Mouse Models of Diabetic Nephropathy

Abstract
Mice provide an experimental model of unparalleled flexibility for studying mammalian diseases. Inbred strains of mice exhibit substantial differences in their susceptibility to the renal complications of diabetes. Much remains to be established regarding the course of diabetic nephropathy (DN) in mice as well as defining those strains and/or mutants that are most susceptible to renal injury from diabetes. Through the use of the unique genetic reagents available in mice (including knockouts and transgenics), the validation of a mouse model reproducing human DN should significantly facilitate the understanding of the underlying genetic mechanisms that contribute to the development of DN. Establishment of an authentic mouse model of DN will undoubtedly facilitate testing of translational diagnostic and therapeutic interventions in mice before testing in humans.
- © 2005 American Society of Nephrology
In this issue
Jump to section
- Article
- Abstract
- Working Definition of DN
- Characterization of DN in Mice
- Assessment of Hyperglycemia in Mice
- Assessment of Renal Function in Mice
- Models of Type 1 Diabetes
- Mouse Models of Type 2 Diabetes
- Inbred Mice: Strain Dependence of DN
- Monogenic Mutations and Transgenic Mice
- Conclusions
- Acknowledgments
- References
- Figures & Data Supps
- Info & Metrics
- View PDF
More in this TOC Section
Cited By...
- Drug Testing for Residual Progression of Diabetic Kidney Disease in Mice Beyond Therapy with Metformin, Ramipril, and Empagliflozin
- Systematic review and meta-analysis of mouse models of diabetes-associated ulcers
- Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic disorders
- Changes in excitability and ion channel expression in neurons of the major pelvic ganglion in female type II diabetic mice
- Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function
- Effects of insulin and the glucagon-like peptide 1 receptor agonist liraglutide on the kidney proteome in db/db mice
- Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility
- Comparison of Glomerular and Podocyte mRNA Profiles in Streptozotocin-Induced Diabetes
- Low-Dose IL-17 Therapy Prevents and Reverses Diabetic Nephropathy, Metabolic Syndrome, and Associated Organ Fibrosis
- Four-and-a-Half LIM Domains Protein 2 Is a Coactivator of Wnt Signaling in Diabetic Kidney Disease
- Diabetes Induces Aberrant DNA Methylation in the Proximal Tubules of the Kidney
- Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy
- Vascular Endothelial Growth Factor-A165b Is Protective and Restores Endothelial Glycocalyx in Diabetic Nephropathy
- Renoprotective effects of combined SGLT2 and ACE inhibitor therapy in diabetic Dahl S rats
- Progressive Renal Decline: The New Paradigm of Diabetic Nephropathy in Type 1 Diabetes
- Endogenous Fructose Production and Fructokinase Activation Mediate Renal Injury in Diabetic Nephropathy
- Loss of the Podocyte-Expressed Transcription Factor Tcf21/Pod1 Results in Podocyte Differentiation Defects and FSGS
- CD73-Dependent Generation of Adenosine and Endothelial Adora2b Signaling Attenuate Diabetic Nephropathy
- Knockdown of Glyoxalase 1 Mimics Diabetic Nephropathy in Nondiabetic Mice
- Phlorizin Pretreatment Reduces Acute Renal Toxicity in a Mouse Model for Diabetic Nephropathy
- A Role for the Endothelium in Vascular Calcification
- Celecoxib modifies glomerular basement membrane, mesangium and podocytes in OVE26 mice, but ibuprofen is more detrimental
- Direct Evidence for Intrarenal Chymase-Dependent Angiotensin II Formation on the Diabetic Renal Microvasculature
- A Transcriptional Blueprint for Human and Murine Diabetic Kidney Disease
- eNOS Deficiency Predisposes Podocytes to Injury in Diabetes
- Intrarenal Dopamine Inhibits Progression of Diabetic Nephropathy
- Transgenerational Glucose Intolerance With Igf2/H19 Epigenetic Alterations in Mouse Islet Induced by Intrauterine Hyperglycemia
- Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice
- Arginase-2 Mediates Diabetic Renal Injury
- Knockout of Toll-Like Receptor-2 Attenuates Both the Proinflammatory State of Diabetes and Incipient Diabetic Nephropathy
- Esculetin induced changes in Mmp13 and Bmp6 gene expression and histone H3 modifications attenuate development of glomerulosclerosis in diabetic rats
- Thyroid hormone ameliorates diabetic nephropathy in a mouse model of type II diabetes
- Activation of Vascular Bone Morphogenetic Protein Signaling in Diabetes Mellitus
- The Protective Role of Smad7 in Diabetic Kidney Disease: Mechanism and Therapeutic Potential
- Antiatherosclerotic and Renoprotective Effects of Ebselen in the Diabetic Apolipoprotein E/GPx1-Double Knockout Mouse
- BTBR Ob/Ob Mutant Mice Model Progressive Diabetic Nephropathy
- Inhibition or Deletion of Soluble Epoxide Hydrolase Prevents Hyperglycemia, Promotes Insulin Secretion, and Reduces Islet Apoptosis
- Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse
- Mouse Models of Diabetic Nephropathy
- Vasohibin-1, a Negative Feedback Regulator of Angiogenesis, Ameliorates Renal Alterations in a Mouse Model of Diabetic Nephropathy
- Effect of the Monocyte Chemoattractant Protein-1/CC Chemokine Receptor 2 System on Nephrin Expression in Streptozotocin-Treated Mice and Human Cultured Podocytes
- Activation of the Succinate Receptor GPR91 in Macula Densa Cells Causes Renin Release
- The Use of Animal Models in the Study of Diabetes Mellitus
- Enhanced Expression of Janus Kinase-Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy
- Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase
- Overexpression of Calmodulin in Pancreatic {beta} Cells Induces Diabetic Nephropathy
- From Fibrosis to Sclerosis: Mechanisms of Glomerulosclerosis in Diabetic Nephropathy
- Long-term hyperglucagonaemia induces early metabolic and renal phenotypes of Type 2 diabetes in mice
- Overexpression of Angiotensinogen Increases Tubular Apoptosis in Diabetes
- Can rodent models of diabetic kidney disease clarify the significance of early hyperfiltration?: recognizing clinical and experimental uncertainties
- Thrombospondin-1 Is an Endogenous Activator of TGF-{beta} in Experimental Diabetic Nephropathy In Vivo
- L-Carnosine, a Substrate of Carnosinase-1, Influences Glucose Metabolism
- The Vascular Ectonucleotidase ENTPD1 Is a Novel Renoprotective Factor in Diabetic Nephropathy
- Targeting glucagon receptor signalling in treating metabolic syndrome and renal injury in Type 2 diabetes: theory versus promise
- Renal Fibrosis and Glomerulosclerosis in a New Mouse Model of Diabetic Nephropathy and Its Regression by Bone Morphogenic Protein-7 and Advanced Glycation End Product Inhibitors
- Interstitial Vascular Rarefaction and Reduced VEGF-A Expression in Human Diabetic Nephropathy
- Recipes for Creating Animal Models of Diabetic Cardiovascular Disease
- Diabetic Endothelial Nitric Oxide Synthase Knockout Mice Develop Advanced Diabetic Nephropathy
- A Sensitized Screen of N-ethyl-N-nitrosourea-Mutagenized Mice Identifies Dominant Mutants Predisposed to Diabetic Nephropathy
- Poly(ADP-Ribose) Polymerase Inhibitors Ameliorate Nephropathy of Type 2 Diabetic Leprdb/db Mice
- Endothelial Nitric Oxide Synthase Deficiency Produces Accelerated Nephropathy in Diabetic Mice
- Heme Oxygenase-2 Deficiency Contributes to Diabetes-Mediated Increase in Superoxide Anion and Renal Dysfunction
- Frontiers in Diabetic Nephropathy: Can We Predict Who Will Get Sick?
- Leukocyte Recruitment and Vascular Injury in Diabetic Nephropathy
- Glucose-Induced Reactive Oxygen Species Cause Apoptosis of Podocytes and Podocyte Depletion at the Onset of Diabetic Nephropathy
- Activation of G{alpha}q-Coupled Signaling Pathways in Glomerular Podocytes Promotes Renal Injury
- Antiangiogenic Endostatin Peptide Ameliorates Renal Alterations in the Early Stage of a Type 1 Diabetic Nephropathy Model
- Characterization of Susceptibility of Inbred Mouse Strains to Diabetic Nephropathy
- Accelerated Glucose Intolerance, Nephropathy, and Atherosclerosis in Prostaglandin D2 Synthase Knock-out Mice
Similar Articles
Related Articles
- No related articles found.