This Month's Highlights:

This Month’s Highlights

J Am Soc Nephrol 18: 353-355. [Full Text] [PDF]  

Nephrology beyond JASN:

Role of Renal Angiotensin II Type 1 Receptors in the Genesis of Hypertension: Guyton Revisited: Angiotensin II Causes Hypertension and Cardiac Hypertrophy through Its Receptors in the Kidney. Proc Natl Acad Sci U S A 103: 17985–17990, 2006

S.D. Crowley, S.B. Gurley, M.J. Herrera, P. Ruiz, R. Griffiths, A.P. Kumar, H.-S. Kim, O. Smithies, T.H. Le, T.M. Coffman, J. Martin, and P. Lopez

J Am Soc Nephrol 18: 356-363. [Full Text] [PDF]  

Editorials:

Toward a Mouse Model of Diabetic Nephropathy: Is Endothelial Nitric Oxide Synthase the Missing Link?

Susan E. Quaggin and Thomas M. Coffman

J Am Soc Nephrol 18: 364-366. [Full Text] [PDF]  

Cyclooxygenases, Prostanoids, and Glomerular Injury: Complex Relationships

Andrey V. Cybulsky

J Am Soc Nephrol 18: 367-368. [Full Text] [PDF]  

Calciotropic Hormones and Arterial Physiology: "D"-lightful Insights

Dwight A. Towler

J Am Soc Nephrol 18: 369-373. [Full Text] [PDF]  

Special feature:

Chronic Kidney Disease: Common, Harmful, and Treatable—World Kidney Day 2007

Andrew S. Levey, Sharon P. Andreoli, Thomas DuBose, Robert Provenzano, and Allan J. Collins

J Am Soc Nephrol 18: 374-378. [Full Text] [PDF]  

Frontiers in Nephrology:

Iron Regulation

Jonathan Himmelfarb

J Am Soc Nephrol 18: 379-381. [Full Text] [PDF]  

Clinical Aspects of Iron Use in the Anemia of Kidney Disease

Walter H. Hörl

J Am Soc Nephrol 18: 382-393. [Full Text] [PDF]  

Molecular Control of Iron Transport

Tomas Ganz

J Am Soc Nephrol 18: 394-400. [Abstract] [Full Text] [PDF]  

Renal Iron Metabolism: Transferrin Iron Delivery and the Role of Iron Regulatory Proteins

Deliang Zhang, Esther Meyron-Holtz, and Tracey A. Rouault

J Am Soc Nephrol 18: 401-406. [Full Text] [PDF]  

Dual Action of Neutrophil Gelatinase–Associated Lipocalin

Kai M. Schmidt-Ott, Kiyoshi Mori, Jau Yi Li, Avtandil Kalandadze, David J. Cohen, Prasad Devarajan, and Jonathan Barasch

J Am Soc Nephrol 18: 407-413. [Abstract] [Full Text] [PDF]  

Physiology and Pathophysiology of Heme: Implications for Kidney Disease

Michal J. Tracz, Jawed Alam, and Karl A. Nath

J Am Soc Nephrol 18: 414-420. [Abstract] [Full Text] [PDF]  

Cell and Transport Physiology:

Downregulation of Renal Sodium Transporters and Tonicity-Responsive Enhancer Binding Protein by Long-Term Treatment with Cyclosporin A

Sun Woo Lim, Kyung Ohk Ahn, Mee Rie Sheen, Un Sil Jeon, Jin Kim, Chul Woo Yang, and H. Moo Kwon

J Am Soc Nephrol 18: 421-429. [Abstract] [Full Text] [PDF]  

Human Renal Organic Anion Transporter 4 Operates as an Asymmetric Urate Transporter

Yohannes Hagos, Daniel Stein, Bernhard Ugele, Gerhard Burckhardt, and Andrew Bahn

J Am Soc Nephrol 18: 430-439. [Abstract] [Full Text] [PDF]  

Renal Function in Mice with Targeted Disruption of the A Isoform of the Na-K-2Cl Co-Transporter

Mona Oppermann, Diane Mizel, Soo Mi Kim, Limeng Chen, Robert Faulhaber-Walter, Yuning Huang, Cuiling Li, Chuxia Deng, Josie Briggs, Jurgen Schnermann, and Hayo Castrop

J Am Soc Nephrol 18: 440-448. [Abstract] [Full Text] [PDF]  

Cell Biology:

Tubular Epithelial Cell Dedifferentiation Is Driven by the Helix-Loop-Helix Transcriptional Inhibitor Id1

Yingjian Li, Junwei Yang, Jian-Hua Luo, Shoukat Dedhar, and Youhua Liu

J Am Soc Nephrol 18: 449-460. [Abstract] [Full Text] [PDF]  

Genetics and Development:

Identification of a Unique Transgenic Mouse Line That Develops Megabladder, Obstructive Uropathy, and Renal Dysfunction

Sunita Singh, Melissa Robinson, Fatin Nahi, Brian Coley, Michael L. Robinson, Carlton M. Bates, Karl Kornacker, and Kirk M. McHugh

J Am Soc Nephrol 18: 461-471. [Abstract] [Full Text] [PDF] [Data Supplements]  

A Pathogenic Role for c-Jun Amino-Terminal Kinase Signaling in Renal Fibrosis and Tubular Cell Apoptosis

Frank Y. Ma, Robert S. Flanc, Greg H. Tesch, Yingjie Han, Robert C. Atkins, Brydon L. Bennett, Glenn C. Friedman, Jui-Hsiang Fan, and David J. Nikolic-Paterson

J Am Soc Nephrol 18: 472-484. [Abstract] [Full Text] [PDF]  

Hemodynamics and Vascular Regulation:

Pkd2^+/– Vascular Smooth Muscles Develop Exaggerated Vasocontraction in Response to Phenylephrine Stimulation

Qi Qian, Larry W. Hunter, Hui Du, Qun Ren, Young Han, and Gary C. Sieck

J Am Soc Nephrol 18: 485-493. [Abstract] [Full Text] [PDF]  

Mineral Metabolism and Arterial Functions in End-Stage Renal Disease: Potential Role of 25-Hydroxyvitamin D Deficiency

Gérard M. London, Alain P. Guérin, Francis H. Verbeke, Bruno Pannier, Pierre Boutouyrie, Sylvain J. Marchais, and Fabien Mëtivier

J Am Soc Nephrol 18: 613-620. [Abstract] [Full Text] [PDF]  

Local Shear Stress and Brachial Artery Functions in End-Stage Renal Disease

Francis H. Verbeke, Mohsen Agharazii, Pierre Boutouyrie, Bruno Pannier, Alain P. Guérin, and Gérard M. London

J Am Soc Nephrol 18: 621-628. [Abstract] [Full Text] [PDF]  

Basic Immunology and Pathology:

P2Y1 Gene Deficiency Protects from Renal Disease Progression and Capillary Rarefaction during Passive Crescentic Glomerulonephritis

Bernd Hohenstein, Sindy Renk, Kathrin Lang, Christoph Daniel, Monique Freund, Catherine Léon, Kerstin U. Amann, Christian Gachet, and Christian P.M. Hugo

J Am Soc Nephrol 18: 494-505. [Abstract] [Full Text] [PDF]  

Hemolytic Uremic Syndrome: A Factor H Mutation (E1172Stop) Causes Defective Complement Control at the Surface of Endothelial Cells

Stefan Heinen, Mihály Józsi, Andrea Hartmann, Marina Noris, Giuseppe Remuzzi, Christine Skerka, and Peter F. Zipfel

J Am Soc Nephrol 18: 506-514. [Abstract] [Full Text] [PDF]  

Pathophysiology of Renal Disease and Progression:

Angiotensin II Type 1 Receptor Blockade Inhibits the Development and Progression of HIV-Associated Nephropathy in a Mouse Model

Noriyuki Hiramatsu, Keiju Hiromura, Tetsuya Shigehara, Takashi Kuroiwa, Hiroshi Ideura, Noriyuki Sakurai, Shigeru Takeuchi, Mai Tomioka, Hidekazu Ikeuchi, Yoriaki Kaneko, Kazue Ueki, Jeffrey B. Kopp, and Yoshihisa Nojima

J Am Soc Nephrol 18: 515-527. [Abstract] [Full Text] [PDF]  

Advanced Oxidation Protein Products Accelerate Renal Fibrosis in a Remnant Kidney Model

Hong Yan Li, Fan Fan Hou, Xun Zhang, Ping Yan Chen, Shang Xi Liu, Jian Xun Feng, Zhi Qiang Liu, Yue Xin Shan, Guo Bao Wang, Zhan Mei Zhou, Jian Wei Tian, and Di Xie

J Am Soc Nephrol 18: 528-538. [Abstract] [Full Text] [PDF]  

Diabetic Endothelial Nitric Oxide Synthase Knockout Mice Develop Advanced Diabetic Nephropathy

Takahiko Nakagawa, Waichi Sato, Olena Glushakova, Marcelo Heinig, Tracy Clarke, Martha Campbell-Thompson, Yukio Yuzawa, Mark A. Atkinson, Richard J. Johnson, and Byron Croker

J Am Soc Nephrol 18: 539-550. [Abstract] [Full Text] [PDF]  

Overexpression of Cyclooxygenase-2 Predisposes to Podocyte Injury

Huifang Cheng, Suwan Wang, Young-Il Jo, Chuan-Ming Hao, Mingzhi Zhang, Xiaofeng Fan, Chris Kennedy, Matthew D. Breyer, Gilbert W. Moeckel, and Raymond C. Harris

J Am Soc Nephrol 18: 551-559. [Abstract] [Full Text] [PDF]  

Endothelin B Receptor Blockade Accelerates Disease Progression in a Murine Model of Autosomal Dominant Polycystic Kidney Disease

Ming-Yang Chang, Emma Parker, Meguid El Nahas, John L. Haylor, and Albert C.M. Ong

J Am Soc Nephrol 18: 560-569. [Abstract] [Full Text] [PDF]  

Nitrite-Derived Nitric Oxide Protects the Rat Kidney against Ischemia/Reperfusion Injury In Vivo: Role for Xanthine Oxidoreductase

Pinpat Tripatara, Nimesh S.A. Patel, Andrew Webb, Krishnaraj Rathod, Florence M.J. Lecomte, Emanuela Mazzon, Salvatore Cuzzocrea, Mohammed M. Yaqoob, Amrita Ahluwalia, and Christoph Thiemermann

J Am Soc Nephrol 18: 570-580. [Abstract] [Full Text] [PDF]  

Molecular Mechanisms of Cyclosporin A Inhibition of the Cytokine-Induced Matrix Metalloproteinase-9 in Glomerular Mesangial Cells

Anke Doller, El-Sayed Akool, Roswitha Müller, Paul Gutwein, Christine Kurowski, Josef Pfeilschifter, and Wolfgang Eberhardt

J Am Soc Nephrol 18: 581-592. [Abstract] [Full Text] [PDF]  

Clinical Nephrology:

Reduced Systolic Myocardial Function in Children with Chronic Renal Insufficiency

Marcello Chinali, Giovanni de Simone, Maria Chiara Matteucci, Stefano Picca, Antonio Mastrostefano, Ali Anarat, Salim Çaliskan, Nikola Jeck, Thomas J. Neuhaus, Amira Peco-Antic, Licia Peruzzi, Sara Testa, Otto Mehls, Elke Wühl, Franz Schaefer for the ESCAPE Trial Group

J Am Soc Nephrol 18: 593-598. [Abstract] [Full Text] [PDF]  

Antineutrophil Cytoplasmic Autoantibody–Negative Pauci-immune Crescentic Glomerulonephritis

Min Chen, Feng Yu, Su-Xia Wang, Wan-Zhong Zou, Ming-Hui Zhao, and Hai-Yan Wang

J Am Soc Nephrol 18: 599-605. [Abstract] [Full Text] [PDF]  

Human Genetics:

Nephrogenic Syndrome of Inappropriate Antidiuresis in Adults: High Phenotypic Variability in Men and Women from a Large Pedigree

Guy Decaux, Frédéric Vandergheynst, Yasmina Bouko, Jasmine Parma, Gilbert Vassart, and Catheline Vilain

J Am Soc Nephrol 18: 606-612. [Abstract] [Full Text] [PDF]  

Epidemiology and Outcomes:

Kidney Function and Risk of Peripheral Arterial Disease: Results from the Atherosclerosis Risk in Communities (ARIC) Study

Keattiyoat Wattanakit, Aaron R. Folsom, Elizabeth Selvin, Josef Coresh, Alan T. Hirsch, and Beth D. Weatherley

J Am Soc Nephrol 18: 629-636. [Abstract] [Full Text] [PDF]  

What Predicts Progression and Regression of Urinary Albumin Excretion in the Nondiabetic Population?

Auke H. Brantsma, Jarir Atthobari, Stephan J.L. Bakker, Dick de Zeeuw, Paul E. de Jong, Ronald T. Gansevoort for the PREVEND Study Group

J Am Soc Nephrol 18: 637-645. [Abstract] [Full Text] [PDF]  

Clinical Dialysis:

Center Effects in Anemia Management of Dialysis Patients

Jeffrey C. Fink, Van Doren Hsu, Min Zhan, Lori D. Walker, C. Daniel Mullins, Charlotte Jones-Burton, Patricia Langenberg, and Stephen L. Seliger

J Am Soc Nephrol 18: 646-653. [Abstract] [Full Text] [PDF]  

Human Mineral Metabolism:

Differences in 24-Hour Urine Composition between Black and White Women

Eric N. Taylor and Gary C. Curhan

J Am Soc Nephrol 18: 654-659. [Abstract] [Full Text] [PDF]  

Announcements:

Announcements

J Am Soc Nephrol 18: 660. [Full Text] [PDF]  

ASN News:

ASN News

J Am Soc Nephrol 18: A25-A27. [Full Text] [PDF]  

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