This Month's Highlights:

This Month’s Highlights

J Am Soc Nephrol 17: 2343-2344. [Full Text] [PDF]  

Nephrology beyond JASN:

Lowering of Blood Pressure—The Lower, the Better?: Dogma Disputed: Can Aggressively Lowering Blood Pressure in Hypertensive Patients with Coronary Artery Disease Be Dangerous? Ann Intern Med 144: 884–893, 2006

F.H. Messerli, G. Mancia, C.R. Conti, A.C. Hewkin, S. Kupfer, A. Champion, R. Kolloch, A. Benetos, C.J. Pepine, K. Nakagawa, V.R. Holla, Y. Wei, W.H. Wang, A. Gatica, S. Wei, S. Mei, C.M. Miller, D.R. Cha, E. Price, Jr., R. Zent, A. Pozzi, M.D. Breyer, Y. Guan, J.R. Falck, M.R. Waterman, and J.H. Capdevila

J Am Soc Nephrol 17: 2345-2352. [Full Text] [PDF]  

Editorials:

Protecting the Microvasculature: A Tie-ght Connection to Ameliorating Chronic Kidney Disease?

Jill T. Norman

J Am Soc Nephrol 17: 2353-2355. [Full Text] [PDF]  

Developmental Origins of Hypertension: Biology Meets Statistics

Susan P. Bagby

J Am Soc Nephrol 17: 2356-2358. [Full Text] [PDF]  

Fast Track:

Nephrogenic Systemic Fibrosis: Suspected Causative Role of Gadodiamide Used for Contrast-Enhanced Magnetic Resonance Imaging

Peter Marckmann, Lone Skov, Kristian Rossen, Anders Dupont, Mette Brimnes Damholt, James Goya Heaf, and Henrik S. Thomsen

J Am Soc Nephrol 17: 2359-2362. [Abstract] [Full Text] [PDF]  

Hemodialysis Acutely Improves Hepatic CYP3A4 Metabolic Activity

Thomas D. Nolin, Kofi Appiah, Scott A. Kendrick, Phuong Le, Ellen McMonagle, and Jonathan Himmelfarb

J Am Soc Nephrol 17: 2363-2367. [Abstract] [Full Text] [PDF]  

Homer W. Smith Award Lecture:

Acid-Base Transport by the Renal Proximal Tubule

Walter F. Boron

J Am Soc Nephrol 17: 2368-2382. [Abstract] [Full Text] [PDF]  

Young Investigator Award Lecture:

Proteinuria with and without Renal Glomerular Podocyte Effacement

Raghu Kalluri

J Am Soc Nephrol 17: 2383-2389. [Abstract] [Full Text] [PDF]  

Reviews:

Regrow or Repair: Potential Regenerative Therapies for the Kidney

Melissa H. Little

J Am Soc Nephrol 17: 2390-2401. [Abstract] [Full Text] [PDF]  

Cell and Transport Physiology:

Dietary Electrolyte–Driven Responses in the Renal WNK Kinase Pathway In Vivo

Michelle O’Reilly, Elaine Marshall, Thomas MacGillivray, Manish Mittal, Wei Xue, Chris J. Kenyon, and Roger W. Brown

J Am Soc Nephrol 17: 2402-2413. [Abstract] [Full Text] [PDF]  

Cell Biology:

Akt and Mammalian Target of Rapamycin Regulate Separate Systems of Proteolysis in Renal Tubular Cells

Wen Shen, Nikia S. Brown, Patrick F. Finn, J. Fred Dice, and Harold A. Franch

J Am Soc Nephrol 17: 2414-2423. [Abstract] [Full Text] [PDF]  

Nephrocystin Specifically Localizes to the Transition Zone of Renal and Respiratory Cilia and Photoreceptor Connecting Cilia

Manfred Fliegauf, Judit Horvath, Christian von Schnakenburg, Heike Olbrich, Dominik Müller, Julia Thumfart, Bernhard Schermer, Gregory J. Pazour, Hartmut P.H. Neumann, Hanswalter Zentgraf, Thomas Benzing, and Heymut Omran

J Am Soc Nephrol 17: 2424-2433. [Abstract] [Full Text] [PDF] [Supplemental Videos]  

Dependence of Cisplatin-Induced Cell Death In Vitro and In Vivo on Cyclin-Dependent Kinase 2

Peter M. Price, Fang Yu, Philipp Kaldis, Eiman Aleem, Grazyna Nowak, Robert L. Safirstein, and Judit Megyesi

J Am Soc Nephrol 17: 2434-2442. [Abstract] [Full Text] [PDF]  

Genetics and Development:

Isolation and Characterization of Multipotent Progenitor Cells from the Bowman’s Capsule of Adult Human Kidneys

Costanza Sagrinati, Giuseppe Stefano Netti, Benedetta Mazzinghi, Elena Lazzeri, Francesco Liotta, Francesca Frosali, Elisa Ronconi, Claudia Meini, Mauro Gacci, Roberta Squecco, Marco Carini, Loreto Gesualdo, Fabio Francini, Enrico Maggi, Francesco Annunziato, Laura Lasagni, Mario Serio, Sergio Romagnani, and Paola Romagnani

J Am Soc Nephrol 17: 2443-2456. [Abstract] [Full Text] [PDF]  

Hemodynamics and Vascular Regulation:

Ouabain Inhibits Tubuloglomerular Feedback in Mutant Mice with Ouabain-Sensitive 1 Na,K-ATPase

John N. Lorenz, Iva Dostanic-Larson, Gary E. Shull, and Jerry B. Lingrel

J Am Soc Nephrol 17: 2457-2463. [Abstract] [Full Text] [PDF]  

Gender Differences in the Renal Response to Renin-Angiotensin System Blockade

Judith A. Miller, David Z. Cherney, John A. Duncan, Vesta Lai, Kevin D. Burns, Christopher R.J. Kennedy, Joseph Zimpelmann, Wei Gao, Daniel C. Cattran, and James W. Scholey

J Am Soc Nephrol 17: 2554-2560. [Abstract] [Full Text] [PDF]  

Pathophysiology of Renal Disease and Progression:

Anti-Inflammatory Effect of Hepatocyte Growth Factor in Chronic Kidney Disease: Targeting the Inflamed Vascular Endothelium

Rujun Gong, Abdalla Rifai, and Lance D. Dworkin

J Am Soc Nephrol 17: 2464-2473. [Abstract] [Full Text] [PDF]  

COMP–Angiopoietin-1 Ameliorates Renal Fibrosis in a Unilateral Ureteral Obstruction Model

Won Kim, Sang-Ok Moon, Sang Yong Lee, Kyu Yun Jang, Chung-Hyun Cho, Gou Young Koh, Kyu-Sil Choi, Kwon-Ha Yoon, Mi Jeong Sung, Duk Hoon Kim, Sik Lee, Kyung Pyo Kang, and Sung Kwang Park

J Am Soc Nephrol 17: 2474-2483. [Abstract] [Full Text] [PDF] [Supplemental Material]  

Connective Tissue Growth Factor Plays an Important Role in Advanced Glycation End Product–Induced Tubular Epithelial-to-Mesenchymal Transition: Implications for Diabetic Renal Disease

Wendy C. Burns, Stephen M. Twigg, Josephine M. Forbes, Josefa Pete, Christos Tikellis, Vicki Thallas-Bonke, Merlin C. Thomas, Mark E. Cooper, and Phillip Kantharidis

J Am Soc Nephrol 17: 2484-2494. [Abstract] [Full Text] [PDF]  

Contribution of Nonproteolytically Activated Prorenin in Glomeruli to Hypertensive Renal Damage

Atsuhiro Ichihara, Yuki Kaneshiro, Tomoko Takemitsu, Mariyo Sakoda, Tsutomu Nakagawa, Akira Nishiyama, Hiroshi Kawachi, Fujio Shimizu, and Tadashi Inagami

J Am Soc Nephrol 17: 2495-2503. [Abstract] [Full Text] [PDF]  

Renal Bone Morphogenetic Protein-7 Protects against Diabetic Nephropathy

Shinong Wang, Mark de Caestecker, Jeffrey Kopp, Grace Mitu, Janine LaPage, and Raimund Hirschberg

J Am Soc Nephrol 17: 2504-2512. [Abstract] [Full Text] [PDF]  

Induction of Glomerular Heparanase Expression in Rats with Adriamycin Nephropathy Is Regulated by Reactive Oxygen Species and the Renin-Angiotensin System

Andrea Kramer, Mabel van den Hoven, Angelique Rops, Tessa Wijnhoven, Lambert van den Heuvel, Joost Lensen, Toin van Kuppevelt, Harry van Goor, Johan van der Vlag, Gerjan Navis, and Jo H.M. Berden

J Am Soc Nephrol 17: 2513-2520. [Abstract] [Full Text] [PDF]  

Basic Transplantation:

CCL19-IgG Prevents Allograft Rejection by Impairment of Immune Cell Trafficking

Ekkehard Ziegler, Faikah Gueler, Song Rong, Michael Mengel, Oliver Witzke, Andreas Kribben, Hermann Haller, Ulrich Kunzendorf, and Stefan Krautwald

J Am Soc Nephrol 17: 2521-2532. [Abstract] [Full Text] [PDF]  

Disease of the Month:

Multiple Myeloma

Stephen M. Korbet and Melvin M. Schwartz

J Am Soc Nephrol 17: 2533-2545. [Full Text] [PDF]  

Clinical Nephrology:

Falling into the Doughnut Hole: Drug Spending among Beneficiaries with End-Stage Renal Disease under Medicare Part D Plans

Uptal D. Patel and Matthew M. Davis

J Am Soc Nephrol 17: 2546-2553. [Abstract] [Full Text] [PDF]  

Epidemiology and Outcomes:

Prospective Study of the Effect of Blood Pressure on Renal Function in Old Age: The Leiden 85-Plus Study

Thomas van Bemmel, Karen Woittiez, Gerard J. Blauw, Femke van der Sman-de Beer, Friedo W. Dekker, Rudi G.J. Westendorp, and Jacobijn Gussekloo

J Am Soc Nephrol 17: 2561-2566. [Abstract] [Full Text] [PDF]  

High Urinary Calcium Excretion and Genetic Susceptibility to Hypertension and Kidney Stone Disease

Andrew Mente, R. John D’ A. Honey, John M. McLaughlin, Shelley B. Bull, and Alexander G. Logan

J Am Soc Nephrol 17: 2567-2575. [Abstract] [Full Text] [PDF]  

Racial Disparities in the Association between Birth Weight in the Term Infant and Blood Pressure at Age 7 Years: Results from the Collaborative Perinatal Project

Anusha H. Hemachandra, Mark A. Klebanoff, and Susan L. Furth

J Am Soc Nephrol 17: 2576-2581. [Abstract] [Full Text] [PDF]  

Macroalbuminuria Is a Better Risk Marker than Low Estimated GFR to Identify Individuals at Risk for Accelerated GFR Loss in Population Screening

Nynke Halbesma, Dirk-Sjoerd Kuiken, Auke H. Brantsma, Stephan J.L. Bakker, Jack F.M. Wetzels, Dick De Zeeuw, Paul E. De Jong, Ronald T. Gansevoort for the PREVEND Study Group

J Am Soc Nephrol 17: 2582-2590. [Abstract] [Full Text] [PDF]  

Meta-Analysis: Peritoneal Membrane Transport, Mortality, and Technique Failure in Peritoneal Dialysis

K. Scott Brimble, Michelle Walker, Peter J. Margetts, Kiran K. Kundhal, and Christian G. Rabbat

J Am Soc Nephrol 17: 2591-2598. [Abstract] [Full Text] [PDF]  

Adiponectin and Mortality in Patients with Chronic Kidney Disease

Vandana Menon, Lijun Li, Xuelei Wang, Tom Greene, Vaidyanathapuram Balakrishnan, Magdalena Madero, Arema A. Pereira, Gerald J. Beck, John W. Kusek, Allan J. Collins, Andrew S. Levey, and Mark J. Sarnak

J Am Soc Nephrol 17: 2599-2606. [Abstract] [Full Text] [PDF]  

Clinical Dialysis:

Alleviation of Sleep Apnea in Patients with Chronic Renal Failure by Nocturnal Cycler–Assisted Peritoneal Dialysis Compared with Conventional Continuous Ambulatory Peritoneal Dialysis

Sydney C.W. Tang, Bing Lam, Pui Pui Ku, Wah Shing Leung, Chung Ming Chu, Yiu Wing Ho, Mary S.M. Ip, and Kar Neng Lai

J Am Soc Nephrol 17: 2607-2616. [Abstract] [Full Text] [PDF]  

Chronic Kidney Disease:

Cardiovascular Disease in Early Stages of Chronic Kidney Disease in a Chinese Population

LuXia Zhang, Li Zuo, Fang Wang, Mei Wang, ShuYu Wang, JiCheng Lv, LiSheng Liu, and HaiYan Wang

J Am Soc Nephrol 17: 2617-2621. [Abstract] [Full Text] [PDF]  

Clinical Transplantation:

Untreated Rejection in 6-Month Protocol Biopsies Is Not Associated with Fibrosis in Serial Biopsies or with Loss of Graft Function

Eduard M. Scholten, Ajda T. Rowshani, Serge Cremers, Frederike J. Bemelman, Michael Eikmans, Erik van Kan, Marko J. Mallat, Sandrine Florquin, Janto Surachno, Ineke J. ten Berge, Ingeborg M. Bajema, and Johan W. de Fijter

J Am Soc Nephrol 17: 2622-2632. [Abstract] [Full Text] [PDF]  

Announcements:

Announcements

J Am Soc Nephrol 17: 2633. [Full Text] [PDF]  

ASN News:

ASN News

J Am Soc Nephrol 17: A25-A26. [Full Text] [PDF]  

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