David Weiner

J Am Soc Nephrol 17: 2670-2679. [Abstract] [Full Text] [PDF]  

Vasopressin Increases Plasma Membrane Accumulation of Urea Transporter UT-A1 in Rat Inner Medullary Collecting Ducts

Janet D. Klein, Otto Fröhlich, Mitsi A. Blount, Christopher F. Martin, Tekla D. Smith, and Jeff M. Sands

J Am Soc Nephrol 17: 2680-2686. [Abstract] [Full Text] [PDF]  

Mitogen-Activated Protein Kinases Inhibit the ROMK (Kir 1.1)-Like Small Conductance K Channels in the Cortical Collecting Duct

Elisa Babilonia, Dimin Li, Zhijian Wang, Peng Sun, Dao-Hong Lin, Yan Jin, and Wen-Hui Wang

J Am Soc Nephrol 17: 2687-2696. [Abstract] [Full Text] [PDF]  

Cell Biology:

A Non-Nephrotoxic Gentamicin Congener That Retains Antimicrobial Efficacy

Ruben M. Sandoval, James P. Reilly, William Running, Silvia B. Campos, Joseph R. Santos, Carrie L. Phillips, and Bruce A. Molitoris

J Am Soc Nephrol 17: 2697-2705. [Abstract] [Full Text] [PDF]  

Genetics and Development:

Polycystin-2 Immunolocalization and Function in Zebrafish

Tomoko Obara, Steven Mangos, Yan Liu, Jinhua Zhao, Stephanie Wiessner, Albrecht G. Kramer-Zucker, Felix Olale, Alexander F. Schier, and Iain A. Drummond

J Am Soc Nephrol 17: 2706-2718. [Abstract] [Full Text] [PDF]  

A Truncated Polycystin-2 Protein Causes Polycystic Kidney Disease and Retinal Degeneration in Transgenic Rats

Anna Rachel Gallagher, Sigrid Hoffmann, Nelson Brown, Anna Cedzich, Sujatha Meruvu, Dirk Podlich, Yuxi Feng, Vera Könecke, Uwe de Vries, Hans-Peter Hammes, Norbert Gretz, and Ralph Witzgall

J Am Soc Nephrol 17: 2719-2730. [Abstract] [Full Text] [PDF] [Data Supplements]  

Chronic Kidney Disease:

CD4⁺CD25⁺ Regulatory T Cells Protect against Injury in an Innate Murine Model of Chronic Kidney Disease

Deepika Mahajan, Yiping Wang, Xiahong Qin, Ying Wang, Guoping Zheng, Yuan Min Wang, Stephen I. Alexander, and David C.H. Harris

J Am Soc Nephrol 17: 2731-2741. [Abstract] [Full Text] [PDF]  

Baseline Predictors of Renal Disease Progression in the African American Study of Hypertension and Kidney Disease

Keith C. Norris, Tom Greene, Joel Kopple, Janice Lea, Julia Lewis, Mike Lipkowitz, Pete Miller, Annie Richardson, Stephen Rostand, Xuelei Wang, Lawrence J. Appel for the AASK Study Group

J Am Soc Nephrol 17: 2928-2936. [Abstract] [Full Text] [PDF]  

Modified Glomerular Filtration Rate Estimating Equation for Chinese Patients with Chronic Kidney Disease

Ying-Chun Ma, Li Zuo, Jiang-Hua Chen, Qiong Luo, Xue-Qing Yu, Ying Li, Jin-Sheng Xu, Song-Min Huang, Li-Ning Wang, Wen Huang, Mei Wang, Guo-Bin Xu, Hai-Yan Wang on behalf of the Chinese eGFR Investigation Collaboration

J Am Soc Nephrol 17: 2937-2944. [Abstract] [Full Text] [PDF]  

Hemodynamics and Vascular Regulation:

Maximizing the Renal Cyclic 3'-5'-Guanosine Monophosphate System with Type V Phosphodiesterase Inhibition and Exogenous Natriuretic Peptide: A Novel Strategy to Improve Renal Function in Experimental Overt Heart Failure

Horng H. Chen, Brenda K. Huntley, John A. Schirger, Alessandro Cataliotti, and John C. Burnett, Jr

J Am Soc Nephrol 17: 2742-2747. [Abstract] [Full Text] [PDF]  

Basic Immunology and Pathology:

Synaptic Vesicle Protein 2B Is Expressed in Podocyte, and Its Expression Is Altered in Proteinuric Glomeruli

Naoko Miyauchi, Akira Saito, Tamaki Karasawa, Yutaka Harita, Koichi Suzuki, Hiroko Koike, Gi Dong Han, Fujio Shimizu, and Hiroshi Kawachi

J Am Soc Nephrol 17: 2748-2759. [Abstract] [Full Text] [PDF]  

Renal Effects of Coxsackie B4 Virus in Hyper-IgA Mice

Yukihiko Kawasaki, Hosoya Mitsuaki, Masato Isome, Ruriko Nozawa, and Hitoshi Suzuki

J Am Soc Nephrol 17: 2760-2769. [Abstract] [Full Text] [PDF]  

Pathophysiology of Renal Disease and Progression:

Parietal Podocytes in Normal Human Glomeruli

Jean Bariety, Chantal Mandet, Gary S. Hill, and Patrick Bruneval

J Am Soc Nephrol 17: 2770-2780. [Abstract] [Full Text] [PDF]  

Downregulation of SnoN Expression in Obstructive Nephropathy Is Mediated by an Enhanced Ubiquitin-Dependent Degradation

Ruoyun Tan, Jinglan Zhang, Xiaoyue Tan, Xianghong Zhang, Junwei Yang, and Youhua Liu

J Am Soc Nephrol 17: 2781-2791. [Abstract] [Full Text] [PDF]  

Leptospiral Outer Membrane Protein Induces Extracellular Matrix Accumulation through a TGF-1/Smad-Dependent Pathway

Ya-Chung Tian, Yung-Chang Chen, Cheng-Chieh Hung, Chiz-Tzung Chang, Mai-Szu Wu, Aled O. Phillips, and Chih-Wei Yang

J Am Soc Nephrol 17: 2792-2798. [Abstract] [Full Text] [PDF] [Data Supplement]  

Blockade of p38 Mitogen-Activated Protein Kinase and TGF-1/Smad Signaling Pathways Rescues Bone Marrow–Derived Peritubular Capillary Endothelial Cells in Adriamycin-Induced Nephrosis

Jinhua Li, James A. Deane, Naomi V. Campanale, John F. Bertram, and Sharon D. Ricardo

J Am Soc Nephrol 17: 2799-2811. [Abstract] [Full Text] [PDF] [Data Supplements]  

Wnt/-Catenin Signaling Modulates Survival of High Glucose–Stressed Mesangial Cells

Chun-Liang Lin, Jeng-Yi Wang, Yu-Ting Huang, Yu-Hsia Kuo, Kameswaran Surendran, and Feng-Sheng Wang

J Am Soc Nephrol 17: 2812-2820. [Abstract] [Full Text] [PDF]  

Development of Polycystic Kidney Disease in Juvenile Cystic Kidney Mice: Insights into Pathogenesis, Ciliary Abnormalities, and Common Features with Human Disease

Laurie A. Smith, Nikolay O. Bukanov, Hervé Husson, Ryan J. Russo, Tiffany C. Barry, Ava L. Taylor, David R. Beier, and Oxana Ibraghimov-Beskrovnaya

J Am Soc Nephrol 17: 2821-2831. [Abstract] [Full Text] [PDF] [Data Supplements]  

HIV-1 Genes vpr and nef Synergistically Damage Podocytes, Leading to Glomerulosclerosis

Yiqin Zuo, Taiji Matsusaka, Jianyong Zhong, Ji Ma, Li-jun Ma, Zaher Hanna, Paul Jolicoeur, Agnes B. Fogo, and Iekuni Ichikawa

J Am Soc Nephrol 17: 2832-2843. [Abstract] [Full Text] [PDF]  

Basic Transplantation:

A Novel Mechanism of Action for Anti-Thymocyte Globulin: Induction of CD4⁺CD25⁺Foxp3⁺ Regulatory T Cells

Marta Lopez, Michael R. Clarkson, Monica Albin, Mohamed H. Sayegh, and Nader Najafian

J Am Soc Nephrol 17: 2844-2853. [Abstract] [Full Text] [PDF]  

Disease of the Month:

Collapsing Glomerulopathy

Mamdouh Albaqumi, Timothy J. Soos, Laura Barisoni, and Peter J. Nelson

J Am Soc Nephrol 17: 2854-2863. [Abstract] [Full Text] [PDF]  

Human Genetics:

Prevalence of Mutations in Renal Developmental Genes in Children with Renal Hypodysplasia: Results of the ESCAPE Study

Stefanie Weber, Vincent Moriniere, Tanja Knüppel, Marina Charbit, Jirí Dusek, Gian Marco Ghiggeri, Augustina Jankauskiené, Sevgi Mir, Giovanni Montini, Amira Peco-Antic, Elke Wühl, Aleksandra M. Zurowska, Otto Mehls, Corinne Antignac, Franz Schaefer, and Remi Salomon

J Am Soc Nephrol 17: 2864-2870. [Abstract] [Full Text] [PDF]  

Epidemiology and Outcomes:

Associations of Increases in Serum Creatinine with Mortality and Length of Hospital Stay after Coronary Angiography

Steven D. Weisbord, Huanyu Chen, Roslyn A. Stone, Kevin E. Kip, Michael J. Fine, Melissa I. Saul, and Paul M. Palevsky

J Am Soc Nephrol 17: 2871-2877. [Abstract] [Full Text] [PDF]  

Association of Mortality and Hospitalization with Achievement of Adult Hemoglobin Targets in Adolescents Maintained on Hemodialysis

Sandra Amaral, Wenke Hwang, Barbara Fivush, Alicia Neu, Diane Frankenfield, and Susan Furth

J Am Soc Nephrol 17: 2878-2885. [Abstract] [Full Text] [PDF]  

Increase in Creatinine and Cardiovascular Risk in Patients with Systolic Dysfunction after Myocardial Infarction

Powell Jose, Hicham Skali, Nagesh Anavekar, Charles Tomson, Harlan M. Krumholz, Jean L. Rouleau, Lemuel Moye, Marc A. Pfeffer, Scott D. Solomon for the SAVE Investigators

J Am Soc Nephrol 17: 2886-2891. [Abstract] [Full Text] [PDF]  

Risks for End-Stage Renal Disease, Cardiovascular Events, and Death in Hispanic versus Non-Hispanic White Adults with Chronic Kidney Disease

Carmen A. Peralta, Michael G. Shlipak, Dongjie Fan, Juan Ordoñez, James P. Lash, Glenn M. Chertow, and Alan S. Go

J Am Soc Nephrol 17: 2892-2899. [Abstract] [Full Text] [PDF]  

Validation of Creatinine-Based Estimates of GFR When Evaluating Risk Factors in Longitudinal Studies of Kidney Disease

Xuelei Wang, Julia Lewis, Lawrence Appel, DeAnna Cheek, Gabriel Contreras, Marquetta Faulkner, Harold Feldman, Jennifer Gassman, Janice Lea, Joel Kopple, Mohammed Sika, Robert Toto, Tom Greene for the AASK Investigators

J Am Soc Nephrol 17: 2900-2909. [Abstract] [Full Text] [PDF]  

Revisiting Survival Differences by Race and Ethnicity among Hemodialysis Patients: The Dialysis Outcomes and Practice Patterns Study

Bruce M. Robinson, Marshall M. Joffe, Ronald L. Pisoni, Friedrich K. Port, and Harold I. Feldman

J Am Soc Nephrol 17: 2910-2918. [Abstract] [Full Text] [PDF]  

Clinical Immunology and Pathology:

Involvement of Drug-Specific T Cells in Acute Drug-Induced Interstitial Nephritis

Zoi Spanou, Monika Keller, Markus Britschgi, Nikhil Yawalkar, Thomas Fehr, Jörg Neuweiler, Mathias Gugger, Markus Mohaupt, and Werner J. Pichler

J Am Soc Nephrol 17: 2919-2927. [Abstract] [Full Text] [PDF] [Data Supplements]  

Announcements:

Announcements

J Am Soc Nephrol 17: 2945. [Full Text] [PDF]  

ASN News:

ASN News

J Am Soc Nephrol 17: A20-A22. [Full Text] [PDF]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.