Article Figures & Data
Figures
Figure 1. Nondiabetic adults in NHANES III. Weighted distribution of level of predicted GFR (MDRD categories) in ml/min per 1.73 m2 by age (in decades) and stratified by race and gender.
Figure 2. Nondiabetic adults in NHANES III. Weighted distribution of level of creatinine clearance (Cockcroft-Gault [CG] categories) in ml/min by age (in decades) and stratified by race and gender.
Figure 3. Nondiabetic adults in NHANES III. Weighted distribution of level of predicted GFR (Couchoud categories) in ml/min per 1.73 m2 by age (in decades) and stratified by race and gender. For (L/creatinine) ×100, the cutpoint of 80 ml/min corresponds to serum creatinine of 1.25 mg/dl; 60 ml/min to 1.67 mg/dl; and 30 ml/min to 3.33 mg/dl.
Figure 4. Nondiabetic adults in NHANES III. Weighted distribution of level of predicted GFR (reciprocal of creatinine categories) in dl/mg by age (in decades) and stratified by race and gender. For (L/creatinine) × 100, the cutpoint of 80 ml/min corresponds to serum creatinine of 1.25 mg/dl; 60 ml/min to 1.67 mg/dl; and 30 ml/min to 3.33 mg/dl.
Tables
- Table 1.
NHANES III participants who met inclusion criteria. Comparison of those selected for analysis with those excluded on the basis of missing biochemical data for clearance calculationsa
Parameter Excluded Included P a Data are mean (standard error [SE]) for continuous variables and proportions (SE) for discrete variables. Missing data: all variables had 98.6% or more complete information. P values for proportions were assessed by χ2 test, and for continuous variables with t test for independent samples. n 365 13,251 Age 20 to 39 yr 53.6% (4.3) 48.4% (1.0) 0.2 40 to 59 yr 20.0% (3.1) 31.9% (0.5) <0.01 60 to 79 yr 21.1% (2.1) 17.1% (0.7) 0.08 ≥80 yr 5.4% (1.5) 2.6% (0.8) 0.03 Gender (women) 49.9% (4.2) 51.9% (0.4) 0.6 Race (black) 19.1% (2.0) 11.0% (0.2) <0.001 Past medical history hypertension 22.8% (3.2) 21.9% (0.7) 0.7 myocardial infarction 6.6% (1.3) 2.7% (0.3) 0.005 stroke 1.2% (0.6) 1.4% (0.2) 0.80 congestive heart failure 3.1% (1.0) 1.5% (0.1) 0.15 smoking (ever) 52.6% (3.3) 54.7% (0.8) 0.53 kidney stones 6.8% (2.7) 5.4% (0.4) 0.65 Systolic BP (mmHg) 122 (1.2) 121 (0.4) 0.33 Diastolic BP (mmHg) 73 (0.9) 74 (0.2) 0.46 - Table 2.
Further characteristics of the 13,251 NHANES III nondiabetic adult participants included in the analysisa
Parameter Conventional Units SI Units a Data are mean (SE). Missing data: all variables had 99.4% or more complete information. b Body surface area (m2) = 0.20247 × [height (m)]0.725 × [weight (kg)]0.425 (58). c Body mass index = [weight (kg)]/[height (m)]2. d MDRD GFR (ml/min per 1.73 m2) = 170 × [serum creatinine (mg/dl)]−0.999 × [age]−0.176 × [0.762 if patient is female] × [1.180 if patient is black] × [serum urea nitrogen (mg/dl)]−0.170 × [serum albumin (g/dL)]0.318. e Cockcroft-Gault creatinine clearance = ([140 − age] × [weight (kg)])/(72 × [serum creatinine (mg/dl)]) × [0.85 if female]. Body wt 75 (0.3) kg Height 169 (0.2) cm 1.69 (0.002) m Body surface areab 1.85 (0.004) m2 Body mass indexc 26.3 (0.08) kg/m2 MDRD GFRd 77 (0.4) ml/min per 1.73m2 0.74 (0.004) ml/s per m2 Cockcroft-Gault creatinine clearancee 89 (0.9) ml/min 1.48 (0.02) ml/s Serum creatinine 1.07 (0.002) mg/dl 94.5 (0.2) mmol/L Serum urea 14.0 (0.08) mg/dl 5.0 (0.03) mmol/L Serum cholesterol 203 (0.8) mg/dl 5.26 (0.02) mmol/L Serum albumin 4.20 (0.01) g/dl 42.0 (0.1) g/L Glycated hemoglobin 5.2 (0.01)% - Table 3.
Nondiabetic adults in NHANES III 95% confidence intervals (CI) for weighted distribution of level of GFRa
GFR Category (ml/min per 1.73m2) 20 to 29 yr 30 to 39 yr 40 to 49 yr 50 to 59 yr 60 to 69 yr 70 to 79 yr ≥80 yr Total a All values are % within race-gender-age stratum. GFR is categorized according to the MDRD equation and stratified by age (in decades), race, and gender. Point estimates for this analysis are shown in Figure 1. ≥80 white male 75 to 83 54 to 63 31 to 42 18 to 25 11 to 17 6.2 to 11 1.4 to 4.7 43 to 48 white female 61 to 69 41 to 49 19 to 26 9.3 to 17 4.7 to 9.7 1.6 to 4.0 0.7 to 3.7 30 to 34 black male 89 to 94 74 to 82 60 to 72 42 to 56 30 to 44 13 to 33 3.8 to 35 69 to 73 black female 88 to 94 74 to 82 54 to 65 27 to 42 14 to 27 7.6 to 22 0 to 8.0 63 to 68 60 to 79 white male 17 to 24 36 to 45 55 to 65 61 to 69 55 to 62 44 to 54 28 to 42 43 to 47 white female 30 to 39 46 to 55 61 to 69 59 to 69 49 to 57 35 to 45 21 to 30 48 to 52 black male 5.4 to 10 17 to 25 26 to 39 38 to 52 38 to 54 36 to 54 29 to 63 23 to 27 black female 6.0 to 11 17 to 24 34 to 43 51 to 65 40 to 60 38 to 60 20 to 48 26 to 30 30 to 59 white male 0 to 1.2 0 to 1.4 2.0 to 5.4 9.2 to 18 23 to 30 35 to 46 54 to 68 8 to 10 white female 0.1 to 1.3 2.3 to 5.3 8.7 to 16 19 to 27 35 to 44 51 to 61 64 to 72 15 to 20 black male 0 to 1.1 0 to 0.7 0.3 to 2.5 2.9 to 8.0 11 to 22 20 to 41 21 to 49 3.2 to 4.6 black female 0 to 0.2 0.1 to 1.8 0.6 to 2.9 3.1 to 11 20 to 36 26 to 48 43 to 68 4.8 to 7.0 <30 white male 0 to 0 0 to 0 0 to 0 0 to 0.1 0 to 1.3 0.2 to 3.5 0.5 to 2.2 0.1 to 0.3 white female 0 to 0 0 to 0.1 0 to 0 0 to 0 0.1 to 1.5 0 to 1.6 2.0 to 5.7 0.1 to 0.5 black male 0 to 0 0 to 0.7 0 to 0 0 to 1.9 0 to 2.5 0 to 3.3 0 to 0 0 to 0.5 black female 0 to 0.4 0 to 1.0 0 to 1.4 0 to 0 0.1 to 2.7 0 to 0 1.9 to 15 0.2 to 0.8 - Table 4.
Relationship between MDRD GFR and Cockcroft-Gault (CG) creatinine clearance in white and black participantsa
MDRD GFR(ml/min per 1.73 m2) CG CrCl (ml/min) White Participants Black Participants <30 30 to 59 60 to 79 ≥80 <30 0 to 59 60 to 79 ≥80 a The number of participants and the percentages that would be classified into the same clearance category by both estimating equations are shown in bold. Numbers and percentages for noncongruent results (i.e., participants who would be categorized differently by the two formulae) are also shown. n represents the actual number of participants in each cell (i.e., unweighted data), whereas percentages are derived from weighted analyses. MDRD GFR estimated according to MDRD Equation 7. CG CrCl Cockcroft-Gault creatinine clearance. <30 n 31 6 14 1 % within MDRD GFR category 74 26 95 5.1 % within CG CrCl category 23 0.5 37 0.2 30 to 59 n 140 1082 319 112 27 174 29 13 % within MDRD GFR category 4.4 56 27 13 11 69 14 6.7 % within CG CrCl category 74 54 15 2.9 53 35 2.9 0.5 60 to 79 n 11 790 1440 1761 5 237 403 433 % within MDRD GFR category <0.1 13 35 53 0.4 18 38 44 % within CG CrCl category 2.9 43 67 42 10 49 44 18 ≥80 n 56 452 3231 79 477 1928 % within MDRD GFR category 0.9 12 87 2.5 18 80 % within CG CrCl category 2.5 18 56 17 54 82
Prevalence of Low Glomerular Filtration Rate in Nondiabetic Americans: Third National Health and Nutrition Examination Survey (NHANES III)
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