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Dialysis
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Relative Contribution of Residual Renal Function and Peritoneal Clearance to Adequacy of Dialysis: A Reanalysis of the CANUSA Study

JOANNE M. BARGMAN, KEVIN E. THORPE, DAVID N. CHURCHILL and ; the CANUSA Peritoneal Dialysis Study Group
JASN October 2001, 12 (10) 2158-2162;
JOANNE M. BARGMAN
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KEVIN E. THORPE
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DAVID N. CHURCHILL
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    Table 1.

    GFR, peritoneal creatinine clearance, and fluid removal at volumes baseline and at 6, 12, 18, and 24 months of follow-upa

    Parameter Baseline 6 Mo 12 Mo 18 Mo 24 Mo
    aCcrp, peritoneal creatinine clearance; UF, ultrafiltration. GFR and Ccrp are normalized to 1.73 m2.
    n 601 469 290 147 69
    GFR (L/wk) 37.7 28.7 21.4 19.4 14.8
    Ccrp (L/wk) 44.3 45.8 46.4 45.3 47.2
    Urine volume (ml/24 h) 670 519 428 379 335
    Net peritoneal UF (ml/24 h) 958 1478 1807 1677 1951
    Total fluid removal (ml/24 h) 1628 1997 2235 2056 2286
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    Table 2.

    Cox model of relative risk of death with time-dependent Ccr divided into peritoneal clearance and GFR and entered as time-dependent covariatesa

    Variable Relative Risk 95% Confidence Limit
    aCVD, cardiovascular disease; LA, low average; HA, high average; H, high; SGA, subjective global assessment.
    Age 1.02 1.005-1.044
    CVD 2.42 1.499-3.904
    Diabetes mellitus 1.25 0.769-2.036
    Serum albumin 0.96 0.912-1.000
    LA transport 1.66 0.379-7.218
    HA transport 2.33 0.554-9.801
    H transport 2.01 0.430-9.357
    SGA 0.74 0.647-0.842
    Ccrp (5 L/wk per 1.73 m2 greater) 1.00 0.898-1.105
    GFR (5 L/wk per 1.73 m2 greater) 0.88 0.829-0.943
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    Table 3.

    Cox model of relative risk for death with urine volume forced in as a time-dependent covariate

    Variable Relative Risk 95% Confidence Limits
    Age (1 yr older) 1.02 1.002-1.041
    CVD 2.37 1.465-3.821
    Diabetes mellitus 1.31 0.807-2.134
    Serum albumin (1 g/L increase) 0.96 0.914-1.003
    LA transport 1.84 0.418-8.075
    HA transport 2.71 0.631-11.623
    H transport 2.46 0.523-11.590
    SGA (1 unit greater) 0.78 0.672-0.876
    Ccrp (5 L/wk per 1.73 m2 greater) 0.93 0.795-1.079
    GFR (5 L/wk per 1.73 m2 greater) 0.99 0.943-1.044
    Urine volume (250 ml daily greater) 0.64 0.508-0.800
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Journal of the American Society of Nephrology: 12 (10)
Journal of the American Society of Nephrology
Vol. 12, Issue 10
1 Oct 2001
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Relative Contribution of Residual Renal Function and Peritoneal Clearance to Adequacy of Dialysis: A Reanalysis of the CANUSA Study
JOANNE M. BARGMAN, KEVIN E. THORPE, DAVID N. CHURCHILL
JASN Oct 2001, 12 (10) 2158-2162;

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Relative Contribution of Residual Renal Function and Peritoneal Clearance to Adequacy of Dialysis: A Reanalysis of the CANUSA Study
JOANNE M. BARGMAN, KEVIN E. THORPE, DAVID N. CHURCHILL
JASN Oct 2001, 12 (10) 2158-2162;
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