Article Figures & Data
Figures
Figure 1. Frequency distribution of recipients and donors by age. (A) Recipients (mean age, 44 yr). (B) Donors. Donor age had a bimodal distribution, with the first peak at age 20 yr and the second peak at 45 yr; mean donor age was 33 yr.
Figure 2. Frequency distribution of transplantations by donor-recipient age difference. Donor recipient age difference = (donor age) − (recipient age). Donors averaged 11 yr younger than recipients.
Figure 3. Distribution of deceased donor kidneys by donor and recipient age. % difference from expected = ([actual no. of transplants] − [expected no. of transplants])/(expected no of transplants × 100).
Figure 4. Adjusted patient survival based on HLA mismatch. Survival curves were plotted at the mean of the covariates for the population.
Figure 5. Adjusted patient survival based on donor age group. Survival curves were plotted at the mean of the covariates for the population.
Figure 6. Adjusted patient survival with graft function based on donor age. Survival curves were plotted at the mean of the covariates for the population.
Figure 7. Patient survival at 5 and 10 yr based on donor age. Percentage survival was calculated from adjusted curves for each donor age group at the mean of the covariates.
Tables
Table 1. Mean donor and recipient age and number of transplants by transplant year
Transplant Year Mean Donor Age (yr) Mean Recipient Age (yr) Number of Transplants 1990 31.2 42.7 5744 1991 31.2 43.1 5791 1992 33.0 43.7 5864 1993 32.8 44.1 6360 1994 33.4 44.4 6556 1995 33.7 44.8 6611 1996 35.1 45.8 6687 1997 35.4 46.5 6707 Total 33.3 44.5 50320 Table 2. Distribution of cadaveric kidneys by donor and recipient age
Donor Age Actual Number of Transplants (Expected for Random Age Allocation) for Recipient Agea 0 to 17 yr 18 to 39 yr 40 to 54 yr 55+ yr a Numbers outside the parentheses are the actual number of transplants received. The numbers in the parentheses are the numbers expected if kidney randomly allocated by donor age. 0–6 yr 203 (83) 778 (660) 718 (835) 442 (564) 7–17 yr 511 (323) 2741 (2586) 3221 (3271) 1916 (2209) 18–29 yr 537 (487) 4109 (3897) 4926 (4929) 3070 (3329) 30–41 yr 355 (374) 3067 (2999) 3858 (3793) 2449 (2562) 42–54 yr 268 (415) 3276 (3317) 4338 (4196) 2879 (2834) 55+ yr 65 (257) 1541 (2052) 2558 (2596) 2494 (1753) Table 3. Risk factors for survival in recipients of first deceased donor renal transplants: 1990–1997
Variable (Reference Group) Relative Risk (95% CI) P value Transplant year (1997) 1990 1.327 (1.215 to 1.448) <0.001 1991 1.257 (1.152 to 1.372) <0.001 1992 1.28 (1.173 to 1.396) <0.001 1993 1.188 (1.088 to 1.296) <0.001 1994 1.117 (1.024 to 1.220) 0.013 1995 1.092 (0.999 to 1.193) 0.052 1996 0.988 (0.902 to 1.083) 0.803 CMV status (CMV d−r−) CMV d−r+ 1.070 (1.001 to 1.143) 0.046 CMV d+r+ 1.108 (1.040 to 1.179) 0.001 CMV d+r− 1.154 (1.077 to 1.236) <0.001 Kidney diagnosis (PKD) diabetes mellitus 2.698 (2.500 to 2.910) <0.001 glomerulonephritis 1.21 (1.115 to 1.313) <0.001 hypertension 1.519 (1.397 to 1.651) <0.001 other 1.564 (1.445 to 1.693) <0.001 Age of recipient per year 1.042 (1.041 to 1.044) <0.001 Recipient race (white) Asian 0.71 (0.626 to 0.807) <0.001 black 1.012 (0.964 to 1.063) 0.638 other/unknown 0.727 (0.627 to 0.843) <0.001 Recipient gender (male) female 0.896 (0.860 to 0.934) <0.001 Peak PRA (0%) 1 to 30% 1.074 (1.029 to 1.121) 0.001 >30% 1.200 (1.124 to 1.282) <0.001 HLA mismatch per mismatch 1.038 (1.025 to 1.052) <0.001 Donor age per year 1.007 (1.006 to 1.008) <0.001 Donor race (white) Asian 1.17 (0.983 to 1.392) 0.078 black 1.146 (1.075 to 1.221) <0.001 other/unknown 0.905 (0.704 to 1.163) 0.434 Donor gender (male) female 1.054 (1.013 to 1.097) 0.009 Dialysis prior to transplant (yes) no 0.926 (0.817 to 1.05) 0.229 unknown 0.763 (0.696 to 0.836) <0.001 Cold ischemia time per hour 1.00 (0.998 to 1.002) 0.873 Table 4. Adjusted 10-yr patient survivals by donor age and recipient age
Donor Age Group Recipient Age Group 0 to 40 yr old 41 to 54 yr old 55 yr or older 0 to 17 yr old 84% 69% 48% 18 to 29 yr old 83% 67% 46% 30 to 41 yr old 82% 66% 45% 42 to 54 yr old 78% 64% 37% 55 Yrs or older 76% 58% 35%
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