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Clinical Transplantation
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Access to Quality: Evaluation of the Allocation of Deceased Donor Kidneys for Transplantation

Jesse D. Schold, Bruce Kaplan, Neale R. Chumbler, Richard J. Howard, Titte R. Srinivas, Linan Ma and Herwig-Ulf Meier-Kriesche
JASN October 2005, 16 (10) 3121-3127; DOI: https://doi.org/10.1681/ASN.2005050517
Jesse D. Schold
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Bruce Kaplan
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Neale R. Chumbler
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Richard J. Howard
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Titte R. Srinivas
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Linan Ma
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Herwig-Ulf Meier-Kriesche
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Abstract

Disparities in both access to the kidney transplant waiting list and waiting times for transplant candidates have been extensively documented with regard to ethnicity, gender, socioeconomic factors, and region. However, the issue of access to equivalent quality organs has garnered less attention. The principal aim of this study was to determine whether certain patient populations were more likely to receive lower quality organs. This was a retrospective cohort study of all deceased-donor adult renal transplant recipients in the United States from 1996 to 2002 (n = 45,832). Using previously reported categorization of donor quality (I to V), the propensity of transplant recipients to receive lower-quality kidneys in a cumulative logit model was evaluated. Older patients were progressively more likely to receive lower-quality organs (age ≥ 65 yr, odds ratio [OR] = 2.1, P < 0.01) relative to recipients aged 18 to 24 yr. African American and Asian recipients had a greater likelihood of receiving lower-quality organs relative to non-Hispanic Caucasians. Regional allocation networks were highly variable with regard to donor quality. Neither recipient gender (OR = 1.00, P = 0.81) nor patient’s primary diagnosis were associated with donor quality. Findings suggest that disparities in the quality of deceased donor kidneys to transplant recipients exist among certain patient groups that have previously documented access barriers. The extent to which these disparities are in line with broad policies of equity and potentially modifiable will have to be examined in the context of allocation policy.

The scarcity of available donor kidneys and the need for transplantation among the ESRD wait-listed population is a pervasive problem in United States. According to the Organ Procurement and Transplantation Network (OPTN), >60,000 candidates were listed for kidney transplantation in 2005, with only 14,664 transplants being performed in 2004 (of which 8577 were deceased-donor transplants) (1). Kidney transplantation continues to be regarded as the preferred therapy for the ESRD population relative to maintenance dialysis and has demonstrated benefit across ethnic, age, gender, and primary diagnosis strata (2). In 1998, Alexander et al. characterized distinct steps toward receiving a renal transplant and demonstrated significant disparities for patients throughout the process with regard to ethnicity, gender, income, age, primary diagnosis, and previous years on dialysis (3). These access barriers to transplant receipt have been confirmed in other studies (4,5). Additional impediments have been documented in transplantation for this population based on individual patient perceptions and preferences (6,7), referral rates (8), patient primary insurance type (9), and geographic region (10,11).

When patients are placed on the deceased-donor waiting list, kidneys are allocated based on national policy as rigorously defined by the OPTN (12). This national kidney allocation policy accounts for regional factors, recipient panel reactive antibody (PRA) level, human leukocyte antigen (HLA) matching, waiting time on dialysis, blood type, and patient age (only adult versus pediatric). Additionally, there remains a certain degree of discretion by hospitals, Organ Procurement Organizations (OPO), and physicians concerning the appropriateness of transplanting donor organs to a particular recipient given the specific conditions of the potential transplant. Ultimately, patients and patient advocates must decide whether to accept a particular organ given their particular circumstances and the available information regarding the nature of the donated organ. To further add to the complexity of the transplant process, the characteristics of a potential donor organ are highly variable. Ideally, candidates benefit most from a living donor transplant. However, even among deceased-donor transplants there exists wide variability in the quality of the donated kidneys and consequently the expected outcomes of patient and graft survival. In fact, recent research reported a donor risk categorization (grades I to V) with a nearly three-fold adjusted risk for graft loss associated with the lowest quality (grade V) deceased-donor kidney relative to the highest quality (grade I) (13). In an attempt to streamline the allocation of organs of marginal quality, the United Network of Organ Sharing (UNOS) established the expanded donor criteria (ECD) in 2002, which dichotomously characterized kidneys at high-risk, defined as those kidneys that conveyed a 70% or greater increased risk of graft loss relative to standard kidneys (14).

The principal aim of our study was to assess the degree to which previously documented factors associated with access barriers to transplantation among ESRD patients exist with regard to access to high-quality, deceased-donor kidneys. A secondary aim was to assess the impact of both national and alternative allocation processes in contributing to any existing disparities and subsequent outcomes.

Materials and Methods

We evaluated all solitary adult primary deceased donor renal transplants in the United States listed in the Scientific Registry of Transplant Recipients (SRTR) database between the years 1996 and 2002.

Measures

We categorized patient level data derived from applicable transplant forms by demographic characteristics. We recoded recipient age into the following age groups: 18 to 24, 25 to 34, 35 to 44, 45 to 54, 55 to 64, and ≥65 yr. Race/ethnicity was recoded into six categories: (1) Hispanic; (2) Caucasian, non-Hispanic; (3) African American, (4) Native American; (5) Asian/Pacific Islander; and (6) other (including multiracial, native Hawaiian or other Pacific Islander, Arab or other Middle Eastern, and Indian subcontinent). Indications of Hispanic ethnicity were used as a separate grouping regardless of race designation; however, 93.4% of the cohort indicating Hispanic ethnicity was also listed as Caucasian. Recipient PRA percentage was categorized into groups of 0, 1 to 10, 11 to 30, and ≥31. The recipient’s primary diagnosis was categorized into hypertension, glomerulonephritis, neoplasms, diabetes, congenital disorders, and other groupings. Pretransplant dialysis time was categorized as 0 to 6 mo, 7 to 24 mo, 25 to 36 mo, and ≥36 months. We used the 11 defined OPTN regions as a measure of the impact of geographic location as defined in the database. The states included in each region were as follows: Region 1 (CT, ME, MA, NH, RI), region 2 (DE, MD, NJ, PA, WV, Washington DC), region 3 (AL, AR, FL, GA, LA, MS, Puerto Rico), region 4 (OK, TX), region 5 (AZ, CA, NV, NM, UT), region 6 (AK, HI, ID, MT, OR, WA), region 7 (IL, MN, ND, SD, WI), region 8 (CO, IA, KS, MO, NE, WY), region 9 (NY, VT), region 10 (IN, MI, OH), region 11 (KY, NC, SC, TN, VA). Recipient primary insurance provider was categorized as: Medicare, Medicaid, Private, or other insurance (including the Department of Veterans Affairs, self-pay, and foreign sources). Utilization rates were calculated as the percentage of transplanted kidneys of all those recovered for transplant.

Outcome Measure

We used the Schold et al. (13) five-risk strata to categorize deceased-donor kidneys into quality groups (grades I to V). These quality grades incorporated the weighted effects of characteristics related to the quality of the donor organ and donor and recipient match based on a model for graft loss. The donor risk levels incorporated donor age, donor race, HLA (A, B, and DR) matching, cold ischemia time, donor and recipient cytomegalovirus status, donor cause of death, and donor history of diabetes and hypertension. This study reported progressive associations of donor grade with the risk for death-censored graft loss and overall graft loss. We also replicated models using standard ECD dichotomous stratification, which incorporates donor creatinine, donor history of hypertension, donor cause of death, and donor age as factors in defining high-risk organs utilized for transplantation.

Statistical Analyses

The dependent variable representing the five donor risk grades had five ordered levels (1 = lowest risk through 5 = highest risk). Therefore, we generated a multivariate, cumulative logit model to test the adjusted odds ratio (AOR) of receiving a lower-quality kidney relative to the defined reference groupings. Binary logistic models were utilized for the ECD designation as the dependent variable. Variables of interest included recipient age, recipient gender, recipient race/ethnic group, OPTN region, primary diagnosis, and primary insurance type. The model was additionally adjusted for waiting time on dialysis, recipient PRA level, and blood type. We also examined the interaction of recipient race (limited to non-Hispanic Caucasian and African American) and recipient age for the outcome of receiving a lower-grade kidney. In a separate adjusted Cox proportional hazard model, we examined the interaction of donor and recipient race for the outcome of overall graft loss. χ2 tests were used to test the unadjusted independence of recipient characteristics with donor characteristics. Survival models were censored by the last individual follow-up variable available in database, with the last period through July 2003. Hypothesis tests and confidence intervals (CI) used 0.05 as the type I error level. All analyses were conducted using SAS v.9.1 (Cary, NC).

Results

The overall distribution of deceased-donor kidneys by grade was 11.1% (I), 32.5% (II), 34.4% (III), 17.0% (IV), and 5.1% (V). ECD transplants represented 16.2% of the cohort. Figure 1 provides the distribution of donor risk groups by recipient age. More than 50% of recipients aged 18 to 24 yr received a kidney from the two lowest risk grades, as compared with 38% of individuals aged 65 yr or older who received a similar quality kidney (P < 0.001). Over the same period, only 1.6% of recipients aged 18 to 24 yr received the highest risk level organ (grade V), whereas 10.8% of recipients aged 65 yr or older received the highest risk level kidney. Almost half (47.4%) of non-Hispanic Caucasian recipients received an organ from the two lowest risk levels (grade I or II). In contrast, 38.4% of their African American and 32.8% of their Asian counterparts received these low risk donations (P < 0.001). More than one third (34.5%) of the grade I kidneys were six-antigen–matched transplants. Recipients with private insurance as their primary payer had a higher rate of receiving kidneys from the two lowest risk grades relative to recipients with Medicare as their primary insurance (45.4% versus 42.8% respectively, P < 0.001). Males and females had similar rates of receiving the two lowest risk grades (43.4% and 43.7% respectively, P = 0.56). Of recipients with a primary diagnosis of diabetes, 44% received a kidney from the two lowest grades, with a similar percent (43.4%) of recipients without diabetes as a primary diagnosis received the same quality level kidneys (P = 0.20). There was also a progressively higher rate of ECD transplants by recipient age: 18 to 24 yr (6.2%), 25 to 34 yr (9.0%), 35 to 44 yr (10.8%), 45 to 54 yr (15.2%), 55 to 64 yr (21.5%), and ≥65 yr (27.6%). The rate of ECD transplants in Asian recipients (18.1%, P = 0.02) and other race groups (20.0%, P = 0.01) were higher relative to non-Hispanic Caucasians (16.0%).

Figure 1.
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Figure 1.

Distribution of recipient age at transplant by donor risk grade.

Table 1 displays the AOR for receiving a lower-quality grade transplant using the five risk strata and the ECD designation by recipient characteristics. There was a progressive, increased likelihood of receiving a higher-risk kidney associated with increased recipient age when adjusting for potential confounding factors. Recipients >65 yr of age had >two-fold greater odds of receiving a lower-grade kidney (AOR = 2.07, CI = 1.86, 2.30) relative to recipients aged 18 to 24 yr. This effect was exacerbated when limited to the ECD criteria, with recipients ≥65 having a >five-fold higher likelihood of receiving a high-risk transplant relative to recipients 18 to 24 yr old. In this same model, as compared with non-Hispanic Caucasians, African Americans had 48% greater odds (AOR = 1.48, CI = 1.42, 1.55), Asians/Pacific Islanders had 76% greater odds (AOR = 1.76, CI = 1.61, 1.92), Hispanics had 19% greater odds (AOR = 1.19, CI = 1.12, 1.26), and other ethnic groups 47% greater odds (AOR = 1.47, CI = 1.26, 1.70) of receiving a lower-grade kidney. However, when using the ECD designation as the response variable, the magnitude of the association of donor risk and race/ethnicity was substantially reduced, but remained statistically significant. Recipient gender was not significantly associated with donor quality in the adjusted model, male recipients (AOR = 1.00, CI = 0.96, 1.03) relative to females. Recipient primary insurance type was significantly associated with donor quality using the five donor grades, but showed no significant association with receipt of an ECD transplant.

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Table 1.

Adjusted OR of receiving a lower-quality, deceased donor kidney by recipient characteristicsa

Figure 2 displays the alignment of transplant regions (15) along with the associated risks for lower-grade donations from the adjusted model. Regions 2 and 9 were associated with the highest risks of receiving a lower-quality organ, while region 8 was associated with the lowest risk. These effects were corroborated using the ECD designation; for regions 1 through 9, respectively, the relative risks for receiving a ECD transplant (with region 5 as reference) were: region 1 (AOR = 1.15; CI = 0.99, 1.34), 2 (AOR = 1.69; CI = 1.53, 1.85), 3 (AOR = 0.81; CI = 0.73, 0.90), 4 (AOR = 0.68; CI = 0.60, 0.77), 6 (AOR = 1.40; CI = 1.22, 1.62), 7 (AOR = 1.37; CI = 1.22, 1.52), 8 (AOR = 0.54; CI = 0.46, 0.63), 9 (AOR = 1.81; CI = 1.61, 2.04), 10 (AOR = 0.88; CI = 0.78, 0.99), 11 (AOR = 1.02; CI = 0.91, 1.15). Regions 2 and 9 had higher rates of kidney discard as compared with the remaining cohort, 16.0% (P < 0.001) and 15.4% (P = 0.003), respectively. The overall discard rate of kidneys over this period was 13.8%. Extended waiting time on pretransplant dialysis was associated with lower donor quality relative to transplants with <6 mo of pretransplant dialysis, (>36 mo on dialysis; AOR = 1.25; CI = 1.18, 1.33). Stratifying the analysis by patients with shorter (<12 mo) and longer (>36 mo) dialysis times revealed consistent significant associations. In a similar fashion, repeating the analysis limited to recipients with a peak PRA level of zero resulted in consistent results.

Figure 2.
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Figure 2.

Adjusted odds ratio for receiving a lower-quality grade kidney by Organ Procurement and Transplantation Network (OPTN) region. Model also adjusted for recipient primary insurance type, recipient age, recipient race/ethnicity, time on dialysis, recipient gender, recipient primary diagnosis, and recipient panel reactive antibody level.

We examined individual donor characteristics by recipient race/ethnic groups (as displayed in Table 2). Asian (17.6%, P = 0.04) and other race/ethnic groups (18.9%, P = 0.04) recipients had significantly higher probability of receiving an older donor kidney among racial groups relative to non-Hispanic Caucasians (15.8%). Other race/ethnic (23.6%, P = 0.01), Asian (22.8%, P < 0.001), and African American (21.9%, P < 0.001) individuals received transplants from donors with a history of hypertension more frequently than non-Hispanic Caucasians (19.0%). The rate of transplants with 4 to 6 HLA mismatches was significantly higher in Asian (74.8%, P < 0.001), other race/ethnic (65.1%, P < 0.001), and African American (64.7%, P < 0.001) recipients relative to non-Hispanic Caucasians (42.5%). African Americans were more than three times as likely to receive a donation from an African American donor relative to non-Hispanic Caucasians (21.2% versus 6.5%, P < 0.001).

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Table 2.

Donor risk characteristics by recipient race/ethnic grouping

Results of the adjusted model for overall graft loss by donor and recipient race combinations (for African Americans and non-Hispanic Caucasians only) indicated that African American donations were significantly associated with increased graft loss for both non-Hispanic Caucasians and African American recipients. Non-Hispanic Caucasian recipients were 24% more likely to incur graft loss over the study period when transplanted with an African American donor kidney (adjusted hazard ratio [AHR] = 1.24; CI = 1.17, 1.31). African American recipients with a Caucasian donation had a greater risk for graft loss (AHR = 1.23; CI = 1.12, 1.36) relative to non-Hispanic Caucasian recipients, but an even more elevated risk (AHR = 1.44; CI = 1.33, 1.56) with an African American donation. Additionally, African Americans had significantly lower graft survival relative to Caucasians, limiting transplants to the highest donor grade I (AHR = 1.34; CI = 1.11, 1.62).

Discussion

The principal study findings indicated that significant disparities in the quality of deceased donor transplants existed for recipients by (i) age; (ii) race/ethnicity, (iii) and region of the country. Older recipients were progressively more likely to receive lower quality donations. Certain minority groups were more likely to receive lower-quality organs, which was largely due to lower rates of HLA-matching. OPTN regions 2 and 9 had the highest risk for lower-quality organs in the country.

The disparity in donor organ quality by recipient age suggests that allocation processes beyond those outlined in national policy play a significant role in determining donor and recipient match. As age is not a factor in allocation for adult patients, the observed disparities are likely a function of noncodified processes. These alternative processes potentially include patient consent as well as physician and center selection. One explanation for our observations is that a tacit policy of steering lower-quality organs to older age recipients is practiced at a local or center level. It is possible that older patients, who are sicker on average, are also more likely to accept lower quality organs as an alternative to remaining on dialysis. The progressive association of lower donor quality with older recipients appeared to be consistent in all donor grades, with the possible exception of the lowest-risk organs (grade I). As more than one third of the grade I organs were 6-antigen–matched transplants, this may suggest that this policy deters some of the local distribution patterns. This association was even stronger when utilizing the ECD designation as the effects appear strongest among the highest-risk organs. Our results were also congruent when restricting the study population to recipients that were not sensitized, constituting a more homogenous cohort that was not as limited by donor cross-match. The ECD policy, implemented in late 2002, voluntarily consents patients to receive high-risk kidneys, and was considered to result in shorter waiting times for these transplants. Our findings indicated that older recipients were more likely to receive high-risk organs before implementation of this policy. How this policy will affect future allocation patterns may depend on the manner by which candidates are consented to receive these higher risk organs. However, as donor risk represents a wide continuum of quality beyond the ECD designation, alternative processes will likely continue to influence allocation. As the association of donor quality and recipient age is relatively strong and progressive, this may suggest that there is some degree of matching higher-quality kidneys with younger patients with longer expected survival. In fact, recent research has suggested that there may be significant utilitarian and economic benefits from this mechanism of allocation (16). Although this relationship may be justified in certain circumstances, the question remains whether it would be useful to standardize this process more rigorously (allocating kidneys based on age or survival expectancy) rather than leave this to variable application and other subjective criteria that could potentially detrimentally affect those groups with access barriers. Additional factors associated with patient access to higher quality of care among this population not ascertainable in this analysis may include education and income levels, and those candidates more proactive and involved in the transplant process. In addition, physician perceptions of patients’ social support network or patients’ proclivity to be noncompliant with medication regimens may also contribute to observed disparities.

A certain degree of variation is probably to be expected across the eleven transplant regions due to demographic variations in the population as well as differences in the medical communities. The risk level for lower-quality donations also appeared to correlate with the regions with extended waiting times. Region 9 had an elevated risk of lower-quality donation and also had the longest waiting time for transplant from a 2004 OPTN report (17). According to this report, among patients with type O blood who were wait-listed in 1997 and 1998, the median waiting time in region 9 for a transplant was 7.1 yr, whereas no other region reported a waiting time >5.1 yr. Conversely, region 8, which represented the lowest donor risk among all regions, had the shortest waiting time for transplant at 2.6 yr. As time on dialysis confers a heightened risk for patient death and future graft loss, it is possible that patients with longer waiting times may be less selective regarding organ quality (18). However, as regions with lower-quality transplants also had higher discard rates, it may not simply be heightened selectivity that drives the variability in regional quality. This is in no way an indictment of procurement or transplant practice in particular regions; in fact, significant variation likely exists at a much more granular level within each region. However, the question arises whether the regional networks could be more optimally aligned to balance donor quality across geographic areas. Potential recipients who are cognizant of these issues may gain significant advantages by listing (or multiple-listing) in areas with lower waiting times and higher donor quality relative to those without this knowledge. Clearly this is a complex issue, and beyond the scope of this analysis, but it is important to recognize donor quality when considering regional alignment, equity, and allocation policy.

Results utilizing the five-level donor-risk strata suggest a relatively large association between donor quality and race/ethnic group; however, when utilizing the ECD criteria, which incorporates neither impact of HLA-matching nor donor race, the magnitude of the effect was substantially decreased. HLA-matching has previously been documented to disproportionately negatively impact outcomes in African Americans (5,19). The lower availability of potential HLA-matched organs for minority groups has been addressed previously, and recently the elimination of allocation points for the B antigen (other than for 6-antigen matches) is thought to ameliorate some degree of racial disparities (20,21). In addition, there have been considerable efforts to increase donation rates among minorities, which would also likely help rectify quality disparities. One implication of our results could be that further de-emphasis or elimination of HLA-matching in allocation policy would reduce the disparity of donor quality by race. As the benefit of matched antigens to the recipient is partially driven by decreased waiting time through the allocation point system, the effect of reducing its effect should result in more equitable distribution. In addition, this policy change could have the secondary effect of allowing for better management of the waiting list given more fixed knowledge concerning the priority of candidates and more transparent patient information regarding their expected time to transplant. However, the dynamic relationship between overall utility of resources and equitable distribution are often competing interests, and as HLA-matching has always been associated with increased graft survival, such amendments must be balanced with potential deleterious effects. Another contribution to the disparities in quality derives from the allocation of deceased-donor transplants from African Americans. African American kidneys have previously been reported as a risk factor for graft loss (22,23). Findings from this study demonstrated that this risk is present among African American recipients, yet African American donations are disproportionately allocated to African American recipients. This association may be affected by geographic factors as well as HLA-matching. Whether realigned transplant regions would ameliorate these disparities is another important consideration for allocation policy. Our analysis does not imply that outcomes among racial and ethnic groups could be equated with a shift in allocation policy alone, as our results indicated that outcomes among African American recipients were diminished relative to Caucasians even with the highest donor quality.

Equitable access to healthcare is a pervasive issue in our society, with economic, ethical, and sociological implications. The ESRD population in the US has grown substantially over the past 20 yr and access to appropriate health care services for this population is a growing societal concern. There have been limited improvements in deceased-donor transplant rates over the past decade despite valiant efforts to bridge the growing chasm between the need for transplantation and available organs. One of the implications of this disparity is the growing value of the available donations. While alternative allocation strategies likely exist that enhance the overall graft survival of this population, the implications for particular subgroups must always be considered. Allocation policy and donor quality are complex issues that elicit highly asymmetric knowledge between patients and caregivers. In this sense, much of the responsibility to ensure equitable and standardized processes rests with the transplant community. One of the challenging paradoxes concerning allocation policy is that for individual patients there is significant incentive to acquire the highest-quality donor organs, but from a collective utilitarian perspective, the use of all donatious (including higher-risk organs) is beneficial to this population as a whole (24). As we have argued, transplantation represents a wide spectrum of access potential, and policies that govern allocation should consider the aspect of donor quality with all equitable considerations.

Acknowledgments

The data reported here have been supplied by the University Renal Research and Education Association (URREA) as the contractor for the Scientific Registry of Transplant Recipients (SRTR). The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as an official policy of or interpretation by the SRTR or the US government. Institutional Review Board approval or exemption determination is the responsibility of the authors as well.

This material is the result of work supported with resources and the use of the facilities at the Department of Veterans Affairs Health Services Research and Development/Rehabilitation Research and Development/Rehabilitation Outcomes Research Center, North Florida/South Georgia Veterans Health System.

A portion of this material was presented as an oral abstract at the annual American Transplant Congress in Seattle, WA, May 21 to 25, 2005.

Footnotes

  • Published online ahead of print. Publication date available at www.jasn.org.

  • © 2005 American Society of Nephrology

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Journal of the American Society of Nephrology: 16 (10)
Journal of the American Society of Nephrology
Vol. 16, Issue 10
1 Oct 2005
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Access to Quality: Evaluation of the Allocation of Deceased Donor Kidneys for Transplantation
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Access to Quality: Evaluation of the Allocation of Deceased Donor Kidneys for Transplantation
Jesse D. Schold, Bruce Kaplan, Neale R. Chumbler, Richard J. Howard, Titte R. Srinivas, Linan Ma, Herwig-Ulf Meier-Kriesche
JASN Oct 2005, 16 (10) 3121-3127; DOI: 10.1681/ASN.2005050517

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Access to Quality: Evaluation of the Allocation of Deceased Donor Kidneys for Transplantation
Jesse D. Schold, Bruce Kaplan, Neale R. Chumbler, Richard J. Howard, Titte R. Srinivas, Linan Ma, Herwig-Ulf Meier-Kriesche
JASN Oct 2005, 16 (10) 3121-3127; DOI: 10.1681/ASN.2005050517
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More in this TOC Section

  • Immunosuppressant Medication Use in Patients with Kidney Allograft Failure: A Prospective Multicenter Canadian Cohort Study
  • Mycophenolate Mofetil versus Azathioprine for Prevention of Chronic Allograft Dysfunction in Renal Transplantation: The MYSS Follow-Up Randomized, Controlled Clinical Trial
  • Hemodialysis Vintage, Black Ethnicity, and Pretransplantation Antidonor Cellular Immunity in Kidney Transplant Recipients
Show more Clinical Transplantation

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  • Barriers to Evaluation and Wait Listing for Kidney Transplantation
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  • Race and Kidney Disease Outcomes: Genes or Environment?
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