JASN -- Table of Contents (18 [1])

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This Month's Highlights:

This Month’s Highlights: J Am Soc Nephrol 18: 1-2. [Full Text] [PDF]

Nephrology beyond JASN:

Hemoglobin-Independent Organ Protection by EPO in Humans: Amelioration of Cognitive Loss in Chronic Schizophrenia: H. Ehrenreich, D. Hinze-Selch, S. Stawicki, C. Aust, S. Knolle-Veentjer, S. Wilms, G. Heinz, S. Erdag, H. Jahn, D. Degner, M. Ritzen, A. Mohr, M. Wagner, U. Schneider, M. Bohn, M. Huber, A. Czernik, T. Pollmächer, W. Maier, A.-L. Sirén, J. Klosterkötter, P. Falkai, E. Rüther, J.B. Aldenhoff, and H. Krampe; J Am Soc Nephrol 18: 3-6. [Abstract] [Full Text] [PDF]

Editorials:

Novel Approaches in the Investigation of Acute Kidney Injury: David P. Basile; J Am Soc Nephrol 18: 7-9. [Full Text] [PDF]

Mechanism of Injury in Uromodulin-Associated Kidney Disease: Satish Kumar; J Am Soc Nephrol 18: 10-12. [Full Text] [PDF]

The Heat Is On: An Expanding Role for Hypoxia-Inducible Factors in Kidney Transplantation: Masaomi Nangaku; J Am Soc Nephrol 18: 13-15. [Full Text] [PDF]

Review:

Oxidants in Chronic Kidney Disease: Sudhir V. Shah, Radhakrishna Baliga, Mohan Rajapurkar, and Vivian A. Fonseca; J Am Soc Nephrol 18: 16-28. [Abstract] [Full Text] [PDF]

Fast Track:

Induction of TRPC6 Channel in Acquired Forms of Proteinuric Kidney Disease: Clemens C. Möller, Changli Wei, Mehmet M. Altintas, Jing Li, Anna Greka, Takamoto Ohse, Jeffrey W. Pippin, Maria P. Rastaldi, Stefan Wawersik, Susan Schiavi, Anna Henger, Matthias Kretzler, Stuart J. Shankland, and Jochen Reiser; J Am Soc Nephrol 18: 29-36. [Abstract] [Full Text] [PDF]

Cell and Transport Physiology:

Multidrug Resistance–Associated Protein 4 Is Involved in the Urinary Excretion of Hydrochlorothiazide and Furosemide: Maki Hasegawa, Hiroyuki Kusuhara, Masashi Adachi, John D. Schuetz, Kenji Takeuchi, and Yuichi Sugiyama; J Am Soc Nephrol 18: 37-45. [Abstract] [Full Text] [PDF]

Ouabain Binds with High Affinity to the Na,K-ATPase in Human Polycystic Kidney Cells and Induces Extracellular Signal–Regulated Kinase Activation and Cell Proliferation: Anh-Nguyet T. Nguyen, Darren P. Wallace, and Gustavo Blanco; J Am Soc Nephrol 18: 46-57. [Abstract] [Full Text] [PDF]

Cell Biology:

Inhibition of Histone Deacetylase Activity Suppresses Epithelial-to-Mesenchymal Transition Induced by TGF- $beta$ 1 in Human Renal Epithelial Cells: Masahiro Yoshikawa, Keiichi Hishikawa, Takeshi Marumo, and Toshiro Fujita; J Am Soc Nephrol 18: 58-65. [Abstract] [Full Text] [PDF]

TGF- $beta$ 1 Regulates the PINCH-1–Integrin-Linked Kinase– ${alpha}$ -Parvin Complex in Glomerular Cells: Kyu Yong Jung, Ka Chen, Matthias Kretzler, and Chuanyue Wu; J Am Soc Nephrol 18: 66-73. [Abstract] [Full Text] [PDF]

Expression and Targeting of CX₃CL1 (Fractalkine) in Renal Tubular Epithelial Cells: Anne M. Durkan, R. Todd Alexander, Guang-Ying Liu, Min Rui, Giuseppe Femia, and Lisa A. Robinson; J Am Soc Nephrol 18: 74-83. [Abstract] [Full Text] [PDF]

Myocardial Function, Energy Provision, and Carnitine Deficiency in Experimental Uremia: Veena Reddy, Sunil Bhandari, and Anne-Marie L. Seymour; J Am Soc Nephrol 18: 84-92. [Abstract] [Full Text] [PDF]

Retinoic Acid Inhibits HIV-1–Induced Podocyte Proliferation through the cAMP Pathway: John Cijiang He, Ting-Chi Lu, Margaret Fleet, Masaaki Sunamoto, Mohammad Husain, Wei Fang, Susana Neves, Yibang Chen, Stuart Shankland, Ravi Iyengar, and Paul E. Klotman; J Am Soc Nephrol 18: 93-102. [Abstract] [Full Text] [PDF]

Genetics and Development:

A Sensitized Screen of N-ethyl-N-nitrosourea–Mutagenized Mice Identifies Dominant Mutants Predisposed to Diabetic Nephropathy: Elena E. Tchekneva, Eugene M. Rinchik, Dina Polosukhina, Linda S. Davis, Veronika Kadkina, Yassir Mohamed, Steve R. Dunn, Kumar Sharma, Zhonghua Qi, Agnes B. Fogo, and Matthew D. Breyer; J Am Soc Nephrol 18: 103-112. [Abstract] [Full Text] [PDF]

Development of Overt Proteinuria in the Munich Wistar Frömter Rat Is Suppressed by Replacement of Chromosome 6 in a Consomic Rat Strain: Angela Schulz, Judith Weiss, Maria Schlesener, Jonna Hänsch, Markus Wehland, Norbert Wendt, Peter Kossmehl, Anika Sietmann, Daniela Grimm, Monika Stoll, Jens Randel Nyengaard, and Reinhold Kreutz; J Am Soc Nephrol 18: 113-121. [Abstract] [Full Text] [PDF] [Data Supplement]

Basic Mineral Metabolism and Bone Disease:

Reversal of the Adynamic Bone Disorder and Decreased Vascular Calcification in Chronic Kidney Disease by Sevelamer Carbonate Therapy: Suresh Mathew, Richard J. Lund, Frank Strebeck, Kimberly S. Tustison, Theresa Geurs, and Keith A. Hruska; J Am Soc Nephrol 18: 122-130. [Abstract] [Full Text] [PDF]

Hemodynamics and Vascular Regulation:

EGF Receptor Activity Modulates Apoptosis Induced by Inhibition of the Proteasome of Vascular Smooth Muscle Cells: Wei-Zhong Ying, Huang-Ge Zhang, and Paul W. Sanders; J Am Soc Nephrol 18: 131-142. [Abstract] [Full Text] [PDF]

Pathophysiology of Renal Disease and Progression:

Endothelin A Receptor Blockade Reduces Diabetic Renal Injury via an Anti-Inflammatory Mechanism: Jennifer M. Sasser, Jennifer C. Sullivan, Janet L. Hobbs, Tatsuo Yamamoto, David M. Pollock, Pamela K. Carmines, and Jennifer S. Pollock; J Am Soc Nephrol 18: 143-154. [Abstract] [Full Text] [PDF]

Acute Renal Failure after Bilateral Nephrectomy Is Associated with Cytokine-Mediated Pulmonary Injury: Thomas S. Hoke, Ivor S. Douglas, Christina L. Klein, Zhibin He, Wenfeng Fang, Joshua M. Thurman, Yunxia Tao, Belda Dursun, Norbert F. Voelkel, Charles L. Edelstein, and Sarah Faubel; J Am Soc Nephrol 18: 155-164. [Abstract] [Full Text] [PDF]

Bone Marrow–Derived Myofibroblasts Contribute to the Renal Interstitial Myofibroblast Population and Produce Procollagen I after Ischemia/Reperfusion in Rats: Martine Broekema, Martin C. Harmsen, Marja J.A. van Luyn, Jasper A. Koerts, Arjen H. Petersen, Theo G. van Kooten, Harry van Goor, Gerjan Navis, and Eliane R. Popa; J Am Soc Nephrol 18: 165-175. [Abstract] [Full Text] [PDF]

Peroxisome Proliferator–Activated Receptor ${alpha}$ Protects against Glomerulonephritis Induced by Long-Term Exposure to the Plasticizer Di-(2-Ethylhexyl)Phthalate: Yuji Kamijo, Kazuhiko Hora, Tamie Nakajima, Keiichi Kono, Kyoko Takahashi, Yuki Ito, Makoto Higuchi, Kendo Kiyosawa, Hidekazu Shigematsu, Frank J. Gonzalez, and Toshifumi Aoyama; J Am Soc Nephrol 18: 176-188. [Abstract] [Full Text] [PDF]

RhoA Activation in Mesangial Cells by Mechanical Strain Depends on Caveolae and Caveolin-1 Interaction: Fangfang Peng, Dongcheng Wu, Alistair J. Ingram, Baifang Zhang, Bo Gao, and Joan C. Krepinsky; J Am Soc Nephrol 18: 189-198. [Abstract] [Full Text] [PDF]

Compartmentalization of cAMP-Dependent Signaling by Phosphodiesterase-4D Is Involved in the Regulation of Vasopressin-Mediated Water Reabsorption in Renal Principal Cells: Eduard Stefan, Burkhard Wiesner, George S. Baillie, Rustam Mollajew, Volker Henn, Dorothea Lorenz, Jens Furkert, Katja Santamaria, Pavel Nedvetsky, Christian Hundsrucker, Michael Beyermann, Eberhard Krause, Peter Pohl, Irene Gall, Andrew N. MacIntyre, Sebastian Bachmann, Miles D. Houslay, Walter Rosenthal, and Enno Klussmann; J Am Soc Nephrol 18: 199-212. [Abstract] [Full Text] [PDF]

Basic Transplantation:

Mitochondrial Targeting with Antioxidant Peptide SS-31 Prevents Mitochondrial Depolarization, Reduces Islet Cell Apoptosis, Increases Islet Cell Yield, and Improves Posttransplantation Function: Dolca A. Thomas, Craig Stauffer, Kesheng Zhao, Hua Yang, Vijay K. Sharma, Hazel H. Szeto, and Manikkam Suthanthiran; J Am Soc Nephrol 18: 213-222. [Abstract] [Full Text] [PDF]

Disease of the Month:

Pathogenesis and Prevention of Bone Loss in Patients Who Have Kidney Disease and Receive Long-Term Immunosuppression: John Cunningham; J Am Soc Nephrol 18: 223-234. [Abstract] [Full Text] [PDF]

Clinical Nephrology:

Central Obesity, Incident Microalbuminuria, and Change in Creatinine Clearance in the Epidemiology of Diabetes Interventions and Complications Study: Ian H. de Boer, Shalamar D. Sibley, Bryan Kestenbaum, Joshua N. Sampson, Bessie Young, Patricia A. Cleary, Michael W. Steffes, Noel S. Weiss, John D. Brunzell for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group; J Am Soc Nephrol 18: 235-243. [Abstract] [Full Text] [PDF]

Severe Lupus Nephritis: Racial Differences in Presentation and Outcome: Stephen M. Korbet, Melvin M. Schwartz, Joni Evans, Edmund J. Lewis for the Collaborative Study Group; J Am Soc Nephrol 18: 244-254. [Abstract] [Full Text] [PDF]

Human Genetics:

NADPH Oxidase p22phox and Catalase Gene Variants Are Associated with Biomarkers of Oxidative Stress and Adverse Outcomes in Acute Renal Failure: Mary C. Perianayagam, Orfeas Liangos, Alexey Y. Kolyada, Ron Wald, Robert W. MacKinnon, Lijun Li, Madhumati Rao, Vaidyanathapuram S. Balakrishnan, Joseph V. Bonventre, Brian J. Pereira, and Bertrand L. Jaber; J Am Soc Nephrol 18: 255-263. [Abstract] [Full Text] [PDF]

Membrane Targeting and Secretion of Mutant Uromodulin in Familial Juvenile Hyperuricemic Nephropathy: Paul Jennings, Sonia Aydin, Peter Kotanko, Judith Lechner, Karl Lhotta, Sian Williams, Rajesh V. Thakker, and Walter Pfaller; J Am Soc Nephrol 18: 264-273. [Abstract] [Full Text] [PDF]

Epidemiology and Outcomes:

Effect of Organic Solvent Exposure on Chronic Kidney Disease Progression: The GN-PROGRESS Cohort Study: Sophie Jacob, Michel Héry, Jean-Claude Protois, Jérôme Rossert, and Bénédicte Stengel; J Am Soc Nephrol 18: 274-281. [Abstract] [Full Text] [PDF]

Association of Kidney Function with Incident Hip Fracture in Older Adults: Linda F. Fried, Mary Louise Biggs, Michael G. Shlipak, Stephen Seliger, Bryan Kestenbaum, Catherine Stehman-Breen, Mark Sarnak, David Siscovick, Tamara Harris, Jane Cauley, Anne B. Newman, and John Robbins; J Am Soc Nephrol 18: 282-286. [Abstract] [Full Text] [PDF]

Plasma Uric Acid Level and Risk for Incident Hypertension Among Men: John P. Forman, Hyon Choi, and Gary C. Curhan; J Am Soc Nephrol 18: 287-292. [Abstract] [Full Text] [PDF]

Association between Serum Lipids and Survival in Hemodialysis Patients and Impact of Race: Ryan D. Kilpatrick, Charles J. McAllister, Csaba P. Kovesdy, Stephen F. Derose, Joel D. Kopple, and Kamyar Kalantar-Zadeh; J Am Soc Nephrol 18: 293-303. [Abstract] [Full Text] [PDF]

Inverse Association between Lipid Levels and Mortality in Men with Chronic Kidney Disease Who Are Not Yet on Dialysis: Effects of Case Mix and the Malnutrition-Inflammation-Cachexia Syndrome: Csaba P. Kovesdy, John E. Anderson, and Kamyar Kalantar-Zadeh; J Am Soc Nephrol 18: 304-311. [Abstract] [Full Text] [PDF]

Clinical Dialysis:

Automated External Defibrillators and Survival from Cardiac Arrest in the Outpatient Hemodialysis Clinic: Ruediger W. Lehrich, Patrick H. Pun, Nadine D. Tanenbaum, Stephen R. Smith, and John P. Middleton; J Am Soc Nephrol 18: 312-320. [Abstract] [Full Text] [PDF]

N-Terminal Pro-Brain Natriuretic Peptide: An Independent Risk Predictor of Cardiovascular Congestion, Mortality, and Adverse Cardiovascular Outcomes in Chronic Peritoneal Dialysis Patients: Angela Yee-Moon Wang, Christopher Wai-Kei Lam, Cheuk-Man Yu, Mei Wang, Iris Hiu-Shuen Chan, Yan Zhang, Siu-Fai Lui, and John E. Sanderson; J Am Soc Nephrol 18: 321-330. [Abstract] [Full Text] [PDF]

Clinical Immunology and Pathology:

Oxidized Low-Density Lipoproteins Activate CD4⁺ T Cell Apoptosis in Patients with End-Stage Renal Disease through Fas Engagement: Pascal Meier, François Spertini, Edouard Blanc, and Michel Burnier; J Am Soc Nephrol 18: 331-342. [Abstract] [Full Text] [PDF]

Clinical Transplantation:

Immunohistochemical Detection of Hypoxia-Inducible Factor-1 ${alpha}$ in Human Renal Allograft Biopsies: Christian Rosenberger, Johann Pratschke, Birgit Rudolph, Samuel N. Heyman, Ralf Schindler, Nina Babel, Kai-Uwe Eckardt, Ulrich Frei, Seymour Rosen, and Petra Reinke; J Am Soc Nephrol 18: 343-351. [Abstract] [Full Text] [PDF]

Announcements:

Announcements: J Am Soc Nephrol 18: 352. [Full Text] [PDF]

ASN News:

ASN News: J Am Soc Nephrol 18: A18-A19. [Full Text] [PDF]