This Month's Highlights:

This Month’s Highlights

J Am Soc Nephrol 18: 661-662. [Full Text] [PDF]  

Nephrology beyond JASN:

Endothelial Cell Dysfunction—Can One Outsmart Oxidative Stress by Direct Interaction with the Pathological Oxidized or Heme-Free Soluble Guanyl-Cyclase?: Targeting the Heme-Oxydized Nitric Oxide Receptor for Selective Vasodilatation of Diseased Blood Vessels. J Clin Invest 116: 2552–2561, 2006

J.-P. Stasch, P.M. Schmidt, P.I. Nedvetsky, T.Y. Arun Nedvetskaya, H.S. Kumar, S. Meurer, M. Deile, A. Taye, A. Knorr, H. Lapp, H. Müller, Y. Turgay, C. Rothkegel, A. Tersteegen, B. Kemp-Harper, W. Müller-Esterl, H. Schmidt, I. Urakawa, Y. Yamazaki, T. Shimada, K. Iijima, H. Hasegawa, K. Okawa, T. Fujita, S. Fukumoto, and T. Yamashita

J Am Soc Nephrol 18: 663-669. [Full Text] [PDF]  

Editorials:

Critical Role of Urea in the Urine-Concentrating Mechanism

Jeff M. Sands

J Am Soc Nephrol 18: 670-671. [Full Text] [PDF]  

Breaking Down the Barrier: Evidence against a Role for Heparan Sulfate in Glomerular Permselectivity

Scott J. Harvey and Jeffrey H. Miner

J Am Soc Nephrol 18: 672-674. [Full Text] [PDF]  

Uremic Retention Solutes: The Free and the Bound

Thomas Depner and Jonathan Himmelfarb

J Am Soc Nephrol 18: 675-676. [Full Text] [PDF]  

Special Tribute:

In Memoriam: Fokke Johannes van der Woude 1953–2006

J Am Soc Nephrol 18: 677-678. [Full Text] [PDF]  

Review:

Urea and Renal Function in the 21st Century: Insights from Knockout Mice

Robert A. Fenton and Mark A. Knepper

J Am Soc Nephrol 18: 679-688. [Abstract] [Full Text] [PDF]  

Cell Biology:

Expression and Subcellular Distribution of Novel Glomerulus-Associated Proteins Dendrin, Ehd3, Sh2d4a, Plekhh2, and 2310066E14Rik

Jaakko Patrakka, Zhijie Xiao, Masatoshi Nukui, Minoru Takemoto, Liqun He, Asmundur Oddsson, Ljubica Perisic, Anne Kaukinen, Cristina Al-Khalili Szigyarto, Mathias Uhlén, Hannu Jalanko, Christer Betsholtz, and Karl Tryggvason

J Am Soc Nephrol 18: 689-697. [Abstract] [Full Text] [PDF]  

Distribution of -Galactosidase A in Normal Human Kidney and Renal Accumulation and Distribution of Recombinant -Galactosidase A in Fabry Mice

Erik I. Christensen, Qun Zhou, Søren S. Sørensen, Åse K. Rasmussen, Christian Jacobsen, Ulla Feldt-Rasmussen, and Rikke Nielsen

J Am Soc Nephrol 18: 698-706. [Abstract] [Full Text] [PDF]  

Genetics and Development:

Cystic Fibrosis Is Associated with a Defect in Apical Receptor–Mediated Endocytosis in Mouse and Human Kidney

François Jouret, Alfred Bernard, Cédric Hermans, Geneviève Dom, Sara Terryn, Teresinha Leal, Patrick Lebecque, Jean-Jacques Cassiman, Bob J. Scholte, Hugo R. de Jonge, Pierre J. Courtoy, and Olivier Devuyst

J Am Soc Nephrol 18: 707-718. [Abstract] [Full Text] [PDF] [Supplemental Data]  

Impaired Glomerular Maturation and Lack of VEGF165b in Denys-Drash Syndrome

Valérie Anne Schumacher, Stefanie Jeruschke, Frank Eitner, Jan Ulrich Becker, Gerald Pitschke, Yasemin Ince, Jeffrey H. Miner, Ivo Leuschner, Rainer Engers, Anne Schulze Everding, Monika Bulla, and Brigitte Royer-Pokora

J Am Soc Nephrol 18: 719-729. [Abstract] [Full Text] [PDF]  

Hemodynamics and Vascular Regulation:

Lack of Endothelial Nitric Oxide Synthase Promotes Endothelin-Induced Hypertension: Lessons from Endothelin-1 Transgenic/Endothelial Nitric Oxide Synthase Knockout Mice

Thomas Quaschning, Florian Voss, Katharina Relle, Philipp Kalk, Nicolas Vignon-Zellweger, Thiemo Pfab, Christian Bauer, Franziska Theilig, Sebastian Bachmann, Annette Kraemer-Guth, Christoph Wanner, Franz Theuring, Jan Galle, and Berthold Hocher

J Am Soc Nephrol 18: 730-740. [Abstract] [Full Text] [PDF]  

Insulin Induces Renal Vasodilation, Increases Plasma Renin Activity, and Sensitizes the Renal Vasculature to Angiotensin Receptor Blockade in Healthy Subjects

Todd S. Perlstein, Marie Gerhard-Herman, Norman K. Hollenberg, Gordon H. Williams, and Abraham Thomas

J Am Soc Nephrol 18: 944-951. [Abstract] [Full Text] [PDF]  

Chronic Kidney Disease:

Role of Nitric Oxide–Producing and –Degrading Pathways in Coronary Endothelial Dysfunction in Chronic Kidney Disease

Satoru Tatematsu, Shu Wakino, Takeshi Kanda, Koichiro Homma, Kyoko Yoshioka, Kazuhiro Hasegawa, Naoki Sugano, Masumi Kimoto, Takao Saruta, and Koichi Hayashi

J Am Soc Nephrol 18: 741-749. [Abstract] [Full Text] [PDF]  

Long-Term, High-Dosage Candesartan Suppresses Inflammation and Injury in Chronic Kidney Disease: Nonhemodynamic Renal Protection

Chen Yu, Rujun Gong, Abdlla Rifai, Evelyn M. Tolbert, and Lance D. Dworkin

J Am Soc Nephrol 18: 750-759. [Abstract] [Full Text] [PDF]  

Association between Multidisciplinary Care and Survival for Elderly Patients with Chronic Kidney Disease

Brenda R. Hemmelgarn, Braden J. Manns, Jianguo Zhang, Marcello Tonelli, Scott Klarenbach, Michael Walsh, Bruce F. Culleton for the Alberta Kidney Disease Network

J Am Soc Nephrol 18: 993-999. [Abstract] [Full Text] [PDF]  

Basic Immunology and Pathology:

Endogenous Myeloperoxidase Promotes Neutrophil-Mediated Renal Injury, but Attenuates T Cell Immunity Inducing Crescentic Glomerulonephritis

Dragana Odobasic, A. Richard Kitching, Timothy J. Semple, and Stephen R. Holdsworth

J Am Soc Nephrol 18: 760-770. [Abstract] [Full Text] [PDF]  

Presentation of the Goodpasture Autoantigen Requires Proteolytic Unlocking Steps That Destroy Prominent T Cell Epitopes

Juan Zou, Lorna Henderson, Vicky Thomas, Patricia Swan, A. Neil Turner, and Richard. G. Phelps

J Am Soc Nephrol 18: 771-779. [Abstract] [Full Text] [PDF] [Data Supplement]  

DEC-205–Mediated Internalization of HIV-1 Results in the Establishment of Silent Infection in Renal Tubular Cells

Ikusuke Hatsukari, Priyanka Singh, Naoko Hitosugi, Davorka Messmer, Elsa Valderrama, Saul Teichberg, Wayne Chaung, Eleanore Gross, Helena Schmidtmayerova, and Pravin C. Singhal

J Am Soc Nephrol 18: 780-787. [Abstract] [Full Text] [PDF]  

Thrombospondin 2 Functions as an Endogenous Regulator of Angiogenesis and Inflammation in Experimental Glomerulonephritis in Mice

Christoph Daniel, Kerstin Amann, Bernd Hohenstein, Paul Bornstein, and Christian Hugo

J Am Soc Nephrol 18: 788-798. [Abstract] [Full Text] [PDF]  

Active Focal Segmental Glomerulosclerosis Is Associated with Massive Oxidation of Plasma Albumin

Luca Musante, Giovanni Candiano, Andrea Petretto, Maurizio Bruschi, Nazzareno Dimasi, Gianluca Caridi, Barbara Pavone, Piero Del Boccio, Monica Galliano, Andrea Urbani, Francesco Scolari, Flavio Vincenti, and Gian Marco Ghiggeri

J Am Soc Nephrol 18: 799-810. [Abstract] [Full Text] [PDF]  

Unrestricted C3 Activation Occurs in Crry-Deficient Kidneys and Rapidly Leads to Chronic Renal Failure

Lihua Bao, Ying Wang, Anthony Chang, Andrew W. Minto, Jian Zhou, Hong Kang, Mark Haas, and Richard J. Quigg

J Am Soc Nephrol 18: 811-822. [Abstract] [Full Text] [PDF]  

Pathophysiology of Renal Disease and Progression:

In Vivo Degradation of Heparan Sulfates in the Glomerular Basement Membrane Does Not Result in Proteinuria

Tessa J.M. Wijnhoven, Joost F.M. Lensen, Ronnie G.P. Wismans, Mohammed Lamrani, Leo A.H. Monnens, Ron A. Wevers, Angelique L.W.M.M. Rops, Johan van der Vlag, Jo H.M. Berden, Lambert P.W.J. van den Heuvel, and Toin H. van Kuppevelt

J Am Soc Nephrol 18: 823-832. [Abstract] [Full Text] [PDF]  

Protective Role of Ecto-5'-Nucleotidase (CD73) in Renal Ischemia

Almut Grenz, Hua Zhang, Tobias Eckle, Michel Mittelbronn, Manfred Wehrmann, Christoph Köhle, Doris Kloor, Linda F. Thompson, Hartmut Osswald, and Holger K. Eltzschig

J Am Soc Nephrol 18: 833-845. [Abstract] [Full Text] [PDF]  

Plasmin(ogen) Promotes Renal Interstitial Fibrosis by Promoting Epithelial-to-Mesenchymal Transition: Role of Plasmin-Activated Signals

Guoqiang Zhang, Kelly A. Kernan, Sarah J. Collins, Xiaohe Cai, Jesús M. López-Guisa, Jay L. Degen, Yigal Shvil, and Allison A. Eddy

J Am Soc Nephrol 18: 846-859. [Abstract] [Full Text] [PDF]  

Role of Protein C in Renal Dysfunction after Polymicrobial Sepsis

Akanksha Gupta, David T. Berg, Bruce Gerlitz, Ganesh R. Sharma, Samreen Syed, Mark A. Richardson, George Sandusky, Josef G. Heuer, Elizabeth J. Galbreath, and Brian W. Grinnell

J Am Soc Nephrol 18: 860-867. [Abstract] [Full Text] [PDF]  

Basic Dialysis:

Increasing the Clearance of Protein-Bound Solutes by Addition of a Sorbent to the Dialysate

Timothy W. Meyer, John W.T. Peattie, Jared D. Miller, Diana C. Dinh, Natalie S. Recht, Jason L. Walther, and Thomas H. Hostetter

J Am Soc Nephrol 18: 868-874. [Abstract] [Full Text] [PDF]  

Disease of the Month:

Metabolic Bone Disease in Chronic Kidney Disease

Kevin J. Martin and Esther A. González

J Am Soc Nephrol 18: 875-885. [Abstract] [Full Text] [PDF]  

Clinical Nephrology:

Efficient Removal of Immunoglobulin Free Light Chains by Hemodialysis for Multiple Myeloma: In Vitro and In Vivo Studies

Colin A. Hutchison, Paul Cockwell, Steven Reid, Katie Chandler, Graham P. Mead, John Harrison, John Hattersley, Neil D. Evans, Mike J. Chappell, Mark Cook, Hermann Goehl, Markus Storr, and Arthur R. Bradwell

J Am Soc Nephrol 18: 886-895. [Abstract] [Full Text] [PDF]  

Glycated Albumin Is a Better Glycemic Indicator than Glycated Hemoglobin Values in Hemodialysis Patients with Diabetes: Effect of Anemia and Erythropoietin Injection

Masaaki Inaba, Senji Okuno, Yasuro Kumeda, Shinsuke Yamada, Yasuo Imanishi, Tsutomu Tabata, Mikio Okamura, Shigeki Okada, Tomoyuki Yamakawa, Eiji Ishimura, Yoshiki Nishizawa, and and the Osaka CKD Expert Research Group

J Am Soc Nephrol 18: 896-903. [Abstract] [Full Text] [PDF]  

Urinary N-Acetyl--(D)-Glucosaminidase Activity and Kidney Injury Molecule-1 Level Are Associated with Adverse Outcomes in Acute Renal Failure

Orfeas Liangos, Mary C. Perianayagam, Vishal S. Vaidya, Won K. Han, Ron Wald, Hocine Tighiouart, Robert W. MacKinnon, Lijun Li, Vaidyanathapuram S. Balakrishnan, Brian J.G. Pereira, Joseph V. Bonventre, and Bertrand L. Jaber

J Am Soc Nephrol 18: 904-912. [Abstract] [Full Text] [PDF]  

Urine Biomarkers Predict the Cause of Glomerular Disease

Sanju A. Varghese, T. Brian Powell, Milos N. Budisavljevic, Jim C. Oates, John R. Raymond, Jonas S. Almeida, and John M. Arthur

J Am Soc Nephrol 18: 913-922. [Abstract] [Full Text] [PDF]  

Human Genetics:

Anomalies of the TCF2 Gene Are the Main Cause of Fetal Bilateral Hyperechogenic Kidneys

Stéphane Decramer, Olivier Parant, Sandrine Beaufils, Séverine Clauin, Cécile Guillou, Sylvie Kessler, Jacqueline Aziza, Flavio Bandin, Joost P. Schanstra, and Christine Bellanné-Chantelot

J Am Soc Nephrol 18: 923-933. [Abstract] [Full Text] [PDF]  

Identification of a Forskolin-Like Molecule in Human Renal Cysts

William C. Putnam, Sarah M. Swenson, Gail A. Reif, Darren P. Wallace, George M. Helmkamp, Jr., and Jared J. Grantham

J Am Soc Nephrol 18: 934-943. [Abstract] [Full Text] [PDF]  

Epidemiology and Outcomes:

Infection-Related Hospitalization Rates in Pediatric versus Adult Patients with End-Stage Renal Disease in the United States

Blanche M. Chavers, Craig A. Solid, David T. Gilbertson, and Allan J. Collins

J Am Soc Nephrol 18: 952-959. [Abstract] [Full Text] [PDF]  

Lowest Systolic Blood Pressure Is Associated with Stroke in Stages 3 to 4 Chronic Kidney Disease

Daniel E. Weiner, Hocine Tighiouart, Andrew S. Levey, Essam Elsayed, John L. Griffith, Deeb N. Salem, and Mark J. Sarnak

J Am Soc Nephrol 18: 960-966. [Abstract] [Full Text] [PDF]  

Association between Body Mass Index and Mortality Is Similar in the Hemodialysis Population and the General Population at High Age and Equal Duration of Follow-Up

Renée de Mutsert, Marieke B. Snijder, Femke van der Sman-de Beer, Jacob C. Seidell, Elisabeth W. Boeschoten, Raymond T. Krediet, Jacqueline M. Dekker, Jan P. Vandenbroucke, Friedo W. Dekker for the Netherlands Cooperative Study on the Adequacy of Dialysis-2 (NECOSAD) Study Group

J Am Soc Nephrol 18: 967-974. [Abstract] [Full Text] [PDF]  

Clinical Dialysis:

Ferric Gluconate Is Highly Efficacious in Anemic Hemodialysis Patients with High Serum Ferritin and Low Transferrin Saturation: Results of the Dialysis Patients’ Response to IV Iron with Elevated Ferritin (DRIVE) Study

Daniel W. Coyne, Toros Kapoian, Wadi Suki, Ajay K. Singh, John E. Moran, Naomi V. Dahl, Adel R. Rizkala, and the DRIVE Study Group

J Am Soc Nephrol 18: 975-984. [Abstract] [Full Text] [PDF]  

Far-Infrared Therapy: A Novel Treatment to Improve Access Blood Flow and Unassisted Patency of Arteriovenous Fistula in Hemodialysis Patients

Chih-Ching Lin, Chao-Fu Chang, Ming-Yu Lai, Tzen-Wen Chen, Pui-Ching Lee, and Wu-Chang Yang

J Am Soc Nephrol 18: 985-992. [Abstract] [Full Text] [PDF]  

Clinical Transplantation:

Outcome of Multipair Donor Kidney Exchange by a Web-Based Algorithm

Beom Seok Kim, Yu Seun Kim, Soon Il Kim, Myoung Soo Kim, Ho Yung Lee, Yong-Lim Kim, Chan Duck Kim, Chul Woo Yang, Bum Soon Choi, Duck Jong Han, Yon Su Kim, Sung Joo Kim, Ha-Young Oh, and Dae Joong Kim

J Am Soc Nephrol 18: 1000-1006. [Abstract] [Full Text] [PDF]  

Regulatory T Cells and T Cell Depletion: Role of Immunosuppressive Drugs

Marina Noris, Federica Casiraghi, Marta Todeschini, Paolo Cravedi, Daniela Cugini, Giuseppe Monteferrante, Sistiana Aiello, Linda Cassis, Eliana Gotti, Flavio Gaspari, Dario Cattaneo, Norberto Perico, and Giuseppe Remuzzi

J Am Soc Nephrol 18: 1007-1018. [Abstract] [Full Text] [PDF]  

Announcements:

Announcements

J Am Soc Nephrol 18: 1019. [Full Text] [PDF]  

ASN News:

ASN News

J Am Soc Nephrol 18: A27-A30. [Full Text] [PDF]  

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