JASN -- Table of Contents (17 [7])

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This Month's Highlights:

This Month’s Highlights: J Am Soc Nephrol 17: 1757-1758. [Full Text] [PDF]

Nephrology beyond JASN:

Losartan in Marfan Syndrome—Beyond Blood Pressure Lowering: Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome. Science 312: 117–121, 2006: J.P. Habashi, D.P. Judge, T.M. Holm, R.D Cohn, B. Loeys, T.K. Cooper, L. Myers, E.C. Klein, G. Liu, C. Calvi, M. Podowski, E.R. Neptune, M.K. Halushka, D. Bedja, K. Gabrielson, D.B. Rifkin, L. Carta, F. Ramirez, D.L. Huso, H.C. Dietz, J.T. Bridgham, S.M. Carroll, and J.W. Thornton; J Am Soc Nephrol 17: 1759-1764. [Full Text] [PDF]

Special Tribute:

In Memoriam Norman J. Siegel, MD 1943–2006: William G. Couser and Allison A. Eddy; J Am Soc Nephrol 17: 1765-1766. [Full Text] [PDF]

Editorials:

Uric Acid: An Old Dog with New Tricks?: Paul W. Sanders; J Am Soc Nephrol 17: 1767-1768. [Full Text] [PDF]

Toll-Like Receptors: The Interface between Innate and Adaptive Immunity: Peter G. Tipping; J Am Soc Nephrol 17: 1769-1771. [Full Text] [PDF]

Molecular Dissection of Target Antigens and Nephritogenic Antibodies in Membranous Nephropathy: Towards Epitope-Driven Therapies: Pierre Ronco and Hanna Debiec; J Am Soc Nephrol 17: 1772-1774. [Full Text] [PDF]

Atypical HUS and Complement Dysregulation: Timothy H.J. Goodship; J Am Soc Nephrol 17: 1775-1776. [Full Text] [PDF]

Special Features:

Why Kidneys Fail: Report from an American Society of Nephrology Advances in Research Conference: H. William Schnaper and Jeffrey B. Kopp; J Am Soc Nephrol 17: 1777-1781. [Abstract] [Full Text] [PDF]

Genetics of Kidneys in Diabetes (GoKinD) Study: A Genetics Collection Available for Identifying Genetic Susceptibility Factors for Diabetic Nephropathy in Type 1 Diabetes: Patricia W. Mueller, John J. Rogus, Patricia A. Cleary, Yuan Zhao, Adam M. Smiles, Michael W. Steffes, Jean Bucksa, Therese B. Gibson, Suzanne K. Cordovado, Andrzej S. Krolewski, Concepcion R. Nierras, and James H. Warram; J Am Soc Nephrol 17: 1782-1790. [Abstract] [Full Text] [PDF] [Data Supplements]

Fast Track:

Human Vascular Smooth Muscle Cells Express a Urate Transporter: Karen L. Price, Yuri Y. Sautin, David A. Long, Li Zhang, Hiroki Miyazaki, Wei Mu, Hitoshi Endou, and Richard J. Johnson; J Am Soc Nephrol 17: 1791-1795. [Abstract] [Full Text] [PDF]

An Ancestral Haplotype Defines Susceptibility to Doxorubicin Nephropathy in the Laboratory Mouse: Zongyu Zheng, Paul Pavlidis, Streamson Chua, Vivette D. D’Agati, and Ali G. Gharavi; J Am Soc Nephrol 17: 1796-1800. [Abstract] [Full Text] [PDF]

Formation of Primary Cilia in the Renal Epithelium Is Regulated by the von Hippel-Lindau Tumor Suppressor Protein: Miguel A. Esteban, Sarah K. Harten, Maxine G. Tran, and Patrick H. Maxwell; J Am Soc Nephrol 17: 1801-1806. [Abstract] [Full Text] [PDF]

Reviews:

Protein Degradation by the Ubiquitin–Proteasome Pathway in Normal and Disease States: Stewart H. Lecker, Alfred L. Goldberg, and William E. Mitch; J Am Soc Nephrol 17: 1807-1819. [Full Text] [PDF]

Body Water Homeostasis: Clinical Disorders of Urinary Dilution and Concentration: Robert W. Schrier; J Am Soc Nephrol 17: 1820-1832. [Full Text] [PDF]

Cell and Transport Physiology:

Phosphorylation of S⁹⁵⁵ at the Protein Kinase A Consensus Promotes Maturation of the ${alpha}$ Subunit of the Colonic H⁺,K⁺-ATPase: Juan Codina, Jingfang Liu, Anthony J. Bleyer, Raymond B. Penn, and Thomas D. DuBose, Jr.; J Am Soc Nephrol 17: 1833-1840. [Abstract] [Full Text] [PDF]

Intraluminal ATP Concentrations in Rat Renal Tubules: Renu M. Vekaria, Robert J. Unwin, and David G. Shirley; J Am Soc Nephrol 17: 1841-1847. [Abstract] [Full Text] [PDF]

Low Doses of Ouabain Protect from Serum Deprivation–Triggered Apoptosis and Stimulate Kidney Cell Proliferation via Activation of NF- ${kappa}$ B: Juan Li, Sergey Zelenin, Anita Aperia, and Oleg Aizman; J Am Soc Nephrol 17: 1848-1857. [Abstract] [Full Text] [PDF] [Data Supplement][Ouabain rescues from renal apoptosis via activation of NF-kappaB]

Vacuolar H⁺-ATPase B1 Subunit Mutations that Cause Inherited Distal Renal Tubular Acidosis Affect Proton Pump Assembly and Trafficking in Inner Medullary Collecting Duct Cells: Qiongqiong Yang, Guangmu Li, Satish K. Singh, Edward A. Alexander, and John H. Schwartz; J Am Soc Nephrol 17: 1858-1866. [Abstract] [Full Text] [PDF]

WNK1 Affects Surface Expression of the ROMK Potassium Channel Independent of WNK4: Georgina Cope, Meena Murthy, Amir P. Golbang, Abbas Hamad, Che-Hsiung Liu, Alan W. Cuthbert, and Kevin M. O’Shaughnessy; J Am Soc Nephrol 17: 1867-1874. [Abstract] [Full Text] [PDF]

Cell Biology:

Cytoprotective Effects of Hypoxia against Cisplatin-Induced Tubular Cell Apoptosis: Involvement of Mitochondrial Inhibition and p53 Suppression: Jinzhao Wang, Mangatt P. Biju, Mong-Heng Wang, Volker H. Haase, and Zheng Dong; J Am Soc Nephrol 17: 1875-1885. [Abstract] [Full Text] [PDF]

Angiotensin Type 1 Receptor Blocker Restores Podocyte Potential to Promote Glomerular Endothelial Cell Growth: Xiu-Bin Liang, Li-Jun Ma, Takashi Naito, Yihan Wang, Michael Madaio, Roy Zent, Ambra Pozzi, and Agnes B. Fogo; J Am Soc Nephrol 17: 1886-1895. [Abstract] [Full Text] [PDF]

Genetics and Development:

Kidney Side Population Reveals Multilineage Potential and Renal Functional Capacity but also Cellular Heterogeneity: Grant A. Challen, Ivan Bertoncello, James A. Deane, Sharon D. Ricardo, and Melissa H. Little; J Am Soc Nephrol 17: 1896-1912. [Abstract] [Full Text] [PDF] [Data Supplement]

A Hypomorphic Mutation in the Mouse Laminin ${alpha}$ 5 Gene Causes Polycystic Kidney Disease: M. Brendan Shannon, Bruce L. Patton, Scott J. Harvey, and Jeffrey H. Miner; J Am Soc Nephrol 17: 1913-1922. [Abstract] [Full Text] [PDF]

Basic Mineral Metabolism:

Parathyroid Hormone 7-84 Induces Hypocalcemia and Inhibits the Parathyroid Hormone 1-84 Secretory Response to Hypocalcemia in Rats with Intact Parathyroid Glands: Jinxing Huan, Klaus Olgaard, Lars Bo Nielsen, and Ewa Lewin; J Am Soc Nephrol 17: 1923-1930. [Abstract] [Full Text] [PDF]

Basic Immunology and Pathology:

Toll-Like Receptor 2 Agonists Exacerbate Accelerated Nephrotoxic Nephritis: Heather J. Brown, Steven H. Sacks, and Michael G. Robson; J Am Soc Nephrol 17: 1931-1939. [Abstract] [Full Text] [PDF]

Anti-Neutrophil Cytoplasmic Antibodies and Effector CD4⁺ Cells Play Nonredundant Roles in Anti-Myeloperoxidase Crescentic Glomerulonephritis: Amanda-Jane Ruth, A. Richard Kitching, Rain Y.Q. Kwan, Dragana Odobasic, Joshua D.K. Ooi, Jennifer R. Timoshanko, Michael J. Hickey, and Stephen R. Holdsworth; J Am Soc Nephrol 17: 1940-1949. [Abstract] [Full Text] [PDF]

Pathophysiology of Renal Disease and Progression:

Prorenin Receptor Blockade Inhibits Development of Glomerulosclerosis in Diabetic Angiotensin II Type 1a Receptor–Deficient Mice: Atsuhiro Ichihara, Fumiaki Suzuki, Tsutomu Nakagawa, Yuki Kaneshiro, Tomoko Takemitsu, Mariyo Sakoda, A.H.M. Nurun Nabi, Akira Nishiyama, Takeshi Sugaya, Matsuhiko Hayashi, and Tadashi Inagami; J Am Soc Nephrol 17: 1950-1961. [Abstract] [Full Text] [PDF]

Loss of ${alpha}$ 3/ ${alpha}$ 4(IV) Collagen from the Glomerular Basement Membrane Induces a Strain-Dependent Isoform Switch to ${alpha}$ 5 ${alpha}$ 6(IV) Collagen Associated with Longer Renal Survival in Col4a3^–/– Alport Mice: Jeong Suk Kang, Xu-Ping Wang, Jeffrey H. Miner, Roy Morello, Yoshikazu Sado, Dale R. Abrahamson, and Dorin-Bogdan Borza; J Am Soc Nephrol 17: 1962-1969. [Abstract] [Full Text] [PDF]

Preconditional Activation of Hypoxia-Inducible Factors Ameliorates Ischemic Acute Renal Failure: Wanja M. Bernhardt, Valentina Câmpean, Sarah Kany, Jan-Steffen Jürgensen, Alexander Weidemann, Christina Warnecke, Michael Arend, Stephen Klaus, Volkmar Günzler, Kerstin Amann, Carsten Willam, Michael S. Wiesener, and Kai-Uwe Eckardt; J Am Soc Nephrol 17: 1970-1978. [Abstract] [Full Text] [PDF]

Nested N-Terminal Megalin Fragments Induce High-Titer Autoantibody and Attenuated Heymann Nephritis: Alfonso Tramontano, Thomas Knight, Domenica Vizzuso, and Sudesh P. Makker; J Am Soc Nephrol 17: 1979-1985. [Abstract] [Full Text] [PDF]

Chronic Renal Failure and Shortened Lifespan in COL4A3^+/– Mice: An Animal Model for Thin Basement Membrane Nephropathy: Bogdan Beirowski, Manfred Weber, and Oliver Gross; J Am Soc Nephrol 17: 1986-1994. [Abstract] [Full Text] [PDF]

Disease of the Month:

Chronic Kidney Disease in Long-Term Survivors of Hematopoietic Cell Transplantation: Epidemiology, Pathogenesis, and Treatment: Sangeeta Hingorani; J Am Soc Nephrol 17: 1995-2005. [Abstract] [Full Text] [PDF]

Clinical Nephrology:

Statins for Improving Renal Outcomes: A Meta-Analysis: Sabrina Sandhu, Natasha Wiebe, Linda F. Fried, and Marcello Tonelli; J Am Soc Nephrol 17: 2006-2016. [Abstract] [Full Text] [PDF]

Genetic and Functional Analyses of Membrane Cofactor Protein (CD46) Mutations in Atypical Hemolytic Uremic Syndrome: Véronique Fremeaux-Bacchi, Elizabeth A. Moulton, David Kavanagh, Marie-Agnès Dragon-Durey, Jacques Blouin, Amy Caudy, Nadia Arzouk, Roxanna Cleper, Maud Francois, Genevieve Guest, Jacques Pourrat, Roland Seligman, Wolf Herman Fridman, Chantal Loirat, and John P. Atkinson; J Am Soc Nephrol 17: 2017-2025. [Abstract] [Full Text] [PDF]

Type 2 Diabetes Increases the Risk for Uric Acid Stones: Michel Daudon, Olivier Traxer, Pierre Conort, Bernard Lacour, and Paul Jungers; J Am Soc Nephrol 17: 2026-2033. [Abstract] [Full Text] [PDF]

Chronic Kidney Disease:

Chronic Kidney Disease and Mortality Risk: A Systematic Review: Marcello Tonelli, Natasha Wiebe, Bruce Culleton, Andrew House, Chris Rabbat, Mei Fok, Finlay McAlister, and Amit X. Garg; J Am Soc Nephrol 17: 2034-2047. [Abstract] [Full Text] [PDF]

Influence of Genomic Loci on Measures of Chronic Kidney Disease in Hypertensive Sibships: Stephen T. Turner, Sharon L.R. Kardia, Thomas H. Mosley, Andrew D. Rule, Eric Boerwinkle, and Mariza de Andrade; J Am Soc Nephrol 17: 2048-2055. [Abstract] [Full Text] [PDF]

Epidemiology and Outcomes:

Peripheral Arterial Disease and Renal Transplantation: Jon J. Snyder, Bertram L. Kasiske, and Ross Maclean; J Am Soc Nephrol 17: 2056-2068. [Abstract] [Full Text] [PDF]

Incidental Renal Artery Stenosis Is an Independent Predictor of Mortality in Patients with Peripheral Vascular Disease: Kwok-Wai Mui, Mengalvio Sleeswijk, Huib van den Hout, Jef van Baal, Gerjan Navis, and Arend-Jan Woittiez; J Am Soc Nephrol 17: 2069-2074. [Abstract] [Full Text] [PDF]

ASN News:

Renal Week 2006: J Am Soc Nephrol 17: A17-A18. [Full Text] [PDF]