Article Figures & Data
Figures
- Figure 1.
Photomicrographs demonstrating the histologic appearances of kidneys from wild type (WT; A), interleukin-12 (IL-12) chimeric (B), and IL-12—deficient (C) mice before induction of glomerulonephritis (GN). After induction of GN, WT mice developed proliferative GN with prominent crescent formation (D). Proliferative GN was less severe and crescent formation was less frequent in IL-12 chimeric mice compared with WT mice (E), and only mild glomerular hypercellularity was apparent in IL-12—deficient mice (F). Magnifications: ×200 in A through C (periodic acid-Schiff [PAS] stain); ×400 in D through F (PAS stain).
- Figure 2.
Photomicrographs demonstrating CD4+ T cells (A) and macrophages (B) in glomeruli of WT mice with GN. Confocal images demonstrating IL-12 expression (red) on tubules (C) and in glomeruli of WT mice with GN (D). Co-localization of IL-12 (yellow) on the surface of intraglomerular macrophages (green) can be seen (arrows). Periglomerular macrophages did not express IL-12. In chimeric mice (E), IL-12 expression was restricted to areas adjacent to intraglomerular macrophages (arrows). IL-12 expression could not be detected in IL-12—deficient mice after induction of GN (F). Magnification, ×400 (immunoperoxidase, hematoxylin counterstain in A through C; confocal immunofluorescent images under oil immersion in D through F).
- Figure 3.
The incidence of crescent formation (% glomeruli affected) and glomerular infiltration of CD4+ T cells and macrophages (cells/ per glomerular cross-section [c/gcs]) in normal (WT), sham chimeric, IL-12 chimeric, and IL-12—deficient (IL-12 -/-) mice developing crescentic glomerulonephritis.
- Figure 4.
Proteinuria (mg/24 h), serum creatinine (μmol/L), and interstitial cell counts (cells/mm2) in WT, sham chimeric, IL-12 chimeric, and IL-12—deficient (IL-12 -/-) mice developing GN. The dotted line represents the mean proteinuria, creatinine, and interstitial infiltrate in normal mice.
- Figure 5.
Serum titers of mouse anti-sheep globulin Ab in WT (♦), sham chimeric (○), IL-12 chimeric ([UNK]), and IL-12—deficient (⋄) mice developing crescentic glomerulonephritis. A titration of normal mouse serum (▪) is shown for comparison.
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