TABLE OF CONTENTS: Volume 20, Issue 8, August 2009

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UP FRONT MATTERS

Obituary
Editorials
Clinical Commentary
Brief Reviews
Pathophysiology of the Renal Biopsy

This Month's Highlights

BRIEF COMMUNICATION

BASIC RESEARCH

CLINICAL EPIDEMIOLOGY

CLINICAL RESEARCH

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This Month's Highlights

This Month's Highlights
J Am Soc Nephrol 20: A12. [Full Text] [PDF]

UP FRONT MATTERS

Obituary

Franklin H. Epstein: Reminiscences of a Brilliant Physician-Scientist and Master Clinician
John N. Forrest, Jr. J Am Soc Nephrol 20: 1651-1653. [Full Text] [PDF]

Editorials

LAMPs and NETs in the Pathogenesis of ANCA Vasculitis
Xavier Bosch J Am Soc Nephrol 20: 1654-1656. [Full Text] [PDF]

The Development of Urinary Biomarkers for Kidney Disease Is the Search for Our Renal Troponin
Lynda Anne Szczech J Am Soc Nephrol 20: 1656-1657. [Full Text] [PDF]

Does Idiopathic Hypercalciuria Trigger Calcium-Sensing Receptor–Mediated Protection from Urinary Supersaturation?
Elaine M. Worcester and Fredric L. Coe J Am Soc Nephrol 20: 1657-1659. [Full Text] [PDF]

The SDF-1/CXCR4 Axis Is a Novel Driver of Vascular Development of the Glomerulus
Jürgen Floege, Bart Smeets, and Marcus J. Moeller J Am Soc Nephrol 20: 1659-1661. [Full Text] [PDF]

A Novel Role for Nephrin in the Maintenance of Glomerular Structure
Neil S. Sheerin J Am Soc Nephrol 20: 1661-1663. [Full Text] [PDF]

Low Calcidiol Levels and Coronary Artery Calcification: True, True, and Related?
Michal L. Melamed and Ravi Thadhani J Am Soc Nephrol 20: 1663-1665. [Full Text] [PDF]

Clinical Commentary

Is There Added Value to Adding ARB to ACE Inhibitors in the Management of CKD?
Debbie L. Cohen and Raymond R. Townsend J Am Soc Nephrol 20: 1666-1668. [Abstract] [Full Text] [PDF]

Brief Reviews

The Role of Podocalyxin in Health and Disease
Julie S. Nielsen and Kelly M. McNagny J Am Soc Nephrol 20: 1669-1676. [Abstract] [Full Text] [PDF]

Recently Discovered T Cell Subsets Cannot Keep Their Commitments
Terry B. Strom and Maria Koulmanda J Am Soc Nephrol 20: 1677-1680. [Abstract] [Full Text] [PDF]

Pathophysiology of the Renal Biopsy

Nephrotic Syndrome Due to an Amyloidogenic Mutation in Fibrinogen A ${alpha}$ Chain
Maria M. Picken and Reinhold P. Linke J Am Soc Nephrol 20: 1681-1685. [Abstract] [Full Text] [PDF]

BRIEF COMMUNICATION

Urinary NGAL Marks Cystic Disease in HIV-Associated Nephropathy
Neal Paragas, Thomas L. Nickolas, Christina Wyatt, Catherine S. Forster, Meghan Sise, Susan Morgello, Bernd Jagla, Charles Buchen, Peter Stella, Simone Sanna-Cherchi, Maria Luisa Carnevali, Silvia Mattei, Achiropita Bovino, Lucia Argentiero, Andrea Magnano, Prasad Devarajan, Kai M. Schmidt-Ott, Landino Allegri, Paul Klotman, Vivette D'Agati, Ali G. Gharavi, and Jonathan Barasch J Am Soc Nephrol 20: 1687-1692. [Abstract] [Full Text] [PDF]

BASIC RESEARCH

Parathyroid Hormone Activates TRPV5 via PKA-Dependent Phosphorylation
Theun de Groot, Kyupil Lee, Michiel Langeslag, Qi Xi, Kees Jalink, René J.M. Bindels, and Joost G.J. Hoenderop J Am Soc Nephrol 20: 1693-1704. [Abstract] [Full Text] [PDF] [Supplemental Data]

The Calcium-Sensing Receptor Promotes Urinary Acidification to Prevent Nephrolithiasis
Kirsten Y. Renkema, Ana Velic, Henry B. Dijkman, Sjoerd Verkaart, Annemiete W. van der Kemp, Marta Nowik, Kim Timmermans, Alain Doucet, Carsten A. Wagner, René J. Bindels, and Joost G. Hoenderop J Am Soc Nephrol 20: 1705-1713. [Abstract] [Full Text] [PDF] [Supplemental Data]

The CXCL12 (SDF-1)/CXCR4 Axis Is Essential for the Development of Renal Vasculature
Yoshitsugu Takabatake, Tatsuki Sugiyama, Hiroshi Kohara, Taiji Matsusaka, Hidetake Kurihara, Pandelakis A. Koni, Yasuyuki Nagasawa, Takayuki Hamano, Isao Matsui, Noritaka Kawada, Enyu Imai, Takashi Nagasawa, Hiromi Rakugi, and Yoshitaka Isaka J Am Soc Nephrol 20: 1714-1723. [Abstract] [Full Text] [PDF] [Supplemental Data]

Connexin 30 Deficiency Impairs Renal Tubular ATP Release and Pressure Natriuresis
Arnold Sipos, Sarah L. Vargas, Ildikó Toma, Fiona Hanner, Klaus Willecke, and János Peti-Peterdi J Am Soc Nephrol 20: 1724-1732. [Abstract] [Full Text] [PDF]

Nephrin Deficiency Activates NF- ${kappa}$ B and Promotes Glomerular Injury
Sagair Hussain, Leile Romio, Moin Saleem, Peter Mathieson, Manuel Serrano, Jorge Moscat, Maria Diaz-Meco, Peter Scambler, and Ania Koziell J Am Soc Nephrol 20: 1733-1743. [Abstract] [Full Text] [PDF]

Regulatory T Cells Suppress Innate Immunity in Kidney Ischemia-Reperfusion Injury
Gilbert R. Kinsey, Rahul Sharma, Liping Huang, Li Li, Amy L. Vergis, Hong Ye, Shyr-Te Ju, and Mark D. Okusa J Am Soc Nephrol 20: 1744-1753. [Abstract] [Full Text] [PDF] [Supplemental Data]

siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury
Bruce A. Molitoris, Pierre C. Dagher, Ruben M. Sandoval, Silvia B. Campos, Hagit Ashush, Eduard Fridman, Anat Brafman, Alexander Faerman, Simon J. Atkinson, James D. Thompson, Hagar Kalinski, Rami Skaliter, Shai Erlich, and Elena Feinstein J Am Soc Nephrol 20: 1754-1764. [Abstract] [Full Text] [PDF]

Pirfenidone Is Renoprotective in Diabetic Kidney Disease
Satish P. RamachandraRao, Yanqing Zhu, Timothy Ravasi, Tracy A. McGowan, Irene Toh, Stephen R. Dunn, Shinichi Okada, Michael A. Shaw, and Kumar Sharma J Am Soc Nephrol 20: 1765-1775. [Abstract] [Full Text] [PDF] [Supplemental Data]

The Calcineurin Homologous Protein-1 Increases Na⁺/H⁺-Exchanger 3 Trafficking via Ezrin Phosphorylation
Francesca Di Sole, Victor Babich, and Orson W. Moe J Am Soc Nephrol 20: 1776-1786. [Abstract] [Full Text] [PDF] [Supplemental Data]

BRG1 Increases Transcription of Proinflammatory Genes in Renal Ischemia
Masayo Naito, Richard A. Zager, and Karol Bomsztyk J Am Soc Nephrol 20: 1787-1796. [Abstract] [Full Text] [PDF]

CLINICAL EPIDEMIOLOGY

High Protein Intake Associates with Cardiovascular Events but not with Loss of Renal Function
Nynke Halbesma, Stephan J.L. Bakker, Desiree F. Jansen, Ronald P. Stolk, Dick De Zeeuw, Paul E. De Jong, Ronald T. Gansevoort, and for the PREVEND study group J Am Soc Nephrol 20: 1797-1804. [Abstract] [Full Text] [PDF]

25-Hydroxyvitamin D Levels Inversely Associate with Risk for Developing Coronary Artery Calcification
Ian H. de Boer, Bryan Kestenbaum, Abigail B. Shoben, Erin D. Michos, Mark J. Sarnak, and David S. Siscovick J Am Soc Nephrol 20: 1805-1812. [Abstract] [Full Text] [PDF]

Albuminuria and Kidney Function Independently Predict Cardiovascular and Renal Outcomes in Diabetes
Toshiharu Ninomiya, Vlado Perkovic, Bastiaan E. de Galan, Sophia Zoungas, Avinesh Pillai, Meg Jardine, Anushka Patel, Alan Cass, Bruce Neal, Neil Poulter, Carl-Erik Mogensen, Mark Cooper, Michel Marre, Bryan Williams, Pavel Hamet, Giuseppe Mancia, Mark Woodward, Stephen MacMahon, John Chalmers on behalf of the ADVANCE Collaborative Group J Am Soc Nephrol 20: 1813-1821. [Abstract] [Full Text] [PDF] [Supplemental Data]

CLINICAL RESEARCH

Urine Neutrophil Gelatinase-Associated Lipocalin Moderately Predicts Acute Kidney Injury in Critically Ill Adults
Edward D. Siew, Lorraine B. Ware, Tebeb Gebretsadik, Ayumi Shintani, Karel G. M. Moons, Nancy Wickersham, Frederick Bossert, and T. Alp Ikizler J Am Soc Nephrol 20: 1823-1832. [Abstract] [Full Text] [PDF] [Supplemental Data][Press Release]

Family History of Renal Disease Severity Predicts the Mutated Gene in ADPKD
Moumita Barua, Onur Cil, Andrew D. Paterson, Kairon Wang, Ning He, Elizabeth Dicks, Patrick Parfrey, and York Pei J Am Soc Nephrol 20: 1833-1838. [Abstract] [Full Text] [PDF]

Expression of Complement Components Differs Between Kidney Allografts from Living and Deceased Donors
Maarten Naesens, Li Li, Lihua Ying, Poonam Sansanwal, Tara K. Sigdel, Szu-Chuan Hsieh, Neeraja Kambham, Evelyne Lerut, Oscar Salvatierra, Atul J. Butte, and Minnie M. Sarwal J Am Soc Nephrol 20: 1839-1851. [Abstract] [Full Text] [PDF] [Supplemental Data]