TABLE OF CONTENTS: Volume 18, Issue 6, June 2007

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This Month's Highlights

This Month's Highlights
J Am Soc Nephrol 18: 1617-1618. [Full Text] [PDF]

Nephrology beyond JASN

Metabolic Syndrome—What We Know and What We Don't Know: LPR6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors. Science 315: 1278–1282, 2007
Ar. Mani, J. Radhakrishnan, H. Wang, Al. Mani, M.A. Mani, C. Nelson-Williams, K.S. Carew, S. Mane, H. Najmabadi, D. Wu, and R.P. Lifton J Am Soc Nephrol 18: 1619-1623. [Full Text] [PDF]

Editorials

Opening Pandora's Box in the Tight Junction
Daniel F. Balkovetz J Am Soc Nephrol 18: 1624-1625. [Full Text] [PDF]

Developmental Hypertension, Nephrogenesis, and Mother's Milk: Programming the Neonate
Susan P. Bagby J Am Soc Nephrol 18: 1626-1629. [Full Text] [PDF]

More on Renal Disease Progression: Is Interstitial Inflammation Truly Protective?
Norberto Perico, Mauro Abbate, and Giuseppe Remuzzi J Am Soc Nephrol 18: 1630-1632. [Full Text] [PDF]

Is Proteinuria Reduction by Angiotensin-Converting Enzyme Inhibition Enough to Prove Its Role in Renal Protection in IgA Nephropathy?
Daniel C. Cattran J Am Soc Nephrol 18: 1633-1634. [Full Text] [PDF]

Renal Replacement Therapy in the Developing World: Are We on the Right Track, or Should There Be a New Paradigm?
Ricardo Correa-Rotter J Am Soc Nephrol 18: 1635-1636. [Full Text] [PDF]

Review

How Fibroblast Growth Factor 23 Works
Shiguang Liu and L. Darryl Quarles J Am Soc Nephrol 18: 1637-1647. [Abstract] [Full Text] [PDF]

Special Feature

JASN Moves On
William G. Couser, Carol Hill, and Allison A. Eddy J Am Soc Nephrol 18: 1648-1651. [Full Text] [PDF]

Cell and Transport Physiology

Acute Regulation of the Epithelial Na⁺ Channel by Phosphatidylinositide 3-OH Kinase Signaling in Native Collecting Duct Principal Cells
Alexander Staruschenko, Oleh Pochynyuk, Alain Vandewalle, Vladislav Bugaj, and James D. Stockand J Am Soc Nephrol 18: 1652-1661. [Abstract] [Full Text] [PDF]

Role for TGF- $beta$ in Cyclosporine-Induced Modulation of Renal Epithelial Barrier Function
Gemma Feldman, Breda Kiely, Natalia Martin, Gavin Ryan, Tara McMorrow, and Michael P. Ryan J Am Soc Nephrol 18: 1662-1671. [Abstract] [Full Text] [PDF]

Increased Renal Responsiveness to Vasopressin and Enhanced V2 Receptor Signaling in RGS2^–/– Mice
Annie Mercier Zuber, Dustin Singer, Josef M. Penninger, Bernard C. Rossier, and Dmitri Firsov J Am Soc Nephrol 18: 1672-1678. [Abstract] [Full Text] [PDF] [Data Supplement]

Impairment of Sodium Balance in Mice Deficient in Renal Principal Cell Mineralocorticoid Receptor
Caroline Ronzaud, Johannes Loffing, Markus Bleich, Norbert Gretz, Hermann-Josef Gröne, Günther Schütz, and Stefan Berger J Am Soc Nephrol 18: 1679-1687. [Abstract] [Full Text] [PDF]

Genetics and Development

Normal Lactational Environment Restores Nephron Endowment and Prevents Hypertension after Placental Restriction in the Rat
Mary E. Wlodek, Amy Mibus, Adeline Tan, Andrew L. Siebel, Julie A. Owens, and Karen M. Moritz J Am Soc Nephrol 18: 1688-1696. [Abstract] [Full Text] [PDF]

Crim1^{KST264/KST264} Mice Implicate Crim1 in the Regulation of Vascular Endothelial Growth Factor-A Activity during Glomerular Vascular Development
Lorine Wilkinson, Thierry Gilbert, Genevieve Kinna, Leah-Anne Ruta, David Pennisi, Michelle Kett, and Melissa H. Little J Am Soc Nephrol 18: 1697-1708. [Abstract] [Full Text] [PDF]

Mouse Embryonic Stem Cell–Derived Embryoid Bodies Generate Progenitors That Integrate Long Term into Renal Proximal Tubules In Vivo
Cécile Vigneau, Katalin Polgar, Gary Striker, Justine Elliott, Deborah Hyink, Odile Weber, Hans-Joerg Fehling, Gordon Keller, Christopher Burrow, and Patricia Wilson J Am Soc Nephrol 18: 1709-1720. [Abstract] [Full Text] [PDF] [Supplemental Data]

Basic Immunology and Pathology

Inhibition of Toll-Like Receptor-7 (TLR-7) or TLR-7 plus TLR-9 Attenuates Glomerulonephritis and Lung Injury in Experimental Lupus
Rahul D. Pawar, Allam Ramanjaneyulu, Onkar P. Kulkarni, Maciej Lech, Stephan Segerer, and Hans-Joachim Anders J Am Soc Nephrol 18: 1721-1731. [Abstract] [Full Text] [PDF]

Toll-Like Receptor 4 Ligation on Intrinsic Renal Cells Contributes to the Induction of Antibody-Mediated Glomerulonephritis via CXCL1 and CXCL2
Heather J. Brown, Helen R. Lock, Tim G.A.M. Wolfs, Wim A. Buurman, Steven H. Sacks, and Michael G. Robson J Am Soc Nephrol 18: 1732-1739. [Abstract] [Full Text] [PDF]

Pathophysiology of Renal Disease and Progression

PKD1 Haploinsufficiency Causes a Syndrome of Inappropriate Antidiuresis in Mice
Ali K. Ahrabi, Sara Terryn, Giovanna Valenti, Nathalie Caron, Claudine Serradeil-Le Gal, Danielle Raufaste, Soren Nielsen, Shigeo Horie, Jean-Marc Verbavatz, and Olivier Devuyst J Am Soc Nephrol 18: 1740-1753. [Abstract] [Full Text] [PDF] [Data Supplement][Data Supplement]

Mesenchymal Stem Cells Prevent Progressive Experimental Renal Failure but Maldifferentiate into Glomerular Adipocytes
Uta Kunter, Song Rong, Peter Boor, Frank Eitner, Gerhard Müller-Newen, Zivka Djuric, Claudia R. van Roeyen, Andrzej Konieczny, Tammo Ostendorf, Luigi Villa, Maja Milovanceva-Popovska, Dontscho Kerjaschki, and Jürgen Floege J Am Soc Nephrol 18: 1754-1764. [Abstract] [Full Text] [PDF]

Interstitial Vascular Rarefaction and Reduced VEGF-A Expression in Human Diabetic Nephropathy
Maja T. Lindenmeyer, Matthias Kretzler, Anissa Boucherot, Silvia Berra, Yoshinari Yasuda, Anna Henger, Felix Eichinger, Stefanie Gaiser, Holger Schmid, Maria P. Rastaldi, Robert W. Schrier, Detlef Schlöndorff, and Clemens D. Cohen J Am Soc Nephrol 18: 1765-1776. [Abstract] [Full Text] [PDF] [Data Supplement]

Smad7 Gene Therapy Ameliorates an Autoimmune Crescentic Glomerulonephritis in Mice
Shuk-Man Ka, Xiao-Ru Huang, Hui-Yao Lan, Pei-Yi Tsai, Shun-Min Yang, Hao-Ai Shui, and Ann Chen J Am Soc Nephrol 18: 1777-1788. [Abstract] [Full Text] [PDF]

Slowly Progressive, Angiotensin II–Independent Glomerulosclerosis in Human (Pro)renin Receptor–Transgenic Rats
Yuki Kaneshiro, Atsuhiro Ichihara, Mariyo Sakoda, Tomoko Takemitsu, A.H.M. Nurun Nabi, M. Nasir Uddin, Tsutomu Nakagawa, Akira Nishiyama, Fumiaki Suzuki, Tadashi Inagami, and Hiroshi Itoh J Am Soc Nephrol 18: 1789-1795. [Abstract] [Full Text] [PDF]

Combination Therapy with an Angiotensin-Converting Enzyme Inhibitor and a Vitamin D Analog Suppresses the Progression of Renal Insufficiency in Uremic Rats
Masahide Mizobuchi, Jeremiah Morrissey, Jane L. Finch, Daniel R. Martin, Helen Liapis, Tadao Akizawa, and Eduardo Slatopolsky J Am Soc Nephrol 18: 1796-1806. [Abstract] [Full Text] [PDF]

Evidence for the Role of Reactive Nitrogen Species in Polymicrobial Sepsis-Induced Renal Peritubular Capillary Dysfunction and Tubular Injury
Liping Wu, Neriman Gokden, and Philip R. Mayeux J Am Soc Nephrol 18: 1807-1815. [Abstract] [Full Text] [PDF]

Genes Expressed by Both Mesangial Cells and Bone Marrow–Derived Cells Underlie Genetic Susceptibility to Crescentic Glomerulonephritis in the Rat
Jennifer Smith, Ping-Chin Lai, Jacques Behmoaras, Candice Roufosse, Gurjeet Bhangal, John P McDaid, Timothy Aitman, Frederick WK Tam, Charles D. Pusey, and H. Terence Cook J Am Soc Nephrol 18: 1816-1823. [Abstract] [Full Text] [PDF]

Chronic Kidney Disease

Abrogation of Protein Uptake through Megalin-Deficient Proximal Tubules Does Not Safeguard against Tubulointerstitial Injury
Franziska Theilig, Wilhelm Kriz, Timo Jerichow, Petra Schrade, Brunhilde Hähnel, Thomas Willnow, Michel Le Hir, and Sebastian Bachmann J Am Soc Nephrol 18: 1824-1834. [Abstract] [Full Text] [PDF]

Estimated Glomerular Filtration Rate and Urinary Albumin Excretion Are Independently Associated with Greater Arterial Stiffness: The Hoorn Study
Marc M.H. Hermans, Ronald Henry, Jacqueline M. Dekker, Jeroen P. Kooman, Piet J. Kostense, Giel Nijpels, Robert J. Heine, and Coen D.A. Stehouwer J Am Soc Nephrol 18: 1942-1952. [Abstract] [Full Text] [PDF]

Myocardial Ultrasound Tissue Characterization in Patients with Chronic Renal Failure
Massimo Salvetti, Maria Lorenza Muiesan, Anna Paini, Cristina Monteduro, Bianca Bonzi, Gloria Galbassini, Eugenia Belotti, Ezio Movilli, Giovanni Cancarini, and Enrico Agabiti-Rosei J Am Soc Nephrol 18: 1953-1958. [Abstract] [Full Text] [PDF]

Progression Risk, Urinary Protein Excretion, and Treatment Effects of Angiotensin-Converting Enzyme Inhibitors in Nondiabetic Kidney Disease
David M. Kent, Tazeen H. Jafar, Rodney A. Hayward, Hocine Tighiouart, Marcia Landa, Paul de Jong, Dick de Zeeuw, Giuseppe Remuzzi, Anne-Lise Kamper, Andrew S. Levey for the AIRPD Study Group J Am Soc Nephrol 18: 1959-1965. [Abstract] [Full Text] [PDF]

Carotid Intima Media Thickness Predicts Cardiovascular Diseases in Chinese Predialysis Patients with Chronic Kidney Disease
Cheuk-Chun Szeto, Kai-Ming Chow, Kam-Sang Woo, Ping Chook, Bonnie Ching-Ha Kwan, Chi-Bon Leung, and Philip Kam-Tao Li J Am Soc Nephrol 18: 1966-1972. [Abstract] [Full Text] [PDF]

Basic Transplantation

Selective Binding and Presentation of CCL5 by Discrete Tissue Microenvironments during Renal Inflammation
Stephan Segerer, Roghieh Djafarzadeh, Hermann-Josef Gröne, Christian Weingart, Dontscho Kerjaschki, Christian Weber, Andreas J. Kungl, Heinz Regele, Amanda E.I. Proudfoot, and Peter J. Nelson J Am Soc Nephrol 18: 1835-1844. [Abstract] [Full Text] [PDF]

Disease of the Month

Exercise in the End-Stage Renal Disease Population
Kirsten L. Johansen J Am Soc Nephrol 18: 1845-1854. [Abstract] [Full Text] [PDF] A general review of the topic discussed in this article is available through UpToDate in Nephrology. [Physical activity in end-stage renal disease and renal transplantation]

Nephronophthisis-Associated Ciliopathies
Friedhelm Hildebrandt and Weibin Zhou J Am Soc Nephrol 18: 1855-1871. [Abstract] [Full Text] [PDF] A general review of the topic discussed in this article is available through UpToDate in Nephrology. [Nephronophthisis-medullary cystic kidney disease complex]

Clinical Nephrology

Lower Progression Rate of End-Stage Renal Disease in Patients with Peripheral Arterial Disease Using Statins or Angiotensin-Converting Enzyme Inhibitors
Harm H.H. Feringa, Stefanos E. Karagiannis, Michel Chonchol, Radosav Vidakovic, Peter G. Noordzij, Abdou Elhendy, Ron T. van Domburg, Gijs Welten, Olaf Schouten, Jeroen J. Bax, Tomas Berl, and Don Poldermans J Am Soc Nephrol 18: 1872-1879. [Abstract] [Full Text] [PDF] A general review of the topic discussed in this article is available through UpToDate in Nephrology. [Peripheral arterial disease in chronic kidney disease]

IgACE: A Placebo-Controlled, Randomized Trial of Angiotensin-Converting Enzyme Inhibitors in Children and Young People with IgA Nephropathy and Moderate Proteinuria
Rosanna Coppo, Licia Peruzzi, Alessandro Amore, Antonio Piccoli, Pierre Cochat, Rosario Stone, Martin Kirschstein, Tommy Linné on behalf of the EC Biomed Concerted Action Project BMH4-97-2487(DG 12-SSMI) and IgACE European Collaborative Group J Am Soc Nephrol 18: 1880-1888. [Abstract] [Full Text] [PDF] A general review of the topic discussed in this article is available through UpToDate in Nephrology. [Treatment and prognosis of IgA nephropathy]

Renoprotection of Optimal Antiproteinuric Doses (ROAD) Study: A Randomized Controlled Study of Benazepril and Losartan in Chronic Renal Insufficiency
Fan Fan Hou, Di Xie, Xun Zhang, Ping Yan Chen, Wei Ru Zhang, Min Liang, Zhi Jian Guo, and Jian Ping Jiang J Am Soc Nephrol 18: 1889-1898. [Abstract] [Full Text] [PDF]

A Randomized, Controlled Trial of Steroids and Cyclophosphamide in Adults with Nephrotic Syndrome Caused by Idiopathic Membranous Nephropathy
Vivekanand Jha, Anirban Ganguli, Tarun K. Saha, Harbir S. Kohli, Kamal Sud, Krishan L. Gupta, Kusum Joshi, and Vinay Sakhuja J Am Soc Nephrol 18: 1899-1904. [Abstract] [Full Text] [PDF]

Human Genetics

Comprehensive Mutation Screening in 55 Probands with Type 1 Primary Hyperoxaluria Shows Feasibility of a Gene-Based Diagnosis
Carla G. Monico, Sandro Rossetti, Heidi A. Schwanz, Julie B. Olson, Patrick A. Lundquist, D. Brian Dawson, Peter C. Harris, and Dawn S. Milliner J Am Soc Nephrol 18: 1905-1914. [Abstract] [Full Text] [PDF]

A Common Variant of the PAX2 Gene Is Associated with Reduced Newborn Kidney Size
Jacklyn Quinlan, Mathieu Lemire, Thomas Hudson, Huiqi Qu, Alice Benjamin, Anne Roy, Elena Pascuet, Meigan Goodyer, Chandhana Raju, Zhao Zhang, Fiona Houghton, and Paul Goodyer J Am Soc Nephrol 18: 1915-1921. [Abstract] [Full Text] [PDF]

Epidemiology and Outcomes

Survival among Patients with Kidney Failure in Jalisco, Mexico
Guillermo Garcia-Garcia, Gregorio Briseño-Rentería, Victor H. Luquín-Arellan, Zhiwei Gao, John Gill, and Marcello Tonelli J Am Soc Nephrol 18: 1922-1927. [Abstract] [Full Text] [PDF]

A Population-Based, Prospective Study of Blood Pressure and Risk for End-Stage Renal Disease in China
Kristi Reynolds, Dongfeng Gu, Paul Muntner, John W. Kusek, Jing Chen, Xigui Wu, Xiufang Duan, Chung-Shiuan Chen, Michael J. Klag, Paul K. Whelton, and Jiang He J Am Soc Nephrol 18: 1928-1935. [Abstract] [Full Text] [PDF]

Clinical Dialysis

Comparison of Survival of Upper Arm Arteriovenous Fistulas and Grafts after Failed Forearm Fistula
Timmy Lee, Jill Barker, and Michael Allon J Am Soc Nephrol 18: 1936-1941. [Abstract] [Full Text] [PDF] A general review of the topic discussed in this article is available through UpToDate in Nephrology. [Chronic hemodialysis vascular access: Types and placement]

Clinical Transplantation

Mycophenolate Mofetil versus Azathioprine for Prevention of Chronic Allograft Dysfunction in Renal Transplantation: The MYSS Follow-Up Randomized, Controlled Clinical Trial
Giuseppe Remuzzi, Paolo Cravedi, Marco Costantini, Mariadomenica Lesti, Maria Ganeva, Giulia Gherardi, Bogdan Ene-Iordache, Eliana Gotti, Donato Donati, Maurizio Salvadori, Silvio Sandrini, Giuseppe Segoloni, Stefano Federico, Paolo Rigotti, Vito Sparacino, Piero Ruggenenti for the MYSS Follow-Up Study Group J Am Soc Nephrol 18: 1973-1985. [Abstract] [Full Text] [PDF]

Announcements

Announcements
J Am Soc Nephrol 18: 1986. [Full Text] [PDF]

ASN News

ASN News
J Am Soc Nephrol 18: A45-A46. [Full Text] [PDF]