Journal of the American Society of Nephrology: 15 (3)

March 01, 2004; Volume 15,Issue 3

THIS MONTH'S HIGHLIGHTS

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This Month’s Highlights
JASN March 2004, 15 (3) A24-A26;

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ASN NEWS

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ASN News
JASN March 2004, 15 (3) A39-A40;

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FRONTIERS IN NEPHROLOGY

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Overview: Increased Cardiovascular Risk in Patients with Minor Renal Dysfunction: An Emerging Issue with Far-Reaching Consequences
Eberhard Ritz and William M. McClellan

JASN March 2004, 15 (3) 513-516; DOI: https://doi.org/10.1097/01.ASN.0000115398.92270.30

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How Does Minor Renal Dysfunction Influence Cardiovascular Risk and the Management of Cardiovascular Disease?
Tobias Pinkau, Karl F. Hilgers, Roland Veelken and Johannes F. E. Mann

JASN March 2004, 15 (3) 517-523; DOI: https://doi.org/10.1097/01.ASN.0000107565.17553.71

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Sympathetic Hyperactivity in Chronic Renal Failure: A Wake-up Call
Hein A. Koomans, Peter J. Blankestijn and Jaap A. Joles

JASN March 2004, 15 (3) 524-537; DOI: https://doi.org/10.1097/01.ASN.0000113320.57127.B9

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The Role of Oxidative Stress–Altered Lipoprotein Structure and Function and Microinflammation on Cardiovascular Risk in Patients with Minor Renal Dysfunction
George A. Kaysen and Jason P. Eiserich

JASN March 2004, 15 (3) 538-548; DOI: https://doi.org/10.1097/01.ASN.0000111744.00916.E6

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Cell and Transport Physiology

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Downregulation of Ca²⁺ and Mg²⁺ Transport Proteins in the Kidney Explains Tacrolimus (FK506)-Induced Hypercalciuria and Hypomagnesemia
Tom Nijenhuis, Joost G.J. Hoenderop and René J.M. Bindels

JASN March 2004, 15 (3) 549-557; DOI: https://doi.org/10.1097/01.ASN.0000113318.56023.B6

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Aldosterone Decreases UT-A1 Urea Transporter Expression via the Mineralocorticoid Receptor
Randy A. Gertner, Janet D. Klein, James L. Bailey, Dong-un Kim, Xiao H. Luo, Serena M. Bagnasco and Jeff M. Sands

JASN March 2004, 15 (3) 558-565; DOI: https://doi.org/10.1097/01.ASN.0000113244.37857.AC

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Cell Biology

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Angiopoietin 1 and Vascular Endothelial Growth Factor Modulate Human Glomerular Endothelial Cell Barrier Properties
Simon C. Satchell, Karen L. Anderson and Peter W. Mathieson

JASN March 2004, 15 (3) 566-574; DOI: https://doi.org/10.1097/01.ASN.0000115397.22519.03

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Exogenous Attenuation of p21^Waf1/Cip1 Decreases Mesangial Cell Hypertrophy as a Result of Hyperglycemia and IGF-1
Ya-ping Fan and Robert H. Weiss

JASN March 2004, 15 (3) 575-584; DOI: https://doi.org/10.1097/01.ASN.0000114557.75244.5F

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The STAT3 DNA-Binding Domain Mediates Interaction with NF-κB p65 and Inducible Nitric Oxide Synthase Transrepression in Mesangial Cells
Zhiyuan Yu and Bruce C. Kone

JASN March 2004, 15 (3) 585-591; DOI: https://doi.org/10.1097/01.ASN.0000114556.19556.F9

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Genetics and Development

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The Autosomal Recessive Polycystic Kidney Disease Protein Is Localized to Primary Cilia, with Concentration in the Basal Body Area
Shixuan Wang, Ying Luo, Patricia D. Wilson, George B. Witman and Jing Zhou

JASN March 2004, 15 (3) 592-602; DOI: https://doi.org/10.1097/01.ASN.0000113793.12558.1D

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Immunology and Pathology

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Lymphatic Neoangiogenesis in Human Kidney Transplants Is Associated with Immunologically Active Lymphocytic Infiltrates
Dontscho Kerjaschki, Heinrich M. Regele, Isabella Moosberger, Katalyn Nagy-Bojarski, Bruno Watschinger, Afschin Soleiman, Peter Birner, Sigurd Krieger, Anny Hovorka, Georg Silberhumer, Pirjo Laakkonen, Tatiana Petrova, Brigitte Langer and Ingrid Raab

JASN March 2004, 15 (3) 603-612; DOI: https://doi.org/10.1097/01.ASN.0000113316.52371.2E

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Identification and Functional Characterization of Dendritic Cells in the Healthy Murine Kidney and in Experimental Glomerulonephritis
Thilo Krüger, Dirk Benke, Frank Eitner, Andreas Lang, Monika Wirtz, Emma E. Hamilton-Williams, Daniel Engel, Bernd Giese, Gerhard Müller-Newen, Jürgen Floege and Christian Kurts

JASN March 2004, 15 (3) 613-621; DOI: https://doi.org/10.1097/01.ASN.0000114553.36258.91

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Glycosylation and Size of IgA1 Are Essential for Interaction with Mesangial Transferrin Receptor in IgA Nephropathy
Ivan C. Moura, Michelle Arcos-Fajardo, Charlotte Sadaka, Valérie Leroy, Marc Benhamou, Jan Novak, François Vrtovsnik, Elie Haddad, Koteswara R. Chintalacharuvu and Renato C. Monteiro

JASN March 2004, 15 (3) 622-634; DOI: https://doi.org/10.1097/01.ASN.0000115401.07980.0C

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Pathophysiology of Renal Disease and Progression

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Effect of Angiotensin II Receptor Blockage on Osteopontin Expression and Calcium Oxalate Crystal Deposition in Rat Kidneys
Tohru Umekawa, Yuji Hatanaka, Takashi Kurita and Saeed R. Khan

JASN March 2004, 15 (3) 635-644; DOI: https://doi.org/10.1097/01.ASN.0000113321.49771.2D

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Role of Leptin Deficiency in Early Acute Renal Failure during Endotoxemia in ob/ob Mice
Wei Wang, Brian Poole, Amit Mitra, Sandor Falk, Giamila Fantuzzi, Scott Lucia and Robert Schrier

JASN March 2004, 15 (3) 645-649; DOI: https://doi.org/10.1097/01.ASN.0000113551.14276.0B

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Alterations in the Renal Elastin-Elastase System in Type 1 Diabetic Nephropathy Identified by Proteomic Analysis
Visith Thongboonkerd, Michelle T. Barati, Kenneth R. McLeish, Charaf Benarafa, Eileen Remold-O’Donnell, Shirong Zheng, Brad H. Rovin, William M. Pierce, Paul N. Epstein and Jon B. Klein

JASN March 2004, 15 (3) 650-662; DOI: https://doi.org/10.1097/01.ASN.0000115334.65095.9B

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Mercuric Conjugates of Cysteine Are Transported by the Amino Acid Transporter System b^0,+: Implications of Molecular Mimicry
Christy C. Bridges, Christian Bauch, François Verrey and Rudolfs K. Zalups

JASN March 2004, 15 (3) 663-673; DOI: https://doi.org/10.1097/01.ASN.0000113553.62380.F5

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CD44 Deficiency Increases Tubular Damage But Reduces Renal Fibrosis in Obstructive Nephropathy
Kasper M.A. Rouschop, Miguel E. Sewnath, Nike Claessen, Joris J.T.H. Roelofs, Inge Hoedemaeker, Ronald van der Neut, Jan Aten, Steven T. Pals, Jan J. Weening and Sandrine Florquin

JASN March 2004, 15 (3) 674-686; DOI: https://doi.org/10.1097/01.ASN.0000115703.30835.96

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Basic Transplantation

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Chronic Rejection: Insights from a Novel Immunosuppressive-Free Model of Kidney Transplantation
Martin Gasser, Ana Maria Waaga-Gasser, Joana E. Kist-van Holthe, Xueli Yuan, Susanne M. Lenhard, Kald A. Abdallah and Anil Chandraker

JASN March 2004, 15 (3) 687-694; DOI: https://doi.org/10.1097/01.ASN.0000112022.26224.E5

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IFN-γ Regulation in Anti-CD4 Antibody–Induced T Cell Unresponsiveness
Birgit Sawitzki, Brit Kieselbach, Marion Fisser, Christian Meisel, Katrin Vogt, Matthias Gaestel, Manfred Lehmann, Kirsten Risch, Gerald Grütz and Hans-Dieter Volk

JASN March 2004, 15 (3) 695-703; DOI: https://doi.org/10.1097/01.ASN.0000115523.50962.C0

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SPECIAL FEATURES

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Fighting Renal Diseases in Poor Countries: Building a Global Fund with the Help of the Pharmaceutical Industry
Arrigo Schieppati and Giuseppe Remuzzi

JASN March 2004, 15 (3) 704-707; DOI: https://doi.org/10.1097/01.ASN.0000113317.64112.99

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The Chronic Kidney Disease Initiative
Thomas F. Parker, Roland Blantz, Thomas Hostetter, Jonathan Himmelfarb, Alan Kliger, Michael Lazarus, Allen R. Nissenson, Brian Pereira and James Weiss

JASN March 2004, 15 (3) 708-716; DOI: https://doi.org/10.1097/01.ASN.0000112129.20838.3F

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Clinical Nephrology

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Prospective Study of TNFα Blockade with Infliximab in Anti-Neutrophil Cytoplasmic Antibody-Associated Systemic Vasculitis
Anthony Booth, Lorraine Harper, Tariq Hammad, Paul Bacon, Megan Griffith, Jeremy Levy, Caroline Savage, Charles Pusey and David Jayne

JASN March 2004, 15 (3) 717-721; DOI: https://doi.org/10.1097/01.ASN.0000114554.67106.28

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Human Genetics

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Patients with Mutations in NPHS2 (Podocin) Do Not Respond to Standard Steroid Treatment of Nephrotic Syndrome
Rainer G. Ruf, Anne Lichtenberger, Stephanie M. Karle, Johannes P. Haas, Franzisco E. Anacleto, Michael Schultheiss, Isabella Zalewski, Anita Imm, Eva-Maria Ruf, Bettina Mucha, Arvind Bagga, Thomas Neuhaus, Arno Fuchshuber, Aysin Bakkaloglu, Friedhelm Hildebrandt and the Arbeitsgemeinschaft für Pädiatrische Nephrologie Study Group

JASN March 2004, 15 (3) 722-732; DOI: https://doi.org/10.1097/01.ASN.0000113552.59155.72

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Epidemiology and Outcomes

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Malnutrition and Atherosclerosis in Dialysis Patients
Srinivasan Beddhu, Lisa M. Pappas, Nirupama Ramkumar and Matthew H. Samore

JASN March 2004, 15 (3) 733-742; DOI: https://doi.org/10.1097/01.ASN.0000113319.57131.28

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Changes in Quality of Life during Hemodialysis and Peritoneal Dialysis Treatment: Generic and Disease Specific Measures
Albert W. Wu, Nancy E. Fink, Jane V.R. Marsh-Manzi, Klemens B. Meyer, Frederic O. Finkelstein, Michelle M. Chapman and Neil R. Powe

JASN March 2004, 15 (3) 743-753; DOI: https://doi.org/10.1097/01.ASN.0000113315.81448.CA

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A Randomized Evaluation of Two Health Care Quality Improvement Program (HCQIP) Interventions to Improve the Adequacy of Hemodialysis Care of ESRD Patients: Feedback Alone versus Intensive Intervention
William M. McClellan, Emily Hodgin, Stephen Pastan, Lisa McAdams and Michael Soucie

JASN March 2004, 15 (3) 754-760; DOI: https://doi.org/10.1097/01.ASN.0000115701.51613.D7

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N-Acetylcysteine for the Prevention of Radiocontrast Induced Nephropathy: A Meta-Analysis of Prospective Controlled Trials
Abhijit V. Kshirsagar, Charles Poole, Amy Mottl, David Shoham, Nora Franceschini, Gail Tudor, Malay Agrawal, Cindy Denu-Ciocca, E. Magnus Ohman and William F. Finn

JASN March 2004, 15 (3) 761-769; DOI: https://doi.org/10.1097/01.ASN.0000116241.47678.49

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Mineral Metabolism and Bone Disease

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Calcium, Phosphate, and Parathyroid Hormone Levels in Combination and as a Function of Dialysis Duration Predict Mortality: Evidence for the Complexity of the Association between Mineral Metabolism and Outcomes
Lesley A. Stevens, Ognjenka Djurdjev, Savannah Cardew, E. C. Cameron and Adeera Levin

JASN March 2004, 15 (3) 770-779; DOI: https://doi.org/10.1097/01.ASN.0000113243.24155.2F

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Hemodynamics and Vascular Regulation

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Effects of Oral Contraceptive Use on the Renal and Systemic Vascular Response to Angiotensin II Infusion
Sofia B. Ahmed, Amrit K. Kang, Kevin D. Burns, Christopher R. J. Kennedy, Vesta Lai, Daniel C. Cattran, James W. Scholey and Judith A. Miller

JASN March 2004, 15 (3) 780-786; DOI: https://doi.org/10.1097/01.ASN.0000114555.16297.5A

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Clinical Immunology and Pathology

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Heterozygous and Homozygous Factor H Deficiencies Associated with Hemolytic Uremic Syndrome or Membranoproliferative Glomerulonephritis: Report and Genetic Analysis of 16 Cases
Marie-Agnès Dragon-Durey, Véronique Frémeaux-Bacchi, Chantal Loirat, Jacques Blouin, Patrick Niaudet, Georges Deschenes, Paul Coppo, Wolf Herman Fridman and Laurence Weiss

JASN March 2004, 15 (3) 787-795; DOI: https://doi.org/10.1097/01.ASN.0000115702.28859.A7

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Activation of Syk in Neutrophils by Antineutrophil Cytoplasm Antibodies Occurs via Fcγ Receptors and CD18
Peter Hewins, Julie M. Williams, Michael J.O. Wakelam and Caroline O.S. Savage

JASN March 2004, 15 (3) 796-808; DOI: https://doi.org/10.1097/01.ASN.0000113241.98702.77

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Transplantation

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Long-Term Benefits with Sirolimus-Based Therapy after Early Cyclosporine Withdrawal
Henri Kreis, Rainer Oberbauer, Josep M. Campistol, Timothy Mathew, Pierre Daloze, Francesco P. Schena, James T. Burke, Yves Brault, Martine Gioud-Paquet, Joseph A. Scarola, John F. Neylan and ; for the Rapamune Maintenance Regimen Trial

JASN March 2004, 15 (3) 809-817; DOI: https://doi.org/10.1097/01.ASN.0000113248.59077.76

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Leukocyte Reduction of Red Blood Cell Transfusions Does not Decrease Allosensitization Rates in Potential Kidney Transplant Candidates
Martin Karpinski, Denise Pochinco, Iga Dembinski, Willie Laidlaw, James Zacharias and Peter Nickerson

JASN March 2004, 15 (3) 818-824; DOI: https://doi.org/10.1097/01.ASN.0000115399.80913.B1

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EDITORIALS

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Not Just an Inhibitor: A Role for p21 Beyond The Cell Cycle—“The Truth Is Rarely Pure and Never Simple”
Siân V. Griffin and Stuart J. Shankland

JASN March 2004, 15 (3) 825-826; DOI: https://doi.org/10.1097/01.ASN.0000117896.79378.43

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Emphatically Lymphatic
Robert B. Colvin

JASN March 2004, 15 (3) 827-829; DOI: https://doi.org/10.1097/01.ASN.0000117895.24143.87

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Off-Label Use of Approved Drugs: Therapeutic Opportunity and Challenges
William M. Bennett

JASN March 2004, 15 (3) 830-831; DOI: https://doi.org/10.1097/01.ASN.0000118323.41076.01

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Podocin and Nephrotic Syndrome: Implications for the Clinician
Patrick Niaudet

JASN March 2004, 15 (3) 832-834; DOI: https://doi.org/10.1097/01.ASN.0000118135.00519.B0

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ERRATA

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Correction
JASN March 2004, 15 (3) 835-836;

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Correction
JASN March 2004, 15 (3) 836;

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ANNOUNCEMENTS

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JASN March 2004, 15 (3) 837;

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Table of Contents

THIS MONTH'S HIGHLIGHTS

ASN NEWS

FRONTIERS IN NEPHROLOGY

Cell and Transport Physiology

Cell Biology

Genetics and Development

Immunology and Pathology

Pathophysiology of Renal Disease and Progression

Basic Transplantation

SPECIAL FEATURES

Clinical Nephrology

Human Genetics

Epidemiology and Outcomes

Mineral Metabolism and Bone Disease

Hemodynamics and Vascular Regulation

Clinical Immunology and Pathology

Transplantation

EDITORIALS

ERRATA

ANNOUNCEMENTS

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